LOCUS       NM_001290771            3350 bp    mRNA    linear   ROD 07-AUG-2023
DEFINITION  Mus musculus trophinin (Tro), transcript variant 5, mRNA.
ACCESSION   NM_001290771 XM_006528919
VERSION     NM_001290771.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3350)
  AUTHORS   Park SK, Yoon J, Wang L, Shibata TK, Motamedchaboki K, Shim KJ,
            Chang MS, Lee SH, Tamura N, Hatakeyama S, Nadano D, Sugihara K and
            Fukuda MN.
  TITLE     Enhancement of mouse sperm motility by trophinin-binding peptide
  JOURNAL   Reprod Biol Endocrinol 10, 101 (2012)
   PUBMED   23194061
  REMARK    GeneRIF: The expression of trophinin in the mouse sperm tail causes
            a significant increase in sperm motility.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3350)
  AUTHORS   Shaut CA, Keene DR, Sorensen LK, Li DY and Stadler HS.
  TITLE     HOXA13 Is essential for placental vascular patterning and labyrinth
            endothelial specification
  JOURNAL   PLoS Genet 4 (5), e1000073 (2008)
   PUBMED   18483557
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3350)
  AUTHORS   Miyamoto-Sato E, Ishizaka M, Horisawa K, Tateyama S, Takashima H,
            Fuse S, Sue K, Hirai N, Masuoka K and Yanagawa H.
  TITLE     Cell-free cotranslation and selection using in vitro virus for
            high-throughput analysis of protein-protein interactions and
            complexes
  JOURNAL   Genome Res 15 (5), 710-717 (2005)
   PUBMED   15867431
REFERENCE   4  (bases 1 to 3350)
  AUTHORS   Bertrand M, Huijbers I, Chomez P and De Backer O.
  TITLE     Comparative expression analysis of the MAGED genes during
            embryogenesis and brain development
  JOURNAL   Dev Dyn 230 (2), 325-334 (2004)
   PUBMED   15162511
  REMARK    GeneRIF: Maged3 expression is restricted to the central nervous
            system where it was mostly detected in postmitotic neurons
REFERENCE   5  (bases 1 to 3350)
  AUTHORS   Nadano D, Sugihara K, Paria BC, Saburi S, Copeland NG, Gilbert DJ,
            Jenkins NA, Nakayama J and Fukuda MN.
  TITLE     Significant differences between mouse and human trophinins are
            revealed by their expression patterns and targeted disruption of
            mouse trophinin gene
  JOURNAL   Biol Reprod 66 (2), 313-321 (2002)
   PUBMED   11804944
  REMARK    GeneRIF: Targeted disruption of the trophinin gene in the mouse
            showed a partial embryonic lethality in a 129/SvJ background
REFERENCE   6  (bases 1 to 3350)
  AUTHORS   Saburi S, Nadano D, Akama TO, Hirama K, Yamanouchi K, Naito K, Tojo
            H, Tachi C and Fukuda MN.
  TITLE     The trophinin gene encodes a novel group of MAGE proteins,
            magphinins, and regulates cell proliferation during gametogenesis
            in the mouse
  JOURNAL   J Biol Chem 276 (52), 49378-49389 (2001)
   PUBMED   11590179
REFERENCE   7  (bases 1 to 3350)
  AUTHORS   Chomez P, De Backer O, Bertrand M, De Plaen E, Boon T and Lucas S.
  TITLE     An overview of the MAGE gene family with the identification of all
            human members of the family
  JOURNAL   Cancer Res 61 (14), 5544-5551 (2001)
   PUBMED   11454705
REFERENCE   8  (bases 1 to 3350)
  AUTHORS   Suzuki N, Nadano D, Paria BC, Kupriyanov S, Sugihara K and Fukuda
            MN.
  TITLE     Trophinin expression in the mouse uterus coincides with
            implantation and is hormonally regulated but not induced by
            implanting blastocysts
  JOURNAL   Endocrinology 141 (11), 4247-4254 (2000)
   PUBMED   11089559
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672150.19.
