LOCUS       NM_007957               1615 bp    mRNA    linear   ROD 15-NOV-2022
DEFINITION  Mus musculus extraembryonic, spermatogenesis, homeobox 1 (Esx1),
            mRNA.
ACCESSION   NM_007957 XM_906956
VERSION     NM_007957.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1615)
  AUTHORS   Solmonson A, Faubert B, Gu W, Rao A, Cowdin MA, Menendez-Montes I,
            Kelekar S, Rogers TJ, Pan C, Guevara G, Tarangelo A, Zacharias LG,
            Martin-Sandoval MS, Do D, Pachnis P, Dumesnil D, Mathews TP,
            Tasdogan A, Pham A, Cai L, Zhao Z, Ni M, Cleaver O, Sadek HA,
            Morrison SJ and DeBerardinis RJ.
  TITLE     Compartmentalized metabolism supports midgestation mammalian
            development
  JOURNAL   Nature 604 (7905), 349-353 (2022)
   PUBMED   35388219
REFERENCE   2  (bases 1 to 1615)
  AUTHORS   Shafiei S and Dufort D.
  TITLE     Maternal Cripto is critical for proper development of the mouse
            placenta and the placental vasculature
  JOURNAL   Placenta 107, 13-23 (2021)
   PUBMED   33730615
REFERENCE   3  (bases 1 to 1615)
  AUTHORS   Rhee C, Edwards M, Dang C, Harris J, Brown M, Kim J and Tucker HO.
  TITLE     ARID3A is required for mammalian placenta development
  JOURNAL   Dev Biol 422 (2), 83-91 (2017)
   PUBMED   27965054
REFERENCE   4  (bases 1 to 1615)
  AUTHORS   Chou AM, Sem KP, Lam WJ, Ahmed S and Lim CY.
  TITLE     Redundant functions of I-BAR family members, IRSp53 and IRTKS, are
            essential for embryonic development
  JOURNAL   Sci Rep 7, 40485 (2017)
   PUBMED   28067313
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1615)
  AUTHORS   Fiorenzano A, Pascale E, D'Aniello C, Acampora D, Bassalert C,
            Russo F, Andolfi G, Biffoni M, Francescangeli F, Zeuner A, Angelini
            C, Chazaud C, Patriarca EJ, Fico A and Minchiotti G.
  TITLE     Cripto is essential to capture mouse epiblast stem cell and human
            embryonic stem cell pluripotency
  JOURNAL   Nat Commun 7, 12589 (2016)
   PUBMED   27586544
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1615)
  AUTHORS   Morasso MI, Grinberg A, Robinson G, Sargent TD and Mahon KA.
  TITLE     Placental failure in mice lacking the homeobox gene Dlx3
  JOURNAL   Proc Natl Acad Sci U S A 96 (1), 162-167 (1999)
   PUBMED   9874789
REFERENCE   7  (bases 1 to 1615)
  AUTHORS   Li Y and Behringer RR.
  TITLE     Esx1 is an X-chromosome-imprinted regulator of placental
            development and fetal growth
  JOURNAL   Nat Genet 20 (3), 309-311 (1998)
   PUBMED   9806555
REFERENCE   8  (bases 1 to 1615)
  AUTHORS   Pitman JL, Lin TP, Kleeman JE, Erickson GF and MacLeod CL.
  TITLE     Normal reproductive and macrophage function in Pem homeobox
            gene-deficient mice
  JOURNAL   Dev Biol 202 (2), 196-214 (1998)
   PUBMED   9769172
REFERENCE   9  (bases 1 to 1615)
  AUTHORS   Li Y, Lemaire P and Behringer RR.
  TITLE     Esx1, a novel X chromosome-linked homeobox gene expressed in mouse
            extraembryonic tissues and male germ cells
  JOURNAL   Dev Biol 188 (1), 85-95 (1997)
   PUBMED   9245514
REFERENCE   10 (bases 1 to 1615)
  AUTHORS   Branford WW, Zhao GQ, Valerius MT, Weinstein M, Birkenmeier EH,
            Rowe LB and Potter SS.
  TITLE     Spx1, a novel X-linked homeobox gene expressed during
            spermatogenesis
  JOURNAL   Mech Dev 65 (1-2), 87-98 (1997)
   PUBMED   9256347
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF085715.1.
            
