LOCUS       NM_001285896            1909 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus calreticulin 4 (Calr4), transcript variant 3, mRNA.
ACCESSION   NM_001285896
VERSION     NM_001285896.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1909)
  AUTHORS   Diaz Del Moral S, Barrena S, Hernandez-Torres F, Aranega A,
            Villaescusa JM, Gomez Doblas JJ, Franco D, Jimenez-Navarro M,
            Munoz-Chapuli R and Carmona R.
  TITLE     Deletion of the Wilms' Tumor Suppressor Gene in the Cardiac
            Troponin-T Lineage Reveals Novel Functions of WT1 in Heart
            Development
  JOURNAL   Front Cell Dev Biol 9, 683861 (2021)
   PUBMED   34368133
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1909)
  AUTHORS   Ansarullah, Jain C, Far FF, Homberg S, Wissmiller K, von Hahn FG,
            Raducanu A, Schirge S, Sterr M, Bilekova S, Siehler J, Wiener J,
            Oppenlander L, Morshedi A, Bastidas-Ponce A, Collden G, Irmler M,
            Beckers J, Feuchtinger A, Grzybek M, Ahlbrecht C, Feederle R,
            Plettenburg O, Muller TD, Meier M, Tschop MH, Coskun U and Lickert
            H.
  TITLE     Inceptor counteracts insulin signalling in beta-cells to control
            glycaemia
  JOURNAL   Nature 590 (7845), 326-331 (2021)
   PUBMED   33505018
  REMARK    Erratum:[Nature. 2021 Apr;592(7852):E1. PMID: 33712809]
REFERENCE   3  (bases 1 to 1909)
  AUTHORS   Dey S and Matsunami H.
  TITLE     Calreticulin chaperones regulate functional expression of
            vomeronasal type 2 pheromone receptors
  JOURNAL   Proc Natl Acad Sci U S A 108 (40), 16651-16656 (2011)
   PUBMED   21933956
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK139540.1, AK077094.1 and BG083829.2.
            
            Transcript Variant: This variant (3) has alternate 5' exon
            structure and it thus differs in the 5' UTR and initiates
            translation at a downstream in-frame start codon, compared to
            variant 1. The encoded isoform (c) is shorter at the N-terminus,
            compared to isoform a. Variants 3, 4 and 5 all encode isoform c.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK139540.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               AK139540.1         3-162
            161-254             AK077094.1         253-346
            255-1075            AK139540.1         257-1077
            1076-1209           AK077094.1         1168-1301
            1210-1889           AK139540.1         1212-1891
            1890-1909           BG083829.2         516-535
FEATURES             Location/Qualifiers
     source          1..1909
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 51.1 cM"
     gene            1..1909
                     /gene="Calr4"
                     /gene_synonym="4933403L16Rik"
                     /note="calreticulin 4"
                     /db_xref="GeneID:108802"
                     /db_xref="MGI:MGI:2140435"
     exon            1..119
                     /gene="Calr4"
                     /gene_synonym="4933403L16Rik"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    95..97
                     /gene="Calr4"
                     /gene_synonym="4933403L16Rik"
                     /note="upstream in-frame stop codon"
     exon            120..221
                     /gene="Calr4"
                     /gene_synonym="4933403L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            222..425
                     /gene="Calr4"
                     /gene_synonym="4933403L16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             392..1333
                     /gene="Calr4"
                     /gene_synonym="4933403L16Rik"
                     /note="isoform c is encoded by transcript variant 3"
                     /codon_start=1
                     /product="calreticulin 4 isoform c"
                     /protein_id="NP_001272825.1"
                     /db_xref="CCDS:CCDS71441.1"
                     /db_xref="GeneID:108802"
                     /db_xref="MGI:MGI:2140435"
                     /translation="

