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Previous release (v1)
2025-09-19 23:27:27, GGRNA.v2 : RefSeq release 231 (Jul, 2025)
LOCUS NM_001441112 4589 bp mRNA linear PRI 07-JUN-2025
DEFINITION Homo sapiens formin binding protein 4 (FNBP4), transcript variant
15, mRNA.
ACCESSION NM_001441112 XM_047426654 XM_054332410 XM_054368198
VERSION NM_001441112.1
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4589)
AUTHORS Das,A., Bhattacharya,S., Bhattacharjee,S., Bagchi,A. and
Dasgupta,R.
TITLE Computational analyses of the length and compositional variations
of the FNBP4 gene across 10 different species
JOURNAL Gene 575 (2 Pt 3), 765-777 (2016)
PUBMED 26456197
REFERENCE 2 (bases 1 to 4589)
AUTHORS Nourashrafeddin,S., Aarabi,M., Modarressi,M.H., Rahmati,M. and
Nouri,M.
TITLE The Evaluation of WBP2NL-Related Genes Expression in Breast Cancer
JOURNAL Pathol Oncol Res 21 (2), 293-300 (2015)
PUBMED 25417742
REFERENCE 3 (bases 1 to 4589)
AUTHORS Das,A., Bhattacharya,S., Bagchi,A. and Dasgupta,R.
TITLE In-silico characterization of Formin Binding Protein 4 Family of
proteins
JOURNAL Interdiscip Sci 7 (1), 43-64 (2015)
PUBMED 25183348
REFERENCE 4 (bases 1 to 4589)
AUTHORS Kondo,Y., Koshimizu,E., Megarbane,A., Hamanoue,H., Okada,I.,
Nishiyama,K., Kodera,H., Miyatake,S., Tsurusaki,Y., Nakashima,M.,
Doi,H., Miyake,N., Saitsu,H. and Matsumoto,N.
TITLE Whole-exome sequencing identified a homozygous FNBP4 mutation in a
family with a condition similar to microphthalmia with limb
anomalies
JOURNAL Am J Med Genet A 161A (7), 1543-1546 (2013)
PUBMED 23703728
REMARK GeneRIF: A c.683C>T (p.Thr228Met) mutation in FNBP4 was found as a
primary candidate to microphthalmia with limb anomalies
REFERENCE 5 (bases 1 to 4589)
AUTHORS Aspenstrom,P.
TITLE Formin-binding proteins: modulators of formin-dependent actin
polymerization
JOURNAL Biochim Biophys Acta 1803 (2), 174-182 (2010)
PUBMED 19589360
REMARK Review article
REFERENCE 6 (bases 1 to 4589)
AUTHORS Zucconi,A., Dente,L., Santonico,E., Castagnoli,L. and Cesareni,G.
TITLE Selection of ligands by panning of domain libraries displayed on
phage lambda reveals new potential partners of synaptojanin 1
JOURNAL J Mol Biol 307 (5), 1329-1339 (2001)
PUBMED 11292345
REFERENCE 7 (bases 1 to 4589)
AUTHORS Bedford,M.T., Sarbassova,D., Xu,J., Leder,P. and Yaffe,M.B.
TITLE A novel pro-Arg motif recognized by WW domains
JOURNAL J Biol Chem 275 (14), 10359-10369 (2000)
PUBMED 10744724
REFERENCE 8 (bases 1 to 4589)
AUTHORS Depraetere,V. and Golstein,P.
TITLE WW domain-containing FBP-30 is regulated by p53
JOURNAL Cell Death Differ 6 (9), 883-889 (1999)
PUBMED 10510470
REFERENCE 9 (bases 1 to 4589)
AUTHORS Chan,D.C. and Leder,P.
TITLE Genetic evidence that formins function within the nucleus
JOURNAL J Biol Chem 271 (38), 23472-23477 (1996)
PUBMED 8798555
REFERENCE 10 (bases 1 to 4589)
AUTHORS Chan,D.C., Bedford,M.T. and Leder,P.
TITLE Formin binding proteins bear WWP/WW domains that bind proline-rich
peptides and functionally resemble SH3 domains
JOURNAL EMBO J 15 (5), 1045-1054 (1996)
PUBMED 8605874
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC021443.27.
On or before Jun 7, 2025 this sequence version replaced
XM_047426654.1, XM_054332410.1, XM_054368198.1.
