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Previous release (v1)
2025-12-13 08:54:13, GGRNA.v2 : RefSeq release 232 (Sep, 2025)
LOCUS NM_010545 1239 bp mRNA linear ROD 29-JUL-2025
DEFINITION Mus musculus CD74 antigen (invariant polypeptide of major
histocompatibility complex, class II antigen-associated) (Cd74),
transcript variant 2, mRNA.
ACCESSION NM_010545
VERSION NM_010545.3
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 1239)
AUTHORS Guo,J., Zheng,J., Li,R., Yao,J., Zhang,H., Wang,X. and Zhang,C.
TITLE Single-cell transcriptome analysis reveals abnormal angiogenesis
and placentation by loss of imprinted glutaminyl-peptide
cyclotransferase
JOURNAL J Zhejiang Univ Sci B 26 (6), 589-608 (2025)
PUBMED 40571662
REFERENCE 2 (bases 1 to 1239)
AUTHORS Tang,Z., Hu,J., Li,X.C., Wang,W., Zhang,H.Y., Guo,Y.Y., Shuai,X.,
Chu,Q., Xie,C., Lin,D. and Zhong,B.
TITLE A subset of neutrophils activates anti-tumor immunity and inhibits
non-small-cell lung cancer progression
JOURNAL Dev Cell 60 (3), 379-395 (2025)
PUBMED 39515330
REFERENCE 3 (bases 1 to 1239)
AUTHORS Araujo David,B., Atif,J., Vargas E Silva Castanheira,F., Yasmin,T.,
Guillot,A., Ait Ahmed,Y., Peiseler,M., Hommes,J.W., Salm,L.,
Brundler,M.A., Surewaard,B.G.J., Elhenawy,W., MacParland,S.,
Ginhoux,F., McCoy,K. and Kubes,P.
TITLE Kupffer cell reverse migration into the liver sinusoids mitigates
neonatal sepsis and meningitis
JOURNAL Sci Immunol 9 (101), eadq9704 (2024)
PUBMED 39485859
REFERENCE 4 (bases 1 to 1239)
AUTHORS Mori,S., Kohyama,M., Yasumizu,Y., Tada,A., Tanzawa,K., Shishido,T.,
Kishida,K., Jin,H., Nishide,M., Kawada,S., Motooka,D., Okuzaki,D.,
Naito,R., Nakai,W., Kanda,T., Murata,T., Terao,C., Ohmura,K.,
Arase,N., Kurosaki,T., Fujimoto,M., Suenaga,T., Kumanogoh,A.,
Sakaguchi,S., Ogawa,Y. and Arase,H.
TITLE Neoself-antigens are the primary target for autoreactive T cells in
human lupus
JOURNAL Cell 187 (21), 6071-6087 (2024)
PUBMED 39276775
REFERENCE 5 (bases 1 to 1239)
AUTHORS Carabana,C., Sun,W., Veludo Ramos,C., Huyghe,M., Perkins,M.,
Maillot,A., Journot,R., Hartani,F., Faraldo,M.M., Lloyd-Lewis,B.
and Fre,S.
TITLE Spatially distinct epithelial and mesenchymal cell subsets along
progressive lineage restriction in the branching embryonic mammary
gland
JOURNAL EMBO J 43 (12), 2308-2336 (2024)
PUBMED 38760574
REFERENCE 6 (bases 1 to 1239)
AUTHORS Kolk,D.P. and Floyd-Smith,G.
TITLE The HXY box regulatory element modulates expression of the murine
IA antigen-associated invariant chain in L fibroblasts
JOURNAL DNA Cell Biol 11 (10), 745-754 (1992)
PUBMED 1457043
REFERENCE 7 (bases 1 to 1239)
AUTHORS Mock,B.A., Contente,S., Kenyon,K., Friedman,R.M. and Kozak,C.A.
TITLE The gene for lysyl oxidase maps to mouse chromosome 18
JOURNAL Genomics 14 (3), 822-823 (1992)
PUBMED 1358813
REFERENCE 8 (bases 1 to 1239)
AUTHORS Justice,M.J., Gilbert,D.J., Kinzler,K.W., Vogelstein,B.,
Buchberg,A.M., Ceci,J.D., Matsuda,Y., Chapman,V.M., Patriotis,C.,
Makris,A. et al.
TITLE A molecular genetic linkage map of mouse chromosome 18 reveals
extensive linkage conservation with human chromosomes 5 and 18
JOURNAL Genomics 13 (4), 1281-1288 (1992)
PUBMED 1354644
REFERENCE 9 (bases 1 to 1239)
AUTHORS Wegener,A.M., Letourneur,F., Hoeveler,A., Brocker,T., Luton,F. and
Malissen,B.
TITLE The T cell receptor/CD3 complex is composed of at least two
autonomous transduction modules
JOURNAL Cell 68 (1), 83-95 (1992)
PUBMED 1531041
REFERENCE 10 (bases 1 to 1239)
AUTHORS Byrd,L., Grossmann,M., Potter,M. and Shen-Ong,G.L.
TITLE Chronic multifocal osteomyelitis, a new recessive mutation on
chromosome 18 of the mouse
JOURNAL Genomics 11 (4), 794-798 (1991)
PUBMED 1686018
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AK002232.1 and AW123644.1.
