LOCUS       NM_010461               2645 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus homeobox B8 (Hoxb8), mRNA.
ACCESSION   NM_010461
VERSION     NM_010461.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2645)
  AUTHORS   Frenette,B., Gueno,J., Houde,N., Landry-Truchon,K., Giguere,A.,
            Ashok,T., Ryckman,A., Morton,B.R., Mansfield,J.H. and Jeannotte,L.
  TITLE     Loss of Hoxa5 function affects Hox gene expression in different
            biological contexts
  JOURNAL   Sci Rep 14 (1), 30903 (2024)
   PUBMED   39730789
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2645)
  AUTHORS   Hung,Y.S., Lin,W.M., Wang,Y.C., Kuo,W.C., Chen,Y.Y., Fann,M.J.,
            Yu,J.Y. and Wong,Y.H.
  TITLE     Protogenin facilitates trunk-to-tail HOX code transition via
            modulating GDF11/SMAD2 signaling in mammalian embryos
  JOURNAL   Commun Biol 7 (1), 1669 (2024)
   PUBMED   39702818
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2645)
  AUTHORS   Bohic,M., Upadhyay,A., Eisdorfer,J.T., Keating,J., Simon,R.C.,
            Briones,B.A., Azadegan,C., Nacht,H.D., Oputa,O., Martinez,A.M.,
            Bethell,B.N., Gradwell,M.A., Romanienko,P., Ramer,M.S., Stuber,G.D.
            and Abraira,V.E.
  TITLE     A new Hoxb8FlpO mouse line for intersectional approaches to dissect
            developmentally defined adult sensorimotor circuits
  JOURNAL   Front Mol Neurosci 16, 1176823 (2023)
   PUBMED   37603775
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2645)
  AUTHORS   Qu,F., Li,W., Xu,J., Zhang,R., Ke,J., Ren,X., Meng,X., Qin,L.,
            Zhang,J., Lu,F., Zhou,X., Luo,X., Zhang,Z., Wang,M., Wu,G., Pei,D.,
            Chen,J., Cui,G., Suo,S. and Peng,G.
  TITLE     Three-dimensional molecular architecture of mouse organogenesis
  JOURNAL   Nat Commun 14 (1), 4599 (2023)
   PUBMED   37524711
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2645)
  AUTHORS   Kumar,S., Alam,S.S., Bareke,E., Beauchamp,M.C., Dong,Y., Chan,W.,
            Majewski,J. and Jerome-Majewska,L.A.
  TITLE     Sf3b4 regulates chromatin remodeler splicing and Hox expression
  JOURNAL   Differentiation 131, 59-73 (2023)
   PUBMED   37167859
REFERENCE   6  (bases 1 to 2645)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   7  (bases 1 to 2645)
  AUTHORS   Zwartkruis,F., Hoeijmakers,T., Deschamps,J. and Meijlink,F.
  TITLE     The murine Hox-2.4 promoter contains a functional octamer motif
  JOURNAL   Nucleic Acids Res 20 (7), 1599-1606 (1992)
   PUBMED   1349742
REFERENCE   8  (bases 1 to 2645)
  AUTHORS   Jones,F.S., Prediger,E.A., Bittner,D.A., De Robertis,E.M. and
            Edelman,G.M.
  TITLE     Cell adhesion molecules as targets for Hox genes: neural cell
            adhesion molecule promoter activity is modulated by cotransfection
            with Hox-2.5 and -2.4
  JOURNAL   Proc Natl Acad Sci U S A 89 (6), 2086-2090 (1992)
   PUBMED   1347944
REFERENCE   9  (bases 1 to 2645)
  AUTHORS   Ben-David,L., Aberdam,D., Sachs,L. and Blatt,C.
  TITLE     A deletion and a rearrangement distinguish between the
            intracisternal A-particle of Hox-2.4 and that of interleukin-3 in
            the same leukemic cells
  JOURNAL   Virology 182 (1), 382-387 (1991)
   PUBMED   1673811
REFERENCE   10 (bases 1 to 2645)
  AUTHORS   Aberdam,D., Negreanu,V., Sachs,L. and Blatt,C.
  TITLE     The oncogenic potential of an activated Hox-2.4 homeobox gene in
            mouse fibroblasts
  JOURNAL   Mol Cell Biol 11 (1), 554-557 (1991)
   PUBMED   1670897
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645478.15, AK083980.1 and AK131612.1.
            
            On Dec 21, 2006 this sequence version replaced NM_010461.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X13721.1, BC139209.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-466               AL645478.15        96505-96970
            467-729             AK083980.1         2-264
            730-1482            AL645478.15        97234-97986
            1483-1585           AL645478.15        98763-98865
            1586-2635           AK131612.1         461-1510
            2636-2645           AL645478.15        99916-99925
FEATURES             Location/Qualifiers
     source          1..2645
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 59.82 cM"
     gene            1..2645
                     /gene="Hoxb8"
                     /gene_synonym="Hox-2.4"
                     /note="homeobox B8"
                     /db_xref="GeneID:15416"
                     /db_xref="MGI:MGI:96189"
     exon            1..1482
                     /gene="Hoxb8"
                     /gene_synonym="Hox-2.4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    666..668
                     /gene="Hoxb8"
                     /gene_synonym="Hox-2.4"
                     /note="upstream in-frame stop codon"
     CDS             1059..1790
                     /gene="Hoxb8"
                     /gene_synonym="Hox-2.4"
                     /note="homeobox protein Hox-2.4; homeo box B8"
                     /codon_start=1
                     /product="homeobox protein Hox-B8"
                     /protein_id="NP_034591.1"
                     /db_xref="CCDS:CCDS25293.1"
                     /db_xref="GeneID:15416"
                     /db_xref="MGI:MGI:96189"
                     /translation="

