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Previous release (v1)
2024-06-29 20:23:09, GGRNA.v2 : RefSeq release 224 (May, 2024)
LOCUS NM_013658 3224 bp mRNA linear ROD 19-MAR-2024
DEFINITION Mus musculus sema domain, immunoglobulin domain (Ig), transmembrane
domain (TM) and short cytoplasmic domain, (semaphorin) 4A (Sema4a),
transcript variant 1, mRNA.
ACCESSION NM_013658
VERSION NM_013658.3
KEYWORDS RefSeq; RefSeq Select.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 3224)
AUTHORS Naito,Y., Koyama,S., Masuhiro,K., Hirai,T., Uenami,T., Inoue,T.,
Osa,A., Machiyama,H., Watanabe,G., Sax,N., Villa,J.,
Kinugasa-Katayama,Y., Nojima,S., Yaga,M., Hosono,Y., Okuzaki,D.,
Satoh,S., Tsuda,T., Nakanishi,Y., Suga,Y., Morita,T., Fukushima,K.,
Nishide,M., Shiroyama,T., Miyake,K., Iwahori,K., Hirata,H.,
Nagatomo,I., Yano,Y., Tamiya,M., Kumagai,T., Takemoto,N.,
Inohara,H., Yamasaki,S., Yamashita,K., Aoshi,T., Akbay,E.A.,
Hosen,N., Shintani,Y., Takamatsu,H., Mori,M., Takeda,Y. and
Kumanogoh,A.
TITLE Tumor-derived semaphorin 4A improves PD-1-blocking antibody
efficacy by enhancing CD8+ T cell cytotoxicity and proliferation
JOURNAL Sci Adv 9 (20), eade0718 (2023)
PUBMED 37205755
REFERENCE 2 (bases 1 to 3224)
AUTHORS Martins,L.F., Brambilla,I., Motta,A., de Pretis,S., Bhat,G.P.,
Badaloni,A., Malpighi,C., Amin,N.D., Imai,F., Almeida,R.D.,
Yoshida,Y., Pfaff,S.L. and Bonanomi,D.
TITLE Motor neurons use push-pull signals to direct vascular remodeling
critical for their connectivity
JOURNAL Neuron 110 (24), 4090-4107 (2022)
PUBMED 36240771
REFERENCE 3 (bases 1 to 3224)
AUTHORS Xu,R., Hoss,C., Swiercz,J.M., Brandt,D.T., Lutz,V., Petersen,N.,
Li,R., Zhao,D., Oleksy,A., Creigh-Pulatmen,T., Trokter,M.,
Fedorova,M., Atzberger,A., Strandby,R.B., Olsen,A.A., Achiam,M.P.,
Matthews,D., Huber,M., Grone,H.J., Offermanns,S. and Worzfeld,T.
TITLE A semaphorin-plexin-Rasal1 signaling pathway inhibits gastrin
expression and protects against peptic ulcers
JOURNAL Sci Transl Med 14 (654), eabf1922 (2022)
PUBMED 35857828
REFERENCE 4 (bases 1 to 3224)
AUTHORS Suga,Y., Nagatomo,I., Kinehara,Y., Koyama,S., Okuzaki,D., Osa,A.,
Naito,Y., Takamatsu,H., Nishide,M., Nojima,S., Ito,D., Tsuda,T.,
Nakatani,T., Nakanishi,Y., Futami,Y., Koba,T., Satoh,S., Hosono,Y.,
Miyake,K., Fukushima,K., Shiroyama,T., Iwahori,K., Hirata,H.,
Takeda,Y. and Kumanogoh,A.
TITLE IL-33 Induces Sema4A Expression in Dendritic Cells and Exerts
Antitumor Immunity
JOURNAL J Immunol 207 (5), 1456-1467 (2021)
PUBMED 34380650
REFERENCE 5 (bases 1 to 3224)
AUTHORS Limoni,G., Murthy,S., Jabaudon,D., Dayer,A. and Niquille,M.
