LOCUS       NM_001359294            8266 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus phosphatase and actin regulator 2 (Phactr2),
            transcript variant E, mRNA.
ACCESSION   NM_001359294 XM_017313880
VERSION     NM_001359294.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8266)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 8266)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8266)
  AUTHORS   Jiang,W., Shi,J., Zhao,J., Wang,Q., Cong,D., Chen,F., Zhang,Y.,
            Liu,Y., Zhao,J., Chen,Q., Gu,L., Zhou,W., Wang,C., Fang,Z.,
            Geng,S., Xie,W., Chen,L.N., Yang,Y., Bai,Y., Lin,H. and Li,X.
  TITLE     ZFP57 dictates allelic expression switch of target imprinted genes
  JOURNAL   Proc Natl Acad Sci U S A 118 (5) (2021)
   PUBMED   33500348
REFERENCE   4  (bases 1 to 8266)
  AUTHORS   Kim,J.Y., Choi,S.Y., Moon,Y., Kim,H.J., Chin,J.H., Kim,H. and
            Sun,W.
  TITLE     Different expression patterns of Phactr family members in normal
            and injured mouse brain
  JOURNAL   Neuroscience 221, 37-46 (2012)
   PUBMED   22766235
  REMARK    GeneRIF: This study demonistrated that the mRNA expression of
            phactr2 was progressively increased in the injury penumbra.
REFERENCE   5  (bases 1 to 8266)
  AUTHORS   Wilson,C.H., Crombie,C., van der Weyden,L., Poulogiannis,G.,
            Rust,A.G., Pardo,M., Gracia,T., Yu,L., Choudhary,J., Poulin,G.B.,
            McIntyre,R.E., Winton,D.J., March,H.N., Arends,M.J., Fraser,A.G.
            and Adams,D.J.
  TITLE     Nuclear receptor binding protein 1 regulates intestinal progenitor
            cell homeostasis and tumour formation
  JOURNAL   EMBO J 31 (11), 2486-2497 (2012)
   PUBMED   22510880
REFERENCE   6  (bases 1 to 8266)
  AUTHORS   Allen,P.B., Greenfield,A.T., Svenningsson,P., Haspeslagh,D.C. and
            Greengard,P.
  TITLE     Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (18), 7187-7192 (2004)
   PUBMED   15107502
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ060660.1, AL713985.10 and BE650511.1.
            
            On Dec 30, 2017 this sequence version replaced XM_017313880.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-475               CJ060660.1         2-476
            476-526             CJ060660.1         636-686
            527-1025            AL713985.10        73940-74438
            1026-1219           AL713985.10        80585-80778
            1220-1376           AL713985.10        82213-82369
            1377-1432           AL713985.10        87815-87870
            1433-1458           AL713985.10        93569-93594
            1459-2045           BE650511.1         1-587
            2046-8266           AL713985.10        113843-120063
FEATURES             Location/Qualifiers
     source          1..8266
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 4.72 cM"
     gene            1..8266
                     /gene="Phactr2"
                     /note="phosphatase and actin regulator 2"
                     /db_xref="GeneID:215789"
                     /db_xref="MGI:MGI:2446138"
     exon            1..226
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    148..150
                     /gene="Phactr2"
                     /note="upstream in-frame stop codon"
     CDS             181..1725
                     /gene="Phactr2"
                     /note="isoform E is encoded by transcript variant E"
                     /codon_start=1