Summary: This gene encodes a protein containing two tryptophan-rich
WW domains that binds the proline-rich formin homology 1 domains of
formin family proteins, suggesting a role in the regulation of
cytoskeletal dynamics during cell division and migration. It also
binds intersectin family proteins suggesting a role in the
maintenance of membrane curvature at sites of nascent vesicle
formation. Naturally occurring mutations in this gene are
associated with Waardenburg anophthalmia syndrome. [provided by
RefSeq, Apr 2017].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR14038191.1984107.1,
SRR18074968.679320.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA1965299,
SAMEA1966682 [ECO:0006172]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-273 AC021443.27 119556-119828 c
274-366 AC021443.27 117757-117849 c
367-503 AC021443.27 107015-107151 c
504-690 AC021443.27 105403-105589 c
691-838 AC021443.27 103630-103777 c
839-959 AC021443.27 103403-103523 c
960-1298 AC021443.27 98543-98881 c
1299-1509 AC021443.27 96440-96650 c
1510-1634 AC021443.27 89103-89227 c
1635-1739 AC021443.27 86512-86616 c
1740-1873 AC021443.27 85024-85157 c
1874-2061 AC021443.27 83861-84048 c
2062-4589 AC021443.27 80147-82674 c
FEATURES Location/Qualifiers
source 1..4589
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11p11.2"
gene 1..4589
/gene="FNBP4"
/gene_synonym="FBP30"
/note="formin binding protein 4"
/db_xref="GeneID:23360"
/db_xref="HGNC:HGNC:19752"
/db_xref="MIM:615265"
exon 1..273
/gene="FNBP4"
/gene_synonym="FBP30"
/inference="alignment:Splign:2.1.0"
CDS 54..2099
/gene="FNBP4"
/gene_synonym="FBP30"
/note="isoform 15 is encoded by transcript variant 15;
formin-binding protein 30"
/codon_start=1
/product="formin-binding protein 4 isoform 15"
/protein_id="NP_001428041.1"
/db_xref="GeneID:23360"
/db_xref="HGNC:HGNC:19752"
/db_xref="MIM:615265"
/translation="
MGKKSRAVPGRRPILQLSPPGPRGSTPGRDPEPEPDTEPDSTAAVPSQPAPSAATTTTTAVTAAAASDDSPSEDEQEAVQEVPRVVQNPPKPVMTTRPTAVKATGGLCLLGAYADSDDDDNDVSEKLAQSKETNGNQSTDIDSTLANFLAEIDAITAPQPAAPVGASAPPPTPPRPEPKEAATSTLSSSTSNGTDSTQTSGWQYDTQCSLAGVGIEMGDWQEVWDENTGCYYYWNTQTNEVTWELPQYLATQVQGLQHYQPSSVPGAETSFVVNTDIYSKEKTISVSSSKSGPVIAKREVKKEVNEGIQALSNSEEEKKGVAASLLAPLLPEGIKEEEERWRRKVICKEEPVSEVKETSTTVEEATTIVKPQEIMLDNIEDPSQEDLCSVVQSGESEEEEEQDTLELELVLERKKAELRALEEGDGSVSGSSPRSDISQPASQDGMRRLMSKRGKWKMFVRATSPESTSRSSSKTGRDTPENGETAIGAENSEKIDENSDKEMEVEESPEKIKVQTTPKVEEEQDLKFQIGELANTLTSKFEFLGINRQSISNFHVLLLQTETRIADWREGALNGNYLKRKLQDAAEQLKQYEINATPKGWSCHWDRDHRRYFYVNEQSGESQWEFPDGEEEEEESQAQENRDETLAKQTLKDKTGTDSNSTESSETSTVNELKRLDRSSG"
misc_feature 54..476
/gene="FNBP4"
/gene_synonym="FBP30"
/note="propagated from UniProtKB/Swiss-Prot (Q8N3X1.3);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 105..107
/gene="FNBP4"
/gene_synonym="FBP30"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:17081983,
ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163;
propagated from UniProtKB/Swiss-Prot (Q8N3X1.3);
phosphorylation site"
misc_feature 399..401
/gene="FNBP4"
/gene_synonym="FBP30"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:18669648,
ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163;
propagated from UniProtKB/Swiss-Prot (Q8N3X1.3);
phosphorylation site"
misc_feature 423..425
/gene="FNBP4"
/gene_synonym="FBP30"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q6ZQ03; propagated from
UniProtKB/Swiss-Prot (Q8N3X1.3); phosphorylation site"
misc_feature 531..659
/gene="FNBP4"
/gene_synonym="FBP30"
/note="propagated from UniProtKB/Swiss-Prot (Q8N3X1.3);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 567..569
/gene="FNBP4"
/gene_synonym="FBP30"
/note="Phosphothreonine.