            
            On Mar 19, 2014 this sequence version replaced XM_006528919.1.
            
            Transcript Variant: This variant (5) uses an alternate splice site
            in the 3' coding region, which results in a frameshift, compared to
            variant 1. The encoded isoform (4) has a distinct C-terminus and is
            shorter than isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF288605.1, SRR7345562.1800739.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                AL672150.19        107882-107973       c
            93-162              AL672150.19        106421-106490       c
            163-1788            AL672150.19        104526-106151       c
            1789-1893           AL672150.19        103829-103933       c
            1894-1957           AL672150.19        103657-103720       c
            1958-2037           AL672150.19        103378-103457       c
            2038-2129           AL672150.19        102821-102912       c
            2130-2209           AL672150.19        102090-102169       c
            2210-2252           AL672150.19        101953-101995       c
            2253-2315           AL672150.19        101514-101576       c
            2316-2430           AL672150.19        100971-101085       c
            2431-2538           AL672150.19        100085-100192       c
            2539-3350           AL672150.19        95247-96058         c
FEATURES             Location/Qualifiers
     source          1..3350
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 68.46 cM"
     gene            1..3350
                     /gene="Tro"
                     /gene_synonym="Maged3; Maged3l; magphinin; Tnn; Trol"
                     /note="trophinin"
                     /db_xref="GeneID:56191"
                     /db_xref="MGI:MGI:1928994"
     exon            1..92
                     /gene="Tro"
                     /gene_synonym="Maged3; Maged3l; magphinin; Tnn; Trol"
                     /inference="alignment:Splign:2.1.0"
     exon            93..162
                     /gene="Tro"
                     /gene_synonym="Maged3; Maged3l; magphinin; Tnn; Trol"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    103..105
                     /gene="Tro"
                     /gene_synonym="Maged3; Maged3l; magphinin; Tnn; Trol"
                     /note="upstream in-frame stop codon"
     CDS             118..2634
                     /gene="Tro"
                     /gene_synonym="Maged3; Maged3l; magphinin; Tnn; Trol"
                     /note="isoform 4 is encoded by transcript variant 5;
                     melanoma antigen, family D, 3; trophinin-2; necdin and
                     trophinin like"
                     /codon_start=1
                     /product="trophinin isoform 4"
                     /protein_id="NP_001277700.1"
                     /db_xref="CCDS:CCDS72448.1"
                     /db_xref="GeneID:56191"
                     /db_xref="MGI:MGI:1928994"
                     /translation="

