2024-05-03 06:14:11, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NR_039609 79 bp RNA linear PRI 17-MAY-2020 DEFINITION Homo sapiens microRNA 378e (MIR378E), microRNA. ACCESSION NR_039609 VERSION NR_039609.1 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 79) AUTHORS Ding C, Wu Z, You H, Ge H, Zheng S, Lin Y, Wu X, Lin Z and Kang D. TITLE CircNFIX promotes progression of glioma through regulating miR-378e/RPN2 axis JOURNAL J. Exp. Clin. Cancer Res. 38 (1), 506 (2019) PUBMED 31888753 REMARK GeneRIF: Knockdown of circNFIX inhibits progression of glioma in vitro and in vivo by increasing miR-378e and decreasing RPN2, providing a novel mechanism for understanding the pathogenesis of glioma. Publication Status: Online-Only REFERENCE 2 (bases 1 to 79) AUTHORS Enomoto Y, Takagi R, Naito Y, Kiniwa T, Tanaka Y, Hamada-Tsutsumi S, Kawano M, Matsushita S, Ochiya T and Miyajima A. TITLE Identification of the novel 3' UTR sequences of human IL-21 mRNA as potential targets of miRNAs JOURNAL Sci Rep 7 (1), 7780 (2017) PUBMED 28798470 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 79) AUTHORS Navarini AA, Simpson MA, Weale M, Knight J, Carlavan I, Reiniche P, Burden DA, Layton A, Bataille V, Allen M, Pleass R, Pink A, Creamer D, English J, Munn S, Walton S, Willis C, Deret S, Voegel JJ, Spector T, Smith CH, Trembath RC and Barker JN. CONSRTM Acne Genetic Study Group TITLE Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris JOURNAL Nat Commun 5, 4020 (2014) PUBMED 24927181 REMARK Publication Status: Online-Only REFERENCE 4 (bases 1 to 79) AUTHORS Kozomara A and Griffiths-Jones S. TITLE miRBase: integrating microRNA annotation and deep-sequencing data JOURNAL Nucleic Acids Res. 39 (Database issue), D152-D157 (2011) PUBMED 21037258 REFERENCE 5 (bases 1 to 79) AUTHORS Jima DD, Zhang J, Jacobs C, Richards KL, Dunphy CH, Choi WW, Au WY, Srivastava G, Czader MB, Rizzieri DA, Lagoo AS, Lugar PL, Mann KP, Flowers CR, Bernal-Mizrachi L, Naresh KN, Evens AM, Gordon LI, Luftig M, Friedman DR, Weinberg JB, Thompson MA, Gill JI, Liu Q, How T, Grubor V, Gao Y, Patel A, Wu H, Zhu J, Blobe GC, Lipsky PE, Chadburn A and Dave SS. CONSRTM Hematologic Malignancies Research Consortium TITLE Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs JOURNAL Blood 116 (23), e118-e127 (2010) PUBMED 20733160 REFERENCE 6 (bases 1 to 79) AUTHORS Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A and Enright AJ. TITLE miRBase: microRNA sequences, targets and gene nomenclature JOURNAL Nucleic Acids Res. 34 (Database issue), D140-D144 (2006) PUBMED 16381832 COMMENT PROVISIONAL REFSEQ: This record is based on preliminary annotation provided by NCBI staff in collaboration with miRBase. The reference sequence was derived from AC026695.5. Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM611276.1 [ECO:0000345] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-79 AC026695.5 80568-80646 c FEATURES Location/Qualifiers source 1..79 /organism="Homo sapiens" /mol_type="transcribed RNA" /db_xref="taxon:9606" /chromosome="5" /map="5q35.1" gene 1..79 /gene="MIR378E" /gene_synonym="mir-378e" /note="microRNA 378e" /db_xref="GeneID:100616498" /db_xref="HGNC:HGNC:41671" /db_xref="miRBase:MI0016750" precursor_RNA 1..79 /gene="MIR378E" /gene_synonym="mir-378e" /product="microRNA 378e" /db_xref="GeneID:100616498" /db_xref="HGNC:HGNC:41671" /db_xref="miRBase:MI0016750" exon 1..79 /gene="MIR378E" /gene_synonym="mir-378e" /inference="alignment:Splign:2.1.0" variation 4 /gene="MIR378E" /gene_synonym="mir-378e" /replace="a" /replace="g" /db_xref="dbSNP:1017552447" variation 10 /gene="MIR378E" /gene_synonym="mir-378e" /replace="g" /replace="t" /db_xref="dbSNP:1756005195" variation 11 /gene="MIR378E" /gene_synonym="mir-378e" /replace="c" /replace="g" /replace="t" /db_xref="dbSNP:367764573" variation 23 /gene="MIR378E" /gene_synonym="mir-378e" /replace="a" /replace="g" /db_xref="dbSNP:1756005510" variation 24 /gene="MIR378E" /gene_synonym="mir-378e" /replace="a" /replace="g" /db_xref="dbSNP:1756005619" variation 25 /gene="MIR378E" /gene_synonym="mir-378e" /replace="g" /replace="t" /db_xref="dbSNP:887357721" variation 26 /gene="MIR378E" /gene_synonym="mir-378e" /replace="a" /replace="c" /db_xref="dbSNP:1756005876" variation 29 /gene="MIR378E" /gene_synonym="mir-378e" /replace="a" /replace="g" /db_xref="dbSNP:978649817" variation 30 /gene="MIR378E" /gene_synonym="mir-378e" /replace="c" /replace="g" /db_xref="dbSNP:1756006068" variation 34 /gene="MIR378E" /gene_synonym="mir-378e" /replace="a" /replace="g" /db_xref="dbSNP:1756006186" variation 43 /gene="MIR378E" /gene_synonym="mir-378e" /replace="a" /replace="c" /db_xref="dbSNP:1756006325" variation 48 /gene="MIR378E" /gene_synonym="mir-378e" /replace="g" /replace="t" /db_xref="dbSNP:371300444" variation 49 /gene="MIR378E" /gene_synonym="mir-378e" /replace="a" /replace="c" /db_xref="dbSNP:955832869" variation 50 /gene="MIR378E" /gene_synonym="mir-378e" /replace="c" /replace="g" /db_xref="dbSNP:992890475" ncRNA 58..76 /ncRNA_class="miRNA" /gene="MIR378E" /gene_synonym="mir-378e" /product="hsa-miR-378e" /db_xref="miRBase:MIMAT0018927" /db_xref="GeneID:100616498" /db_xref="HGNC:HGNC:41671" /db_xref="miRBase:MI0016750" variation 59 /gene="MIR378E" /gene_synonym="mir-378e" /replace="a" /replace="c" /db_xref="dbSNP:1756006863" variation 60 /gene="MIR378E" /gene_synonym="mir-378e" /replace="c" /replace="t" /db_xref="dbSNP:376752141" variation 63 /gene="MIR378E" /gene_synonym="mir-378e" /replace="a" /replace="t" /db_xref="dbSNP:1756007079" variation 64 /gene="MIR378E" /gene_synonym="mir-378e" /replace="c" /replace="t" /db_xref="dbSNP:1756007177" variation 67 /gene="MIR378E" /gene_synonym="mir-378e" /replace="a" /replace="g" /db_xref="dbSNP:1756007301" variation 68 /gene="MIR378E" /gene_synonym="mir-378e" /replace="a" /replace="g" /db_xref="dbSNP:1298291117" variation 72 /gene="MIR378E" /gene_synonym="mir-378e" /replace="c" /replace="t" /db_xref="dbSNP:1756007454" variation 73 /gene="MIR378E" /gene_synonym="mir-378e" /replace="a" /replace="g" /db_xref="dbSNP:2113831952" ORIGIN
ctgactccagtgtccaggccaggggcagacagtggacagagaacagtgcccaagaccactggacttggagtcaggacat
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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