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2024-07-03 11:57:05, GGRNA.v2 : RefSeq release 224 (May, 2024)

LOCUS       NM_001411829            9971 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus dicer 1, ribonuclease type III (Dicer1), transcript
            variant 1, mRNA.
ACCESSION   NM_001411829
VERSION     NM_001411829.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9971)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 9971)
  AUTHORS   Kompotis,K., Mang,G.M., Hubbard,J., Jimenez,S., Emmenegger,Y.,
            Polysopoulos,C., Hor,C.N., Wigger,L., Hebert,S.S., Mongrain,V. and
            Franken,P.
  TITLE     Cortical miR-709 links glutamatergic signaling to NREM sleep EEG
            slow waves in an activity-dependent manner
  JOURNAL   Proc Natl Acad Sci U S A 121 (3), e2220532121 (2024)
   PUBMED   38207077
REFERENCE   3  (bases 1 to 9971)
  AUTHORS   Oikawa,S., Yuan,S., Kato,Y. and Akimoto,T.
  TITLE     Skeletal muscle-enriched miRNAs are highly unstable in vivo and may
            be regulated in a Dicer-independent manner
  JOURNAL   FEBS J 290 (24), 5692-5703 (2023)
   PUBMED   37525425
  REMARK    GeneRIF: Skeletal muscle-enriched miRNAs are highly unstable in
            vivo and may be regulated in a Dicer-independent manner.
REFERENCE   4  (bases 1 to 9971)
  AUTHORS   Wang,Y., Chen,S.Y., Ta,M., Senz,J., Tao,L.V., Thornton,S.,
            Tamvada,N., Yang,W., Moscovitz,Y., Li,E., Guo,J., Shen,C.,
            Douglas,J.M., Ei-Naggar,A.M., Kommoss,F.K.F., Underhill,T.M.,
            Singh,N., Gilks,C.B., Morin,G.B. and Huntsman,D.G.
  TITLE     Biallelic Dicer1 Mutations in the Gynecologic Tract of Mice Drive
            Lineage-Specific Development of DICER1 Syndrome-Associated Cancer
  JOURNAL   Cancer Res 83 (21), 3517-3528 (2023)
   PUBMED   37494476
  REMARK    GeneRIF: Biallelic Dicer1 Mutations in the Gynecologic Tract of
            Mice Drive Lineage-Specific Development of DICER1
            Syndrome-Associated Cancer.
REFERENCE   5  (bases 1 to 9971)
  AUTHORS   Reyes-Castro,R.A., Chen,S.Y., Seemann,J., Kundu,S.T., Gibbons,D.L.
            and Arur,S.
  TITLE     Phosphorylated nuclear DICER1 promotes open chromatin state and
            lineage plasticity of AT2 tumor cells in lung adenocarcinomas
  JOURNAL   Sci Adv 9 (30), eadf6210 (2023)
   PUBMED   37494452
  REMARK    GeneRIF: Phosphorylated nuclear DICER1 promotes open chromatin
            state and lineage plasticity of AT2 tumor cells in lung
            adenocarcinomas.
REFERENCE   6  (bases 1 to 9971)
  AUTHORS   Bernstein,E., Kim,S.Y., Carmell,M.A., Murchison,E.P., Alcorn,H.,
            Li,M.Z., Mills,A.A., Elledge,S.J., Anderson,K.V. and Hannon,G.J.
  TITLE     Dicer is essential for mouse development
  JOURNAL   Nat Genet 35 (3), 215-217 (2003)
   PUBMED   14528307
  REMARK    GeneRIF: role in lethality early in development
            Erratum:[Nat Genet. 2003 Nov;35(3):287]
REFERENCE   7  (bases 1 to 9971)
  AUTHORS   Doi,N., Zenno,S., Ueda,R., Ohki-Hamazaki,H., Ui-Tei,K. and Saigo,K.
  TITLE     Short-interfering-RNA-mediated gene silencing in mammalian cells
            requires Dicer and eIF2C translation initiation factors
  JOURNAL   Curr Biol 13 (1), 41-46 (2003)
   PUBMED   12526743
REFERENCE   8  (bases 1 to 9971)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 9971)
  AUTHORS   Nicholson,R.H. and Nicholson,A.W.