MDRRNDHGHRVPTFQGPLPPAGSLGLPFSPDVQSETTEKDPPIASRSKKNKNKKNSIKPMDKTTPAPPPVPSANDNASNKPKVTLQALNLPMFTQISQASATTEAPNIQASVTSQTQKAKTMRVTPKVSLTGSEDATTQLKPPLQALNLPVTTPTIQTPVANESANSLASTAVNKSKKASTANNAANKTVPSAAEISLASAATHTVTTQGQAAKETGSIQTIAATARSKKNSKGKRTPAKTTNTDNEYVEASNAIEASSRQIGASGRQTEASNRQIEASSRQTEASNRQTEASSRQTEASSRQTETSNRQIGASNRQIMASNRQIGASNRQIEASNRQIGASNRQTEVSSRQIEASNRQIGASNRQTEASNRQIGASNRQTEASNRQIGASNRQTDASNRQTDASNRQTEASSRQTEASSRQTEASSRQTEASSRQIEASAAAVRPKKPRGKKGNNKGSNSASEPSEAPPAIQTVTNHALSVTVRIRRGSRARKAANKNRATESQAQIAEQGAQASEASISALETQVAAAVQALADDYLAQLSLEPTTRTRGKRNRKSKHPNGEERTGNNYRRIPWGRRLPPPRDVAILQERANKLVKYLLVKDQTKIPIKRSDMLKDVIQEYEDYFPEIIERASYALEKMFRVNLKEIDKQNNLYILISTQESSAGIMGTTKDTPKLGLLMVILSVIFMNGNKASEAVIWEVLRKLGLHPGVKHSLFGEVKKLITDEFVKQKYLEYKRVPNSRPPEYEFFWGLRSYHETSKMKVLKFACKVQKKDPKDWAAQYREAVEMDIQAAAVAVAEAKARAEACSPCLQITLTATILPMEPMCSFGIVVHAAA"

     misc_feature    <175..>846
                     /gene="Tro"
                     /gene_synonym="Maged3; Maged3l; magphinin; Tnn; Trol"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    931..>1587
                     /gene="Tro"
                     /gene_synonym="Maged3; Maged3l; magphinin; Tnn; Trol"
                     /note="MSCRAMM family adhesin clumping factor ClfA;
                     Region: MSCRAMM_ClfA; NF033609"
                     /db_xref="CDD:468110"
     misc_feature    1903..2385
                     /gene="Tro"
                     /gene_synonym="Maged3; Maged3l; magphinin; Tnn; Trol"
                     /note="MAGE homology domain; Region: MAGE; pfam01454"
                     /db_xref="CDD:426270"
     exon            163..1788
                     /gene="Tro"
                     /gene_synonym="Maged3; Maged3l; magphinin; Tnn; Trol"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1893
                     /gene="Tro"
                     /gene_synonym="Maged3; Maged3l; magphinin; Tnn; Trol"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..1957
                     /gene="Tro"
                     /gene_synonym="Maged3; Maged3l; magphinin; Tnn; Trol"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2037
                     /gene="Tro"
                     /gene_synonym="Maged3; Maged3l; magphinin; Tnn; Trol"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2129
                     /gene="Tro"
                     /gene_synonym="Maged3; Maged3l; magphinin; Tnn; Trol"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2209
                     /gene="Tro"
                     /gene_synonym="Maged3; Maged3l; magphinin; Tnn; Trol"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2252
                     /gene="Tro"
                     /gene_synonym="Maged3; Maged3l; magphinin; Tnn; Trol"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2315
                     /gene="Tro"
                     /gene_synonym="Maged3; Maged3l; magphinin; Tnn; Trol"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2430
                     /gene="Tro"
                     /gene_synonym="Maged3; Maged3l; magphinin; Tnn; Trol"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2538
                     /gene="Tro"
                     /gene_synonym="Maged3; Maged3l; magphinin; Tnn; Trol"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..3350
                     /gene="Tro"
                     /gene_synonym="Maged3; Maged3l; magphinin; Tnn; Trol"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

aggaccacttccggccaggggggcgggttacaagctcagacctgaggagaggcttggagagagcagacgtcctctcggctcacgagggcgaggctcggctattagcctttcagaaagatggatagaagaaatgaccatggtcatcgggtgcccacattccagggccctctgcctcccgctgggagcctagggcttcctttctctccagatgtacagtcggagaccacagaaaaggacccaccaattgccagccgatctaagaaaaacaagaacaagaagaattctattaagcctatggataagaccacaccggctccccctccagtcccatctgccaatgataatgctagcaacaagcctaaagtaactttgcaggctttaaacctaccaatgttcacccagatcagtcaggcttcagctactactgaggcacccaatatccaggcttcagttacttctcagacccagaaagccaagacaatgagagttactcccaaggtatccctaactggcagtgaggatgccactacacagctgaagccaccattacaggccctaaacctaccagttaccacaccgactatccagactccagttgccaatgagtcagctaattccctggcctcaacagctgtcaacaaatccaagaaagcttctacggcaaacaatgctgccaataagactgtacctagtgctgctgagatctcattggcttcggctgctacccacacagttactacccaaggccaagctgccaaggagacaggtagtatccagactatagcagccactgcccgaagcaagaaaaattccaaaggaaaaagaacacctgctaagaccacaaatactgacaatgaatatgtagaggcctcaaatgccattgaggcatctagcagacagattggggcatctggcagacagactgaggcatctaacagacagattgaggcatctagcagacagactgaggcatctaacagacagactgaggcatctagcagacagactgaagcatctagcagacagactgaaacatctaacagacagattggggcatctaacagacagatcatggcatctaacagacagattggggcatctaacagacagattgaggcatctaacagacagattggggcatctaacagacagacagaggtatctagcagacagattgaggcatctaacagacagattggggcatctaacagacaaactgaggcatctaacagacagattggggcatctaacagacagactgaggcatctaacagacagattggggcatctaacagacagactgatgcatctaacagacagactgatgcatctaacagacagactgaggcatctagcagacagacagaggcatctagcagacagacagaggcatctagcagacagactgaggcatctagcagacaaattgaggcatcagctgcagctgtgaggcccaaaaagcccagggggaagaagggtaacaataaaggctcaaattctgcttctgagccctctgaggctccacctgccattcaaacggttacaaaccatgccctatctgtcactgtacggatcaggagagggtctagggctcgaaaggctgccaataagaatcgggcaactgaaagccaagctcagatcgctgaacaaggagctcaggcctctgaggccagcataagtgccctggagactcaggttgctgctgctgtccaggccttggcagatgactatctggctcagttgagtttagaacccacgaccagaacccggggcaagaggaaccgaaagtctaagcatcccaatggagaagaaagaactggaaataattacaggcggatcccatggggcaggcggcttccaccaccccgagatgtggccattttgcaggaaagggcaaataagttggtgaaatatctgttggttaaagaccagacaaagatcccaatcaagcgctcagatatgctgaaggatgtcatccaagaatatgaggactatttcccagagatcattgaacgagcaagctacgctctggagaagatgtttcgagtcaatctgaaggaaattgataagcaaaataacttgtatattcttatcagcactcaggagtcatctgcaggcataatgggaacgaccaaggacacacctaagctgggtctcctcatggtgattctgagtgtcattttcatgaatggcaacaaggccagtgaggctgtcatctgggaggtgctgcgcaagttgggactgcaccctggggtaaaacattcactctttggagaagtgaagaaactcatcacagatgaatttgtgaagcagaaatatctggaatacaagagggtccccaacagcagaccacctgagtatgaattcttctggggcctacggtcttaccatgagactagcaagatgaaagtcctgaaatttgcatgcaaggtacagaagaaagatcccaaagactgggctgctcagtaccgcgaggcagttgagatggacattcaggctgcagctgtggctgtggctgaggctaaggccagggctgaggcttgttccccctgtttacagataacgctaactgcaacaatacttcccatggagccaatgtgcagctttggaattgttgtccacgcagcagcctgagcactattacccatcagctgagtgaaacactgaaaaatctgctgttcctgctttgtgtttgcttcctgtgttgttgtcatattttggtattagagttacattaaatttgccaaaggaacctgagcttattctgtcctttaatgtgactgcatgtgatgttttgggttcatagaacagctagggttcaacttaactttttgggaaccatggggctccagctaaaaggcaggcatttctcagagtcagagagctctgggaaagtgttctctggtaggccaagggataatagcttgagcaaagatatggaagcgggaagcctaaggtatagggcaaatagaaagtaaactcatattaattttgggtagttgtgtaagaatatagggataagaagggaagaaactaggaattgacctgggagcaagagggcattttcttgggataggaaagaaaacatagtatggtgtgtagggcctagatcaattgagagactggggactggtatggaagataagtatgagatggagctagagagatggctccgtggttaagagcactgacagctcttccaaaggttctgagtggctcacaaccatctgtaatgggatctgatgcccttttctgtgtgtctgaagacagctacagtgtactcctaataaataaataaataaataaataaataaataaataaataaagtgtgagatggtggaaagggtaa

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