2024-06-29 21:35:28, GGRNA.v2 : RefSeq release 224 (May, 2024)
LOCUS NM_001163491 3096 bp mRNA linear ROD 19-MAR-2024 DEFINITION Mus musculus sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A (Sema4a), transcript variant 4, mRNA. ACCESSION NM_001163491 VERSION NM_001163491.2 KEYWORDS RefSeq. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. REFERENCE 1 (bases 1 to 3096) AUTHORS Naito,Y., Koyama,S., Masuhiro,K., Hirai,T., Uenami,T., Inoue,T., Osa,A., Machiyama,H., Watanabe,G., Sax,N., Villa,J., Kinugasa-Katayama,Y., Nojima,S., Yaga,M., Hosono,Y., Okuzaki,D., Satoh,S., Tsuda,T., Nakanishi,Y., Suga,Y., Morita,T., Fukushima,K., Nishide,M., Shiroyama,T., Miyake,K., Iwahori,K., Hirata,H., Nagatomo,I., Yano,Y., Tamiya,M., Kumagai,T., Takemoto,N., Inohara,H., Yamasaki,S., Yamashita,K., Aoshi,T., Akbay,E.A., Hosen,N., Shintani,Y., Takamatsu,H., Mori,M., Takeda,Y. and Kumanogoh,A. TITLE Tumor-derived semaphorin 4A improves PD-1-blocking antibody efficacy by enhancing CD8+ T cell cytotoxicity and proliferation JOURNAL Sci Adv 9 (20), eade0718 (2023) PUBMED 37205755 REFERENCE 2 (bases 1 to 3096) AUTHORS Martins,L.F., Brambilla,I., Motta,A., de Pretis,S., Bhat,G.P., Badaloni,A., Malpighi,C., Amin,N.D., Imai,F., Almeida,R.D., Yoshida,Y., Pfaff,S.L. and Bonanomi,D. TITLE Motor neurons use push-pull signals to direct vascular remodeling critical for their connectivity JOURNAL Neuron 110 (24), 4090-4107 (2022) PUBMED 36240771 REFERENCE 3 (bases 1 to 3096) AUTHORS Xu,R., Hoss,C., Swiercz,J.M., Brandt,D.T., Lutz,V., Petersen,N., Li,R., Zhao,D., Oleksy,A., Creigh-Pulatmen,T., Trokter,M., Fedorova,M., Atzberger,A., Strandby,R.B., Olsen,A.A., Achiam,M.P., Matthews,D., Huber,M., Grone,H.J., Offermanns,S. and Worzfeld,T. TITLE A semaphorin-plexin-Rasal1 signaling pathway inhibits gastrin expression and protects against peptic ulcers JOURNAL Sci Transl Med 14 (654), eabf1922 (2022) PUBMED 35857828 REFERENCE 4 (bases 1 to 3096) AUTHORS Suga,Y., Nagatomo,I., Kinehara,Y., Koyama,S., Okuzaki,D., Osa,A., Naito,Y., Takamatsu,H., Nishide,M., Nojima,S., Ito,D., Tsuda,T., Nakatani,T., Nakanishi,Y., Futami,Y., Koba,T., Satoh,S., Hosono,Y., Miyake,K., Fukushima,K., Shiroyama,T., Iwahori,K., Hirata,H., Takeda,Y. and Kumanogoh,A. TITLE IL-33 Induces Sema4A Expression in Dendritic Cells and Exerts Antitumor Immunity JOURNAL J Immunol 207 (5), 1456-1467 (2021) PUBMED 34380650 REFERENCE 5 (bases 1 to 3096) AUTHORS Limoni,G., Murthy,S., Jabaudon,D., Dayer,A. and Niquille,M. TITLE PlexinA4-Semaphorin3A-mediated crosstalk between main cortical interneuron classes is required for superficial interneuron lamination JOURNAL Cell Rep 34 (4), 108644 (2021) PUBMED 33503438 REFERENCE 6 (bases 1 to 3096) AUTHORS Oster,S.F., Bodeker,M.O., He,F. and Sretavan,D.W. TITLE Invariant Sema5A inhibition serves an ensheathing function during optic nerve development JOURNAL Development 130 (4), 775-784 (2003) PUBMED 12506007 REFERENCE 7 (bases 1 to 3096) AUTHORS Dionne,M.S., Brunet,L.J., Eimon,P.M. and Harland,R.M. TITLE Noggin is required for correct guidance of dorsal root ganglion axons JOURNAL Dev Biol 251 (2), 283-293 (2002) PUBMED 12435358 REFERENCE 8 (bases 1 to 3096) AUTHORS Kumanogoh,A., Marukawa,S., Suzuki,K., Takegahara,N., Watanabe,C., Ch'ng,E., Ishida,I., Fujimura,H., Sakoda,S., Yoshida,K. and