LOCUS       XM_054336760            3318 bp    mRNA    linear   PRI 26-AUG-2024
DEFINITION  PREDICTED: Homo sapiens ATPase Na+/K+ transporting subunit alpha 4
            (ATP1A4), transcript variant X1, mRNA.
ACCESSION   XM_054336760
VERSION     XM_054336760.1
DBLINK      BioProject: PRJNA807723
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060925) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3318
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     gene            1..3318
                     /gene="ATP1A4"
                     /gene_synonym="ATP1A1; ATP1AL2"
                     /note="ATPase Na+/K+ transporting subunit alpha 4; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 2 mRNAs, 14 ESTs, 1 long SRA read, 66 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 5 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:480"
                     /db_xref="HGNC:HGNC:14073"
                     /db_xref="MIM:607321"
     CDS             125..3037
                     /gene="ATP1A4"
                     /gene_synonym="ATP1A1; ATP1AL2"
                     /codon_start=1
                     /product="sodium/potassium-transporting ATPase subunit
                     alpha-4 isoform X1"
                     /protein_id="XP_054192735.1"
                     /db_xref="GeneID:480"
                     /db_xref="HGNC:HGNC:14073"
                     /db_xref="MIM:607321"
                     /translation="

MDTTWKKLQMGHSHQRAKEILTRGGPNTVTPPPTTPEWVKFCKQLFGGFSLLLWTGAILCFVAYSIQIYFNEEPTKDNLYLSIVLSVVVIVTGCFSYYQEAKSSKIMESFKNMVPQQALVIRGGEKMQINVQEVVLGDLVEIKGGDRVPADLRLISAQGCKVDNSSLTGESEPQSRSPDFTHENPLETRNICFFSTNCVEGTARGIVIATGDSTVMGRIASLTSGLAVGQTPIAAEIEHFIHLITVVAVFLGVTFFALSLLLGYGWLEAIIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDMTVYEADTTEEQTGKTFTKSSDTWFMLARIAGLCNRADFKANQEILPIAKRATTGDASESALLKFIEQSYSSVAEMREKNPKVAEIPFNSTNKYQMSIHLREDSSQTHVLMMKGAPERILEFCSTFLLNGQEYSMNDEMKEAFQNAYLELGGLGERVLGFCFLNLPSSFSKGFPFNTDEINFPMDNLCFVGLISMIDPPRAAVPDAVSKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGTETAEEVAARLKIPISKVDASAAKAIVVHGAELKDIQSKQLDQILQNHPEIVFARTSPQQKLIIVEGCQRLGAVVAVTGDGVNDSPALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIMYTLTSNIPEITPFLMFIILGIPLPLGTITILCIDLGTDMVPAISLAYESAESDIMKRLPRNPKTDNLVNHRLIGMAYGQIGMIQALAGFFTYFVILAENGFRPVDLLGIRLHWEDKYLNDLEDSYGQQWTYEQRKVVEFTCQTAFFVTIVVVQWADLIISKTRRNSLFQQGMRNKVLIFGILEETLLAAFLSYTPGMDVALRMYPLKITWWLCAIPYSILIFVYDEIRKLLIRQHPDGWVERETYY"

     misc_feature    155..3025
                     /gene="ATP1A4"
                     /gene_synonym="ATP1A1; ATP1AL2"
                     /note="alpha-subunit of Na(+)/K(+)-ATPases and of gastric
                     H(+)/K(+)-ATPase, similar to the human Na(+)/K(+)-ATPase
                     alpha subunits 1-4; Region: P-type_ATPase_Na-K_like;
                     cd02608"
                     /db_xref="CDD:319794"
     misc_feature    order(956..958,965..967,971..973,2312..2314,2321..2323,
                     2396..2398)
                     /gene="ATP1A4"
                     /gene_synonym="ATP1A1; ATP1AL2"
                     /note="K binding site [ion binding]; other site"
                     /db_xref="CDD:319794"
     misc_feature    order(971..973,2312..2314,2321..2323,2396..2398)
                     /gene="ATP1A4"
                     /gene_synonym="ATP1A1; ATP1AL2"
                     /note="Na binding site [ion binding]; other site"
                     /db_xref="CDD:319794"
     misc_feature    order(1097..1105,1319..1321,1328..1330,1412..1417,
                     1421..1423,1430..1432,1436..1438,1490..1498,1619..1627,
                     1814..1822,2039..2041,2048..2050,2057..2059,2114..2128)
                     /gene="ATP1A4"
                     /gene_synonym="ATP1A1; ATP1AL2"
                     /note="ATP-binding site [chemical binding]; other site"
                     /db_xref="CDD:319794"
     misc_feature    order(2297..2299,2309..2311,2408..2410,2753..2755)
                     /gene="ATP1A4"
                     /gene_synonym="ATP1A1; ATP1AL2"
                     /note="Na binding site [ion binding]; other site"
                     /db_xref="CDD:319794"
     misc_feature    order(2309..2314,2321..2323,2396..2398,2408..2410)
                     /gene="ATP1A4"
                     /gene_synonym="ATP1A1; ATP1AL2"
                     /note="K binding site [ion binding]; other site"
                     /db_xref="CDD:319794"
     misc_feature    order(2309..2314,2321..2323,2396..2398)
                     /gene="ATP1A4"
                     /gene_synonym="ATP1A1; ATP1AL2"
                     /note="Na binding site [ion binding]; other site"
                     /db_xref="CDD:319794"
     misc_feature    order(2528..2533,2540..2545,2552..2554,2564..2566,
                     2576..2578,2588..2593,2639..2647,2651..2656,2666..2695,
                     2702..2707,2915..2917,2921..2926,2945..2947,2954..2956,
                     2966..2968,3011..3013,3020..3025)
                     /gene="ATP1A4"
                     /gene_synonym="ATP1A1; ATP1AL2"
                     /note="alpha-subunit/beta-subunit interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:319794"
     misc_feature    2792..2794
                     /gene="ATP1A4"
                     /gene_synonym="ATP1A1; ATP1AL2"
                     /note="phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:319794"
ORIGIN      