TITLE PlexinA4-Semaphorin3A-mediated crosstalk between main cortical
interneuron classes is required for superficial interneuron
lamination
JOURNAL Cell Rep 34 (4), 108644 (2021)
PUBMED 33503438
REFERENCE 6 (bases 1 to 3224)
AUTHORS Oster,S.F., Bodeker,M.O., He,F. and Sretavan,D.W.
TITLE Invariant Sema5A inhibition serves an ensheathing function during
optic nerve development
JOURNAL Development 130 (4), 775-784 (2003)
PUBMED 12506007
REFERENCE 7 (bases 1 to 3224)
AUTHORS Dionne,M.S., Brunet,L.J., Eimon,P.M. and Harland,R.M.
TITLE Noggin is required for correct guidance of dorsal root ganglion
axons
JOURNAL Dev Biol 251 (2), 283-293 (2002)
PUBMED 12435358
REFERENCE 8 (bases 1 to 3224)
AUTHORS Kumanogoh,A., Marukawa,S., Suzuki,K., Takegahara,N., Watanabe,C.,
Ch'ng,E., Ishida,I., Fujimura,H., Sakoda,S., Yoshida,K. and
Kikutani,H.
TITLE Class IV semaphorin Sema4A enhances T-cell activation and interacts
with Tim-2
JOURNAL Nature 419 (6907), 629-633 (2002)
PUBMED 12374982
REFERENCE 9 (bases 1 to 3224)
AUTHORS Puschel,A.W., Adams,R.H. and Betz,H.
TITLE The sensory innervation of the mouse spinal cord may be patterned
by differential expression of and differential responsiveness to
semaphorins
JOURNAL Mol Cell Neurosci 7 (5), 419-431 (1996)
PUBMED 8812066
REFERENCE 10 (bases 1 to 3224)
AUTHORS Puschel,A.W., Adams,R.H. and Betz,H.
TITLE Murine semaphorin D/collapsin is a member of a diverse gene family
and creates domains inhibitory for axonal extension
JOURNAL Neuron 14 (5), 941-948 (1995)
PUBMED 7748561
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BY201883.1, AK153164.1 and AK077976.1.
On Jul 22, 2009 this sequence version replaced NM_013658.2.
Transcript Variant: This variant (1) represents the longest
transcript. All four variants encode the same protein.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK154392.1, AK077976.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMN00849374,
SAMN00849375 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-9 BY201883.1 2-10
10-1808 AK153164.1 2-1800
1809-2096 AK077976.1 1790-2077
2097-2976 AK153164.1 2089-2968
2977-3224 AK077976.1 2958-3205
FEATURES Location/Qualifiers
source 1..3224
/organism="Mus musculus"
/mol_type="mRNA"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="3"
/map="3 38.83 cM"
gene 1..3224
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="sema domain, immunoglobulin domain (Ig),
transmembrane domain (TM) and short cytoplasmic domain,
(semaphorin) 4A"
/db_xref="GeneID:20351"
/db_xref="MGI:MGI:107560"
exon 1..214
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
misc_feature 118..120
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="upstream in-frame stop codon"
exon 215..382
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
CDS 244..2526
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="semaphorin-4A; sema B; semaphorin-B"
/codon_start=1
/product="semaphorin-4A precursor"
/protein_id="NP_038686.3"
/db_xref="CCDS:CCDS17475.1"
/db_xref="GeneID:20351"
/db_xref="MGI:MGI:107560"
/translation="