Kikutani,H. TITLE Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2 JOURNAL Nature 419 (6907), 629-633 (2002) PUBMED 12374982 REFERENCE 9 (bases 1 to 3096) AUTHORS Puschel,A.W., Adams,R.H. and Betz,H. TITLE The sensory innervation of the mouse spinal cord may be patterned by differential expression of and differential responsiveness to semaphorins JOURNAL Mol Cell Neurosci 7 (5), 419-431 (1996) PUBMED 8812066 REFERENCE 10 (bases 1 to 3096) AUTHORS Puschel,A.W., Adams,R.H. and Betz,H. TITLE Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension JOURNAL Neuron 14 (5), 941-948 (1995) PUBMED 7748561 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC102388.7. On Mar 19, 2024 this sequence version replaced NM_001163491.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7345562.3681488.1, SRR17784651.1106350.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375 [ECO:0006172] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-83 AC102388.7 32029-32111 84-251 AC102388.7 36076-36243 252-412 AC102388.7 37791-37951 413-475 AC102388.7 38840-38902 476-574 AC102388.7 39136-39234 575-680 AC102388.7 39472-39577 681-797 AC102388.7 40295-40411 798-922 AC102388.7 40810-40934 923-1095 AC102388.7 41070-41242 1096-1246 AC102388.7 42781-42931 1247-1427 AC102388.7 50044-50224 1428-1546 AC102388.7 52361-52479 1547-1704 AC102388.7 52582-52739 1705-1802 AC102388.7 53022-53119 1803-3096 AC102388.7 53670-54963 FEATURES Location/Qualifiers source 1..3096 /organism="Mus musculus" /mol_type="mRNA" /strain="C57BL/6" /db_xref="taxon:10090" /chromosome="3" /map="3 38.83 cM" gene 1..3096 /gene="Sema4a" /gene_synonym="Semab; SemB" /note="sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A" /db_xref="GeneID:20351" /db_xref="MGI:MGI:107560" exon 1..83 /gene="Sema4a" /gene_synonym="Semab; SemB" /inference="alignment:Splign:2.1.0" misc_feature 23..25 /gene="Sema4a" /gene_synonym="Semab; SemB" /note="upstream in-frame stop codon" exon 84..251 /gene="Sema4a" /gene_synonym="Semab; SemB" /inference="alignment:Splign:2.1.0" CDS 113..2395 /gene="Sema4a" /gene_synonym="Semab; SemB" /note="semaphorin-4A; sema B; semaphorin-B" /codon_start=1 /product="semaphorin-4A precursor" /protein_id="NP_001156963.1" /db_xref="CCDS:CCDS17475.1" /db_xref="GeneID:20351" /db_xref="MGI:MGI:107560" /translation="
MALPSLGQDSWSLLRVFFFQLFLLPSLPPASGTGGQGPMPRVKYHAGDGHRALSFFQQKGLRDFDTLLLSDDGNTLYVGAREAVLALNIQNPGIPRLKNMIPWPASERKKTECAFKKKSNETQCFNFIRVLVSYNATHLYACGTFAFSPACTFIELQDSLLLPILIDKVMDGKGQSPFDPVHKHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDIFLRWLHADASFVAAIPSTQVVYFFFEETASEFDFFEELYISRVAQVCKNDVGGEKLLQKKWTTFLKAQLLCAQPGQLPFNIIRHAVLLPADSPSVSRIYAVFTSQWQVGGTRSSAVCAFSLTDIERVFKGKYKELNKETSRWTTYRGSEVSPRPGSCSMGPSSDKALTFMKDHFLMDEHVVGTPLLVKSGVEYTRLAVESARGLDGSSHVVMYLGTSTGSLHKAVVPQDSSAYLVEEIQLSPDSEPVRNLQLAPAQGAVFAGFSGGIWRVPRANCSVYESCVDCVLARDPHCAWDPESRLCSLLSGSTKPWKQDMERGNPEWVCTRGPMARSPRRQSPPQLIKEVLTVPNSILELPCPHLSALASYHWSHGRAKISEASATVYNGSLLLLPQDGVGGLYQCVATENGYSYPVVSYWVDSQDQPLALDPELAGVPRERVQVPLTRVGGGASMAAQRSYWPHFLIVTVLLAIVLLGVLTLLLASPLGALRARGKVQGCGMLPPREKAPLSRDQHLQPSKDHRTSASDVDADNNHLGAEVA"
