LOCUS       NM_001424887            5470 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Mus musculus transforming growth factor, beta receptor I (Tgfbr1),
            transcript variant 5, mRNA.
ACCESSION   NM_001424887
VERSION     NM_001424887.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5470)
  AUTHORS   Mohamed,F.E.Z.A., Dewidar,B., Lin,T., Ebert,M.P., Dooley,S.,
            Meindl-Beinker,N.M. and Hammad,S.
  TITLE     TGFbetaR1 inhibition drives hepatocellular carcinoma proliferation
            through induction of toll-like-receptor signalling
  JOURNAL   Int J Exp Pathol 105 (2), 64-74 (2024)
   PUBMED   38328944
  REMARK    GeneRIF: TGFbetaR1 inhibition drives hepatocellular carcinoma
            proliferation through induction of toll-like-receptor signalling.
REFERENCE   2  (bases 1 to 5470)
  AUTHORS   Lozovska,A., Korovesi,A.G., Dias,A., Lopes,A., Fowler,D.A.,
            Martins,G.G., Novoa,A. and Mallo,M.
  TITLE     Tgfbr1 controls developmental plasticity between the hindlimb and
            external genitalia by remodeling their regulatory landscape
  JOURNAL   Nat Commun 15 (1), 2509 (2024)
   PUBMED   38509075
  REMARK    GeneRIF: Tgfbr1 controls developmental plasticity between the
            hindlimb and external genitalia by remodeling their regulatory
            landscape.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5470)
  AUTHORS   Bedolla,A.M., McKinsey,G.L., Ware,K., Santander,N., Arnold,T.D. and
            Luo,Y.
  TITLE     A comparative evaluation of the strengths and potential caveats of
            the microglial inducible CreER mouse models
  JOURNAL   Cell Rep 43 (1), 113660 (2024)
   PUBMED   38217856
REFERENCE   4  (bases 1 to 5470)
  AUTHORS   Pluangnooch,P., Soontrapa,K., Pudgerd,A. and Sridurongrit,S.
  TITLE     Expression of constitutively active TbetaRI leads to attenuation of
            ovalbumin-induced allergic airway inflammation associated with
            augmented M2 polarization of alveolar macrophage
  JOURNAL   Respir Investig 62 (1), 90-97 (2024)
   PUBMED   38007853
  REMARK    GeneRIF: Expression of constitutively active TbetaRI leads to
            attenuation of ovalbumin-induced allergic airway inflammation
            associated with augmented M2 polarization of alveolar macrophage.
REFERENCE   5  (bases 1 to 5470)
  AUTHORS   Alsamraae,M., Costanzo-Garvey,D., Teply,B.A., Boyle,S.,
            Sommerville,G., Herbert,Z.T., Morrissey,C., Dafferner,A.J.,
            Abdalla,M.Y., Fallet,R.W., Kielian,T., Jensen-Smith,H.,
            deOliveira,E.I., Chen,K., Bettencourt,I.A., Wang,J.M.,
            McVicar,D.W., Keeley,T., Yu,F. and Cook,L.M.
  TITLE     Androgen receptor inhibition suppresses anti-tumor neutrophil
            response against bone metastatic prostate cancer via regulation of
            TbetaRI expression
  JOURNAL   Cancer Lett 579, 216468 (2023)
   PUBMED   37940068
REFERENCE   6  (bases 1 to 5470)
  AUTHORS   Iseki,S., Osumi-Yamashita,N., Miyazono,K., Franzen,P., Ichijo,H.,
            Ohtani,H., Hayashi,Y. and Eto,K.
  TITLE     Localization of transforming growth factor-beta type I and type II
            receptors in mouse development
  JOURNAL   Exp Cell Res 219 (2), 339-347 (1995)
   PUBMED   7641785
REFERENCE   7  (bases 1 to 5470)
  AUTHORS   Roelen,B.A., Lin,H.Y., Knezevic,V., Freund,E. and Mummery,C.L.
