2024-09-28 09:23:40, GGRNA.v2 : RefSeq release 225 (Jul, 2024)
LOCUS NM_001420745 773 bp mRNA linear ROD 07-MAY-2024 DEFINITION Mus musculus prostaglandin D2 synthase (brain) (Ptgds), transcript variant 3, mRNA. ACCESSION NM_001420745 VERSION NM_001420745.1 KEYWORDS RefSeq. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. REFERENCE 1 (bases 1 to 773) AUTHORS Souali-Crespo,S., Condrea,D., Vernet,N., Feret,B., Klopfenstein,M., Grandgirard,E., Alunni,V., Cerciat,M., Jung,M., Mayere,C., Nef,S., Mark,M., Chalmel,F. and Ghyselinck,N.B. TITLE Loss of NR5A1 in mouse Sertoli cells after sex determination changes cellular identity and induces cell death by anoikis JOURNAL Development 150 (24) (2023) PUBMED 38078651 REFERENCE 2 (bases 1 to 773) AUTHORS Oh,Y., Kasu,M., Bottoms,C.J., Douglas,J.C., Sekulovski,N., Hayashi,K. and MacLean Ii,J.A. TITLE Rhox8 homeobox gene ablation leads to rete testis abnormality and male subfertility in micedagger JOURNAL Biol Reprod 109 (4), 520-532 (2023) PUBMED 37471646 REFERENCE 3 (bases 1 to 773) AUTHORS Horikami,D., Sekihachi,E., Omori,K., Kobayashi,Y., Kobayashi,K., Nagata,N., Kurata,K., Uemura,A. and Murata,T. TITLE Roles of lipocalin-type and hematopoietic prostaglandin D synthases in mouse retinal angiogenesis JOURNAL J Lipid Res 64 (10), 100439 (2023) PUBMED 37666361 REFERENCE 4 (bases 1 to 773) AUTHORS Qu,F., Li,W., Xu,J., Zhang,R., Ke,J., Ren,X., Meng,X., Qin,L., Zhang,J., Lu,F., Zhou,X., Luo,X., Zhang,Z., Wang,M., Wu,G., Pei,D., Chen,J., Cui,G., Suo,S. and Peng,G. TITLE Three-dimensional molecular architecture of mouse organogenesis JOURNAL Nat Commun 14 (1), 4599 (2023) PUBMED 37524711 REMARK Publication Status: Online-Only REFERENCE 5 (bases 1 to 773) AUTHORS Rossitto,M., Dejardin,S., Rands,C.M., Le Gras,S., Migale,R., Rafiee,M.R., Neirijnck,Y., Pruvost,A., Nguyen,A.L., Bossis,G., Cammas,F., Le Gallic,L., Wilhelm,D., Lovell-Badge,R., Boizet-Bonhoure,B., Nef,S. and Poulat,F. TITLE TRIM28-dependent SUMOylation protects the adult ovary from activation of the testicular pathway JOURNAL Nat Commun 13 (1), 4412 (2022) PUBMED 35906245 REMARK Publication Status: Online-Only REFERENCE 6 (bases 1 to 773) AUTHORS Bingham,C.O. 3rd, Murakami,M., Fujishima,H., Hunt,J.E., Austen,K.F. and Arm,J.P. TITLE A heparin-sensitive phospholipase A2 and prostaglandin endoperoxide synthase-2 are functionally linked in the delayed phase of prostaglandin D2 generation in mouse bone marrow-derived mast cells JOURNAL J Biol Chem 271 (42), 25936-25944 (1996) PUBMED 8824228 REFERENCE 7 (bases 1 to 773) AUTHORS Pilz,A., Woodward,K., Povey,S. and Abbott,C. TITLE Comparative mapping of 50 human chromosome 9 loci in the laboratory mouse JOURNAL Genomics 25 (1), 139-149 (1995) PUBMED 7774911 REFERENCE 8 (bases 1 to 773) AUTHORS Chan,P., Simon-Chazottes,D., Mattei,M.G., Guenet,J.L. and Salier,J.P. TITLE Comparative mapping of lipocalin genes