LOCUS       NM_001252260            1401 bp    mRNA    linear   ROD 07-JAN-2026
DEFINITION  Mus musculus nucleophosmin 1 (Npm1), transcript variant 2, mRNA.
ACCESSION   NM_001252260
VERSION     NM_001252260.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1401)
  AUTHORS   Datar,G.K., Khabusheva,E., Anand,A., Beale,J., Sadek,M., Chen,C.W.,
            Potolitsyna,E., Alcantara-Contessoto,N., Liu,G., De La Fuente,J.,
            Dollinger,C., Guzman,A., Martell,A., Wohlan,K., Maiti,A.,
            Short,N.J., Yi,S.S., Andresen,V., Gjertsen,B.T., Falini,B.,
            Rau,R.E., Brunetti,L., Sahni,N., Goodell,M.A. and Riback,J.A.
  TITLE     Disparate leukemia mutations converge on nuclear phase-separated
            condensates
  JOURNAL   Cell 188 (25), 7118-7136 (2025)
   PUBMED   41192422
REFERENCE   2  (bases 1 to 1401)
  AUTHORS   Miluzio,A., Scagliola,A., Ferrari,I., Yilmaz,H., D'Andrea,G.,
            Cassina,L., Oliveto,S., Ricciardi,S., Boletta,A. and Biffo,S.
  TITLE     Recycling of ribosomes at stop codons drives the rate of
            translation and the transition from proliferation to RESt
  JOURNAL   Mol Cell 85 (23), 4410-4425 (2025)
   PUBMED   41290002
REFERENCE   3  (bases 1 to 1401)
  AUTHORS   Li,W., Zhang,J. and Liu,Q.
  TITLE     Kin17 promotes rDNA transcription, ribosomal biogenesis, and
            cortical lamination
  JOURNAL   EMBO Rep 26 (17), 4283-4311 (2025)
   PUBMED   40676207
REFERENCE   4  (bases 1 to 1401)
  AUTHORS   Wu,M., Wu,X., Sun,H., Wang,W., Zhang,L., Liu,X., Zhang,Y.,
            Zhang,X., Liu,J., Shen,B. and Zhou,T.
  TITLE     VIRMA-mediated m6A modification regulates forebrain formation
            through modulating ribosome biogenesis
  JOURNAL   Sci Adv 11 (26), eadq9643 (2025)
   PUBMED   40577453
REFERENCE   5  (bases 1 to 1401)
  AUTHORS   Sakamoto,T., Leca,J., Zhang,X., Meydan,C., Foox,J.,
            Ramachandran,P., Hendrikse,L.D., Zhou,W., Berger,T., Fortin,J.,
            Chan,S.M., Chiang,M.F., Inoue,S., Li,W.Y., Chu,M.F., Duncan,G.S.,
            Wakeham,A., Lemonnier,F., Tobin,C., Mcwilliam,R., Colonna,I.,
            Bontoux,C., Jafari,S.M., Bowman,R.L., Nicolay,B., Ronseaux,S.,
            Narayanaswamy,R., Levine,R.L., Melnick,A.M., Mason,C.E.,
            Minden,M.D. and Mak,T.W.
  TITLE     Mutant IDH1 cooperates with NPM1c or FLT3ITD to drive distinct
            myeloid diseases and molecular outcomes
  JOURNAL   Proc Natl Acad Sci U S A 122 (20), e2415779122 (2025)
   PUBMED   40377995
REFERENCE   6  (bases 1 to 1401)
  AUTHORS   Sowden,J.C., Morrison,K., Putt,W., Beddington,R. and Edwards,Y.H.
  TITLE     The identification of novel sequences expressed in the mouse
            notochord
  JOURNAL   Mamm Genome 8 (1), 42-44 (1997)
   PUBMED   9021147
REFERENCE   7  (bases 1 to 1401)
  AUTHORS   Inouye,C.J. and Seto,E.
  TITLE     Relief of YY1-induced transcriptional repression by protein-protein
            interaction with the nucleolar phosphoprotein B23
  JOURNAL   J Biol Chem 269 (9), 6506-6510 (1994)
   PUBMED   8120001
REFERENCE   8  (bases 1 to 1401)
  AUTHORS   Van den Eynde,B., Lethe,B., Van Pel,A., De Plaen,E. and Boon,T.
  TITLE     The gene coding for a major tumor rejection antigen of tumor P815
            is identical to the normal gene of syngeneic DBA/2 mice
  JOURNAL   J Exp Med 173 (6), 1373-1384 (1991)
   PUBMED   1903428
REFERENCE   9  (bases 1 to 1401)
  AUTHORS   Biggiogera,M., Burki,K., Kaufmann,S.H., Shaper,J.H., Gas,N.,
            Amalric,F. and Fakan,S.
  TITLE     Nucleolar distribution of proteins B23 and nucleolin in mouse
            preimplantation embryos as visualized by immunoelectron microscopy
  JOURNAL   Development 110 (4), 1263-1270 (1990)
   PUBMED   2100262
REFERENCE   10 (bases 1 to 1401)
  AUTHORS   Schmidt-Zachmann,M.S. and Franke,W.W.
  TITLE     DNA cloning and amino acid sequence determination of a major
            constituent protein of mammalian nucleoli. Correspondence of the
            nucleoplasmin-related protein NO38 to mammalian protein B23
  JOURNAL   Chromosoma 96 (6), 417-426 (1988)
   PUBMED   3219912
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA540276.1, BU513690.1, BC089546.1 and CX567338.1.
            
