LOCUS       NM_021442               1263 bp    mRNA    linear   ROD 12-AUG-2025
DEFINITION  Mus musculus MDS1 and EVI1 complex locus (Mecom), transcript
            variant 2, mRNA.
ACCESSION   NM_021442
VERSION     NM_021442.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1263)
  AUTHORS   Morikawa,T., Fujita,S., Sugiura,Y., Tamaki,S., Haraguchi,M.,
            Shiroshita,K., Watanuki,S., Kobayashi,H., Kanai-Sudo,H., Naito,Y.,
            Hayakawa,N., Matsuura,T., Hishiki,T., Matsui,M., Tsutsui,M.,
            Suematsu,M. and Takubo,K.
  TITLE     Decreased non-neurogenic acetylcholine in bone marrow triggers
            age-related defective stem/progenitor cell homing
  JOURNAL   Nat Commun 16 (1), 5475 (2025)
   PUBMED   40593589
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1263)
  AUTHORS   He,H., Bell,S.M., Davis,A.K., Zhao,S., Sridharan,A., Na,C.L.,
            Guo,M., Xu,Y., Snowball,J., Swarr,D.T., Zacharias,W.J. and
            Whitsett,J.A.
  TITLE     PRDM3/16 regulate chromatin accessibility required for NKX2-1
            mediated alveolar epithelial differentiation and function
  JOURNAL   Nat Commun 15 (1), 8112 (2024)
   PUBMED   39284798
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1263)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1263)
  AUTHORS   Nagai,K., Niihori,T., Muto,A., Hayashi,Y., Abe,T., Igarashi,K. and
            Aoki,Y.
  TITLE     Mecom mutation related to radioulnar synostosis with
            amegakaryocytic thrombocytopenia reduces HSPCs in mice
  JOURNAL   Blood Adv 7 (18), 5409-5420 (2023)
   PUBMED   37099686
  REMARK    GeneRIF: Mecom mutation related to radioulnar synostosis with
            amegakaryocytic thrombocytopenia reduces HSPCs in mice.
REFERENCE   5  (bases 1 to 1263)
  AUTHORS   Qu,F., Li,W., Xu,J., Zhang,R., Ke,J., Ren,X., Meng,X., Qin,L.,
            Zhang,J., Lu,F., Zhou,X., Luo,X., Zhang,Z., Wang,M., Wu,G., Pei,D.,
            Chen,J., Cui,G., Suo,S. and Peng,G.
  TITLE     Three-dimensional molecular architecture of mouse organogenesis
  JOURNAL   Nat Commun 14 (1), 4599 (2023)
   PUBMED   37524711
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1263)
  AUTHORS   Lock,L.F., Pines,J., Hunter,T., Gilbert,D.J., Gopalan,G.,
            Jenkins,N.A., Copeland,N.G. and Donovan,P.J.
  TITLE     A single cyclin A gene and multiple cyclin B1-related sequences are
            dispersed in the mouse genome
  JOURNAL   Genomics 13 (2), 415-424 (1992)
   PUBMED   1535334
REFERENCE   7  (bases 1 to 1263)
  AUTHORS   Chen,C.Y., Salles,G., Seldin,M.F., Kister,A.E., Reinherz,E.L. and
            Shipp,M.A.
  TITLE     Murine common acute lymphoblastic leukemia antigen (CD10 neutral
            endopeptidase 24.11). Molecular characterization, chromosomal
            localization, and modeling of the active site
  JOURNAL   J Immunol 148 (9), 2817-2825 (1992)
   PUBMED   1374101
REFERENCE   8  (bases 1 to 1263)
  AUTHORS   Spitkovsky,D.D., Royer-Pokora,B., Delius,H., Kisseljov,F.,
            Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and Royer,H.D.
  TITLE     Tissue restricted expression and chromosomal localization of the
            YB-1 gene encoding a 42 kD nuclear CCAAT binding protein
  JOURNAL   Nucleic Acids Res 20 (4), 797-803 (1992)
   PUBMED   1542575
REFERENCE   9  (bases 1 to 1263)
  AUTHORS   Morishita,K., Parganas,E., Matsugi,T. and Ihle,J.N.
  TITLE     Expression of the Evi-1 zinc finger gene in 32Dc13 myeloid cells
            blocks granulocytic differentiation in response to granulocyte
            colony-stimulating factor
  JOURNAL   Mol Cell Biol 12 (1), 183-189 (1992)
   PUBMED   1370341
REFERENCE   10 (bases 1 to 1263)
  AUTHORS   Siracusa,L.D., Rosner,M.H., Vigano,M.A., Gilbert,D.J., Staudt,L.M.,
            Copeland,N.G. and Jenkins,N.A.
  TITLE     Chromosomal location of the octamer transcription factors, Otf-1,
            Otf-2, and Otf-3, defines multiple Otf-3-related sequences
            dispersed in the mouse genome
  JOURNAL   Genomics 10 (2), 313-326 (1991)
   PUBMED   1676977
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC119995.22 and AL691419.10.
            
