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Previous release (v1)
2024-09-29 09:35:40, GGRNA.v2 : RefSeq release 225 (Jul, 2024)
LOCUS NM_001428658 3096 bp mRNA linear ROD 15-JUN-2024
DEFINITION Mus musculus sema domain, immunoglobulin domain (Ig), transmembrane
domain (TM) and short cytoplasmic domain, (semaphorin) 4A (Sema4a),
transcript variant 6, mRNA.
ACCESSION NM_001428658 XM_011240051
VERSION NM_001428658.1
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 3096)
AUTHORS Bhat,G.P., Maurizio,A., Motta,A., Podini,P., Diprima,S.,
Malpighi,C., Brambilla,I., Martins,L., Badaloni,A., Boselli,D.,
Bianchi,F., Pellegatta,M., Genua,M., Ostuni,R., Del Carro,U.,
Taveggia,C., de Pretis,S., Quattrini,A. and Bonanomi,D.
TITLE Structured wound angiogenesis instructs mesenchymal barrier
compartments in the regenerating nerve
JOURNAL Neuron 112 (2), 209-229 (2024)
PUBMED 37972594
REFERENCE 2 (bases 1 to 3096)
AUTHORS Naito,Y., Koyama,S., Masuhiro,K., Hirai,T., Uenami,T., Inoue,T.,
Osa,A., Machiyama,H., Watanabe,G., Sax,N., Villa,J.,
Kinugasa-Katayama,Y., Nojima,S., Yaga,M., Hosono,Y., Okuzaki,D.,
Satoh,S., Tsuda,T., Nakanishi,Y., Suga,Y., Morita,T., Fukushima,K.,
Nishide,M., Shiroyama,T., Miyake,K., Iwahori,K., Hirata,H.,
Nagatomo,I., Yano,Y., Tamiya,M., Kumagai,T., Takemoto,N.,
Inohara,H., Yamasaki,S., Yamashita,K., Aoshi,T., Akbay,E.A.,
Hosen,N., Shintani,Y., Takamatsu,H., Mori,M., Takeda,Y. and
Kumanogoh,A.
TITLE Tumor-derived semaphorin 4A improves PD-1-blocking antibody
efficacy by enhancing CD8+ T cell cytotoxicity and proliferation
JOURNAL Sci Adv 9 (20), eade0718 (2023)
PUBMED 37205755
REFERENCE 3 (bases 1 to 3096)
AUTHORS Martins,L.F., Brambilla,I., Motta,A., de Pretis,S., Bhat,G.P.,
Badaloni,A., Malpighi,C., Amin,N.D., Imai,F., Almeida,R.D.,
Yoshida,Y., Pfaff,S.L. and Bonanomi,D.
TITLE Motor neurons use push-pull signals to direct vascular remodeling
critical for their connectivity
JOURNAL Neuron 110 (24), 4090-4107 (2022)
PUBMED 36240771
REFERENCE 4 (bases 1 to 3096)
AUTHORS Xu,R., Hoss,C., Swiercz,J.M., Brandt,D.T., Lutz,V., Petersen,N.,
Li,R., Zhao,D., Oleksy,A., Creigh-Pulatmen,T., Trokter,M.,
Fedorova,M., Atzberger,A., Strandby,R.B., Olsen,A.A., Achiam,M.P.,
Matthews,D., Huber,M., Grone,H.J., Offermanns,S. and Worzfeld,T.
TITLE A semaphorin-plexin-Rasal1 signaling pathway inhibits gastrin
expression and protects against peptic ulcers
JOURNAL Sci Transl Med 14 (654), eabf1922 (2022)
PUBMED 35857828
REFERENCE 5 (bases 1 to 3096)
AUTHORS Suga,Y., Nagatomo,I., Kinehara,Y., Koyama,S., Okuzaki,D., Osa,A.,
Naito,Y., Takamatsu,H., Nishide,M., Nojima,S., Ito,D., Tsuda,T.,
Nakatani,T., Nakanishi,Y., Futami,Y., Koba,T., Satoh,S., Hosono,Y.,
Miyake,K., Fukushima,K., Shiroyama,T., Iwahori,K., Hirata,H.,
Takeda,Y. and Kumanogoh,A.