MALPSLGQDSWSLLRVFFFQLFLLPSLPPASGTGGQGPMPRVKYHAGDGHRALSFFQQKGLRDFDTLLLSDDGNTLYVGAREAVLALNIQNPGIPRLKNMIPWPASERKKTECAFKKKSNETQCFNFIRVLVSYNATHLYACGTFAFSPACTFIELQDSLLLPILIDKVMDGKGQSPFDPVHKHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDIFLRWLHADASFVAAIPSTQVVYFFFEETASEFDFFEELYISRVAQVCKNDVGGEKLLQKKWTTFLKAQLLCAQPGQLPFNIIRHAVLLPADSPSVSRIYAVFTSQWQVGGTRSSAVCAFSLTDIERVFKGKYKELNKETSRWTTYRGSEVSPRPGSCSMGPSSDKALTFMKDHFLMDEHVVGTPLLVKSGVEYTRLAVESARGLDGSSHVVMYLGTSTGSLHKAVVPQDSSAYLVEEIQLSPDSEPVRNLQLAPAQGAVFAGFSGGIWRVPRANCSVYESCVDCVLARDPHCAWDPESRLCSLLSGSTKPWKQDMERGNPEWVCTRGPMARSPRRQSPPQLIKEVLTVPNSILELPCPHLSALASYHWSHGRAKISEASATVYNGSLLLLPQDGVGGLYQCVATENGYSYPVVSYWVDSQDQPLALDPELAGVPRERVQVPLTRVGGGASMAAQRSYWPHFLIVTVLLAIVLLGVLTLLLASPLGALRARGKVQGCGMLPPREKAPLSRDQHLQPSKDHRTSASDVDADNNHLGAEVA"
sig_peptide 244..339
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="COORDINATES: ab initio prediction:SignalP:6.0"
mat_peptide 340..2523
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/product="Semaphorin-4A. /id=PRO_0000032323"
/note="propagated from UniProtKB/Swiss-Prot (Q62178.2)"
misc_feature 406..1728
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="The Sema domain, a protein interacting module, of
semaphorins and plexins; Region: Sema; cl15693"
/db_xref="CDD:472829"
misc_feature 601..603
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q62178.2); glycosylation site"
misc_feature 646..648
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q62178.2); glycosylation site"
misc_feature 1729..1863
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="domain found in Plexins, Semaphorins and Integrins;
Region: PSI; smart00423"
/db_xref="CDD:214655"
misc_feature 1729..1731
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q62178.2); glycosylation site"
misc_feature 1951..2154
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="Immunoglobulin domain; Region: Ig; cl11960"
/db_xref="CDD:472250"
misc_feature 1966..1980
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="Ig strand B [structural motif]; Region: Ig strand
B"
/db_xref="CDD:409456"
misc_feature 2002..2016
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="Ig strand C [structural motif]; Region: Ig strand
C"
/db_xref="CDD:409456"
misc_feature 2059..2073
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="Ig strand E [structural motif]; Region: Ig strand
E"
/db_xref="CDD:409456"
misc_feature 2059..2061
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q62178.2); glycosylation site"
misc_feature 2101..2118
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="Ig strand F [structural motif]; Region: Ig strand
F"
/db_xref="CDD:409456"
misc_feature 2290..2352
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="propagated from UniProtKB/Swiss-Prot (Q62178.2);
transmembrane region"
misc_feature 2401..2523
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="propagated from UniProtKB/Swiss-Prot (Q62178.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
exon 383..543
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
exon 544..606
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
exon 607..705
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
exon 706..811
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
exon 812..928
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
exon 929..1053
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
exon 1054..1226
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
exon 1227..1377
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
exon 1378..1558
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
exon 1559..1677
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
exon 1678..1835
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
exon 1836..1933
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
