2024-05-03 10:55:32, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NR_039608 54 bp RNA linear PRI 03-OCT-2021 DEFINITION Homo sapiens microRNA 378d-1 (MIR378D1), microRNA. ACCESSION NR_039608 VERSION NR_039608.1 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 54) AUTHORS Chen Q, Li Z, Xu Z, Chen C, Wang J, Zhu J and Dong Z. TITLE miR-378d is Involved in the Regulation of Apoptosis and Autophagy of and E2 Secretion from Cultured Ovarian Granular Cells Treated by Sodium Fluoride JOURNAL Biol Trace Elem Res 199 (11), 4119-4128 (2021) PUBMED 33405077 REMARK GeneRIF: miR-378d is Involved in the Regulation of Apoptosis and Autophagy of and E2 Secretion from Cultured Ovarian Granular Cells Treated by Sodium Fluoride. REFERENCE 2 (bases 1 to 54) AUTHORS Enomoto Y, Takagi R, Naito Y, Kiniwa T, Tanaka Y, Hamada-Tsutsumi S, Kawano M, Matsushita S, Ochiya T and Miyajima A. TITLE Identification of the novel 3' UTR sequences of human IL-21 mRNA as potential targets of miRNAs JOURNAL Sci Rep 7 (1), 7780 (2017) PUBMED 28798470 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 54) AUTHORS Kozomara A and Griffiths-Jones S. TITLE miRBase: integrating microRNA annotation and deep-sequencing data JOURNAL Nucleic Acids Res 39 (Database issue), D152-D157 (2011) PUBMED 21037258 REFERENCE 4 (bases 1 to 54) AUTHORS Jima DD, Zhang J, Jacobs C, Richards KL, Dunphy CH, Choi WW, Au WY, Srivastava G, Czader MB, Rizzieri DA, Lagoo AS, Lugar PL, Mann KP, Flowers CR, Bernal-Mizrachi L, Naresh KN, Evens AM, Gordon LI, Luftig M, Friedman DR, Weinberg JB, Thompson MA, Gill JI, Liu Q, How T, Grubor V, Gao Y, Patel A, Wu H, Zhu J, Blobe GC, Lipsky PE, Chadburn A and Dave SS. CONSRTM Hematologic Malignancies Research Consortium TITLE Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs JOURNAL Blood 116 (23), e118-e127 (2010) PUBMED 20733160 REFERENCE 5 (bases 1 to 54) AUTHORS Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A and Enright AJ. TITLE miRBase: microRNA sequences, targets and gene nomenclature JOURNAL Nucleic Acids Res 34 (Database issue), D140-D144 (2006) PUBMED 16381832 COMMENT PROVISIONAL REFSEQ: This record is based on preliminary annotation provided by NCBI staff in collaboration with miRBase. The reference sequence was derived from AC092442.5. Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: LM611275.1 [ECO:0000345] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-54 AC092442.5 6992-7045 c FEATURES Location/Qualifiers source 1..54 /organism="Homo sapiens" /mol_type="transcribed RNA" /db_xref="taxon:9606" /chromosome="4" /map="4p16.2" gene 1..54 /gene="MIR378D1" /gene_synonym="mir-378d-1" /note="microRNA 378d-1" /db_xref="GeneID:100616201" /db_xref="HGNC:HGNC:41550" /db_xref="miRBase:MI0016749" precursor_RNA 1..54 /gene="MIR378D1" /gene_synonym="mir-378d-1" /product="microRNA 378d-1" /db_xref="GeneID:100616201" /db_xref="HGNC:HGNC:41550" /db_xref="miRBase:MI0016749" exon 1..54 /gene="MIR378D1" /gene_synonym="mir-378d-1" /inference="alignment:Splign:2.1.0" variation 1 /gene="MIR378D1" /gene_synonym="mir-378d-1" /replace="a" /replace="c" /db_xref="dbSNP:1350266661" variation 2 /gene="MIR378D1" /gene_synonym="mir-378d-1" /replace="c" /replace="g" /replace="t" /db_xref="dbSNP:28645567" variation 3 /gene="MIR378D1" /gene_synonym="mir-378d-1" /replace="g" /replace="t" /db_xref="dbSNP:990958206" variation 4 /gene="MIR378D1" /gene_synonym="mir-378d-1" /replace="a" /replace="g" /db_xref="dbSNP:1717364372" variation 5 /gene="MIR378D1" /gene_synonym="mir-378d-1" /replace="c" /replace="t" /db_xref="dbSNP:1717364182" variation 9 /gene="MIR378D1" /gene_synonym="mir-378d-1" /replace="" /replace="t" /db_xref="dbSNP:1577891645" variation 14..15 /gene="MIR378D1" /gene_synonym="mir-378d-1" /replace="t" /replace="tt" /db_xref="dbSNP:1717363847" variation 15 /gene="MIR378D1" /gene_synonym="mir-378d-1" /replace="c" /replace="t" /db_xref="dbSNP:958209445" variation 17 /gene="MIR378D1" /gene_synonym="mir-378d-1" /replace="c" /replace="t" /db_xref="dbSNP:926751644" variation 20..27 /gene="MIR378D1" /gene_synonym="mir-378d-1" /replace="ttgtt" /replace="ttgttgtt" /db_xref="dbSNP:879129710" variation 21 /gene="MIR378D1" /gene_synonym="mir-378d-1" /replace="g" /replace="t" /db_xref="dbSNP:1216801295" variation 24 /gene="MIR378D1" /gene_synonym="mir-378d-1" /replace="c" /replace="g" /replace="t" /db_xref="dbSNP:1717363095" variation 25 /gene="MIR378D1" /gene_synonym="mir-378d-1" /replace="a" /replace="g" /db_xref="dbSNP:2108739564" ncRNA 31..50 /ncRNA_class="miRNA" /gene="MIR378D1" /gene_synonym="mir-378d-1" /product="hsa-miR-378d" /db_xref="miRBase:MIMAT0018926" /db_xref="GeneID:100616201" /db_xref="HGNC:HGNC:41550" /db_xref="miRBase:MI0016749" variation 34 /gene="MIR378D1" /gene_synonym="mir-378d-1" /replace="a" /replace="g" /db_xref="dbSNP:1344067493" variation 36 /gene="MIR378D1" /gene_synonym="mir-378d-1" /replace="a" /replace="c" /replace="g" /db_xref="dbSNP:1302915342" variation 37 /gene="MIR378D1" /gene_synonym="mir-378d-1" /replace="c" /replace="t" /db_xref="dbSNP:1032722477" variation 38 /gene="MIR378D1" /gene_synonym="mir-378d-1" /replace="c" /replace="t" /db_xref="dbSNP:1717362467" variation 42 /gene="MIR378D1" /gene_synonym="mir-378d-1" /replace="a" /replace="g" /db_xref="dbSNP:1215256756" variation 51 /gene="MIR378D1" /gene_synonym="mir-378d-1" /replace="c" /replace="t" /db_xref="dbSNP:949624071" variation 53 /gene="MIR378D1" /gene_synonym="mir-378d-1" /replace="a" /replace="c" /replace="g" /replace="t" /db_xref="dbSNP:1189859928" ORIGIN
actgtttctgtccttgttcttgttgttattactggacttggagtcagaaacagg
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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