  TITLE     Molecular characterization of a mouse cDNA encoding Dicer, a
            ribonuclease III ortholog involved in RNA interference
  JOURNAL   Mamm Genome 13 (2), 67-73 (2002)
   PUBMED   11889553
REFERENCE   10 (bases 1 to 9971)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124364.4 and AF430845.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF430845.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-325               AC124364.4         149768-150092       c
            326-390             AF430845.1         215-279
            391-513             AC124364.4         129820-129942       c
            514-676             AC124364.4         129040-129202       c
            677-807             AC124364.4         128153-128283       c
            808-942             AC124364.4         127148-127282       c
            943-1103            AC124364.4         126353-126513       c
            1104-1272           AC124364.4         121922-122090       c
            1273-1745           AC124364.4         119991-120463       c
            1746-1878           AC124364.4         112794-112926       c
            1879-2121           AC124364.4         111015-111257       c
            2122-2276           AC124364.4         110201-110355       c
            2277-2409           AC124364.4         108645-108777       c
            2410-2485           AC124364.4         107805-107880       c
            2486-2625           AC124364.4         106796-106935       c
            2626-2805           AC124364.4         104873-105052       c
            2806-3019           AC124364.4         104571-104784       c
            3020-3173           AC124364.4         104233-104386       c
            3174-3356           AC124364.4         103073-103255       c
            3357-3462           AC124364.4         102739-102844       c
            3463-3638           AC124364.4         102086-102261       c
            3639-4419           AC124364.4         100422-101202       c
            4420-4575           AC124364.4         98385-98540         c
            4576-5446           AC124364.4         94294-95164         c
            5447-5715           AC124364.4         92498-92766         c
            5716-5878           AC124364.4         90323-90485         c
            5879-5954           AC124364.4         90147-90222         c
            5955-9971           AC124364.4         85762-89778         c
FEATURES             Location/Qualifiers
     source          1..9971
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 54.83 cM"
     gene            1..9971
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="dicer 1, ribonuclease type III"
                     /db_xref="GeneID:192119"
                     /db_xref="MGI:MGI:2177178"
     exon            1..325
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /inference="alignment:Splign:2.1.0"
     exon            326..513
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    367..369
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="upstream in-frame stop codon"
     CDS             370..6120
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /EC_number="3.1.26.3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     endoribonuclease Dicer; double-strand-specific
                     ribonuclease mDCR-1; Dicer1, Dcr-1 homolog"
                     /codon_start=1
                     /product="endoribonuclease Dicer isoform 1"
                     /protein_id="NP_001398758.1"
                     /db_xref="GeneID:192119"
                     /db_xref="MGI:MGI:2177178"
                     /translation="
MKSPALQPLSMAGLQLMTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAALDHNTIVCLNTGSGKTFIAVLLTKELAHQIRGDLNPHAKRTVFLVNSANQVAQQVSAVRTHSDLKVGEYSDLEVNASWTKERWSQEFTKHQVLIMTCYVALTVLKNGYLSLSDINLLVFDECHLAILDHPYREIMKLCESCPSCPRILGLTASILNGKCDPEELEEKIQKLERILRSDAETATDLVVLDRYTSQPCEIVVDCGPFTDRSGLYERLLMELEAALDFINDCNVAVHSKERDSTLISKQILSDCRAVLVVLGPWCADKVAGMMVRELQKYIKHEQEELHRKFLLFTDTLLRKIHALCEEYFSPASLDLKYVTPKVMKLLEILRKYKPYERQQFESVEWYNNRNQDNYVSWSDSEDDDDDEEIEEKEKPETNFPSPFTNILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHGIGKNQPRSKQMEAEFRKQEEVLRKFRAHETNLLIATSVVEEGVDIPKCNLVVRFDLPTEYRSYVQSKGRARAPISNYVMLADTDKIKSFEEDLKTYKAIEKILRNKCSKSADGAEADVHAGVDDEDAFPPYVLRPDDGGPRVTINTAIGHINRYCARLPSDPFTHLAPKCRTRELPDGTFYSTLYLPINSPLRASIVGPPMDSVRLAERVVALICCEKLHKIGELDEHLMPVGKETVKYEEELDLHDEEETSVPGRPGSTKRRQCYPKAIPECLRESYPKPDQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFTLSQQMLELITRLHQYIFSHILRLEKPALEFKPTGAESAYCVLPLNVVNDSGTLDIDFKFMEDIEKSEARIGIPSTKYSKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPRHLNQKGKALPLSSAEKRKAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHCLLTAEELRAQTASDAGVGVRSLPVDFRYPNLDFGWKKSIDSKSFISSCNSSLAESDNYCKHSTTVVPEHAAHQGATRPSLENHDQMSVNCKRLPAESPAKLQSEVSTDLTAINGLSYNKNLANGSYDLVNRDFCQGNQLNYFKQEIPVQPTTSYPIQNLYNYENQPKPSNECPLLSNTYLDGNANTSTSDGSPAVSTMPAMMNAVKALKDRMDSEQSPSVGYSSRTLGPNPGLILQALTLSNASDGFNLERLEMLGDSFLKHAITTYLFCTYPDAHEGRLSYMRSKKVSNCNLYRLGKKKGLPSRMVVSIFDPPVNWLPPGYVVNQDKSNSEKWEKDEMTKDCLLANGKLGEACEEEEDLTWRAPKEEAEDEDDFLEYDQEHIQFIDSMLMGSGAFVRKISLSPFSASDSAYEWKMPKKASLGSMPFASGLEDFDYSSWDAMCYLDPSKAVEEDDFVVGFWNPSEENCGVDTGKQSISYDLHTEQCIADKSIADCVEALLGCYLTSCGERAAQLFLCSLGLKVLPVIKRTSREKALDPAQENGSSQQKSLSGSCASPVGPRSSAGKDLEYGCLKIPPRCMFDHPDAEKTLNHLISGFETFEKKINYRFKNKAYLLQAFTHASYHYNTITDCYQRLEFLGDAILDYLITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAVSPELFHVIDDFVKFQLEKNEMQGMDSELRRSEEDEEKEEDIEVPKAMGDIFESLAGAIYMDSGMSLEVVWQVYYPMMQPLIEKFSANVPRSPVRELLEMEPETAKFSPAERTYDGKVRVTVEVVGKGKFKGVGRSYRIAKSAAARRALRSLKANQPQVPNS"
     misc_feature    493..1086
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="DEXH-box helicase domain of endoribonuclease Dicer;
                     Region: DEXHc_dicer; cd18034"
                     /db_xref="CDD:350792"
     misc_feature    order(493..504,511..513,562..585,706..708,895..897,
                     988..990)
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350792"
     misc_feature    order(670..675,742..747,820..822,826..831,838..840,
                     913..921)
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="nucleic acid binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:350792"
     misc_feature    892..903
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R418.3);
                     Region: DECH box"
     misc_feature    1135..2154
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R418.3);
                     Region: Required for interaction with PRKRA and TARBP2.
                     /evidence=ECO:0000250"
     misc_feature    1180..1464
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="Partner-binding domain of the endoribonuclease
                     Dicer; Region: Dicer_PBD; cd15903"
                     /db_xref="CDD:277191"
     misc_feature    order(1195..1200,1207..1209,1213..1218,1393..1398,
                     1405..1410,1417..1419,1426..1431,1438..1440)
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="Trbp binding interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:277191"
     misc_feature    1483..2061
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="C-terminal helicase domain of the endoribonuclease
                     Dicer; Region: SF2_C_dicer; cd18802"
                     /db_xref="CDD:350189"
     misc_feature    1594..1668