                     /product="phosphatase and actin regulator 2 isoform E"
                     /protein_id="NP_001346223.1"
                     /db_xref="GeneID:215789"
                     /db_xref="MGI:MGI:2446138"
                     /translation="

MGQTSVSALSPQPGSVDGLDKASIANSDGPPAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLERKISTRQSREELIRRGLLKELPDQAASRAGSSHPKKATGSKASASPSTSSTSSRPRAPKESLAGKAGLVGTTRGKKKISKQPVASRLSPSTTTSDTPSLKGELSDTGIESLTPEETVAGAEEQATSKSKAAIALPPSTAPPSPPALLLPPEDQCTIALDTPMVLVSDGPTLPVSALDTSQLLWTEEPSSRTSPYSSTGLGGSREQAKCFTTKDELGPQLLTPGQMGDSSESFSAPEDEAPREYQANDSDSDGPILYTDDDDEEDDDDDSSGESALASKIRRRDTLAIKLGNRPSKKELEDKNILQRTSEEERQELRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKMELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRKELNEFKSTEMEVHEESRQFTRFHRP"

     misc_feature    397..462
                     /gene="Phactr2"
                     /note="RPEL repeat; Region: RPEL; pfam02755"
                     /db_xref="CDD:460677"
     misc_feature    1249..1326
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1366..1440
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1477..1554
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     exon            227..394
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            395..475
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            476..487
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            488..1025
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1219
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1376
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1432
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1494
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1632
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1709
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..8266
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8244..8249
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phactr2"
                     /note="hexamer: AATAAA"
     polyA_site      8266
                     /gene="Phactr2"
                     /note="major polyA site"
ORIGIN      

atccgctgggccggcttggcggctgccagggccgggcgacccgcgcgcgcggggagaaggtgcggggcctggcgggcgcgggccgcgatgagcgcgcgggaggccggcggcgagcggacgggcgcgcgcaggagcggagcagcccggtgaggcggaggcgcggcggggcggtcacccgccatgggccagacctcggtgtccgccctgtccccgcagcccggcagcgttgatggactagacaaagcctccatagcaaactcagatggccccccagcaggttcccagacacctcccttcaagagaaaggggaaactctccaccattgggaaaatcttcaagccttggaaatggaggaaaaagaagaccagtgacaaatttagagaaacctcagcagtattagagaggaagatatccaccagacaaagtagagaggagctgataagaaggggcctgcttaaggaattgcctgatcaagctgcatccagagctggttcttctcacccgaagaaagcaaccggctccaaagcgtcagcctcaccgtccacttcctccacctcttctcgtcccagagcacccaaggagtcactggctggcaaagcaggcctagtggggaccacgaggggcaagaaaaaaattagcaagcagccggtggcgtcccgactgtcccccagcacgaccacttctgacacgcctagtcttaagggagagctctcagacactgggatagagagcctcacaccagaggagactgttgctggagcagaggagcaggccacaagcaaatccaaggcggccatcgctctgccacctagcacagcaccaccatccccacctgcccttcttctgccccctgaagatcagtgcactattgccttggacactcccatggtcctagtcagtgatggacctaccctgcccgtctctgccttagacacaagtcagctcctttggactgaagaaccatcgagcagaacctctccgtactcaagcactggcttaggtgggagcagagaacaggcaaaatgttttacaaccaaagatgagctgggaccacagttactgacccctgggcagatgggagactcgtcagaatccttcagtgccccagaagatgaggccccaagagagtaccaagccaacgactctgactcagatggacccatcttgtacactgatgatgatgatgaagaagatgatgatgatgacagcagtggagaaagtgcactggcaagcaagataagacgaagggatacacttgccatcaaacttggcaacagaccgtccaagaaagaactggaggataaaaacatcctgcagcgaacatctgaagaggagaggcaggagctgcgacaacagatcggaaccaagctggtcaggagactcagccagaggccaacaacggaagaattagagcaaagaaacatcttaaaacaaaagaacgaagaagaggaacaagaggcgaaaatggagctcaagcggaggctcagccggaagctcagcctgagacctaccgtggcagagctacaagcccgaaggatcctgcggttcaatgagtatgtagaagtgacagattccccagactatgaccgccgagcagacaagccctgggccaggttgacacctgcagacaaggcagcaataaggaaagaactaaatgaatttaaaagcacagaaatggaagttcatgaagagagtcgacagtttacaaggtttcatcgtccataatgaagcgtggaactgctcggaaataaagactgactgcccccggcagaagccctgcttcctgagaccctgccattgcactgagatttgaatgtgtatgtttccgtttcgttgtgggggaggagctgtacaaccggctttggttgagaatgcttcacctcgacagcccagatgaggccaagaagctgagagccagatgcggcaagcctggctgcccaccaccgtgtgcactgacataaggggcactctggtcctctcagctgtcctgcagcaggaatgttaatcaaagaagacgagcagaagacaatcgccagttcaactgccagaaagccaaacatgggttcataaacaatagacattggaattgctgggggtcaccccaaacagggtgagagctaaaactaagaaagaaagagaactgtttcattatgttaatgaagagaagaagaataaagagaggtatatttttgaagtaggcatttggtagctgagaacttcctaagggatttgggaacctactcaaccaatgtagattccttaaagacttcattctagaacattcttgtttcaccaataatggttctgtgtagtaccatttttttcctttatgttgtgccagtgaacccagttgccagaaacaaatatgagtgttcattaaatgcaaggagcttctgccagctcttcccaagcatgcttgctcgcactgtgttgcatgcctctcagtagtacagctaaccacacattttcttatattgctttccttatgtatagcgctctacaagggaaacaggaatacggtcagatgtaatgtgaccctggaaaactgttgcaagccttagaaataaaccttctgctctttccctgtcttcattatctccaaagtcaggaaaccgttctttagttaaggaagatgatatggacagtcacgacaccctttaaacactcagtccagagctccaacttaagcaacatacaagtgtctgctgctttctcaaagttctgagagggaatttaaaaaacataccagttagtttaaaatgctgcattaagaagattttttttttaaagttagatcgctgctatttaaaaaataaaataaaacagcaaagaccaagcacatgaatttcacagaaataccctacggattaaaggaagccagaagactcctggtttatgtaaggaaaccttaccgtcgatgatgaatgtgtgggtcatagccatacacccggtatttactctccatgccagagaaactgtaagatagttggagccagtttcccccaggagcctgtaatcagtcttgtttacattaaaaagctttcttccctcaaactgttcttctctgcagtgttagggcccagcacagaaccccagaagggctcacttgtaatactaccttgaatttcactgtcccttaacgattgttttgggcccctttggattaaaaacaaactgaaaagaaggaggaggagaaggaggcagaatctatatcacacttttttttaaaaaagaaggcagaatgtattccatgtctagctcgttctttgatctggaactatgacaattctaaagccctttagctttaaaatgtggacgcctgtaattttctatttcaactgaatagtcagcgttcagtcagttgagtaagtgtcggtccgccattctgtggtatttggagggaccacttgaaattcgatgatttcatttaaatgtgaaagtggttagctgcagtggactgttgtgaaaggccagaaggaccatgccaagaggtagccagcattattgtacccgtagctgtgcttagctgtttgcattaataaaacggggctgctgtccatactagttcgtccctctaatggcataagacagactttgcttttgaaatagcatctgtgagtgcactggtatttgtctgggggattgtttgatttgttgttttgcagtgctgagattgaaccaggaccctgtgcatgctctgctctgagtactctaacccctgagctacacccctagcctttgttgagacccctagagtctcaactcaaccataaatagtaaccttgttctcatgacttgcaacagtgttttccttcatgagatcctactctcctcttagtggcgtggggaaaatgccaaggcagacgatgcttctctggctatgcttctaatctcagagcattttaaaccttctagtcaagtgttatcagtatgttgtgaatgtaagacaggagcacaggttgtcattcacagtgtgtgtcatagaaagttgctatttggttggtcaaaagaatctttttccccactagtggtgcgagtgatacagttttttactttccacagtgatattcacccactacaaaacaaaatgcaaaatgcctaggctccaagttcaccccccaatgcacaaatgaaaacctgtctcctgacaccatctgtcagatttgtgatacatataacttttattcatactaactgatacacttggagaaattaagaacgctaaaaattaactactagtagtctcatatttaactatcagggaccactgattacttcaatatgatggtctattaactgttttaaaagccatggaaagaattaaaatatcatgagccaagctgtagttctcagaataaggctctattttgctggttaatttgtaaaggcagaaaagtttaaaggctacatagcctcagcagcatcccattcccaggtctccatccaggcatccccacagaaggcaaaggcaaggctctctctccctgtaattacccctctgcccattgccagcattgctgcagtccaaccaacaagctgctattctttaagaaaatgaatatgtgcagagatcgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtatgttgcagttgtaacacaattccagtttttcactaaagcaactgagtgagctttcctgactcctgagttatgataaagaaatgaaaatttgcccatatcactaaaggtcccagcaagaaaaaaactagatgatagaaaagccaaagtggccaattccaccttggtttttaatggaggagggagaccctgttgatattaaggcaatgagaagactctaagtccccttcacgcagcagcctcatggtcattacaactgatgtgacaaacacagccctaatccatgttcgcttggggcagcttgactggtcgtttcctctacgtgtgaaatgtcctgtggttttatgttagctgaaatttatctttatgtttactccttgaatcgtttaacccaaagtctgtgatattcagagaaccatcttgggtatttgagcagctattaattaaaggaaaggcaaacatatcaatctctctgccttacccagaaaggaagctgccttcctggtttcttcttcaaataaagacagttctctgtctctagtgtcagaagaatgttctgaaacttaattgcaaatatatttaaggaaagagaagaatctaatatacttttcaaaaatcaccagatattgaaaacgagttgtgagcccttagtaacagccaggctttttgagggagaaaaaaaaatgtgtgttcacatctcatgtccagatacactccacagcaacacacgccagacaaggccctggaacgttgtgctgtaggcacaatagaaagaggccagcctattgcatagcagaatgtctgcatgtgaacagtaagagatagttcccctttcttcatctcttgctctcaaagtccatcctgtgttacttgagcatgatcctagcagcatattttcaagatatcaacattctttagagtatgtgaaacaggcttaatctaatgcaggatatatagatttatgtcttttccctcagcatggagaatttgtttatgcattcctaaacccccacttcacttgcttatcattacaagtacaagaagctgtattcagagatcattattccttcacgtccgtccagtgcccagattgtcccttcgccccttaaaatgattaatcttttgttagtatttgctgtctccttagagctgatatgtttttatttaacaaagcagaatgaacctttaggagatatgtgctggagaggccaatgggcacaaaataagcacttgtcaaatgaatgagaacagcttcctgacagaaagcacattcctagggagttccaaagagggcctcgcggccccactaccaaggagcacgcagaccaaagggtgatggagatgcaggaagatgcagaagcttaaatcactgttagcacttctagaaagtaactgtaatacagacctgcgcttctttttttttttttttttttttttttttttggtatgactgtattttgttttgttttgtttgtttgttctttgtggccagctttaccccataatttaaaaagaaaaatctctctcttttttttcaacatataaaaatggaaggttttggcaaagaactggagagtcctgtggctgctattccgacctaatgccagattttagccgtgttgggttgtaatgcaggagaatgccatttagctggttgcttctcatacacagttgtatgggaacaaagaacggttgatagatgtttcccagtgggggtgctgttggcatttggatcaggataaatccttgttatgctgaaatgtaccacatgttgcaagatgttcagaatcctgggctcctggtgacttaacaccagacattgtgagaacccccaagaaagcttcccacttgcctgcatagaagggtgaaccccttcacctgaatgtcactgtctactgcaacaagggaccatggtggaatgtgcctgtctctaaataccatgtctactgccttgcatgtctctacccacttctctttcaaagccttctgcttagatgcagcttaaactggcctgttccctagaaaagaggttcctaggtggccttgtccaatacagtgggcagtgggcagcgtgacatggcctgatacctctggagggtacatgaagccaatcttgttcgttacttcagtgttacttcagatctagactcctggttgctggcacacagtggctctgagtcaaacatttgtctaggaactcagcattggagtctacctggtaatattagagaccgggttacaaaagagtttcccttcctcctgttgacagcgcagttaatccacacaaaaaagcacttggactccctcatgtaaacatatccatatggttctgcctttctaataagctgtgcaaatgtgacattgtggcagaaatgtgggtaaactggattgcattcatattgttcacaccacagataggcaaaacaaaatgagttttcccccaggtgcaagctcgatcaagctgtgctaaccatacagaaagatactctttatgccactgaaattgaatagtcaataggtcttgaaaaatatttagatgaattgcagctagctgcaaggatggaattaattcctcccattctaatattttaaaattcaaattctaaagacctttttttttaagcatagcaacttggaatcaataaaggtggttatagtgtaaacctatagatggtgcttaaaaaaaatcttatctttcttaatagcagtatttttaaaaagagagagagagaggatacattgaaagaagtaaatgtggcagaatgctgccccaccctcaggtcaattttgtggtttattaaaatgccaataatatttgtgcacttgccagcatcaggggcttttcccttaatggatgctcttgatgtgatttttgagtgtatcattacattgcttagaaagcatccaccatgaaaatttgccaccgtagtgatgactagcattaggaaagaattatgaagaactgagggttaaaccactttcatcccttaaactataggcactaactctttagtatttcttctgtggcttagacatgtgcccacccatcttcctctctcctctctcctctctcctctctcctctctcctctctcctctctcctctctcctctctcctctctcctctctcctctctcctctctcctctcctctcttccctaagtaacaatgtattttccataatggactgtctgtgttcttttgttcttttgaactttggttaaagtgataaagattcctgtaaactgggatcactgggatccagtgtgtgatctaatctttacacaggtgtgctatctgtgggtattaataactggaactatacccggatatcacgacagtttctccctcattttgttcctaactcattactatattatagtatgtgggtgtgacccctgcaagtatccacactgaagcatatgtattccacgattgtaacctgaaagaccatgtattatcttttttattccatattggtgtttgtgttatttaaaaatggaaaattatactcaatctcgtagtataatatagtaggatactctgctgtgcacaattccaagtgccttagaacaatgtttagctttcctaagaatatgtatatgcatatatgtgtgtataaaattgggaaacgttacctcaataaaatcattgggaaatccta

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