  TITLE     Expression of TGF-beta s and their receptors during implantation
            and organogenesis of the mouse embryo
  JOURNAL   Dev Biol 166 (2), 716-728 (1994)
   PUBMED   7813789
REFERENCE   8  (bases 1 to 5470)
  AUTHORS   ten Dijke,P., Yamashita,H., Ichijo,H., Franzen,P., Laiho,M.,
            Miyazono,K. and Heldin,C.H.
  TITLE     Characterization of type I receptors for transforming growth
            factor-beta and activin
  JOURNAL   Science 264 (5155), 101-104 (1994)
   PUBMED   8140412
REFERENCE   9  (bases 1 to 5470)
  AUTHORS   Suzuki,A., Shioda,N., Maeda,T., Tada,M. and Ueno,N.
  TITLE     A mouse TGF-beta type I receptor that requires type II receptor for
            ligand binding
  JOURNAL   Biochem Biophys Res Commun 198 (3), 1063-1069 (1994)
   PUBMED   8117262
REFERENCE   10 (bases 1 to 5470)
  AUTHORS   Tomoda,T., Kudoh,T., Noma,T., Nakazawa,A., Muramatsu,M. and Arai,K.
  TITLE     Molecular cloning of a mouse counterpart for human TGF-beta type I
            receptor
  JOURNAL   Biochem Biophys Res Commun 198 (3), 1054-1062 (1994)
   PUBMED   8117261
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772232.18 and AL772150.11.
            
            Summary: This gene encodes a member of the transforming growth
            factor beta (TGF-beta) receptor family of proteins. These proteins
            comprise one component of the TGF-beta signaling pathway, which
            transduces extracellular signals into gene expression changes to
            regulate a wide range of cellular responses, including
            proliferation, migration, differentiation and apoptosis. Homozygous
            knockout mice for this gene exhibit impaired angiogenesis and
            embryonic lethality. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR12282455.26247765.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387, SAMN02146468
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               AL772232.18        138526-138664
            140-385             AL772150.11        13850-14095
            386-616             AL772150.11        26456-26686
            617-784             AL772150.11        32904-33071
            785-941             AL772150.11        33471-33627
            942-1066            AL772150.11        35630-35754
            1067-1197           AL772150.11        37023-37153
            1198-5470           AL772150.11        40753-45025
FEATURES             Location/Qualifiers
     source          1..5470
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 26.02 cM"
     gene            1..5470
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /note="transforming growth factor, beta receptor I"
                     /db_xref="GeneID:21812"
                     /db_xref="MGI:MGI:98728"
     exon            1..139
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1323
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /EC_number="2.7.11.30"
                     /note="isoform 5 precursor is encoded by transcript
                     variant 5; TGF-beta receptor type-1; TGF-beta receptor
                     type I; transforming growth factor-beta receptor type I"
                     /codon_start=1
                     /product="TGF-beta receptor type-1 isoform 5 precursor"
                     /protein_id="NP_001411816.1"