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R418.3);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1606..1608
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UPY3; propagated from
                     UniProtKB/Swiss-Prot (Q8R418.3); phosphorylation site"
     misc_feature    1612..1614
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UPY3; propagated from
                     UniProtKB/Swiss-Prot (Q8R418.3); phosphorylation site"
     misc_feature    order(1714..1722,1930..1932,1987..1989,1993..1995)
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350189"
     misc_feature    order(1942..1944,1948..1950,2023..2025,2029..2031)
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350189"
     misc_feature    2257..2523
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="Dicer dimerization domain; Region: Dicer_dimer;
                     pfam03368"
                     /db_xref="CDD:460900"
     misc_feature    2545..2604
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R418.3);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    3025..3393
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="PAZ domain, dicer_like subfamily. Dicer is an RNAse
                     involved in cleaving dsRNA in the RNA interference
                     pathway. It generates dsRNAs which are approximately 20 bp
                     long (siRNAs), which in turn target hydrolysis of
                     homologous RNAs. PAZ domains are named...; Region:
                     PAZ_dicer_like; cd02843"
                     /db_xref="CDD:239209"
     misc_feature    order(3214..3216,3253..3255,3271..3273,3283..3285,
                     3337..3339,3361..3363,3367..3369)
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239209"
     misc_feature    3415..3417
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UPY3; propagated from
                     UniProtKB/Swiss-Prot (Q8R418.3); phosphorylation site"
     misc_feature    3847..3849
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UPY3; propagated from
                     UniProtKB/Swiss-Prot (Q8R418.3); phosphorylation site"
     misc_feature    4255..>4530
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="Ribonuclease III family; Region: RIBOc; smart00535"
                     /db_xref="CDD:197778"
     misc_feature    order(4306..4311,4318..4323,4330..4332,4339..4344,
                     4351..4356,4360..4368,4396..4398)
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238333"
     misc_feature    4735..4737
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UPY3; propagated from
                     UniProtKB/Swiss-Prot (Q8R418.3); phosphorylation site"
     misc_feature    4759..4761
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8R418.3); phosphorylation site"
     misc_feature    4765..4767
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UPY3; propagated from
                     UniProtKB/Swiss-Prot (Q8R418.3); phosphorylation site"
     misc_feature    5161..5247
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R418.3);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    5395..5889
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="Ribonuclease III C terminal domain. This group
                     consists of eukaryotic, bacterial and archeal ribonuclease
                     III (RNAse III) proteins. RNAse III is a double stranded
                     RNA-specific endonuclease. Prokaryotic RNAse III is
                     important in post-transcriptional...; Region: RIBOc;
                     cd00593"
                     /db_xref="CDD:238333"
     misc_feature    order(5455..5460,5467..5472,5479..5481,5488..5493,