            On Sep 7, 2007 this sequence version replaced NM_007957.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF085715.1, AF017735.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1615              AF085715.1         2-1616
FEATURES             Location/Qualifiers
     source          1..1615
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 59.1 cM"
     gene            1..1615
                     /gene="Esx1"
                     /gene_synonym="Spx1"
                     /note="extraembryonic, spermatogenesis, homeobox 1"
                     /db_xref="GeneID:13984"
                     /db_xref="MGI:MGI:1096388"
     exon            1..383
                     /gene="Esx1"
                     /gene_synonym="Spx1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    167..169
                     /gene="Esx1"
                     /gene_synonym="Spx1"
                     /note="upstream in-frame stop codon"
     CDS             299..1447
                     /gene="Esx1"
                     /gene_synonym="Spx1"
                     /note="similar to Prd protein"
                     /codon_start=1
                     /product="homeobox protein ESX1"
                     /protein_id="NP_031983.2"
                     /db_xref="CCDS:CCDS53199.1"
                     /db_xref="GeneID:13984"
                     /db_xref="MGI:MGI:1096388"
                     /translation="

MESHKKCPCCYCTDLKTFVGAVKEETLQDPQPSLSSTLLEGADYQENAESETTFYSDFGASPKEEEVEMENSLFNSMFLEEANYQEPEGFEPSRGEAAAPVAEAPQAWNGNENLGGGFLESNAQLGEADAAPVRQSLMRPLMQPVAQSSPQPLPANPLQAPQQPEEQEEEEEEQPGEEQPQQEPKPRRYRICFTPIQLQELEAFFQRVQYPDLFARVELARRLGLPEPRVQVWFQNRRAKWRRLRRAQAFRNMVPVAMSPPVGVYLDDHYGPIPIVEVIWKCYPMVPRPMHPQMMPLPPRPPPGFRMPPPFRPPPLPPFPWPPVPPDAHIPNAAREYNPFPFPFPFPFPFPNPFPNPNPNPNPNPNPNPNPNQNFAGPRYRY"

     misc_feature    857..1012
                     /gene="Esx1"
                     /gene_synonym="Spx1"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            384..509
                     /gene="Esx1"
                     /gene_synonym="Spx1"
                     /inference="alignment:Splign:2.1.0"
     exon            510..945
                     /gene="Esx1"
                     /gene_synonym="Spx1"
                     /inference="alignment:Splign:2.1.0"
     exon            946..991
                     /gene="Esx1"
                     /gene_synonym="Spx1"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1600
                     /gene="Esx1"
                     /gene_synonym="Spx1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

aacaaacacactccctgtcaccagagcaccccctacaatgtagtcccaccctacagtgtagtcccacccattccgaatggaaacactcctatttctaatgggggcttgagcggaggcacactacgtaaaatctgatccctaagaggcacaagggctgaccaccctataaaaggggcgtgactcctcaacgagcgccactcgggtacgggagaagcagctggtaccacctctggccaggacctcggaagccaagaagtccgcagaagctggtgacttaacaacccaccgcgctccggtcatggaatctcacaaaaagtgcccctgctgctactgcactgacttgaagacctttgttggagcagtgaaggaggaaacacttcaggatccacagcctagcttgagctcaacgcttttggagggagcagactaccaggaaaacgcggaatctgaaacaactttctactccgactttggagccagcccgaaggaggaagaagtggagatggagaactctctgttcaactccatgtttctggaagaagcaaactaccaggaacccgagggattcgaaccctcaagaggagaagcagcagcgccggttgcagaagcaccgcaagcctggaatgggaatgaaaaccttggaggcggcttcctggagtccaacgctcagctgggggaggcggatgccgcccctgtgcggcagtccctgatgcgtcctctgatgcagcctgttgctcagtcttcgccgcaacccctgcccgcaaacccgctgcaggccccgcagcagcccgaggagcaggaggaggaggaggaggagcagccgggggaggagcaaccccaacaggagccgaagcctcgccgctaccgcatctgcttcaccccgatccaactgcaggagctggaggcctttttccagcgcgtccagtacccggacctgtttgctagagtggagcttgcccgacgcctgggcttacctgaacctagagtgcaggtttggtttcagaacagaagggccaagtggagacgacttcggcgggcacaggcattcagaaacatggttccagtcgccatgagtccccctgtgggtgtctatcttgatgatcattatggccccatccctattgtggaggttatttggaagtgctacccaatggtgcctcgtcccatgcatcctcaaatgatgcctcttccacccaggccccctccaggattcagaatgcctccaccatttaggccacctcctctgccaccttttccctggccacctgtaccacctgatgcgcacatacccaatgcagcaagggaatataaccccttccccttccccttcccctttccctttcccttccccaacccattccccaaccccaaccctaaccccaaccccaaccccaaccccaaccccaaccccaaccaaaattttgcaggtcccagatacagatactgaagtctacatcagttttccaaaagtgtttttcaatcagatttatatcgtttgtaaacactatcacgcattacctgtcaagaagctgttaaacgaaatgtacaaagttaatgccttctttgttttgattttcaataaaagtttggattagcagcaaaaaaaaaaaaaaaa

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