/evidence=ECO:0007744|PubMed:17081983; propagated from
UniProtKB/Swiss-Prot (Q8N3X1.3); phosphorylation site"
misc_feature 921..923
/gene="FNBP4"
/gene_synonym="FBP30"
/note="N6-acetyllysine.
/evidence=ECO:0000250|UniProtKB:Q6ZQ03; propagated from
UniProtKB/Swiss-Prot (Q8N3X1.3); acetylation site"
misc_feature 1314..1610
/gene="FNBP4"
/gene_synonym="FBP30"
/note="propagated from UniProtKB/Swiss-Prot (Q8N3X1.3);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 1332..1334
/gene="FNBP4"
/gene_synonym="FBP30"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q6ZQ03; propagated from
UniProtKB/Swiss-Prot (Q8N3X1.3); phosphorylation site"
misc_feature 1347..1349
/gene="FNBP4"
/gene_synonym="FBP30"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:16964243,
ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332,
ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692,
ECO:0007744|PubMed:23186163; propagated from
UniProtKB/Swiss-Prot (Q8N3X1.3); phosphorylation site"
misc_feature 1356..1358
/gene="FNBP4"
/gene_synonym="FBP30"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:19690332; propagated from
UniProtKB/Swiss-Prot (Q8N3X1.3); phosphorylation site"
misc_feature 1365..1367
/gene="FNBP4"
/gene_synonym="FBP30"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q6ZQ03; propagated from
UniProtKB/Swiss-Prot (Q8N3X1.3); phosphorylation site"
misc_feature 1377..1379
/gene="FNBP4"
/gene_synonym="FBP30"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q6ZQ03; propagated from
UniProtKB/Swiss-Prot (Q8N3X1.3); phosphorylation site"
misc_feature 1443..1445
/gene="FNBP4"
/gene_synonym="FBP30"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:20068231; propagated from
UniProtKB/Swiss-Prot (Q8N3X1.3); phosphorylation site"
misc_feature 1488..1490
/gene="FNBP4"
/gene_synonym="FBP30"
/note="Phosphothreonine.
/evidence=ECO:0007744|PubMed:20068231,
ECO:0007744|PubMed:23186163; propagated from
UniProtKB/Swiss-Prot (Q8N3X1.3); phosphorylation site"
misc_feature 1548..1550
/gene="FNBP4"
/gene_synonym="FBP30"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:19690332,
ECO:0007744|PubMed:23186163; propagated from
UniProtKB/Swiss-Prot (Q8N3X1.3); phosphorylation site"
misc_feature 1575..1577
/gene="FNBP4"
/gene_synonym="FBP30"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:20068231,
ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163;
propagated from UniProtKB/Swiss-Prot (Q8N3X1.3);
phosphorylation site"
misc_feature 1599..1601
/gene="FNBP4"
/gene_synonym="FBP30"
/note="Phosphothreonine.
/evidence=ECO:0007744|PubMed:23186163; propagated from
UniProtKB/Swiss-Prot (Q8N3X1.3); phosphorylation site"
misc_feature 1602..1604
/gene="FNBP4"
/gene_synonym="FBP30"
/note="Phosphothreonine.
