2024-09-28 09:23:26, GGRNA.v2 : RefSeq release 225 (Jul, 2024)
LOCUS NM_001013616 3827 bp mRNA linear ROD 30-APR-2024 DEFINITION Mus musculus tripartite motif-containing 6 (Trim6), mRNA. ACCESSION NM_001013616 XM_133616 VERSION NM_001013616.2 KEYWORDS RefSeq; RefSeq Select. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. REFERENCE 1 (bases 1 to 3827) AUTHORS Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A., Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R., Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J., Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z., Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J., Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L., Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J., Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B., Jackson,S.P. and Balmus,G. CONSRTM Sanger Mouse Genetics Project TITLE Genetic determinants of micronucleus formation in vivo JOURNAL Nature 627 (8002), 130-136 (2024) PUBMED 38355793 REFERENCE 2 (bases 1 to 3827) AUTHORS Liu,X., Zhao,J., Dong,P., Du,X., Lu,W., Feng,Y. and Wang,L. TITLE TRIM6 silencing for inhibiting growth and angiogenesis of gliomas by regulating VEGFA JOURNAL J Chem Neuroanat 132, 102291 (2023) PUBMED 37236551 REMARK GeneRIF: TRIM6 silencing for inhibiting growth and angiogenesis of gliomas by regulating VEGFA. REFERENCE 3 (bases 1 to 3827) AUTHORS Zhang,Y., Dong,P., Liu,N., Yang,J.Y., Wang,H.M. and Geng,Q. TITLE TRIM6 Reduces Ferroptosis and Chemosensitivity by Targeting SLC1A5 in Lung Cancer JOURNAL Oxid Med Cell Longev 2023, 9808100 (2023) PUBMED 36654781 REMARK GeneRIF: TRIM6 Reduces Ferroptosis and Chemosensitivity by Targeting SLC1A5 in Lung Cancer. Publication Status: Online-Only REFERENCE 4 (bases 1 to 3827) AUTHORS van Tol,S., Kalveram,B., Ilinykh,P.A., Ronk,A., Huang,K., Aguilera-Aguirre,L., Bharaj,P., Hage,A., Atkins,C., Giraldo,M.I., Wakamiya,M., Gonzalez-Orozco,M., Warren,A.N., Bukreyev,A., Freiberg,A.N. and Rajsbaum,R. TITLE Ubiquitination of Ebola virus VP35 at lysine 309 regulates viral transcription and assembly JOURNAL PLoS Pathog 18 (5), e1010532 (2022) PUBMED 35533195 REMARK Publication Status: Online-Only REFERENCE 5 (bases 1 to 3827) AUTHORS Zeng,G., Lian,C., Yang,P., Zheng,M., Ren,H. and Wang,H. TITLE E3-ubiquitin ligase TRIM6 aggravates myocardial ischemia/reperfusion injury via promoting STAT1-dependent cardiomyocyte apoptosis JOURNAL Aging (Albany NY) 11 (11), 3536-3550 (2019) PUBMED 31171760 REMARK GeneRIF: these results suggest that TRIM6 aggravates MI/R injury through promoting IKKepsilon/STAT1 activation-dependent cardiomyocyte apoptosis REFERENCE 6 (bases 1 to 3827) AUTHORS Rajsbaum,R., Versteeg,G.A., Schmid,S., Maestre,A.M., Belicha-Villanueva,A., Martinez-Romero,C., Patel,J.R., Morrison,J., Pisanelli,G., Miorin,L., Laurent-Rolle,M., Moulton,H.M., Stein,D.A., Fernandez-Sesma,A., tenOever,B.R. and Garcia-Sastre,A. TITLE Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKepsilon kinase-mediated antiviral response JOURNAL Immunity 40 (6), 880-895 (2014) PUBMED 24882218 REFERENCE 7 (bases 1 to 3827) AUTHORS Sato,T., Okumura,F., Ariga,T. and Hatakeyama,S. TITLE TRIM6 interacts with Myc and maintains the pluripotency of mouse embryonic stem cells JOURNAL J Cell Sci 125 (Pt 6), 1544-1555 (2012) PUBMED 22328504 REMARK GeneRIF: TRIM6 regulates the transcriptional activity of Myc during the maintenance of cell pluripotency, suggesting that TRIM6 functions as a novel regulator for Myc-mediated transcription in embryonic stem cells. REFERENCE 8 (bases 1 to 3827) AUTHORS Tareen,S.U., Sawyer,S.L., Malik,H.S. and Emerman,M. TITLE An expanded clade of rodent Trim5 genes JOURNAL Virology 385 (2), 473-483 (2009) PUBMED 19147168 REFERENCE 9 (bases 1 to 3827) AUTHORS Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L., Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A., Minucci,S., Pelicci,P.G. and Ballabio,A. TITLE The tripartite motif family identifies cell compartments JOURNAL EMBO J 20 (9), 2140-2151 (2001) PUBMED 11331580 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB634731.1, AK049238.1 and AC123830.5. On Dec 19, 2006 this sequence version replaced NM_001013616.1. ##Evidence-Data-START## Transcript exon combination :: AK049238.1, AK033396.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849384 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-21 BB634731.1 1-21 22-1902 AK049238.1 2-1882 1903-3653 AC123830.5 35168-36918 c 3654-3827 AK049238.1 3635-3808 FEATURES Location/Qualifiers source 1..3827 /organism="Mus musculus" /mol_type="mRNA" /strain="C57BL/6" /db_xref="taxon:10090" /chromosome="7" /map="7 55.55 cM" gene 1..3827 /gene="Trim6" /gene_synonym="C430046K18Rik; D7Ertd684e" /note="tripartite motif-containing 6" /db_xref="GeneID:94088" /db_xref="MGI:MGI:2137352" exon 1..89 /gene="Trim6" /gene_synonym="C430046K18Rik; D7Ertd684e" /inference="alignment:Splign:2.1.0" misc_feature 21..23 /gene="Trim6" /gene_synonym="C430046K18Rik; D7Ertd684e" /note="upstream in-frame stop codon" exon 90..563 /gene="Trim6" /gene_synonym="C430046K18Rik; D7Ertd684e" /inference="alignment:Splign:2.1.0" CDS 141..1607 /gene="Trim6" /gene_synonym="C430046K18Rik; D7Ertd684e" /EC_number="2.3.2.27" /note="tripartite motif protein 6; RING-type E3 ubiquitin transferase TRIM6" /codon_start=1 /product="tripartite motif-containing protein 6" /protein_id="NP_001013637.1" /db_xref="CCDS:CCDS40065.1" /db_xref="GeneID:94088" /db_xref="MGI:MGI:2137352" /translation="
MTSTVLVDIRDEVTCPICLELLTEPLSIDCGHSFCQVCIIGNSNNSVFGQGGRSSCPVCRTSYQPGNLRPNRHLAAIVKRLREVALCPGKQLEVIFCALHGEKLQLFCKEDGKLICWLCERSQEHRGHHTFLMEEVAQEYQDMFQESLKKLRREQQEAEKLKALIQEKRESWKSQVEPEKRRIQTEFKQLRSILDREEQRELKKLEVEERKGLSIIEKAEGDLIHQSQSLKDLISDLEHRCQGSTVELLQDVGDVTKRSEFWTLRKPQALPTKLKSLFRAPDLRKMLKVFRELTDVQSYWVDVTLNPQTANLNLVLSKNRRQVRFVGAQLSEPSSLEEHYDCSVLGSQHFSSGKYYWEVDVSKKTAWILGVCSTPVDPMFSFSQYSSKQGAYSRYQPQCGYWVIGLQCKHEYRAYEDSSPSLLLSMTVPPRRIGIFLDCEAGTVSFYNVTNHGLPIYTFSKYYFPSALCPYFNPCSCIVPMTLRRPTS"