exon 1934..3224
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
ORIGIN
aagccagccaggatctgtcacaactcgaggtagaaattctggtttccctggcctgaaacccacactggctctggcaggatgggtgcctggagggccgcgcgcccgttccagccaggctgagcctgcttgccttgcctggacccccttctttgcctcggatggcaccctgattcagggtttgaacacaggacttctcagtgtggctggctcaaggaaccatctggtgaccatctcaggctgaccatggccctaccatccctgggccaggactcatggagtctcctgcgtgtttttttcttccaactcttcctgctgccatcactgccacctgcttctgggactggtggtcaggggcccatgcccagagtcaaataccatgctggagacgggcacagggccctcagcttcttccaacaaaaaggcctccgagactttgacacgctgctcctgagtgacgatggcaacactctctatgtgggggctcgagaggccgtcctggccttgaatatccagaacccaggaatcccaaggctaaagaacatgataccctggccagccagtgagagaaaaaagaccgaatgtgcctttaagaagaagagcaatgagacacagtgtttcaacttcattcgagtcctggtctcttacaatgctactcacctctatgcctgtgggacctttgccttcagccctgcctgtaccttcattgaactccaagattccctcctgttgcccatcttgatagacaaggtcatggacgggaagggccaaagcccctttgaccctgttcacaagcacacagctgtcttggtcgatgggatgctttattccggcaccatgaacaacttcctgggcagcgagcccatcctgatgcggacactgggatcccagcctgttctcaagactgacatcttcttacgctggctgcacgcggatgcctccttcgtggcagccattccatccacccaggtcgtctatttcttctttgaggagacagccagcgagtttgacttctttgaagagctgtatatatccagggtggctcaagtctgcaagaacgacgtgggcggtgaaaagctgctgcagaagaagtggaccaccttcctcaaagcccagttgctctgcgctcagccagggcagctgccattcaacatcatccgccacgcggtcctgctgcccgccgattctccctctgtttcccgcatctacgcagtctttacctcccagtggcaggttggcgggaccaggagctcagcagtctgtgccttctctctcacggacattgagcgagtctttaaagggaagtacaaggagctgaacaaggagacctcccgctggaccacttaccggggctcagaggtcagcccgaggccaggcagttgctccatgggcccctcctctgacaaagccttgaccttcatgaaggaccattttctgatggatgagcacgtggtaggaacacccctgctggtgaagtctggtgtggagtacacacggcttgctgtggagtcagctcggggccttgatgggagcagccatgtggtcatgtatctgggtacctccacggggtccctgcacaaggctgtggtgcctcaggacagcagtgcttatctcgtggaggagattcagctgagccctgactctgagcctgttcgaaacctgcagctggcccccgcccagggtgcagtgtttgcaggcttctctggaggcatctggagagttcccagggccaattgcagtgtctacgagagctgtgtggactgtgtgcttgccagggaccctcactgtgcctgggaccctgaatcaagactctgcagccttctgtctggctctaccaagccttggaagcaggacatggaacgcggcaacccggagtgggtatgcacccgtggccccatggccaggagcccccggcgtcagagcccccctcaactaattaaagaagtcctgacagtccccaactccatcctggagctgccctgcccccacctgtcagcactggcctcttaccactggagtcatggccgagccaaaatctcagaagcctctgctaccgtctacaatggctccctcttgctgctgccgcaggatggtgtcgggggcctctaccagtgtgtggcgactgagaacggctactcataccctgtggtctcctattgggtagacagccaggaccagcccctggcgctggaccctgagctggcgggcgttccccgtgagcgtgtgcaggtcccgctgaccagggtcggaggcggagcttccatggctgcccagcggtcctactggccccattttctcatcgttaccgtcctcctggccatcgtgctcctgggagtgctcactctcctcctcgcttccccactgggggcgctgcgggctcggggtaaggttcagggctgtgggatgctgccccccagggaaaaggctccactgagcagggaccagcacctccagccctccaaggaccacaggacctctgccagtgacgtagatgccgacaacaaccatctgggcgccgaagtggcttaaacagggacacagatccgcagctgagcagagcaagccactggccttgttggctatgccaggcacagtgccactctgaccagggtaggaggctctcctgctaacgtgtgtcacctacagcacccagtaggtcctcccctgtgggactctcttctgcaagcacattgggctgtctccatacctgtacttgtgctgtgacaggaagagccagacaggtttctttgattttgattgacccaagagccctcctgtaacaaacgtgctccaggagaccatgaaaggtgtggctgtctgggattctgtggtgacaaacctaagcatccgagcaagctggggctattcctgcaaactccatcctgaacgctgtcactctagaagcagctgctgctttgaacaccagcccaccctccttcccaagagtctctatggagttggccccttgtgtttcctttaccagtcatgccatactgtttgggaagtcatctctgaagtctaaccaccttccttcttgcttcagtttggacagattgttattattgtctctgccctggctagaatggggggcataatctgagccttgttcccttgtccagtgtggctgacccttgacctcttccttcctcctccctttgttttgggattcagaaaactgcttgtcacagacaatttattttttattaaaaaagatataagctttaaag
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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