TITLE IL-33 Induces Sema4A Expression in Dendritic Cells and Exerts
Antitumor Immunity
JOURNAL J Immunol 207 (5), 1456-1467 (2021)
PUBMED 34380650
REFERENCE 6 (bases 1 to 3096)
AUTHORS Oster,S.F., Bodeker,M.O., He,F. and Sretavan,D.W.
TITLE Invariant Sema5A inhibition serves an ensheathing function during
optic nerve development
JOURNAL Development 130 (4), 775-784 (2003)
PUBMED 12506007
REFERENCE 7 (bases 1 to 3096)
AUTHORS Dionne,M.S., Brunet,L.J., Eimon,P.M. and Harland,R.M.
TITLE Noggin is required for correct guidance of dorsal root ganglion
axons
JOURNAL Dev Biol 251 (2), 283-293 (2002)
PUBMED 12435358
REFERENCE 8 (bases 1 to 3096)
AUTHORS Kumanogoh,A., Marukawa,S., Suzuki,K., Takegahara,N., Watanabe,C.,
Ch'ng,E., Ishida,I., Fujimura,H., Sakoda,S., Yoshida,K. and
Kikutani,H.
TITLE Class IV semaphorin Sema4A enhances T-cell activation and interacts
with Tim-2
JOURNAL Nature 419 (6907), 629-633 (2002)
PUBMED 12374982
REFERENCE 9 (bases 1 to 3096)
AUTHORS Puschel,A.W., Adams,R.H. and Betz,H.
TITLE The sensory innervation of the mouse spinal cord may be patterned
by differential expression of and differential responsiveness to
semaphorins
JOURNAL Mol Cell Neurosci 7 (5), 419-431 (1996)
PUBMED 8812066
REFERENCE 10 (bases 1 to 3096)
AUTHORS Puschel,A.W., Adams,R.H. and Betz,H.
TITLE Murine semaphorin D/collapsin is a member of a diverse gene family
and creates domains inhibitory for axonal extension
JOURNAL Neuron 14 (5), 941-948 (1995)
PUBMED 7748561
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC102388.7.
On Mar 19, 2024 this sequence version replaced XM_011240051.3.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR13422597.276330.1,
SRR13422601.2016937.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMN00849374,
SAMN00849375 [ECO:0006172]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-83 AC102388.7 35582-35664
84-251 AC102388.7 36076-36243
252-412 AC102388.7 37791-37951
413-475 AC102388.7 38840-38902
476-574 AC102388.7 39136-39234
575-680 AC102388.7 39472-39577
681-797 AC102388.7 40295-40411
798-922 AC102388.7 40810-40934
923-1095 AC102388.7 41070-41242
1096-1246 AC102388.7 42781-42931
1247-1427 AC102388.7 50044-50224
1428-1546 AC102388.7 52361-52479
1547-1704 AC102388.7 52582-52739
1705-1802 AC102388.7 53022-53119
1803-3096 AC102388.7 53670-54963
FEATURES Location/Qualifiers
source 1..3096
/organism="Mus musculus"
/mol_type="mRNA"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="3"
/map="3 38.83 cM"
gene 1..3096
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="sema domain, immunoglobulin domain (Ig),
transmembrane domain (TM) and short cytoplasmic domain,
(semaphorin) 4A"
/db_xref="GeneID:20351"
/db_xref="MGI:MGI:107560"
exon 1..83
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
misc_feature 62..64
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="upstream in-frame stop codon"
exon 84..251
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
CDS 113..2395
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="semaphorin-4A; sema B; semaphorin-B"
/codon_start=1
/product="semaphorin-4A precursor"
/protein_id="NP_001415587.1"