tgaggaggcagagagtctccaactctgactgtgaggctgccaggacaaaagctgaactaggaatccagccccctaacttcaagtccaacgttcccacccctcaccctctgcctggccacgttccatggacactacctggaaaaagctgcaaatgggccatagccaccaaagggcaaaggaaatcctgactcgaggtggacccaatactgttaccccaccccccaccactccagaatgggtcaaattctgtaagcaactgttcggaggcttctccctcctactatggactggggccattctctgctttgtggcctacagcatccagatatatttcaatgaggagcctaccaaagacaacctctacctgagcatcgtactgtccgtcgtggtcatcgtcactggctgcttctcctattatcaggaggccaagagctccaagatcatggagtcttttaagaacatggtgcctcagcaagctctggtaattcgaggaggagagaagatgcaaattaatgtacaagaggtggtgttgggagacctggtggaaatcaagggtggagaccgagtccctgctgacctccggcttatctctgcacaaggatgtaaggtggacaactcatccttgactggggagtcagaaccccagagccgctcccctgacttcacccatgagaaccctctggagacccgaaacatctgcttcttttccaccaactgtgtggaaggaaccgcccggggtattgtgattgctacgggagactccacagtgatgggcagaattgcctccctgacgtcaggcctggcggttggccagacacctatcgctgctgagatcgaacacttcatccatctgatcactgtggtggccgtcttccttggtgtcactttttttgcgctctcacttctcttgggctatggttggctggaggctatcatttttctcattggcatcattgtggccaatgtgcctgaggggctgttggctacagtcactgtgtgcctgaccctcacagccaagcgcatggcgcggaagaactgcctggtgaagaacctggaggcggtggagacgctgggctccacgtccaccatctgctcagacaagacgggcaccctcacccagaaccgcatgaccgtcgcccacatgtggtttgatatgaccgtgtatgaggccgacaccactgaagaacagactggaaaaacatttaccaagagctctgatacctggtttatgctggcccgaatcgctggcctctgcaaccgggctgactttaaggctaatcaggagatcctgcccattgctaagagggccacaacaggtgatgcttccgagtcagccctcctcaagttcatcgagcagtcttacagctctgtggcggagatgagagagaaaaaccccaaggtggcagagattccctttaattctaccaacaagtaccagatgtccatccaccttcgggaggacagctcccagacccacgtactgatgatgaagggtgctccggagaggatcttggagttttgttctacctttcttctgaatgggcaggagtactcaatgaacgatgaaatgaaggaagccttccaaaatgcctatttagaactgggaggtctgggggaacgtgtgctaggcttctgcttcttgaatctgcctagcagcttctccaagggattcccatttaatacagatgaaataaatttccccatggacaacctttgttttgtgggcctcatatccatgattgaccctccccgagctgcagtgcctgatgctgtgagcaagtgtcgcagtgcaggaattaaggtgatcatggtaacaggagatcatcccattacagctaaggccattgccaagggtgtgggcatcatctcagaaggcactgagacggcagaggaagtcgctgcccggcttaagatccctatcagcaaggtcgatgccagtgctgccaaagccattgtggtgcatggtgcagaactgaaggacatacagtccaagcagcttgatcagatcctccagaaccaccctgagatcgtgtttgctcggacctcccctcagcagaagctcatcattgtcgagggatgtcagaggctgggagccgttgtggccgtgacaggtgacggggtgaacgactcccctgcgctgaagaaggctgacattggcattgccatgggcatctctggctctgacgtctctaagcaggcagccgacatgatcctgctggatgacaactttgcctccatcgtcacgggggtggaggagggccgcctgatctttgacaacctgaagaaatccatcatgtacaccctgaccagcaacatccccgagatcacgcccttcctgatgttcatcatcctcggtatacccctgcctctgggaaccataaccatcctctgcattgatctcggcactgacatggtccctgccatctccttggcttatgagtcagctgaaagcgacatcatgaagaggcttccaaggaacccaaagacggataatctggtgaaccaccgtctcattggcatggcctatggacagattgggatgatccaggctctggctggattctttacctactttgtaatcctggctgagaatggttttaggcctgttgatctgctgggcatccgcctccactgggaagataaatacttgaatgacctggaggacagctacggacagcagtggacctatgagcaacgaaaagttgtggagttcacatgccaaacggccttttttgtcaccatcgtggttgtgcagtgggcggatctcatcatctccaagactcgccgcaactcacttttccagcagggcatgagaaacaaagtcttaatatttgggatcctggaggagacactcttggctgcatttctgtcctacactccaggcatggacgtggccctgcgaatgtacccactcaagataacctggtggctctgtgccattccctacagtattctcatcttcgtctatgatgaaatcagaaaactcctcatccgtcagcacccggatggctgggtggaaagggagacgtactactaaactcagcagatgaagagcttcatgtgacacaggggtgttgtgagagctgggatggggccagagattataagtttgacacaacatctgagacactaggatgaattatcttggatgagaaagatgggcaatcctgggctggcttgagggaatcatgggcagaggatgaggtgggctgaagggaagcccagcctgcatctagctggagccccgcagggaggggcatggtcctgctgaatcccgtagccagtctagacagtaaatgtctggaaaagccctcacca

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