in human and mouse: the four genes for complement C8 gamma chain, prostaglandin-D-synthase, oncogene-24p3, and progestagen-associated endometrial protein map to HSA9 and MMU2 JOURNAL Genomics 23 (1), 145-150 (1994) PUBMED 7829063 REFERENCE 9 (bases 1 to 773) AUTHORS Igarashi,M., Nagata,A., Toh,H., Urade,Y. and Hayaishi,O. TITLE Structural organization of the gene for prostaglandin D synthase in the rat brain JOURNAL Proc Natl Acad Sci U S A 89 (12), 5376-5380 (1992) PUBMED 1608945 REFERENCE 10 (bases 1 to 773) AUTHORS Spies,T. and DeMars,R. TITLE Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter JOURNAL Nature 351 (6324), 323-324 (1991) PUBMED 2034277 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL732557.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CD776351.1, CO039447.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-190 AL732557.4 142333-142522 c 191-330 AL732557.4 141761-141900 c 331-407 AL732557.4 141606-141682 c 408-524 AL732557.4 140845-140961 c 525-626 AL732557.4 140591-140692 c 627-652 AL732557.4 140093-140118 c 653-773 AL732557.4 139484-139604 c FEATURES Location/Qualifiers source 1..773 /organism="Mus musculus" /mol_type="mRNA" /strain="C57BL/6" /db_xref="taxon:10090" /chromosome="2" /map="2 17.28 cM" gene 1..773 /gene="Ptgds" /gene_synonym="21kDa; L-PGDS; PGD2; PGDS; PGDS2; Ptgs3" /note="prostaglandin D2 synthase (brain)" /db_xref="GeneID:19215" /db_xref="MGI:MGI:99261" exon 1..190 /gene="Ptgds" /gene_synonym="21kDa; L-PGDS; PGD2; PGDS; PGDS2; Ptgs3" /inference="alignment:Splign:2.1.0" CDS 77..646 /gene="Ptgds" /gene_synonym="21kDa; L-PGDS; PGD2; PGDS; PGDS2; Ptgs3" /EC_number="5.3.99.2" /note="lipocalin-type prostaglandin-D synthase; prostaglandin-H2 D-isomerase; glutathione-independent PGD synthetase; PGD2 synthase; prostaglandin-D2 synthase; glutathione-independent PGD synthase; prostaglandin D2 synthase (21 kDa, brain)" /codon_start=1 /product="prostaglandin-H2 D-isomerase precursor" /protein_id="NP_001407674.1" /db_xref="GeneID:19215" /db_xref="MGI:MGI:99261" /translation="
MAALRMLWMGLVLLGLLGFPQTPAQGHDTVQPNFQQDKFLGRWYSAGLASNSSWFREKKAVLYMCKTVVAPSTEGGLNLTSTFLRKNQCETKIMVLQPAGAPGHYTYSSPHSGSIHSVSVVEANYDEYALLFSRGTKGPGQDFRMATLYSRTQTLKDELKEKFTTFSKAQGLTEEDIVFLPQPDKCIQE"
sig_peptide 77..148 /gene="Ptgds" /gene_synonym="21kDa; L-PGDS; PGD2; PGDS; PGDS2; Ptgs3" /inference="COORDINATES: ab initio prediction:SignalP:6.0" mat_peptide 149..643 /gene="Ptgds" /gene_synonym="21kDa; L-PGDS; PGD2; PGDS; PGDS2; Ptgs3" /product="Prostaglandin-H2 D-isomerase. /id=PRO_0000017947" /note="propagated from UniProtKB/Swiss-Prot (O09114.1)" misc_feature 149..151 /gene="Ptgds" /gene_synonym="21kDa; L-PGDS; PGD2; PGDS; PGDS2; Ptgs3" /note="Pyrrolidone carboxylic acid. /evidence=ECO:0000250|UniProtKB:P22057; propagated from UniProtKB/Swiss-Prot (O09114.1); pyrrolidone-carboxylic-acid site" misc_feature 164..640 /gene="Ptgds" /gene_synonym="21kDa; L-PGDS; PGD2; PGDS; PGDS2; Ptgs3" /note="lipocalin-type prostaglandin D synthase; Region: lipocalin_L-PGDS; cd19419" /db_xref="CDD:381194" misc_feature order(191..193,203..205,209..211,227..232,236..241, 248..253,260..262,266..268,275..277,281..283,305..307, 311..313,317..319,323..325,350..358,362..364,389..391, 395..397,410..412,422..424,428..430,434..436,461..463, 467..469,473..475,509..511,515..517,521..523) /gene="Ptgds" /gene_synonym="21kDa; L-PGDS; PGD2; PGDS; PGDS2; Ptgs3" /note="ligand binding cavity [chemical binding]; other site" /db_xref="CDD:381194" misc_feature 227..229 /gene="Ptgds" /gene_synonym="21kDa; L-PGDS; PGD2; PGDS; PGDS2; Ptgs3" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0000250; propagated from UniProtKB/Swiss-Prot (O09114.1); glycosylation site" misc_feature 308..310 /gene="Ptgds" /gene_synonym="21kDa; L-PGDS; PGD2; PGDS; PGDS2; Ptgs3" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0000250; propagated from UniProtKB/Swiss-Prot (O09114.1); glycosylation site" exon 191..330 /gene="Ptgds" /gene_synonym="21kDa; L-PGDS; PGD2; PGDS; PGDS2; Ptgs3" /inference="alignment:Splign:2.1.0" exon 331..407 /gene="Ptgds" /gene_synonym="21kDa; L-PGDS; PGD2; PGDS; PGDS2; Ptgs3" /inference="alignment:Splign:2.1.0" exon 408..524 /gene="Ptgds" /gene_synonym="21kDa; L-PGDS; PGD2; PGDS; PGDS2; Ptgs3" /inference="alignment:Splign:2.1.0" exon 525..626 /gene="Ptgds" /gene_synonym="21kDa; L-PGDS; PGD2; PGDS; PGDS2; Ptgs3" /inference="alignment:Splign:2.1.0" exon 627..652 /gene="Ptgds" /gene_synonym="21kDa; L-PGDS; PGD2; PGDS; PGDS2; Ptgs3" /inference="alignment:Splign:2.1.0" exon 653..773 /gene="Ptgds" /gene_synonym="21kDa; L-PGDS; PGD2; PGDS; PGDS2; Ptgs3" /inference="alignment:Splign:2.1.0" regulatory 752..757 /regulatory_class="polyA_signal_sequence" /gene="Ptgds" /gene_synonym="21kDa; L-PGDS; PGD2; PGDS; PGDS2; Ptgs3" /note="hexamer: AATAAA" polyA_site 773 /gene="Ptgds" /gene_synonym="21kDa; L-PGDS; PGD2; PGDS; PGDS2; Ptgs3" /note="major polyA site" ORIGIN
gctccttctgcccagttttccttgctttgtccacattgctggcatcaggcccaggcacctgctctgctctgagcaaatggctgctcttcgcatgctgtggatgggtttggtcctcctgggtctcttgggattcccacagaccccagcccagggccatgacacagtgcagcccaactttcaacaagacaagttcctggggcgctggtacagcgcgggcctcgcctccaactcaagctggttccgggagaagaaagctgtattgtatatgtgcaagacagtggtagccccctccacagaaggcggcctcaatctcacctctaccttcctcaggaaaaaccagtgtgagaccaagatcatggtactgcagcctgcgggggctcctggacactacacctacagcagcccccactcgggcagcatccactccgtgtcagtggtggaggccaactatgacgagtacgctctgctattcagcagaggcaccaagggcccaggccaggacttccgcatggccaccctctacagcagaacccagactctgaaggacgagctgaaggagaaattcaccacctttagcaaggcccagggcctcacagaggaggacattgttttcctgccccaaccggataagtgcattcaagagtaaacgcaggtgacctggcctcaggactcctttgctctgtcactctcaagatcccagccctggctccccaaagtacctctacaccctccagctttgccttgacaaagaaataaaagtccaaagcaagtca
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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