                     /db_xref="GeneID:21812"
                     /db_xref="MGI:MGI:98728"
                     /translation="

MEAAAAAPRRPQLLIVLVAAATLLPGAKALQCFCHLCTKDNFTCETDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGAVTTTYCCNQDHCNKIELPTTGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM"

     sig_peptide     55..141
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    175..177
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q64729.1); glycosylation site"
     exon            140..385
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            386..616
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            617..784
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            785..941
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1066
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1197
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..5470
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5449..5454
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /note="hexamer: AATAAA"
     polyA_site      5470
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /note="major polyA site"
ORIGIN      

gaggagaagctgcggccggggccgggccgggccacaaacagtggcggcgggaccatggaggcggcggccgctgctccacgtcgtccgcagctcctcatcgtgttggtggcggcggcgacgctgctcccgggggcgaaggcattacagtgtttctgccacctctgtacaaaggataattttacctgtgagacagatggtctttgctttgtctcagtcactgagaccacagacaaagttatacacaatagtatgtgtatagctgaaattgacctaattcctcgagacaggccatttgtatgtgcaccatcttcaaaaacaggggcagttactacaacatattgctgcaatcaggaccactgcaataaaatagaactcccaactacaggtttaccactgcttgttcaaagaacaattgccaggaccattgtgttacaagaaagcattggcaaaggtcggtttggagaagtttggcgaggcaaatggcggggagaagaagttgctgtgaagatattctcttctagagaagagcgttcatggttccgagaggcagagatttatcagactgtaatgttacgccatgaaaatatcctgggatttatagcagcagacaacaaagacaatgggacatggacgcagctgtggttggtgtcagattatcatgagcatggatcccttttcgattacttgaatagatacactgttactgtggaaggaatgatcaagcttgctctgtccacagcaagtggtcttgcccatcttcacatggagattgttggtacccaaggaaaaccagctattgcccatagagatttgaaatcaaagaatatcttggtgaagaaaaatggaacctgttgtattgcagacttgggacttgctgtgagacatgattctgccacagatacaattgatattgctccaaaccacagagtaggcactaaaaggtacatggcccctgaagttctagatgattccataaatatgaaacattttgaatccttcaaacgcgctgacatctatgcaatgggcttagtgttctgggaaattgctcgacgctgttctattggtggaatccatgaagactatcagttgccttattatgatcttgtaccttctgatccatcggttgaagaaatgagaaaagtagtttgcgaacagaagttaaggccaaatattccaaacagatggcagagctgtgaggccttgagagtgatggctaaaattatgagagaatgctggtatgccaatggagcagcaaggctgacagctttgcgaattaaaaaaacattgtcacaactcagccaacaggaaggcatcaaaatgtaactgaaacaccgtgggaactctgctctcttcatatctgctcctgggtgtttaggaggctggttgttctacctcactgagagaacagagggctctgcttcctcttgcagcagtggaatatggtcaactgaaagcttcccagggtttctctgggcccagaggcagccgtggggtcctttctgtgcactatggatacttcttccagacagttacagaatgttgtgtagtctacttttgtttttattaacaaagcttgtttttaaagacaactgccagcccttagggagctgctgtgctgttgaccttctgtaagggtgaaggagctggggtgtggcactaaatgaagcacttctgattttcactcctagtagtacattctcagaggactctgaaccactagtgtttccttggttcactttgaatgtactgttctataatttttcaagatcttaaactaacactttaaactctatagtctaaaaaatatgacctcgtggaggcgtgggggcacagttgctccgttgtatttgtgcacagctccttcacactctgaacacaacacaccttcacagtagggttgtgctacaccagtaagtgctacttttgcatctgtctaagtggaaacgaacagaactacttaaaggcggtgttaagtcctgtatcattttcattcaaaaagtttatttttctgagtaacctaaaccttttctgggtttgtttttgttttttgagggtttttgtgatagatgtcattcagtcttcatgcctttctcctacccagatgtgcttgaaccactgaggcaaggctgtagcattgataagcagtgactgccatgcgggaacaccccacaggagcactggagctctgcagttgagacgtttagcctgagtttattttaagaagtgaagtggcactccaaacatgtacagtgctttatggatgtaatcattatggtatacagactccttttgaaaggggaggcttgtctattgccgaaggaaaagttgtatgctgttctgtaagccatttctttttctttatttgatcaaagcagtgttttgttttgttttgatttttcttttttggaaaggaattgcatttaaaattcaaatgtggttaatgttaaataataggcctttttctaggaaggcagatatagttaatatgaatgtacaagtgtaggtgactttcacatgttatgtagctgtaagtatttgtggattctatcttgggaagggtagagttagtggagttttgaggtctcactaccctttgaggaaggcagcttttaattcagtctttttatctcatatgtgcagatcttgcaactgcttgatttacatggtagcaatgaattcagtgccacgttgatactaggagaagcagcaactaatagctattctgagtagaggctctcttcatatattcttggtcatattaaatgtcaaagtcagtccgttgggtcttctcactgctgctggagttaggtggttgagcctgggttttacttcagtgctgtcaaatctttgcagggcttgtgtggctttcaaagtcctttttatcactgtgatcatattctgggcggggaaatgttatcatcattgcttgagacgagatgttgaacatagtgataccaatccccagataaaaaggtcaaaataacctttagtgtttagccaagaagagattgtgactattgatctgaagcagctgggctctgttaatgtcttatttcaaacctagcatacatttgaagactatttggtcttaaaccaaagtaactgtaggacgaatgacatactacctagacattagtgtccgtttcatacgtcagaaacaccatgggaaaaagtacctagagattagtatctttaatacaaatctgagttttttctgtaattatcatgatttcatcaatgtaagtaagggtttgttgttacagttgtatcacctgcttaaataagctcttgtgctataatcaggtacttttggggcctttgttttcagttttttccatttctaacccttcgagatctgctttatagaaatccagggaccaatgtattttatcactaaaactgtttttatataattttaagaccataccaaaagttatctgagttaaagttgtaatacgtttcttactttcttgcaaggaaatgggtttttactgaagacacttctcatgatatctgaagttgaagaatcattatgtttttcttacctaagtggataaaatgtgctttgatgaatcagggaattttttaaagttcgaatttagttctaaattgagtttacatgtttacagctaattttttgtgtagggatagtttgattctctaggtggccaatactgaatataaaaataacttaaaaattgagataggtcatggttaatgtggctataactatatatacatctaattagagaaatatttctatgtaattttgtagtgcagtctgttgtttctattgccaatcaaagacttccccccagccccaaagtgtagtatggctaagacatatcttctgacaaattacatattatcttgtcaataccctggttaagctagcatgaaggaagtatgacttactgaggcttacacaacttgagtcccttatatcttcagctctgtttttcccactctgcctttctgctgccccctggctcagagacttagtgttcctgaccccacctccagcctttggacctaagagctgcttttgagacctaaaatgaagtgattgatggaagctgtgtgacatttttccacttccttgagtcactgggtgttatgagggagtgatctgcaaattggggtagggggtgcccctactggtagccctgctttgatgtcagctctgggcaaagattagggtgacagctaagtggcagtggaagttggcctcagaagtagtggccagctgtgtctctagtaggacagtaaaggcatgaagctcagcctgtaatcctgctactacagtagtactccagaagtgccttgaggccctgtgtggggctgtggccatcaagaattccagattttggttctcgctgcagacttaagtggccatgtagccatttttgtaatccatacatgtttgactcttccctctgcaaattgtcagatacgtaaaaccaatgacaaactactacttaacatgcacaccaaaatctgcccagaagacattgtgatttcattccatgcactgaaggaatgattgtaaatcatttctttgttccttggtcatgggagtgttctggttctacattgtggagattccagctgttgttctgttatagcccagcagaacaagtcgacgtgttgaaattctgaagaatagtttgggagtgcagtacagcttcatgtgttggatgttgaaactttcatgggccctctttagaaaagcagaggactgtcagcacattatttttaatcctgttatgcactcgtacttattgtcagtaacaataagtacgagtattgaaaatattgtcagtaacattcagtctctttcttaaagtgaatttgcttatttttcaatgagatttgtgagtttaatattatgaactgtgttttgataatccctttttcacattgtgccaatggaatggaatatttgatatttctttatatgtcaaggagatgcttcaatatgtcatttgctttaaacttaaattacctctcaagagaccaaggtacatttacctcattgtgtatataatgtttaatatttgtcagcatccaccaggtttgcaattttatttctataaagtgtgagtgttacgttgctaagttactcagatggtactgtattgtttatatctgtaccccaaatgacatcatctagactttgttttctgtgtcttattgtatttgtgcagtcctttaaccctgttggtgtgattgctgccctttcagatatgtgcaggtgtctatagaaattctcatttaaggtgaatggttttgagaaacctgtgaagagagaagcataaactgcatttccccatcagttttttaaatgtacattgtatgtgtagtaatattccagatgaattgtaaataaaagctagggagatgcttaaatttcatcctaacactacagtagaaaatggaagcaatgcaaataaacaactttttcccacca

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