misc_feature 159..377 /gene="Trim6" /gene_synonym="C430046K18Rik; D7Ertd684e" /note="RING finger, HC subclass, found in tripartite motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and similar proteins; Region: RING-HC_TRIM5-like_C-IV; cd16591" /db_xref="CDD:438253" misc_feature order(186..191,195..200,309..314,318..320) /gene="Trim6" /gene_synonym="C430046K18Rik; D7Ertd684e" /note="E2 binding site [polypeptide binding]; other site" /db_xref="CDD:438253" misc_feature 429..542 /gene="Trim6" /gene_synonym="C430046K18Rik; D7Ertd684e" /note="B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins; Region: Bbox2_TRIM5-like; cd19761" /db_xref="CDD:380819" misc_feature <576..>854 /gene="Trim6" /gene_synonym="C430046K18Rik; D7Ertd684e" /note="DNA double-strand break repair ATPase Rad50; Region: PRK03918" /db_xref="CDD:235175" misc_feature 1035..1598 /gene="Trim6" /gene_synonym="C430046K18Rik; D7Ertd684e" /note="PRY/SPRY domain in tripartite motif-binding protein 6 (TRIM6), also known as RING finger protein 89 (RNF89); Region: SPRY_PRY_TRIM6; cd15823" /db_xref="CDD:293995" exon 564..659 /gene="Trim6" /gene_synonym="C430046K18Rik; D7Ertd684e" /inference="alignment:Splign:2.1.0" exon 660..890 /gene="Trim6" /gene_synonym="C430046K18Rik; D7Ertd684e" /inference="alignment:Splign:2.1.0" exon 891..913 /gene="Trim6" /gene_synonym="C430046K18Rik; D7Ertd684e" /inference="alignment:Splign:2.1.0" exon 914..1014 /gene="Trim6" /gene_synonym="C430046K18Rik; D7Ertd684e" /inference="alignment:Splign:2.1.0" exon 1015..1041 /gene="Trim6" /gene_synonym="C430046K18Rik; D7Ertd684e" /inference="alignment:Splign:2.1.0" exon 1042..3827 /gene="Trim6" /gene_synonym="C430046K18Rik; D7Ertd684e" /inference="alignment:Splign:2.1.0" regulatory 3561..3566 /regulatory_class="polyA_signal_sequence" /gene="Trim6" /gene_synonym="C430046K18Rik; D7Ertd684e" /note="hexamer: AATAAA" polyA_site 3582 /gene="Trim6" /gene_synonym="C430046K18Rik; D7Ertd684e" /note="major polyA site" ORIGIN
tttttcctggagtccggctttagtactggaaggagccgtctccttggctgcaagtcctcggcactgatccaggcacggattccagattggattctttttctaagcaagctgggaaggtaggagacgagagagtggctacaatgacttcaacagtcttggtggacatccgagatgaagtaacctgccctatctgcttggagctcctgacagaacccctgagcattgattgtggccatagcttctgccaggtctgcatcataggaaacagtaataattcagtgttcggccaaggagggaggagcagctgtcctgtgtgccggacctcctatcagcctgggaacctccgtcctaatcggcacctggccgccatagtgaagaggctcagagaggttgcgttgtgccctggaaaacaactcgaggtcattttttgtgcgcttcatggagagaaactccagctcttttgcaaggaggatgggaagttaatttgctggctttgtgaacgatctcaggagcaccgtggtcatcacacattcctcatggaggaggtggcccaggagtaccaggacatgttccaggagtctctgaagaaattgaggagggagcagcaggaagccgagaagctaaaagctcttatccaggagaagagggaatcctggaagagtcaggtggagcctgagaaacgccggatccagacagagtttaagcagctccgaagcatcctggacagggaggagcagcgggaactgaagaaactggaagtggaagagaggaaggggctgagcatcatagaaaaggccgagggtgacctgatccaccagagccagtcactgaaggacctcatctcagacctggagcaccggtgccaggggtccaccgtagaactgctgcaggatgtgggtgatgttacaaaaaggagtgagttctggaccctgaggaagccccaagctctccccaccaagctgaaaagtttgtttcgagcaccggatctgaggaagatgctaaaagtctttagagagctgacagatgtccaaagctattgggtggacgtgacactgaatccacagacggctaatttaaatcttgtcctgtcgaaaaatcggagacaggtgaggtttgtgggtgcccagctgtccgagccatccagtctggaagaacattatgactgtagtgtcctgggctctcagcacttctcctcaggaaaatactactgggaagtggacgtgagcaagaagacggcatggatcttgggtgtatgcagtaccccggtggatcccatgttctctttcagccagtactccagcaagcagggcgcctactccaggtatcagccacagtgtggatactgggtgattggcttgcagtgtaagcacgagtacagagcctatgaggattcctccccgtccctgctcctctccatgaccgtgccacctcgacgcatagggattttcttagactgtgaggctggcacggtctccttttataatgtcacaaaccacggcttgcccatctacaccttctcgaagtattactttccttctgccctttgtccctattttaatccctgcagctgtatagtcccgatgaccctgcggcggccaacttcctgaggtctgttacccctgcccacaactaagcagattccttcaaacacatgaatctccattctctgttctcctagtaggataccttccattgctaagagtgcgcacccttaagccatctcatggaaaagcatttagtgttttggggtttttgtatttttgcttttgggttgtttatttttgttttttgttttttatttttagagatagggtttctggaactctgtaggtcaaactggccttaaacttggagagatccgcttgcctctcctgagtgctgggacaccagtctagttgtgttttggttttgggttttttgtttgtttgtttgttttttgtttgtttgtatttttgaaacaggctggccttgaactctgtgattgagaaactaactgagaactgatccagagtcccgattacaagtggacatcaccatacctggctgtgaatttgttttagtgttgtttgagatagggtctccataaatagcccaaactggccacagactcagtccatttgcctcactcccaaatactgattatagatctacctcacagtgcctgactgagctcccaaatactgattatagctctacctcacagcacctgactgagctcccaaatactgattatagatctacctcacagtgcctgactgagctcccaaatactgattatagatctacctcacagcgcctgactgagctctcaaatactgattatagctctacctcacagcgcctgactgagcacatttgacgacttttttctttactaatgtctgtggtcaaatgtaaagaacctctgaattagataggaattttttaataaatattgaattcagtaattttttttctctagttactgagatacttgtgtatcctttctattctgctcctgggtcagcctcactgagttgtctcagttgttacgtttaccactgattcctgaagcaaaactgtcatgtgttacattcagcactttatgtttgctgactctaggtttggtttttgtctctttataaacaaactacctctaagtttgcattctttgttatctgtcaaggcatatcagaaagaaattatggggaagggcttatgtatgtgtatttaggatcacaataaatcctaagtatgtatatttaggattacagtaaaaataataaaatctttggatggtttcaagaagagattgtagctttggttttaacaataaatgctaccacaaccttcagccttcagcataaaattttaagagtggtaataaaaactagaaaatgctcttgaaagggagataaagtaagataaggagaagacttcaatcaaccagtatcagttattatttaggaggaggaagaaattcagttacccattctcacagtgagttattctggtccccccagcccctcttatttcttctgtagagctaggtactgaactcggctttttacttcaagcagagacattttagcaccaagcttaaccccatttttgtgttttgtattgttattattggggtttgtttgtttgtttgttttgttttgctgacacagggttttaacacatttcccaggctggccttgagcttgctatcaagtgcaggctgactttaagctttgcctcagcatcctgagtaactaggtgtttagggtaatactgacttttcatcttagcctggaccttctctttgtgctcatattcaaattgcaaatgagtgaaccgctttggctttgctggaaaggtgcaacaaactttcatattcaactgtgaaaaaagttatagctgtgaagatggaaatgagtgtcgggggaggtgcagctggacttctgacactgcagacaagggctactcgtggcttttggtactctccaatgtactgtaacagtgaaatactgaatttccataaaagcaatgtaaaataatctattatcttacaatgatggtattttggatatattttaaataaaatgttttatttcaggatggagtcttcttactctgtagcccaggctcgccatcaaattgtagtggtagcttcctgccttagcctttcaactgctggggttaaggcataagccaccacaggcagttttccctgtatgttttaaatgtgggtactaggaaattttcagttatacattaactggcttctgttacacttctactgtcaagatgaactttctattcttgggggaaccctagaataataaagacttggccagagaacc
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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