MHSESQYYIMFGPDICGFGNNRLQVILSHKGKYHENNKTLKCRINKDTHLYTLILRPNATYEVKIDNQKVTSGGLEDDWDFLPPKKIKDPYARKPRKWDERQQIEDPDDKKPEDWEDSEFIPDPDAKKPDDWNEAMDGVWEGPLIPNVKYMGEWKPRIIDNPNYQGEWIHPEIDNPKYRPDPTIGHYHNISVLGLDLWQVKSGSIFDNFLLTNDEEFAEEVGNMTWGLRKDVEQQWRELYEEMEKQKEAEETKKKREKERARQEDVWGLDEEDEEDAEEDDEEEAEERLKQEGSAARASLDQKEAHLDQKDEL"

     misc_feature    <392..1024
                     /gene="Calr4"
                     /gene_synonym="4933403L16Rik"
                     /note="Calreticulin family; Region: Calreticulin;
                     pfam00262"
                     /db_xref="CDD:459737"
     exon            426..520
                     /gene="Calr4"
                     /gene_synonym="4933403L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            521..730
                     /gene="Calr4"
                     /gene_synonym="4933403L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            731..844
                     /gene="Calr4"
                     /gene_synonym="4933403L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            845..988
                     /gene="Calr4"
                     /gene_synonym="4933403L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1081
                     /gene="Calr4"
                     /gene_synonym="4933403L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1909
                     /gene="Calr4"
                     /gene_synonym="4933403L16Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gtctagcctaaccagcaagacccaggttatggtgaggtgagaaagtctgtctcaaaaagcaaagacaacatctcaacaactgagtaaggatacctgaggatgttgtctgacctccacatatggatggacaaaacggtgggtacaatctaaacatcagtcagattacggccaattccagctagcctcgggaaaattttatcaagataaagagagagataaaggtctccagaccacagaagatgccaagttctacgccctttccaccaggtttaagccattcagcaatgagaatgagaccttggtggttcagttttcagtaaaacacgagcaaggcatcgattgcggcggtggctacgtgaaactctttcctgccgcactgaaccaggaggacatgcactcagaatcccagtattacatcatgttcggcccggacatctgtggctttggcaacaacagactacaggtcatcctttctcacaaagggaaataccatgagaacaacaagaccctcaagtgcaggattaataaagacactcacctgtacactctgatccttcgccctaatgctacttatgaggttaaaattgacaaccagaaggtgacaagtggaggactggaagatgactgggacttcttgcctcccaagaaaataaaagacccctacgccaggaaaccaaggaaatgggatgaacgacaacagatagaggatcctgacgataagaaacctgaggactgggaggactctgaattcatcccagacccggatgccaagaagccagatgactggaatgaggcgatggatggagtgtgggaagggcccttgataccaaacgtcaagtacatgggagaatggaaacctcggatcattgacaaccccaattaccagggcgagtggattcacccagagatagacaaccccaaatacaggcctgaccccaccattggtcactatcacaacattagtgtccttggtctggatctttggcaggtgaaatcaggcagcatctttgacaatttccttctaacaaatgatgaagagtttgctgaagaggttggaaatatgacctggggattaagaaaggatgtggagcagcagtggagagagctgtatgaggaaatggagaaacagaaggaggcggaggagaccaagaagaagagggaaaaggagagagccaggcaagaggacgtctggggactagatgaggaggatgaggaggacgctgaagaggacgacgaggaggaagcagaggaaaggctcaagcaggaaggcagtgcagcgagggcgtctctggaccagaaggaagcccacttggatcagaaggatgaactgtaactgcacagacactgggtgtggccgaagtcagagacggtgcttagagagggaaatgggccctcgcttagcaaattatgggaagtaaaacgactcattctttttagataaactttggatttatagttctactccccttccctgctctatttgctcattggtagaaagggaatgataattttatctcatgaaatggcccttgggactgaatgaggcaatgcctgtaacatgcccaaagtaaatacttgtaaaaaaaatgtagtagttaaaactactatcattatcatggtgtttatgaaattaattgttggtaaataagcttctatataaacttggttcttactttcaactggggtttttcttttgtttaaatatatgcaattcttagtatttatggagcagtgctaacagttgaacccaatgtttccttttttttttttttttttaaatgtattgagcacctaaagccaaaagcagaacatcctttggacgtttggaaaaatacttcatgaaagtcaccttgtttgcctgctgctcttgccttatgtttaaacaattgttacttgtttgcaagtttgc

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