                     5500..5505,5509..5517,5545..5547,5809..5811,5842..5844)
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238333"
     misc_feature    order(5455..5457,5464..5466,5476..5478,5779..5781,
                     5788..5790)
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="active site"
                     /db_xref="CDD:238333"
     misc_feature    order(5464..5466,5779..5781,5788..5790)
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="metal binding site [ion binding]; metal-binding
                     site"
                     /db_xref="CDD:238333"
     misc_feature    5767..5769
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="Important for activity.
                     /evidence=ECO:0000269|PubMed:18268334; propagated from
                     UniProtKB/Swiss-Prot (Q8R418.3); other site"
     misc_feature    5902..6090
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="double-stranded RNA binding motif of
                     endoribonuclease Dicer and similar proteins; Region:
                     DSRM_DICER; cd10843"
                     /db_xref="CDD:380680"
     misc_feature    order(5902..5907,5911..5916,5923..5928,5935..5940,
                     5950..5952,5965..5973,5977..5979,5983..5985,6034..6045,
                     6052..6054)
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:380680"
     misc_feature    5953..5955
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UPY3; propagated from
                     UniProtKB/Swiss-Prot (Q8R418.3); phosphorylation site"
     exon            514..676
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /inference="alignment:Splign:2.1.0"
     exon            677..807
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /inference="alignment:Splign:2.1.0"
     exon            808..942
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1103
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1272
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1745
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1878
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2121
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2276
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..2409
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..2485
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2625
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /inference="alignment:Splign:2.1.0"
     exon            2626..2805
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /inference="alignment:Splign:2.1.0"
     exon            2806..3019
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /inference="alignment:Splign:2.1.0"
     exon            3020..3173
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /inference="alignment:Splign:2.1.0"
     exon            3174..3356
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /inference="alignment:Splign:2.1.0"
     exon            3357..3462
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /inference="alignment:Splign:2.1.0"
     exon            3463..3638
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /inference="alignment:Splign:2.1.0"
     exon            3639..4419
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /inference="alignment:Splign:2.1.0"
     exon            4420..4575
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /inference="alignment:Splign:2.1.0"
     exon            4576..5446
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /inference="alignment:Splign:2.1.0"
     exon            5447..5715
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /inference="alignment:Splign:2.1.0"
     exon            5716..5878
