LOCUS       NM_001038590             888 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus claudin 19 (Cldn19), transcript variant 1, mRNA.
ACCESSION   NM_001038590
VERSION     NM_001038590.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 888)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 888)
  AUTHORS   Dimke,H., Griveau,C., Ling,W.E., Brideau,G., Cheval,L., Muthan,P.,
            Muller,D., Al-Shebel,A., Houillier,P. and Prot-Bertoye,C.
  TITLE     Claudin-19 localizes to the thick ascending limb where its
            expression is required for junctional claudin-16 localization
  JOURNAL   Ann N Y Acad Sci 1526 (1), 126-137 (2023)
   PUBMED   37344378
  REMARK    GeneRIF: Claudin-19 localizes to the thick ascending limb where its
            expression is required for junctional claudin-16 localization.
REFERENCE   3  (bases 1 to 888)
  AUTHORS   Higashi,A.Y., Higashi,T., Furuse,K., Ozeki,K., Furuse,M. and
            Chiba,H.
  TITLE     Claudin-9 constitutes tight junctions of folliculo-stellate cells
            in the anterior pituitary gland
  JOURNAL   Sci Rep 11 (1), 21642 (2021)
   PUBMED   34737342
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 888)
  AUTHORS   Moruzzo,D., Nobbio,L., Sterlini,B., Consalez,G.G., Benfenati,F.,
            Schenone,A. and Corradi,A.
  TITLE     The Transcription Factors EBF1 and EBF2 Are Positive Regulators of
            Myelination in Schwann Cells
  JOURNAL   Mol Neurobiol 54 (10), 8117-8127 (2017)
   PUBMED   27889898
REFERENCE   5  (bases 1 to 888)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 888)
  AUTHORS   Angelow,S., Ahlstrom,R. and Yu,A.S.
  TITLE     Biology of claudins
  JOURNAL   Am J Physiol Renal Physiol 295 (4), F867-F876 (2008)
   PUBMED   18480174
  REMARK    Review article
REFERENCE   7  (bases 1 to 888)
  AUTHORS   Krause,G., Winkler,L., Mueller,S.L., Haseloff,R.F., Piontek,J. and
            Blasig,I.E.
  TITLE     Structure and function of claudins
  JOURNAL   Biochim Biophys Acta 1778 (3), 631-645 (2008)
   PUBMED   18036336
  REMARK    Review article
REFERENCE   8  (bases 1 to 888)
  AUTHORS   Lee,N.P., Tong,M.K., Leung,P.P., Chan,V.W., Leung,S., Tam,P.C.,
            Chan,K.W., Lee,K.F., Yeung,W.S. and Luk,J.M.
  TITLE     Kidney claudin-19: localization in distal tubules and collecting
            ducts and dysregulation in polycystic renal disease
  JOURNAL   FEBS Lett 580 (3), 923-931 (2006)
   PUBMED   16427635
REFERENCE   9  (bases 1 to 888)
  AUTHORS   Miyamoto,T., Morita,K., Takemoto,D., Takeuchi,K., Kitano,Y.,
            Miyakawa,T., Nakayama,K., Okamura,Y., Sasaki,H., Miyachi,Y.,
            Furuse,M. and Tsukita,S.
  TITLE     Tight junctions in Schwann cells of peripheral myelinated axons: a
            lesson from claudin-19-deficient mice
  JOURNAL   J Cell Biol 169 (3), 527-538 (2005)
   PUBMED   15883201
REFERENCE   10 (bases 1 to 888)
  AUTHORS   Luk,J.M., Tong,M.K., Mok,B.W., Tam,P.C., Yeung,W.S. and Lee,K.F.
  TITLE     Sp1 site is crucial for the mouse claudin-19 gene expression in the
            kidney cells
  JOURNAL   FEBS Lett 578 (3), 251-256 (2004)
   PUBMED   15589828
  REMARK    GeneRIF: Sp1 site is crucial for Cldn19 gene expression in kidney
            cells.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF486651.2.
            