On Jul 22, 2006 this sequence version replaced NM_010545.2.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC096435.1, AK020607.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849374, SAMN00849375
[ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1066 AK002232.1 1-1066
1067-1239 AW123644.1 1-173 c
FEATURES Location/Qualifiers
source 1..1239
/organism="Mus musculus"
/mol_type="mRNA"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="18"
/map="18 34.41 cM"
gene 1..1239
/gene="Cd74"
/gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
/note="CD74 antigen (invariant polypeptide of major
histocompatibility complex, class II antigen-associated)"
/db_xref="GeneID:16149"
/db_xref="MGI:MGI:96534"
exon 1..162
/gene="Cd74"
/gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
/inference="alignment:Splign:2.1.0"
CDS 86..733
/gene="Cd74"
/gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
/note="isoform 2 is encoded by transcript variant 2; H-2
class II histocompatibility antigen gamma chain; ia
antigen-associated invariant chain; Ia-associated
invariant chain; dinucleotide microsatellite; MHC class
II-associated invariant chain; class II-associated
invariant chain peptide; HLA-DR-GAMMA; histocompatibility:
class II antigens, gamma chain of; invariant polypeptide
of major histocompatibility complex, class II
antigen-associated; ii chain"
/codon_start=1
/product="H-2 class II histocompatibility antigen gamma
chain isoform 2"
/protein_id="NP_034675.1"
/db_xref="CCDS:CCDS50299.1"
/db_xref="GeneID:16149"
/db_xref="MGI:MGI:96534"
/translation="
MDDQRDLISNHEQLPILGNRPREPERCSRGALYTGVSVLVALLLAGQATTAYFLYQQQGRLDKLTITSQNLQLESLRMKLPKSAKPVSQMRMATPLLMRPMSMDNMLLGPVKNVTKYGNMTQDHVMHLLTRSGPLEYPQLKGTFPENLKHLKNSMDGVNWKIFESWMKQWLLFEMSKNSLEEKKPTEAPPKEPLDMEDLSSGLGVTRQELGQVTL"
misc_feature 86..421
/gene="Cd74"
/gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
/note="CLIP, MHC2 interacting; Region: MHC2-interact;
pfam09307"
/db_xref="CDD:462750"
misc_feature 86..154
/gene="Cd74"
/gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
/note="propagated from UniProtKB/Swiss-Prot (P04441.3);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 110..112
/gene="Cd74"
/gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:19144319; propagated from
UniProtKB/Swiss-Prot (P04441.3); phosphorylation site"
misc_feature 173..250
/gene="Cd74"
/gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
/note="propagated from UniProtKB/Swiss-Prot (P04441.3);
transmembrane region"
misc_feature 422..424
/gene="Cd74"
/gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P04441.3); glycosylation site"
misc_feature 440..637
/gene="Cd74"
/gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
/note="Class II MHC-associated invariant chain
trimerization domain; Region: MHCassoc_trimer; pfam08831"
/db_xref="CDD:462614"
misc_feature 440..442
/gene="Cd74"
/gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P04441.3); glycosylation site"
exon 163..332
/gene="Cd74"
/gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
/inference="alignment:Splign:2.1.0"
exon 333..412
/gene="Cd74"
/gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
/inference="alignment:Splign:2.1.0"
exon 413..475
/gene="Cd74"
/gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
/inference="alignment:Splign:2.1.0"
exon 476..568
/gene="Cd74"
/gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
/inference="alignment:Splign:2.1.0"
exon 569..659
/gene="Cd74"
/gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
/inference="alignment:Splign:2.1.0"
exon 660..722
/gene="Cd74"
/gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
/inference="alignment:Splign:2.1.0"
exon 723..1223
/gene="Cd74"
/gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
/inference="alignment:Splign:2.1.0"
regulatory 1202..1207
/regulatory_class="polyA_signal_sequence"
/gene="Cd74"
/gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
/note="hexamer: AATAAA"
polyA_site 1221
/gene="Cd74"
/gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
/note="major polyA site"
ORIGIN
agacacacagcagcagcagcagcagcagcagcagcaacagcagcagcagcagcagcgcctgtgggaaaaactagaggctagagccatggatgaccaacgcgacctcatctctaaccatgaacagttgcccatactgggcaaccgccctagagagccagaaaggtgcagccgtggagctctgtacaccggtgtctctgtcctggtggctctgctcttggctgggcaggccaccactgcttacttcctgtaccagcaacagggccgcctagacaagctgaccatcacctcccagaacctgcaactggagagccttcgcatgaagcttccgaaatctgccaaacctgtgagccagatgcggatggctactcccttgctgatgcgtccaatgtccatggataacatgctccttgggcctgtgaagaacgttaccaagtacggcaacatgacccaggaccatgtgatgcatctgctcacgaggtctggacccctggagtacccgcagctgaaggggaccttcccagagaatctgaagcatcttaagaactccatggatggcgtgaactggaagatcttcgagagctggatgaagcagtggctcttgtttgagatgagcaagaactccctggaggagaagaagcccaccgaggctccacctaaagagccactggacatggaagacctatcttctggcctgggagtgaccaggcaggaactgggtcaagtcaccctgtgaagacagaggccagctctgcacagcagcagcgccccctgctctcctgtgcctcagcccttcttatgttccctgatgtcacaccccacttcccgtctccctgcaccctggggcttgagactggtgtctgtttcatcgtcccaggacacggcaaatgaagtcagaacagaaggaggacgctggagggccttgctggctaccgctatctaaagggaacccccatttctgacccattagtagtcttgaatgtggggctctgagataaaggcccgcagacagggacaagggatgccctacccttaacctaggctggacacatttgctgccttctcctcaaggaagaagaacccaagcccctcctcccagtaacccctcctcacatcctgccaccccccctcaagccccaccccctttcaggttccttgctcagccaagcttgtcagcagcctgtaggatcatggttcaagtgacaataaaggaagaaagtagaacaaaaaaaaaaaaaaaaa
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]