            Transcript Variant: This variant (2) lacks an in-frame segment in
            the 5' coding region, compared to variant 1. The resulting isoform
            (2) lacks an internal segment, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784646.1017816.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               CA540276.1         1-144
            145-622             BU513690.1         1-478
            623-748             BU513690.1         480-605
            749-1307            BC089546.1         658-1216
            1308-1401           CX567338.1         632-725
FEATURES             Location/Qualifiers
     source          1..1401
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 19.21 cM"
     gene            1..1401
                     /gene="Npm1"
                     /gene_synonym="B23; NO38; Npm"
                     /note="nucleophosmin 1"
                     /db_xref="GeneID:18148"
                     /db_xref="MGI:MGI:106184"
     exon            1..285
                     /gene="Npm1"
                     /gene_synonym="B23; NO38; Npm"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..1067
                     /gene="Npm1"
                     /gene_synonym="B23; NO38; Npm"
                     /note="isoform 2 is encoded by transcript variant 2;
                     numatrin; nucleolar phosphoprotein B23; nucleolar protein
                     NO38"
                     /codon_start=1
                     /product="nucleophosmin isoform 2"
                     /protein_id="NP_001239189.1"
                     /db_xref="GeneID:18148"
                     /db_xref="MGI:MGI:106184"
                     /translation="

MEDSMDMDMSPLRPQNYLFVDNDENEHQLSLRTVSLGAGAKDELHIVEAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVEEDAESEDEDEEDVKLLGMSGKRSAPGGGNKVPQKKVKLDEDDEDDDEDDEDDEDDDDDDFDEEETEEKVPVKKSVRDTPAKNAQKSNQNGKDLKPSTPRSKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCFRMTDQEAIQDLWQWRKSL"

     misc_feature    288..539
                     /gene="Npm1"
                     /gene_synonym="B23; NO38; Npm"
                     /note="Nucleoplasmin/nucleophosmin domain; Region:
                     Nucleoplasmin; pfam03066"
                     /db_xref="CDD:460792"
     misc_feature    915..1061
                     /gene="Npm1"
                     /gene_synonym="B23; NO38; Npm"
                     /note="Nucleophosmin C-terminal domain; Region: NPM1-C;
                     pfam16276"
                     /db_xref="CDD:465081"
     exon            286..326
                     /gene="Npm1"
                     /gene_synonym="B23; NO38; Npm"
                     /inference="alignment:Splign:2.1.0"
     exon            327..446
                     /gene="Npm1"
                     /gene_synonym="B23; NO38; Npm"
                     /inference="alignment:Splign:2.1.0"
     exon            447..540
                     /gene="Npm1"
                     /gene_synonym="B23; NO38; Npm"
                     /inference="alignment:Splign:2.1.0"
     exon            541..647
                     /gene="Npm1"
                     /gene_synonym="B23; NO38; Npm"
                     /inference="alignment:Splign:2.1.0"
     exon            648..709
                     /gene="Npm1"
                     /gene_synonym="B23; NO38; Npm"
                     /inference="alignment:Splign:2.1.0"
     exon            710..767
                     /gene="Npm1"
                     /gene_synonym="B23; NO38; Npm"
                     /inference="alignment:Splign:2.1.0"
     exon            768..851
                     /gene="Npm1"
                     /gene_synonym="B23; NO38; Npm"
                     /inference="alignment:Splign:2.1.0"
     exon            852..953
                     /gene="Npm1"
                     /gene_synonym="B23; NO38; Npm"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1028
                     /gene="Npm1"
                     /gene_synonym="B23; NO38; Npm"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1383
                     /gene="Npm1"
                     /gene_synonym="B23; NO38; Npm"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ggcgcacgcgcaaaagcgcgactgtgcggggagtgggagggatccagaggaggctcgcggaggcaggactagcgcagatctcgcgagatctcctgcgaccatatatacgtgcggagagcccgcgtcctttccttggcgtgattccgtcctgcgcgtctgttctgtggaacaggaggcagttgttttccgtccggcttctcccacaccgaagtgcgcgcctccacctcatggaagactcgatggatatggacatgagtcctcttaggcctcagaactaccttttcgtggataatgatgaaaatgagcaccagttgtcattaagaacggtcagtttaggagcaggggcaaaagatgagttacacatcgtagaggcagaagcaatgaactatgaaggcagtccaattaaagtaacactggcaactttgaaaatgtctgtacaaccaacagtttccctagggggctttgaaattacaccacctgtggtcttacggttgaagtgtggttcagggcctgtgcacattagtggacagcatctagtagctgtagaggaagatgcagagtctgaagatgaagatgaggaggacgtaaaactcttaggcatgtctggaaagcgatctgctcctggaggtggtaacaaggttccacagaaaaaagtaaaacttgatgaagatgatgaggacgatgatgaggacgatgaggatgatgaggatgatgatgatgatgattttgatgaagaggaaactgaagaaaaggtcccagtgaagaaatctgtacgagataccccagccaaaaatgcacaaaaatcaaaccaaaatggaaaagacttaaaaccatcaacaccgagatcaaagggtcaagagtccttcaaaaaacaggaaaagactcctaaaacaccaaaaggacctagttctgtagaagacattaaggcaaaaatgcaagcaagtatagaaaaaggcggttctcttcccaaagtggaagccaagttcattaattatgtgaagaattgtttccggatgactgaccaggaggctattcaagatctctggcagtggaggaaatctctttaagaaaagggtttaaacagtttgaaatattctgtcttcatttctgtaatagttaatatctggctgtcctttttataatgcaaagtgagaactttccctactgtgtttgataaatgttgtccaggttcacttgccaagaatgtgttgtctaaaatgcctgtttagttttcaaggatggaactccaccctttacttggttttaagtatgtatggaatgttatgataggacatagtaatagtggtcagatgtggaaatggtagggagacaaatatacatgtgaaataaactcagtattttaataaagtagcactgtttctaaaaaaaaaaaaaaaaaaa

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