            Summary: This gene encodes a member of the claudin family. Claudins
            are integral membrane proteins and components of tight junction
            strands. Tight junction strands serve as a physical barrier to
            prevent solutes and water from passing freely through the
            paracellular space between epithelial or endothelial cell sheets,
            and also play critical roles in maintaining cell polarity and
            signal transductions. siRNA knockdown of this gene in mice develops
            the FHHNC (familial hypomagnesemia with hypercalciuria and
            nephrocalcinosis) symptoms of chronic renal wasting of magnesium
            and calcium together with defective renal salt handling. The
            protein encoded by this gene interacts with another family member,
            Claudin 16, and their interaction is required for their assembly
            into tight junctions and for renal reabsorption of magnesium. This
            protein is a constituent of tight junctions in the Schwann cells of
            peripheral myelinated nerves and the gene deficiency affects the
            nerve conduction of peripheral myelinated fibers. Alternatively
            spliced transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Aug 2010].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF486651.2, CK129653.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..888
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 55.34 cM"
     gene            1..888
                     /gene="Cldn19"
                     /note="claudin 19"
                     /db_xref="GeneID:242653"
                     /db_xref="MGI:MGI:3033992"
     exon            1..327
                     /gene="Cldn19"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    36..38
                     /gene="Cldn19"
                     /note="upstream in-frame stop codon"
     CDS             105..779
                     /gene="Cldn19"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="claudin-19 isoform 1"
                     /protein_id="NP_001033679.1"
                     /db_xref="CCDS:CCDS18577.1"
                     /db_xref="GeneID:242653"
                     /db_xref="MGI:MGI:3033992"
                     /translation="

MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTGQVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPTAKSRVAISGGALFLLAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAMLGGSFLCCTCPEPERANSIPQPYRSGPSTAAREPVVKLPASVKGPLGV"

     misc_feature    114..650
                     /gene="Cldn19"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:473919"
     misc_feature    126..188
                     /gene="Cldn19"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ET38.3);
                     transmembrane region"
     misc_feature    348..410
                     /gene="Cldn19"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ET38.3);
                     transmembrane region"
     misc_feature    456..518
                     /gene="Cldn19"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ET38.3);
                     transmembrane region"
     misc_feature    585..647
                     /gene="Cldn19"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ET38.3);
                     transmembrane region"
     exon            328..492
                     /gene="Cldn19"
                     /inference="alignment:Splign:2.1.0"
     exon            493..577
                     /gene="Cldn19"
                     /inference="alignment:Splign:2.1.0"
     exon            578..730
                     /gene="Cldn19"
                     /inference="alignment:Splign:2.1.0"
     exon            731..869
                     /gene="Cldn19"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      869
                     /gene="Cldn19"
                     /note="major polyA site"
ORIGIN      

acttagctccccttttccggctgttcctcttaccatgaccacaacgctcctccacaccctggcccatctctgagtcctggaactctcagactcctacctgggccatggccaactcgggcctccagctcctgggctacttcctagccttgggcggctgggtgggcatcatcgccagcactgccctgccacagtggaagcagtcttcctatgcaggcgatgccatcatcactgccgtgggcctctacgaagggctgtggatgtcttgcgcctctcagagcaccgggcaggtgcaatgcaaactctacgattcactcctggccctggacggtcatatccagtcagcacgagccctgatggtcgtggctgtgctcctgggctttgtggccatggtgctcagtgtcgtgggcatgaagtgcactcgggttggagacagtaaccccactgccaagagccgtgtggccatctccggaggtgctctcttcctcttggcaggtctctgtactttgactgctgtctcctggtatgctaccctggtaacacaggaattcttcaaccccagcactcctgtcaatgccaggtacgaatttggcccagctctgttcgtcggctgggcctcggccggcctggccatgctgggcggttcctttctctgctgcacatgcccagagccggagagggcgaacagcatcccacagccctatcgctctggaccctcaactgctgccagagaacctgttgttaagttgcccgcctcggtcaagggccccctgggtgtgtaaaggccagggttccagccaggcccttccccctaccacctctagactgtgtgtttgatatttttggaaagagaagtgaacattcggccccaaaaaaaaaaaaaaaaaaaaa

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