sig_peptide 113..208 /gene="Sema4a" /gene_synonym="Semab; SemB" /inference="COORDINATES: ab initio prediction:SignalP:6.0" mat_peptide 209..2392 /gene="Sema4a" /gene_synonym="Semab; SemB" /product="Semaphorin-4A. /id=PRO_0000032323" /note="propagated from UniProtKB/Swiss-Prot (Q62178.2)" misc_feature 275..1597 /gene="Sema4a" /gene_synonym="Semab; SemB" /note="The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693" /db_xref="CDD:472829" misc_feature 470..472 /gene="Sema4a" /gene_synonym="Semab; SemB" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (Q62178.2); glycosylation site" misc_feature 515..517 /gene="Sema4a" /gene_synonym="Semab; SemB" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (Q62178.2); glycosylation site" misc_feature 1598..1732 /gene="Sema4a" /gene_synonym="Semab; SemB" /note="domain found in Plexins, Semaphorins and Integrins; Region: PSI; smart00423" /db_xref="CDD:214655" misc_feature 1598..1600 /gene="Sema4a" /gene_synonym="Semab; SemB" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (Q62178.2); glycosylation site" misc_feature 1820..2023 /gene="Sema4a" /gene_synonym="Semab; SemB" /note="Immunoglobulin domain; Region: Ig; cl11960" /db_xref="CDD:472250" misc_feature 1835..1849 /gene="Sema4a" /gene_synonym="Semab; SemB" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409456" misc_feature 1871..1885 /gene="Sema4a" /gene_synonym="Semab; SemB" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409456" misc_feature 1928..1942 /gene="Sema4a" /gene_synonym="Semab; SemB" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409456" misc_feature 1928..1930 /gene="Sema4a" /gene_synonym="Semab; SemB" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (Q62178.2); glycosylation site" misc_feature 1970..1987 /gene="Sema4a" /gene_synonym="Semab; SemB" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409456" misc_feature 2159..2221 /gene="Sema4a" /gene_synonym="Semab; SemB" /note="propagated from UniProtKB/Swiss-Prot (Q62178.2); transmembrane region" misc_feature 2270..2392 /gene="Sema4a" /gene_synonym="Semab; SemB" /note="propagated from UniProtKB/Swiss-Prot (Q62178.2); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" exon 252..412 /gene="Sema4a" /gene_synonym="Semab; SemB" /inference="alignment:Splign:2.1.0" exon 413..475 /gene="Sema4a" /gene_synonym="Semab; SemB" /inference="alignment:Splign:2.1.0" exon 476..574 /gene="Sema4a" /gene_synonym="Semab; SemB" /inference="alignment:Splign:2.1.0" exon 575..680 /gene="Sema4a" /gene_synonym="Semab; SemB" /inference="alignment:Splign:2.1.0" exon 681..797 /gene="Sema4a" /gene_synonym="Semab; SemB" /inference="alignment:Splign:2.1.0" exon 798..922 /gene="Sema4a" /gene_synonym="Semab; SemB" /inference="alignment:Splign:2.1.0" exon 923..1095 /gene="Sema4a" /gene_synonym="Semab; SemB" /inference="alignment:Splign:2.1.0" exon 1096..1246 /gene="Sema4a" /gene_synonym="Semab; SemB" /inference="alignment:Splign:2.1.0" exon 1247..1427 /gene="Sema4a" /gene_synonym="Semab; SemB" /inference="alignment:Splign:2.1.0" exon 1428..1546 /gene="Sema4a" /gene_synonym="Semab; SemB" /inference="alignment:Splign:2.1.0" exon 1547..1704 /gene="Sema4a" /gene_synonym="Semab; SemB" /inference="alignment:Splign:2.1.0" exon 1705..1802 /gene="Sema4a" /gene_synonym="Semab; SemB" /inference="alignment:Splign:2.1.0" exon 1803..3096 /gene="Sema4a" /gene_synonym="Semab; SemB" /inference="alignment:Splign:2.1.0" ORIGIN