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /inference="alignment:Splign:2.1.0"
     exon            5879..5954
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /inference="alignment:Splign:2.1.0"
     exon            5955..9971
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6252..6257
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="hexamer: AATAAA"
     regulatory      6272..6277
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="hexamer: TATAAA"
     polyA_site      6277
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="major polyA site"
     polyA_site      6291
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
     regulatory      9951..9956
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="hexamer: AATAAA"
     polyA_site      9971
                     /gene="Dicer1"
                     /gene_synonym="1110006F08Rik; aviD; D12Ertd7e; mKIAA0928"
                     /note="major polyA site"
ORIGIN      
gcggagcggcggcgcgacgccggtgggattctccaagccgctgtgcgccgtcgccgcgggccgagcgcgggctgcgggcgagcagggcgctgcgcagtctccgcaggcgcgggcgggaggggtcggggcgcggcgcggtgcggcgcgggcggctccgggcccaggtgaatggagtaacctgacagcgggaacgagacgacggcgagcggcaggaaatggcggcggcggcggcggcgccgggcggcaccgggaggcctgggctgtgacgcgcgcgccggagcggggtccgatggttctggaaggcccgcggcgcccagtgctgcagtaagctgtgctagaacaaaatgcaatgaaagaaacactggatgaatgaaaagccctgctttgcagcccctcagcatggcaggcctgcagctcatgacccctgcttcctcaccaatgggtcctttctttggactgccatggcaacaagaagcaattcatgataacatttatacgccaagaaaataccaggttgagctgctggaagcagctctggaccataacacaattgtgtgcttgaacactggctcagggaagacgttcatcgcggtcctgctcaccaaagagctggcccatcagatcaggggcgacctcaacccgcatgcaaaaaggaccgtgttcctcgtcaactctgcaaaccaggttgctcaacaagtgtcagccgtcagaactcactcggatctcaaggttggagagtactcagacctagaagtaaatgcatcttggacaaaagagagatggagccaagagtttactaagcaccaggttctcattatgacttgctatgtcgccttgactgttttgaaaaatggttacttatcactgtcagacattaaccttttggtgtttgatgagtgtcatcttgcgattctagaccacccctatcgtgaaattatgaagctctgtgagagttgtccatcatgccctcgaattttgggactaactgcttccattttaaatgggaaatgtgatccagaggaattggaagagaagattcagaaactggagcgaattctcaggagtgacgctgagacggcgactgacttggtggtcctggacagatacacttctcagccttgtgagattgtggtagactgtggaccgtttactgacagaagtgggctgtatgagagattgctgatggagttagaagcagcacttgattttatcaatgattgtaatgtagctgtacattcaaaggaaagagattctactttgatttccaaacaaatcctctcagactgccgtgcagtgttggttgttctgggaccctggtgtgcagataaagtagctgggatgatggtaagagaacttcagaagtacatcaaacatgagcaagaggagctacacaggaagttcctattgtttacagacaccttgttaaggaaaatacacgccctgtgtgaagagtacttctcacctgcctcacttgacctgaagtatgtaactcccaaagtcatgaaactgctcgagatcctgcgcaaatacaagccctatgagcgacagcagtttgaaagtgttgagtggtacaataacaggaatcaggataattacgtgtcctggagtgattccgaggatgacgatgatgacgaagaaattgaagaaaaagaaaagccagagacaaattttccttctccgtttaccaatattttatgtgggattatttttgtggaaagaagatacacagcagttgtcctaaacagattgataaaggaagctggcaaacaagatccagagctggcttatatcagcagcaactttataactggacacggcattggaaagaaccagcctcgcagcaaacagatggaggcggagttcagaaagcaggaggaggtacttaggaaatttcgagctcatgagaccaacctgctcattgcaacaagtgttgtagaagagggtgtggatattcccaagtgcaatttggtggttcgttttgatttgcctacagagtatcgatcatatgtccagtctaaaggacgggcacgagcgccgatctctaattacgtaatgttagcagatacagacaagataaagagctttgaagaagacctcaagacctacaaagctattgaaaagatcttaaggaacaagtgttcgaagtcagcggatggtgctgaggcggacgtccatgctggtgtagatgatgaggatgctttcccgccatatgtgctgaggcctgatgatgggggtcctcgagtcacaatcaacactgccattggacacatcaacagatattgtgctcgattaccaagtgatccgtttacgcatctagctcccaaatgtagaacccgagaattgcctgatggtacattttattcaactctttatcttccgattaactcacctcttcgagcctccattgttggtccaccgatggacagtgtacggttggctgaaagagtggtagctctcatttgctgtgaaaaactgcacaaaattggtgaactggatgaacacttgatgccagttgggaaagagactgttaaatatgaagaagagctggacttacatgacgaggaggagaccagtgttcccgggagaccagggtccacaaaacgacggcagtgctaccccaaagcaattccagagtgcttgagggagagttaccccaaacccgaccagccttgttacctgtatgtgataggaatggtcttaactacccccctccctgatgaactcaacttcaggcggcggaagctctacccacctgaggacaccacaagatgctttgggatcctgacagccaaacccatacctcagattcctcactttcctgtgtatacacgctctggagaggtcaccatatccatcgagctgaagaagtctggtttcacattgtctcaacaaatgctcgagctgattacaagattgcaccagtacatattctcacatattctccggcttgagaagcctgccctggagtttaaacctacaggcgcggagtcagcctactgtgttctacctcttaatgttgttaatgactccggcactttggacattgactttaaattcatggaggatattgagaagtcggaagctcggataggcattcctagcaccaagtattcaaaggaaacaccgtttgtctttaagttagaagattaccaagatgcagtgatcattccaagataccgcaattttgatcagcctcatcgattttatgtagctgatgtatatacggatcttaccccactcagtaaatttccttcccctgaatatgaaacttttgcagaatattataaaacaaagtataaccttgacctgaccaatctcaaccagccactgctggatgttgaccacacatcttccagactgaaccttttgacacctcggcatttgaatcagaaggggaaagcacttcctctaagcagtgctgagaagaggaaggccaaatgggaaagtctgcagaacaaacagatcctggttccggaactctgtgctatacatccaatcccagcatcactgtggagaaaagcggtttgtctccccagcatactgtatcgccttcactgccttctgactgcagaggaactaagagctcagacagccagcgatgctggtgtgggtgtcagatcacttcccgtggattttagataccctaacttagacttcgggtggaaaaaatctattgatagcaagtctttcatctcaagctgtaactcctcgttggctgagagtgataattactgtaagcacagcacaactgtagtccctgaacatgctgcacatcaaggtgctactagaccctccttagaaaaccatgaccaaatgtctgtgaactgcaaaaggttgcccgctgagtcacctgctaagctccaaagtgaggtttcaacggatcttacagcaattaatggtctttcttacaataaaaaccttgccaatggcagttatgatttagttaacagagacttttgccaaggaaatcagctgaattacttcaagcaggaaatacctgtacaaccaactacctcatatcccattcagaatttgtacaattatgagaaccagcccaagcccagcaatgaatgtcctctactgagtaatacgtaccttgatgggaacgctaacacatctacctcagatggaagccccgcggtgtccacgatgcctgccatgatgaatgctgttaaagcactcaaggacaggatggactctgagcagagcccttctgttgggtactcctcaaggactcttggccccaatccgggactgattctccaggctttgacactgtcaaatgccagtgatgggtttaacctggagcggcttgagatgcttggcgactcctttttaaagcatgctatcaccacatatctgttttgcacgtaccctgatgctcatgaaggccgcctttcatatatgagaagcaaaaaggtcagcaactgtaacctgtatcgccttggcaagaagaagggactgcccagccgcatggtggtgtcgatattcgatcctcctgtgaattggcttcctcctggttatgtggtaaaccaagacaaaagtaactcagagaagtgggaaaaggatgaaatgacaaaagactgcttgctggctaatggcaaactgggtgaggcctgtgaggaggaggaggacctgacgtggagggcccccaaggaggaggccgaggatgaggacgacttcctggagtatgaccaggagcatatccagtttatagacagcatgctcatgggctcgggcgccttcgtgaggaaaatctctctgtcgcccttctcagcctccgactctgcatacgaatggaagatgcccaagaaggcctccttgggcagtatgccgtttgcctcgggccttgaggattttgattacagctcttgggatgcgatgtgctatctggatcctagcaaagccgttgaagaggatgactttgtggtaggtttctggaatccatcagaagagaactgtggcgtcgacacagggaagcagtccatttcttacgacttgcacacggagcagtgcattgctgacaagagcatagcggactgtgtggaggccctgctgggctgctacttaaccagctgcggcgagagggctgctcagctcttcctctgttcgctggggctgaaggtgctcccagtaatcaaaaggaccagccgggagaaggccttggaccctgctcaggagaacggaagcagccaacaaaagagcctttcagggagctgtgcctctccagttggcccacgctcctctgcagggaaagacttggagtacggctgcctgaagatcccaccgaggtgcatgtttgaccatccagacgcagagaaaaccctcaaccacctgatatctgggtttgaaacttttgagaagaaaattaactatagattcaagaataaggcttatcttctgcaggcttttacacacgcctcctaccactacaacactatcactgattgttaccagcgcttagaattcctgggagatgcgattttggactacctcataaccaagcacctttatgaagacccacggcagcattctccaggggtcttgactgacttgcgctctgcccttgtcaataacaccatctttgcatcattggctgtgaagtatgactaccacaagtactttaaagctgtctctcctgagctctttcatgttattgatgactttgtgaagtttcagcttgagaagaacgaaatgcaaggaatggactctgagcttaggagatccgaggaggatgaggagaaagaagaggatatcgaagtccccaaggccatgggggacatttttgagtctcttgctggtgccatttatatggacagtgggatgtctctggaggtggtctggcaggtgtactatccgatgatgcagcctctaatagaaaagttttctgcaaatgtgcctcgttctccagtgagagaattgctcgagatggaaccagaaactgccaagtttagcccagcggagagaacttatgatggaaaggtcagagtcaccgtggaagtggtgggaaaggggaaatttaaaggtgttggccggagctacaggatcgccaagtctgctgcagcacgaagggccctccgcagcctcaaagctaaccagcctcaggttcctaacagctgaagcttccggactcacaggcggcaagacagcggaccagaaccacagctccacggcacaaggatggttcgggctgacacagaacaggaaaactgaaggcagaatttaaagtttgataatgagatagataacagaataaaacatgtaatatgtgtataaactctttggaactaattttggtttagtttttgcgcagacacaatcttgtcttctttacccaccctgctttgcttagtcacaggagtgctttaatcctggtgtttgttagcaaggttttaaaatcattttgacaggtttttggttttgtttgttttgacatttaatttctgtcgactttgcttggtgttagaggccatggagcttaacctctaacagtccctagaactgggtcgtcctgaccttgcggtcccttacactatacctgtcctgctgcggtgtcaagcccaacaaaaagggcagagtgtgcaaaggaagcccccgtgctgtggagggcagtggaggcggggccgggcggaccccgggtactattgcacggaatagtaagggacagattttgagtccgtgttggctgctggtgagtggaggccaggctttcagacgccacattgtgctgcagagaggattcttgccttaaaaggaaggacttgatagtttgcttttttattttgccttccccttattatgcattggatgaaatggggtggcagctcactagggcacttgcaatggaactattgcaggtaggatttctgttgtttgtactgaagacattctaaaacccagagtgagtatatagatttttaaagcatcattatagacaggatacatgactagatgcccggttttcctcagaacttcctgccaggtggtcccagtggcggaaatgcccggtcagctgctgttctgacgaaatgagcctgagatgcagtgtacctagacacgccacaggtctgtactaggcagtgttgccagagtcaccaaagctgtgctctctttcctatggggtcagcattgtggcagactgccaggaccaacccgtctggggtagaagtcaccagtttagataaactaggtcattagttcatctcagactcagaaagtaaagctgtttaggcatttgctgaaggtctcgcctgggcttgtgggcccctcttcacttacacacctcagtccctccctttgcctgcattttcccgttggtgctacgtttatgtatcatgcttgaagtttaattttttgcactgtgactataatacctcttaatttacatttaaaaatgctgtatgggttgcccgtgccctcccaccgacacacaggagagctttgctgcaatttgccctcttacgcttgaagtctcagcaggctgagccagggtagctcgcgttccccacacatctcctgaggctgatgcttcatgtaatgctgcacttaggttcaagtcacccgcccgagagagagagagagagagagagagagagagagagagagagagagatgctgtgtgtgtgcaagcaagcactcgggctgtcaggaaccccatggggagggagagtgagcgtccccaaggatcacgtgctgttgctgttgcccatctgcaaagcaggatctgagttattgtttggtgaaattaatttggctgactcatcttaagtatttaattctaacgtgcgattgtagttgtctgtttgacttagaacatccctctcccccatgcgcgcgcacacacacacacaaaccttaatgcaagacatcctagcatgtgcaaaccaggtgatcttttgaatgttgtagctataatttgtatagtcagatagtaaggtggggtgggattgtgggaggtggagtttgttgtcttatcacagtccttggggatttataaactacctgattctctgcattgtgattcgtgcatttatgtcctgggatggatgctctggcatcctggcaccaaaagcagatggtttcacacttggattcctggtggaagaagaaaatgcctcagtatattttgtaacataaggagagtattttttgttaatattgaaaagttcagaattggatatgcttcgttcatccattctcagggctcaaatgttttgccactattcagaatgttgtatcaatagcaaacttgggctgtttttctttttctttcttccttctttttttgattgctgttagataaaagtacctgataactagtttgaatcatactgtgatttacccagagaccaagtccgaaaaatcaaaagtatgagttagacgcgcgatcaggagtgcgtttgtttgtgttgggggttgtccccaggttcgctggttgaaagactttgcattttagagaaaaagttgttctgccccctccctcgatgactccatgagcctcctccactggtgtagcaggaggaggaggaggagacagccagcgcccatgaggaggaagcagctgcacagatcctgtggctgcatgcgagctcggcgggcactgcactgttgggccgtcccctgtggcccttttgcaatcccaggcaggcagagtgagtgaggccctgtcctctgttgggttgtgtctgtgtggcacaggctgggcagtgctccggcactcacgcttaacccagaggggaggccatgcttgggcctcaccgcggttccgacttgagaacattctgggatgcctgcagcttgtcacacaattgcacatttgaactgttattatttttgtctgtgacattttcttttatctgtaaagttgaaagcatggcagagatttgttgactgaacacttaattatgctttttaaatgttttggttacgtttcttctttttttcgttcatattatgtgaaatgattaaatttagaataacctctaacactcctataattatcgtttaaaataccgatgtttttattttctcgacagtagtccgtcctcagaaagatgcagacaccctgtgtaattagcagggacttgaggctgcttcggttctgccgctcagttcccgtgtacagtcaccagcagccaccagacagtggctgagagcgtggagggagaccagtcaaaaacccacaaccacccgctttgctcgtggggcctgttgatttaaaactactccttgctcggtgaaggcacctagtcctcctgcacaaacttaactgctggcaatccgaggccttgcacctttatttcacagaccctgagctgagcctacagccgcatccttagccacctcgggctctgtgtgtctcctctgtgcttaacaacgcccaagaacccatagcttcccatctgctgattgcttctctggaatttaattatttctcaataaattctgtattttatattgtacgtgagacattttaaagatatgtttgagaccaaggatagttaaaatgactgtaaaggtagtgtgtctgccatggagacggagtgctgtccactggcagggaaaatgatcacctcaaactaatttgcagttattatttgactcattattttcttgtctgtctttctttgataaacaaccacagacagtttaaatgtcatacatggcctcagaatttgccttggctgctggttccatagcagaagcactgaggtgaagggaagaacatatctgccttttgtgctgtaaataaagggaaatgactaacggagtcaggctgagtgttctgccgacaagaaacggaatcacatcacactctgcagccttctaaagaaacctgtatccatgcacacagctatcactgcagagctgtgccagcacctatggaccacagttacctttagcttttccgttttgttttgtttttctttttctttttaataattgtagtcaataaagttattgtctgttca
//

by @meso_cacase at DBCLS
This page is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596. [Full Text]