LOCUS       NM_010545               1239 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus CD74 antigen (invariant polypeptide of major
            histocompatibility complex, class II antigen-associated) (Cd74),
            transcript variant 2, mRNA.
ACCESSION   NM_010545
VERSION     NM_010545.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1239)
  AUTHORS   Tang,Z., Hu,J., Li,X.C., Wang,W., Zhang,H.Y., Guo,Y.Y., Shuai,X.,
            Chu,Q., Xie,C., Lin,D. and Zhong,B.
  TITLE     A subset of neutrophils activates anti-tumor immunity and inhibits
            non-small-cell lung cancer progression
  JOURNAL   Dev Cell (2024) In press
   PUBMED   39515330
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 1239)
  AUTHORS   Mori,S., Kohyama,M., Yasumizu,Y., Tada,A., Tanzawa,K., Shishido,T.,
            Kishida,K., Jin,H., Nishide,M., Kawada,S., Motooka,D., Okuzaki,D.,
            Naito,R., Nakai,W., Kanda,T., Murata,T., Terao,C., Ohmura,K.,
            Arase,N., Kurosaki,T., Fujimoto,M., Suenaga,T., Kumanogoh,A.,
            Sakaguchi,S., Ogawa,Y. and Arase,H.
  TITLE     Neoself-antigens are the primary target for autoreactive T cells in
            human lupus
  JOURNAL   Cell 187 (21), 6071-6087 (2024)
   PUBMED   39276775
REFERENCE   3  (bases 1 to 1239)
  AUTHORS   Carabana,C., Sun,W., Veludo Ramos,C., Huyghe,M., Perkins,M.,
            Maillot,A., Journot,R., Hartani,F., Faraldo,M.M., Lloyd-Lewis,B.
            and Fre,S.
  TITLE     Spatially distinct epithelial and mesenchymal cell subsets along
            progressive lineage restriction in the branching embryonic mammary
            gland
  JOURNAL   EMBO J 43 (12), 2308-2336 (2024)
   PUBMED   38760574
REFERENCE   4  (bases 1 to 1239)
  AUTHORS   Bonnin,E., Rodrigo Riestra,M., Marziali,F., Mena Osuna,R.,
            Denizeau,J., Maurin,M., Saez,J.J., Jouve,M., Bonte,P.E., Richer,W.,
            Nevo,F., Lemoine,S., Girard,N., Lefevre,M., Borcoman,E.,
            Vincent-Salomon,A., Baulande,S., Moreau,H.D., Sedlik,C., Hivroz,C.,
            Lennon-Dumenil,A.M., Tosello Boari,J. and Piaggio,E.
  TITLE     CD74 supports accumulation and function of regulatory T cells in
            tumors
  JOURNAL   Nat Commun 15 (1), 3749 (2024)
   PUBMED   38702311
  REMARK    GeneRIF: CD74 supports accumulation and function of regulatory T
            cells in tumors.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1239)
  AUTHORS   Liu,L., Wang,J., Wang,Y., Chen,L., Peng,L., Bin,Y., Ding,P.,
            Zhang,R., Tong,F. and Dong,X.
  TITLE     Blocking the MIF-CD74 axis augments radiotherapy efficacy for brain
            metastasis in NSCLC via synergistically promoting microglia M1
            polarization
  JOURNAL   J Exp Clin Cancer Res 43 (1), 128 (2024)
   PUBMED   38685050
  REMARK    GeneRIF: Blocking the MIF-CD74 axis augments radiotherapy efficacy
            for brain metastasis in NSCLC via synergistically promoting
            microglia M1 polarization.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1239)
  AUTHORS   Kolk,D.P. and Floyd-Smith,G.
  TITLE     The HXY box regulatory element modulates expression of the murine
            IA antigen-associated invariant chain in L fibroblasts
  JOURNAL   DNA Cell Biol 11 (10), 745-754 (1992)
   PUBMED   1457043
REFERENCE   7  (bases 1 to 1239)
  AUTHORS   Mock,B.A., Contente,S., Kenyon,K., Friedman,R.M. and Kozak,C.A.
  TITLE     The gene for lysyl oxidase maps to mouse chromosome 18
  JOURNAL   Genomics 14 (3), 822-823 (1992)
   PUBMED   1358813
REFERENCE   8  (bases 1 to 1239)
  AUTHORS   Justice,M.J., Gilbert,D.J., Kinzler,K.W., Vogelstein,B.,
            Buchberg,A.M., Ceci,J.D., Matsuda,Y., Chapman,V.M., Patriotis,C.,
            Makris,A. et al.
  TITLE     A molecular genetic linkage map of mouse chromosome 18 reveals
            extensive linkage conservation with human chromosomes 5 and 18
  JOURNAL   Genomics 13 (4), 1281-1288 (1992)
   PUBMED   1354644
REFERENCE   9  (bases 1 to 1239)
  AUTHORS   Wegener,A.M., Letourneur,F., Hoeveler,A., Brocker,T., Luton,F. and
            Malissen,B.
  TITLE     The T cell receptor/CD3 complex is composed of at least two
            autonomous transduction modules
  JOURNAL   Cell 68 (1), 83-95 (1992)
   PUBMED   1531041
REFERENCE   10 (bases 1 to 1239)
  AUTHORS   Byrd,L., Grossmann,M., Potter,M. and Shen-Ong,G.L.
  TITLE     Chronic multifocal osteomyelitis, a new recessive mutation on
            chromosome 18 of the mouse
  JOURNAL   Genomics 11 (4), 794-798 (1991)
   PUBMED   1686018
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK002232.1 and AW123644.1.
            