agagaagtcagaccattgtgtgtaatgctcaacgcagcttccagcactagccagactgagagagggagcccaagaggcactggaaccatctggtgaccatctcaggctgaccatggccctaccatccctgggccaggactcatggagtctcctgcgtgtttttttcttccaactcttcctgctgccatcactgccacctgcttctgggactggtggtcaggggcccatgcccagagtcaaataccatgctggagacgggcacagggccctcagcttcttccaacaaaaaggcctccgagactttgacacgctgctcctgagtgacgatggcaacactctctatgtgggggctcgagaggccgtcctggccttgaatatccagaacccaggaatcccaaggctaaagaacatgataccctggccagccagtgagagaaaaaagaccgaatgtgcctttaagaagaagagcaatgagacacagtgtttcaacttcattcgagtcctggtctcttacaatgctactcacctctatgcctgtgggacctttgccttcagccctgcctgtaccttcattgaactccaagattccctcctgttgcccatcttgatagacaaggtcatggacgggaagggccaaagcccctttgaccctgttcacaagcacacagctgtcttggtcgatgggatgctttattccggcaccatgaacaacttcctgggcagcgagcccatcctgatgcggacactgggatcccagcctgttctcaagactgacatcttcttacgctggctgcacgcggatgcctccttcgtggcagccattccatccacccaggtcgtctatttcttctttgaggagacagccagcgagtttgacttctttgaagagctgtatatatccagggtggctcaagtctgcaagaacgacgtgggcggtgaaaagctgctgcagaagaagtggaccaccttcctcaaagcccagttgctctgcgctcagccagggcagctgccattcaacatcatccgccacgcggtcctgctgcccgccgattctccctctgtttcccgcatctacgcagtctttacctcccagtggcaggttggcgggaccaggagctcagcagtctgtgccttctctctcacggacattgagcgagtctttaaagggaagtacaaggagctgaacaaggagacctcccgctggaccacttaccggggctcagaggtcagcccgaggccaggcagttgctccatgggcccctcctctgacaaagccttgaccttcatgaaggaccattttctgatggatgagcacgtggtaggaacacccctgctggtgaagtctggtgtggagtacacacggcttgctgtggagtcagctcggggccttgatgggagcagccatgtggtcatgtatctgggtacctccacggggtccctgcacaaggctgtggtgcctcaggacagcagtgcttatctcgtggaggagattcagctgagccctgactctgagcctgttcgaaacctgcagctggcccccgcccagggtgcagtgtttgcaggcttctctggaggcatctggagagttcccagggccaattgcagtgtctacgagagctgtgtggactgtgtgcttgccagggaccctcactgtgcctgggaccctgaatcaagactctgcagccttctgtctggctctaccaagccttggaagcaggacatggaacgcggcaacccggagtgggtatgcacccgtggccccatggccaggagcccccggcgtcagagcccccctcaactaattaaagaagtcctgacagtccccaactccatcctggagctgccctgcccccacctgtcagcactggcctcttaccactggagtcatggccgagccaaaatctcagaagcctctgctaccgtctacaatggctccctcttgctgctgccgcaggatggtgtcgggggcctctaccagtgtgtggcgactgagaacggctactcataccctgtggtctcctattgggtagacagccaggaccagcccctggcgctggaccctgagctggcgggcgttccccgtgagcgtgtgcaggtcccgctgaccagggtcggaggcggagcttccatggctgcccagcggtcctactggccccattttctcatcgttaccgtcctcctggccatcgtgctcctgggagtgctcactctcctcctcgcttccccactgggggcgctgcgggctcggggtaaggttcagggctgtgggatgctgccccccagggaaaaggctccactgagcagggaccagcacctccagccctccaaggaccacaggacctctgccagtgacgtagatgccgacaacaaccatctgggcgccgaagtggcttaaacagggacacagatccgcagctgagcagagcaagccactggccttgttggctatgccaggcacagtgccactctgaccagggtaggaggctctcctgctaacgtgtgtcacctacagcacccagtaggtcctcccctgtgggactctcttctgcaagcacattgggctgtctccatacctgtacttgtgctgtgacaggaagagccagacaggtttctttgattttgattgacccaagagccctcctgtaacaaacgtgctccaggagaccatgaaaggtgtggctgtctgggattctgtggtgacaaacctaagcatccgagcaagctggggctattcctgcaaactccatcctgaacgctgtcactctagaagcagctgctgctttgaacaccagcccaccctccttcccaagagtctctatggagttggccccttgtgtttcctttaccagtcatgccatactgtttgggaagtcatctctgaagtctaaccaccttccttcttgcttcagtttggacagattgttattattgtctctgccctggctagaatggggggcataatctgagccttgttcccttgtccagtgtggctgacccttgacctcttccttcctcctccctttgttttgggattcagaaaactgcttgtcacagacaatttattttttattaaaaaagatataagctttaaagaaa
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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