MSSYFVNSLFSKYKTGESLRPNYYDCGFAQDLGGRPTVVYGPSSGGSFQHPSQIQEFYHGPSSLSTAPYQQNPCAVACHGDPGNFYGYDPLQRQSLFGAQDPDLVQYADCKLAAASGLGEEAEGSEQSPSPTQLFPWMRPQAAAGRRRGRQTYSRYQTLELEKEFLFNPYLTRKRRIEVSHALGLTERQVKIWFQNRRMKWKKENNKDKFPSSKCEQEELEKEKLERAPETAEQGDAQKGDKK"

     misc_feature    1458..1475
                     /gene="Hoxb8"
                     /gene_synonym="Hox-2.4"
                     /note="propagated from UniProtKB/Swiss-Prot (P09632.2);
                     Region: Antp-type hexapeptide"
     misc_feature    1497..1667
                     /gene="Hoxb8"
                     /gene_synonym="Hox-2.4"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    1665..1787
                     /gene="Hoxb8"
                     /gene_synonym="Hox-2.4"
                     /note="propagated from UniProtKB/Swiss-Prot (P09632.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            1483..2645
                     /gene="Hoxb8"
                     /gene_synonym="Hox-2.4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2619..2624
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hoxb8"
                     /gene_synonym="Hox-2.4"
                     /note="hexamer: AATAAA"
     polyA_site      2644
                     /gene="Hoxb8"
                     /gene_synonym="Hox-2.4"
                     /note="major polyA site"
ORIGIN      

aagctttaaatatgactacctcgtttgtttgaaaatatgtttaggagaggaagctgtatgatttgataacttgtattaaaataccaattacatttataggaccttttaaaactcggtgcaattaaaccgtgttcttttacatttttccgaagcgaccctgacatttagaaagactccaattgcctcgttaaaatcgcgaaattaacagcgtgcctacgccaggctcagcgttgtggatgtgtgtgtatggtgtttttccgtgactcccccacatcagtctttgggggtggtctgcgaaggtatttgatttgttgtgaggcaagagatatctcattaatgtaggtagttaaacagatttaatccgtattcgttctctctctctcccccctccctctccccccctctccccctctttctccctgggtgtttttttctcttcccctcctttttttctgccctctcctcactccctggcgctctctcgctctagctctctctcgcactcgctctctctcgctctcaccctcgctctgcgttctgtccgggaggagtacccagaagccaataggatgcggggtctctaatggatgcaaatgatggtgaaaagacggggcaaaatatgaaacaactcatttggagggaagtaaatcaccgaaaactgtttatgaactggcatcccttcttcgaaatgtaaagcgaggacctctttaagtggcggtatatttttgtttggggggtggggggtggggggagggcgagcgagccgcggctgccatgcaggcttagacttttgcaggcttcgctcttctattcctggaaatcacaaaaagtgtggcggctttgagatcttcttcgtcttttctttcttttccttccttccttcttttttttcccctcctcccttttcctctcctttcctggcgagggtgactaggagccggcgaatccgcgtttttttttctctctctctccctcccttttccccctccccaccccctccccaacagcccccaactacagcctgcgccgccgccgccgccgcctcaaaattcaataaaatgagctcttatttcgtcaactcactgttctccaaatacaaaaccggggagtccctgcgccccaattattatgactgcggcttcgcccaggacctgggcggccgacccaccgtggtgtacggtcccagcagcggcggcagcttccagcacccttcgcaaatccaggagttctaccacgggccatcgtcgctgtccacagctccctaccagcagaacccgtgcgccgtggcgtgccacggcgaccccggcaacttctacggctacgaccctctgcagcgccagagcctgttcggtgcgcaggatccagacctggtgcagtacgcagactgcaagctcgcggcagccagcggcctgggcgaggaggccgaggggtctgagcagagcccgtcgcccacacagctctttccctggatgcgccctcaagcagccgccggacgcaggcgaggccgccagacctacagtcgctaccagaccctggagctggagaaggagttcctatttaatccctatctgactcgcaagcggaggatcgaggtatcgcacgcgctgggactgacagagagacaggtcaaaatctggttccagaatcggagaatgaagtggaaaaaggagaacaacaaagacaagtttcccagcagtaaatgcgagcaggaggagctggagaaagagaagctggagcgggcaccagagaccgccgagcagggcgatgcgcagaagggtgacaagaagtaggctccagctgggactgctcgggcccggactagcccgcacgtccgccggtcccccccgcgaccacgccgccgccgcccgccccccgcctccgagagctccggccccgcgagcggagccaggagctgggcctcccacagcagcgtcccccgccgcgccagtccccgctagtggtagtatctcgtaatagcttctgtgtgtgagctaccgtggatctccttcccttctcttgggggtccggggggaaaaaaagaaaaggattttaagcaaggactccctcgtcctgcgagggtgatcgactgcggcctggcagaaccccctcgcccccgccccatgtaaaaaagcctccttgtgcaatggtctgtttcctttgaacgtgcttctttgtaatgaccgaggtaccgatttctgctaagttttcccaacaacatgaaactgcctattcacgccgtaattctttctgtctcccgctcactttctctctttctctcgctctctttctctcaccgcgtccccatctttcctcgcaaccccctctccccgctgccctccctagctggctttctctcttgcttctctcttttcctcctgtccccccacccccaccccctttggtttgacaattttgtcttaagtgtttctcaaaagagattactttagttagcatgcgcgctgtgagcattgttaaaagtgttcttaggtttactgtgaagagaatgtatcctgtatctgtgaattgctttatgggggggagggagggctaattatatattttgttgttcctctatactttgttctgttgtctgcgcctgaaaagggcggaagagttacaataaagtttacaagcgagaacccgag

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