/evidence=ECO:0007744|PubMed:23186163; propagated from
UniProtKB/Swiss-Prot (Q8N3X1.3); phosphorylation site"
exon 274..366
/gene="FNBP4"
/gene_synonym="FBP30"
/inference="alignment:Splign:2.1.0"
exon 367..503
/gene="FNBP4"
/gene_synonym="FBP30"
/inference="alignment:Splign:2.1.0"
exon 504..690
/gene="FNBP4"
/gene_synonym="FBP30"
/inference="alignment:Splign:2.1.0"
exon 691..838
/gene="FNBP4"
/gene_synonym="FBP30"
/inference="alignment:Splign:2.1.0"
exon 839..959
/gene="FNBP4"
/gene_synonym="FBP30"
/inference="alignment:Splign:2.1.0"
exon 960..1298
/gene="FNBP4"
/gene_synonym="FBP30"
/inference="alignment:Splign:2.1.0"
exon 1299..1509
/gene="FNBP4"
/gene_synonym="FBP30"
/inference="alignment:Splign:2.1.0"
exon 1510..1634
/gene="FNBP4"
/gene_synonym="FBP30"
/inference="alignment:Splign:2.1.0"
exon 1635..1739
/gene="FNBP4"
/gene_synonym="FBP30"
/inference="alignment:Splign:2.1.0"
exon 1740..1873
/gene="FNBP4"
/gene_synonym="FBP30"
/inference="alignment:Splign:2.1.0"
exon 1874..2061
/gene="FNBP4"
/gene_synonym="FBP30"
/inference="alignment:Splign:2.1.0"
exon 2062..4589
/gene="FNBP4"
/gene_synonym="FBP30"
/inference="alignment:Splign:2.1.0"
regulatory 4567..4572
/regulatory_class="polyA_signal_sequence"
/gene="FNBP4"
/gene_synonym="FBP30"
/note="hexamer: AATAAA"
polyA_site 4589
/gene="FNBP4"
/gene_synonym="FBP30"
/note="major polyA site"
ORIGIN
agtgcccgcccctctcggccgcccgacgctctctgctcgcgcttgggctcgcgatggggaagaagtcccgggcggtacccggccgtaggcccatcctgcaactctctccgccgggtcctcggggcagcacgccgggccgggacccggagccggaacccgacactgagccggactcaaccgcggcggtccccagccagcccgccccgtcggcggcgacgaccaccaccaccgcggtgactgccgccgcggcctcggacgactcgccttcagaagatgaacaggaagcggtgcaggaggttcctagagttgttcagaatcctccaaaaccagtcatgaccactagacccacagctgttaaagcaacaggcggtctatgcttgcttggtgcttatgctgacagtgatgacgatgacaatgatgtttccgaaaaactagcacaatccaaagagacaaatggaaaccagtcaactgatattgatagtacattggccaacttcctagcggagatcgatgccataacagctcctcagcctgcagctcctgtaggagcttctgctccacctccaactccacctcgaccagagccaaaggaagcagcaacatctaccctttcttcttctacttcaaatggaacagactccacccaaacatctggttggcaatatgatactcagtgttcactggcaggagtcggaattgagatgggcgattggcaggaagtctgggatgagaacacgggatgttattattattggaatacacaaacaaatgaagtgacttgggagttaccccaatatcttgccacacaggtacagggattacagcattaccagcccagttctgtgccaggtgctgaaactagttttgtggtaaatacagacatatattctaaggagaaaacgatttctgtttccagtagtaaaagtggaccagtcatagccaagcgagaagttaaaaaggaagtaaatgaaggaattcaggctctctcaaatagtgaggaggagaagaaaggggtggcagcatcgctgcttgctcctttattgcctgagggaataaaagaagaagaagagagatggagaagaaaagtaatttgtaaagaggagccagtttcagaagtaaaagaaacaagtacaacagtagaagaagcaacaacaatagtaaagccacaggaaattatgttggacaatatagaagacccttctcaggaggatctttgcagtgttgtccaatctggagaaagtgaggaggaagaggaacaagatacccttgaactggagctagttttggaaaggaaaaaagcagagttgcgagccttggaggaaggagatggtagtgtgtcagggtctagtccacgttctgatatcagccagccagcatctcaagatggaatgcgtaggcttatgtctaaaagaggaaaatggaagatgtttgttcgagctaccagtccagaatctaccagtaggagttctagtaaaactggacgagatactccagaaaatggagaaactgcaattggtgctgaaaattcagaaaaaatagatgagaattcagataaagagatggaagtagaagaatctccagagaaaataaaagtacagacaacaccaaaagtagaagaagaacaggatttgaaatttcagattggagaactggcaaataccctgacaagtaaattcgagtttctaggcattaatagacaatccatctccaactttcatgtgctgctcttacagactgagactcgaattgcagactggcgggaaggggctcttaatggaaactaccttaaacgaaaacttcaggatgcagcagaacaactaaaacagtatgaaataaacgccactcctaaaggctggtcctgccactgggacagggatcatagacggtatttctatgtaaacgaacagtcgggcgagtctcagtgggagtttccagatggtgaagaggaagaagaagaaagccaagcacaagaaaatagagatgagactcttgccaaacagaccttgaaagacaaaactggcactgattcaaattcaacagaatcctctgaaacttccacagttaatgaactgaagaggcttgatcgtagttctggataggtggctccactcctgaccactgtcaacatcccttatatgttccaaagttgaaaattccactgttaccaattctgaatgttctgtgaacactttagatgagtattaagctgttttctccctttatgacacacatagttgatactgtctggtaaaaggaggctcttgagccattcctatttaattaaaacagaactagttgtagtgtaggaaaaagccactgataaaacaggttatattcttaagcctctctttattgagaacccctagaattgcaggataaacttgatcgaagtaaaatccaaatcttaaactaagttctgtgagatttaagagcaataatcaacagttctaagcctaataaagagagctcttaatcagctcagtggtggttaaaaccagctatcttttaaagaagagaaaaaacaaaacacagcaatgccctgtctcttcagaaaattgttttaaaaagttagccaggcatagttagtggcccacgcctgtagtccgagctgtttgggaggttgaggtgggaagattggttgagcccaagattttgaggctgcagtaagccataattgtaccactgcactccagcctgagcgacagagaacaagaccctgtctcaaaaataaagtgggggaaggggtgcaaaattacactgtgagaagccaagaagtttcaaagttctatttatttttctaagtcatttttaatcattatttgttgtttcagtgtttgaatttaacattatgtttttaaagatggagtggattctaaagatgagttgggttcaagatatccaacatatcttttatattgggcttatgtcacttaggtgaagttgagctcctttttctttttaatctccatggaacaatttgtataatttcttgatttaaattgctaaactgagctcttcattcaaaatactaaacaataatttctctttggggggaaaattaaggaaggctttctatacatagaaataaagatgcctaggccgggtgcagtggctcatgcctgtaatcccaatactttggggggctgaggcgggtggatcacctgaggtcaagagttcaagaccagcctgggcaacatggtgaaaccctgcctctactaaaagtacaaaaattagctgggcgtggtggcagctgcctgtaatcccagctactcggaggctgaggcacgagaatcacttgaacctgggaggcgaaggttgcagtgaaccaagatcatgccattgcactccagcctgggcgacagagcaaaactctttatctaaaaaaaaaaaaaaaaaaaaagacgcctacagaagcaaggttcttaggtgcagtgactcatgcctgtaattccagcactttgggagtttgaggcaagaggatcacttgagctcaggaattcaaaaccagcctgggcaatatggcaagaccccatctttgcagaatattagcctagcttggtagcacgagtatgtggtcctagctacttggaaggctgaggtgggaaggatcacttgagcctggtaggttgaagctgcagtgagctatattcacaccattgcactctagcttgaacaacaaagtgagatcctgtctcaaaaagaaaaaggaaaaattacagctcacggctgtaatcccagcactttgggaggccaaggcgcgcagatcacttgaggtcaggagtttgagaccagccaacatggtatcaccctgtctctactaaaaatacaaaaattagccaggtgtcgtggcgggtgcctgtaatcccagctactcgggaggctgaggcaggagaatcgcttgaacccaggaggcagagattacagtgaaccaagatgacacctctgcactccagcctgggcaacaggcttaaagactccgtcttaaaaaaaaattaagaatttgtattctcataacatattcagttttaagcttgtagcttttaaatctttgagcacgtaataaaagctgcgtaggccaagtgtggtggctcatgcttgtaatcccagcactttgggaggctgaggcaggaggatcacctgaggtcgggagttcaagagcagcttacccaatatgtagaaaccccgcctctactaaaaatacaaaattagccaggcgtggtcgcatgcctgtaatcctagctactcgggaggctgaggcaggagaatcattgaacccaggaggcggaggttgtggtgggccaatatcacaccattgcactccaacctgggcaacaagagcaagagtccatctaaaaaaagagctgtatataccactttaatctgtccttgggcttcagacttaaatattctcttaaacagcaaaaatactaactaagttaaatttaaaagcaaggagaagcatcattgtaatacgacatccatgtgtattcaaactagaattttctgatggtcttcgtaagataaaggagataattgtcatttctatgacacagcttttataatttgaataaacttagttggagattgga
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]