/db_xref="GeneID:20351"
/db_xref="MGI:MGI:107560"
/translation="
MALPSLGQDSWSLLRVFFFQLFLLPSLPPASGTGGQGPMPRVKYHAGDGHRALSFFQQKGLRDFDTLLLSDDGNTLYVGAREAVLALNIQNPGIPRLKNMIPWPASERKKTECAFKKKSNETQCFNFIRVLVSYNATHLYACGTFAFSPACTFIELQDSLLLPILIDKVMDGKGQSPFDPVHKHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDIFLRWLHADASFVAAIPSTQVVYFFFEETASEFDFFEELYISRVAQVCKNDVGGEKLLQKKWTTFLKAQLLCAQPGQLPFNIIRHAVLLPADSPSVSRIYAVFTSQWQVGGTRSSAVCAFSLTDIERVFKGKYKELNKETSRWTTYRGSEVSPRPGSCSMGPSSDKALTFMKDHFLMDEHVVGTPLLVKSGVEYTRLAVESARGLDGSSHVVMYLGTSTGSLHKAVVPQDSSAYLVEEIQLSPDSEPVRNLQLAPAQGAVFAGFSGGIWRVPRANCSVYESCVDCVLARDPHCAWDPESRLCSLLSGSTKPWKQDMERGNPEWVCTRGPMARSPRRQSPPQLIKEVLTVPNSILELPCPHLSALASYHWSHGRAKISEASATVYNGSLLLLPQDGVGGLYQCVATENGYSYPVVSYWVDSQDQPLALDPELAGVPRERVQVPLTRVGGGASMAAQRSYWPHFLIVTVLLAIVLLGVLTLLLASPLGALRARGKVQGCGMLPPREKAPLSRDQHLQPSKDHRTSASDVDADNNHLGAEVA"
sig_peptide 113..208
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="COORDINATES: ab initio prediction:SignalP:6.0"
mat_peptide 209..2392
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/product="Semaphorin-4A. /id=PRO_0000032323"
/note="propagated from UniProtKB/Swiss-Prot (Q62178.2)"
misc_feature 470..472
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q62178.2); glycosylation site"
misc_feature 515..517
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q62178.2); glycosylation site"
misc_feature 1598..1600
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q62178.2); glycosylation site"
misc_feature 1928..1930
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q62178.2); glycosylation site"
misc_feature 2159..2221
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="propagated from UniProtKB/Swiss-Prot (Q62178.2);
transmembrane region"
misc_feature 2270..2392
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="propagated from UniProtKB/Swiss-Prot (Q62178.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
exon 252..412
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
exon 413..475
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
exon 476..574
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
exon 575..680
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
exon 681..797
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
exon 798..922
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
exon 923..1095
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
exon 1096..1246
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
exon 1247..1427
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
exon 1428..1546
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
exon 1547..1704
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
exon 1705..1802
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
exon 1803..3096
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
regulatory 3069..3074
/regulatory_class="polyA_signal_sequence"
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="hexamer: ATTAAA"
polyA_site 3096
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="major polyA site"
ORIGIN