            On Jul 22, 2006 this sequence version replaced NM_010545.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC096435.1, AK020607.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1066              AK002232.1         1-1066
            1067-1239           AW123644.1         1-173               c
FEATURES             Location/Qualifiers
     source          1..1239
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 34.41 cM"
     gene            1..1239
                     /gene="Cd74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
                     /note="CD74 antigen (invariant polypeptide of major
                     histocompatibility complex, class II antigen-associated)"
                     /db_xref="GeneID:16149"
                     /db_xref="MGI:MGI:96534"
     exon            1..162
                     /gene="Cd74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..733
                     /gene="Cd74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
                     /note="isoform 2 is encoded by transcript variant 2; H-2
                     class II histocompatibility antigen gamma chain; ia
                     antigen-associated invariant chain; Ia-associated
                     invariant chain; dinucleotide microsatellite; MHC class
                     II-associated invariant chain; class II-associated
                     invariant chain peptide; HLA-DR-GAMMA; histocompatibility:
                     class II antigens, gamma chain of; invariant polypeptide
                     of major histocompatibility complex, class II
                     antigen-associated; ii chain"
                     /codon_start=1
                     /product="H-2 class II histocompatibility antigen gamma
                     chain isoform 2"
                     /protein_id="NP_034675.1"
                     /db_xref="CCDS:CCDS50299.1"
                     /db_xref="GeneID:16149"
                     /db_xref="MGI:MGI:96534"
                     /translation="

MDDQRDLISNHEQLPILGNRPREPERCSRGALYTGVSVLVALLLAGQATTAYFLYQQQGRLDKLTITSQNLQLESLRMKLPKSAKPVSQMRMATPLLMRPMSMDNMLLGPVKNVTKYGNMTQDHVMHLLTRSGPLEYPQLKGTFPENLKHLKNSMDGVNWKIFESWMKQWLLFEMSKNSLEEKKPTEAPPKEPLDMEDLSSGLGVTRQELGQVTL"

     misc_feature    86..421
                     /gene="Cd74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
                     /note="CLIP, MHC2 interacting; Region: MHC2-interact;
                     pfam09307"
                     /db_xref="CDD:462750"
     misc_feature    86..154
                     /gene="Cd74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
                     /note="propagated from UniProtKB/Swiss-Prot (P04441.3);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    110..112
                     /gene="Cd74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319; propagated from
                     UniProtKB/Swiss-Prot (P04441.3); phosphorylation site"
     misc_feature    173..250
                     /gene="Cd74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
                     /note="propagated from UniProtKB/Swiss-Prot (P04441.3);
                     transmembrane region"
     misc_feature    422..424
                     /gene="Cd74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P04441.3); glycosylation site"
     misc_feature    440..637
                     /gene="Cd74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
                     /note="Class II MHC-associated invariant chain
                     trimerization domain; Region: MHCassoc_trimer; pfam08831"
                     /db_xref="CDD:462614"
     misc_feature    440..442
                     /gene="Cd74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P04441.3); glycosylation site"
     exon            163..332
                     /gene="Cd74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
                     /inference="alignment:Splign:2.1.0"
     exon            333..412
                     /gene="Cd74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
                     /inference="alignment:Splign:2.1.0"
     exon            413..475
                     /gene="Cd74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
                     /inference="alignment:Splign:2.1.0"
     exon            476..568
                     /gene="Cd74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
                     /inference="alignment:Splign:2.1.0"
     exon            569..659
                     /gene="Cd74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
                     /inference="alignment:Splign:2.1.0"
     exon            660..722
                     /gene="Cd74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
                     /inference="alignment:Splign:2.1.0"
     exon            723..1223
                     /gene="Cd74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1202..1207
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
                     /note="hexamer: AATAAA"
     polyA_site      1221
                     /gene="Cd74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
                     /note="major polyA site"
ORIGIN      

agacacacagcagcagcagcagcagcagcagcagcaacagcagcagcagcagcagcgcctgtgggaaaaactagaggctagagccatggatgaccaacgcgacctcatctctaaccatgaacagttgcccatactgggcaaccgccctagagagccagaaaggtgcagccgtggagctctgtacaccggtgtctctgtcctggtggctctgctcttggctgggcaggccaccactgcttacttcctgtaccagcaacagggccgcctagacaagctgaccatcacctcccagaacctgcaactggagagccttcgcatgaagcttccgaaatctgccaaacctgtgagccagatgcggatggctactcccttgctgatgcgtccaatgtccatggataacatgctccttgggcctgtgaagaacgttaccaagtacggcaacatgacccaggaccatgtgatgcatctgctcacgaggtctggacccctggagtacccgcagctgaaggggaccttcccagagaatctgaagcatcttaagaactccatggatggcgtgaactggaagatcttcgagagctggatgaagcagtggctcttgtttgagatgagcaagaactccctggaggagaagaagcccaccgaggctccacctaaagagccactggacatggaagacctatcttctggcctgggagtgaccaggcaggaactgggtcaagtcaccctgtgaagacagaggccagctctgcacagcagcagcgccccctgctctcctgtgcctcagcccttcttatgttccctgatgtcacaccccacttcccgtctccctgcaccctggggcttgagactggtgtctgtttcatcgtcccaggacacggcaaatgaagtcagaacagaaggaggacgctggagggccttgctggctaccgctatctaaagggaacccccatttctgacccattagtagtcttgaatgtggggctctgagataaaggcccgcagacagggacaagggatgccctacccttaacctaggctggacacatttgctgccttctcctcaaggaagaagaacccaagcccctcctcccagtaacccctcctcacatcctgccaccccccctcaagccccaccccctttcaggttccttgctcagccaagcttgtcagcagcctgtaggatcatggttcaagtgacaataaaggaagaaagtagaacaaaaaaaaaaaaaaaaa

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