            On Feb 24, 2018 this sequence version replaced NM_021442.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ010015.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               AC119995.22        82910-83155         c
            247-590             AL691419.10        196756-197099
            591-1263            AL691419.10        197836-198508
FEATURES             Location/Qualifiers
     source          1..1263
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 12.66 cM"
     gene            1..1263
                     /gene="Mecom"
                     /gene_synonym="D630039M04Rik; Evi-1; Evi1; Jbo; Mds; Mds1;
                     Mds1-Evi1; Prdm3; Znfpr1b1"
                     /note="MDS1 and EVI1 complex locus"
                     /db_xref="GeneID:14013"
                     /db_xref="MGI:MGI:95457"
     exon            1..246
                     /gene="Mecom"
                     /gene_synonym="D630039M04Rik; Evi-1; Evi1; Jbo; Mds; Mds1;
                     Mds1-Evi1; Prdm3; Znfpr1b1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    174..176
                     /gene="Mecom"
                     /gene_synonym="D630039M04Rik; Evi-1; Evi1; Jbo; Mds; Mds1;
                     Mds1-Evi1; Prdm3; Znfpr1b1"
                     /note="upstream in-frame stop codon"
     CDS             210..599
                     /gene="Mecom"
                     /gene_synonym="D630039M04Rik; Evi-1; Evi1; Jbo; Mds; Mds1;
                     Mds1-Evi1; Prdm3; Znfpr1b1"
                     /EC_number="2.1.1.367"
                     /note="isoform 2 is encoded by transcript variant 2; MDS1
                     and EVI1 complex locus protein EVI1; MDS1 and EVI1 complex
                     locus protein MDS1; myelodysplasia syndrome 1 protein
                     homolog; ecotropic virus integration site 1 protein;
                     ecotropic viral integration site 1; histone-lysine
                     N-methyltransferase MECOM"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase MECOM isoform
                     2"
                     /protein_id="NP_067417.1"
                     /db_xref="GeneID:14013"
                     /db_xref="MGI:MGI:95457"
                     /translation="

MRSKGRARKLATSNECAYGNYPEIPLEEMPDADADGITSVPSLHIQEPCSPATSSESFTPKEGSPYKAPIYIPDDIPIPDEFELRESTMPGAGLGIWTKRKIEIGEKFGPYMGEQRSDLKDSSYGWENR"

     misc_feature    273..413
                     /gene="Mecom"
                     /gene_synonym="D630039M04Rik; Evi-1; Evi1; Jbo; Mds; Mds1;
                     Mds1-Evi1; Prdm3; Znfpr1b1"
                     /note="propagated from UniProtKB/Swiss-Prot (P14404.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    354..>590
                     /gene="Mecom"
                     /gene_synonym="D630039M04Rik; Evi-1; Evi1; Jbo; Mds; Mds1;
                     Mds1-Evi1; Prdm3; Znfpr1b1"
                     /note="SET (Su(var)3-9, Enhancer-of-zeste, Trithorax)
                     domain superfamily; Region: SET; cl40432"
                     /db_xref="CDD:394802"
     exon            247..590
                     /gene="Mecom"
                     /gene_synonym="D630039M04Rik; Evi-1; Evi1; Jbo; Mds; Mds1;
                     Mds1-Evi1; Prdm3; Znfpr1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            591..1263
                     /gene="Mecom"
                     /gene_synonym="D630039M04Rik; Evi-1; Evi1; Jbo; Mds; Mds1;
                     Mds1-Evi1; Prdm3; Znfpr1b1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gaaagagagagagggagggagagagagtgaaagaccgagtgtgtgcgtgtgtgtgcgtgtgtgagacagaggagagagagagagagagagagagagagagagagagagagagagagagaagggagggggagagagagagcaaaagaaggaaaagatccaagaaaaaaaaaacctaaccacccagcagcggctgcaggactgggcacagcatgagatccaaaggcagggcaaggaaactggccacaagtaatgagtgtgcctatggcaactatcctgaaatacctttggaagaaatgccagatgctgatgcagatgggataaccagtgttccctccctccacattcaagagccatgctctcctgcgacgtccagtgagtcatttactcctaaggagggctcgccatacaaagctcccatctacatccctgatgacatccctattcctgatgagtttgagcttcgagagtcaactatgcctggagcaggacttggaatatggaccaaaaggaagattgaaataggcgaaaagtttgggccatacatgggagagcagagatcagacctgaaagattccagctatggatgggagaacaggtgatgtgcagttctcagttcattactttcttcacccttttgtgccagtacagtatgtaaatatacacattatattaagtttgcttttattttcattgcttgaaatggagttttatttaattgaccacatcagcctggaaccctcactcctgattcatcgtcccagtgcatgctgagactacagacatatgctatcaagcctggcttacttctatagtttgaaaaatgtcgtgactaaatcaaaccatcataatttctggataatctggtctacagcagagcagcttgtaggccacctcggcataggtaagaggaggtcatggagctgtgagagagctttccctttataatatttcagctggatggaaatcagataagcaggattcattttgctatactctcttaatatttatgaccattaatagaatatctgcttagctttatgtagaagtgaatatgcagtacctgcaggatgtaattatttcatctttttgtccccttgtaaaatgtactcgaaattctataatggaaacagcctcactcaaatctgaaatgacagaggctaagttcttgattggacatgattgcacatgagcgtgccttctgtagttttgtccctggacacatccttgggaaggctgtggcttagtaaaatgacttttagacac

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