gaagaaggctagatgggcccgattaagcaagagtcagagcccctgggggctgaggagagggtaggctgtctgcctgggttgggaaccatctggtgaccatctcaggctgaccatggccctaccatccctgggccaggactcatggagtctcctgcgtgtttttttcttccaactcttcctgctgccatcactgccacctgcttctgggactggtggtcaggggcccatgcccagagtcaaataccatgctggagacgggcacagggccctcagcttcttccaacaaaaaggcctccgagactttgacacgctgctcctgagtgacgatggcaacactctctatgtgggggctcgagaggccgtcctggccttgaatatccagaacccaggaatcccaaggctaaagaacatgataccctggccagccagtgagagaaaaaagaccgaatgtgcctttaagaagaagagcaatgagacacagtgtttcaacttcattcgagtcctggtctcttacaatgctactcacctctatgcctgtgggacctttgccttcagccctgcctgtaccttcattgaactccaagattccctcctgttgcccatcttgatagacaaggtcatggacgggaagggccaaagcccctttgaccctgttcacaagcacacagctgtcttggtcgatgggatgctttattccggcaccatgaacaacttcctgggcagcgagcccatcctgatgcggacactgggatcccagcctgttctcaagactgacatcttcttacgctggctgcacgcggatgcctccttcgtggcagccattccatccacccaggtcgtctatttcttctttgaggagacagccagcgagtttgacttctttgaagagctgtatatatccagggtggctcaagtctgcaagaacgacgtgggcggtgaaaagctgctgcagaagaagtggaccaccttcctcaaagcccagttgctctgcgctcagccagggcagctgccattcaacatcatccgccacgcggtcctgctgcccgccgattctccctctgtttcccgcatctacgcagtctttacctcccagtggcaggttggcgggaccaggagctcagcagtctgtgccttctctctcacggacattgagcgagtctttaaagggaagtacaaggagctgaacaaggagacctcccgctggaccacttaccggggctcagaggtcagcccgaggccaggcagttgctccatgggcccctcctctgacaaagccttgaccttcatgaaggaccattttctgatggatgagcacgtggtaggaacacccctgctggtgaagtctggtgtggagtacacacggcttgctgtggagtcagctcggggccttgatgggagcagccatgtggtcatgtatctgggtacctccacggggtccctgcacaaggctgtggtgcctcaggacagcagtgcttatctcgtggaggagattcagctgagccctgactctgagcctgttcgaaacctgcagctggcccccgcccagggtgcagtgtttgcaggcttctctggaggcatctggagagttcccagggccaattgcagtgtctacgagagctgtgtggactgtgtgcttgccagggaccctcactgtgcctgggaccctgaatcaagactctgcagccttctgtctggctctaccaagccttggaagcaggacatggaacgcggcaacccggagtgggtatgcacccgtggccccatggccaggagcccccggcgtcagagcccccctcaactaattaaagaagtcctgacagtccccaactccatcctggagctgccctgcccccacctgtcagcactggcctcttaccactggagtcatggccgagccaaaatctcagaagcctctgctaccgtctacaatggctccctcttgctgctgccgcaggatggtgtcgggggcctctaccagtgtgtggcgactgagaacggctactcataccctgtggtctcctattgggtagacagccaggaccagcccctggcgctggaccctgagctggcgggcgttccccgtgagcgtgtgcaggtcccgctgaccagggtcggaggcggagcttccatggctgcccagcggtcctactggccccattttctcatcgttaccgtcctcctggccatcgtgctcctgggagtgctcactctcctcctcgcttccccactgggggcgctgcgggctcggggtaaggttcagggctgtgggatgctgccccccagggaaaaggctccactgagcagggaccagcacctccagccctccaaggaccacaggacctctgccagtgacgtagatgccgacaacaaccatctgggcgccgaagtggcttaaacagggacacagatccgcagctgagcagagcaagccactggccttgttggctatgccaggcacagtgccactctgaccagggtaggaggctctcctgctaacgtgtgtcacctacagcacccagtaggtcctcccctgtgggactctcttctgcaagcacattgggctgtctccatacctgtacttgtgctgtgacaggaagagccagacaggtttctttgattttgattgacccaagagccctcctgtaacaaacgtgctccaggagaccatgaaaggtgtggctgtctgggattctgtggtgacaaacctaagcatccgagcaagctggggctattcctgcaaactccatcctgaacgctgtcactctagaagcagctgctgctttgaacaccagcccaccctccttcccaagagtctctatggagttggccccttgtgtttcctttaccagtcatgccatactgtttgggaagtcatctctgaagtctaaccaccttccttcttgcttcagtttggacagattgttattattgtctctgccctggctagaatggggggcataatctgagccttgttcccttgtccagtgtggctgacccttgacctcttccttcctcctccctttgttttgggattcagaaaactgcttgtcacagacaatttattttttattaaaaaagatataagctttaaagaaa
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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