LOCUS       NM_001437995           12700 bp    mRNA    linear   PRI 14-APR-2025
DEFINITION  Homo sapiens polyhomeotic homolog 3 (PHC3), transcript variant 3,
            mRNA.
ACCESSION   NM_001437995 XM_005247789 XM_054347942
VERSION     NM_001437995.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12700)
  AUTHORS   Wang,H., Lan,S., Wang,L., Zhao,J., Jia,X., Xu,J., Sun,G., Liu,L.,
            Gong,S., Wang,N., Shan,B., Zhang,F. and Zhang,Z.
  TITLE     Expression of circ-PHC3 enhances ovarian cancer progression via
            regulation of the miR-497-5p/SOX9 pathway
  JOURNAL   J Ovarian Res 16 (1), 142 (2023)
   PUBMED   37468993
  REMARK    GeneRIF: Expression of circ-PHC3 enhances ovarian cancer
            progression via regulation of the miR-497-5p/SOX9 pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12700)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   3  (bases 1 to 12700)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 12700)
  AUTHORS   Crea,F., Di Paolo,A., Liu,H.H., Polillo,M., Clermont,P.L.,
            Guerrini,F., Ciabatti,E., Ricci,F., Barate,C., Fontanelli,G.,
            Barsotti,S., Morganti,R., Danesi,R., Wang,Y., Petrini,M.,
            Galimberti,S. and Helgason,C.D.
  TITLE     Polycomb genes are associated with response to imatinib in chronic
            myeloid leukemia
  JOURNAL   Epigenomics 7 (5), 757-765 (2015)
   PUBMED   26343356
  REMARK    GeneRIF: Data show that polycomb-group proteins BMI1, PHC3, CBX6
            and CBX7 expression was significantly increased during imatinib
            treatment.
REFERENCE   5  (bases 1 to 12700)
  AUTHORS   Crea,F., Sun,L., Pikor,L., Frumento,P., Lam,W.L. and Helgason,C.D.
  TITLE     Mutational analysis of Polycomb genes in solid tumours identifies
            PHC3 amplification as a possible cancer-driving genetic alteration
  JOURNAL   Br J Cancer 109 (6), 1699-1702 (2013)
   PUBMED   23942079
  REMARK    GeneRIF: PHC3 amplification may emerge as a biomarker in cancer.
REFERENCE   6  (bases 1 to 12700)
  AUTHORS   Deshpande,A.M., Akunowicz,J.D., Reveles,X.T., Patel,B.B.,
            Saria,E.A., Gorlick,R.G., Naylor,S.L., Leach,R.J. and Hansen,M.F.
  TITLE     PHC3, a component of the hPRC-H complex, associates with E2F6
            during G0 and is lost in osteosarcoma tumors
  JOURNAL   Oncogene 26 (12), 1714-1722 (2007)
   PUBMED   17001316
  REMARK    GeneRIF: loss of PHC3 may favor tumorigenesis by potentially
            disrupting the ability of cells to remain in G(0)
REFERENCE   7  (bases 1 to 12700)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   8  (bases 1 to 12700)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   9  (bases 1 to 12700)
  AUTHORS   Tonkin,E., Hagan,D.M., Li,W. and Strachan,T.
  TITLE     Identification and characterisation of novel mammalian homologues
            of Drosophila polyhomeoticpermits new insights into relationships
            between members of the polyhomeotic family
  JOURNAL   Hum Genet 111 (4-5), 435-442 (2002)
   PUBMED   12384788
REFERENCE   10 (bases 1 to 12700)
  AUTHORS   Levine,S.S., Weiss,A., Erdjument-Bromage,H., Shao,Z., Tempst,P. and
            Kingston,R.E.
  TITLE     The core of the polycomb repressive complex is compositionally and
            functionally conserved in flies and humans
  JOURNAL   Mol Cell Biol 22 (17), 6070-6078 (2002)
   PUBMED   12167701
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC023891.28 and AC008040.7.
            
            On or before Apr 14, 2025 this sequence version replaced
            XM_005247789.4, XM_054347942.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.1987722.1,
                                           SRR14038194.1556663.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AC023891.28        80228-80259         c
            33-198              AC023891.28        77299-77464         c
            199-354             AC023891.28        71083-71238         c
            355-432             AC023891.28        69899-69976         c
            433-591             AC023891.28        47612-47770         c
            592-690             AC023891.28        43949-44047         c
            691-937             AC023891.28        34945-35191         c
            938-1806            AC023891.28        27210-28078         c
            1807-1854           AC023891.28        26866-26913         c
            1855-2008           AC023891.28        21117-21270         c
            2009-2259           AC023891.28        15752-16002         c
            2260-2419           AC023891.28        11886-12045         c
            2420-2534           AC023891.28        5358-5472           c
            2535-2667           AC008040.7         536-668
            2668-2899           AC008040.7         760-991
            2900-12700          AC008040.7         6086-15886
FEATURES             Location/Qualifiers
     source          1..12700
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.2"
     gene            1..12700
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /note="polyhomeotic homolog 3"
                     /db_xref="GeneID:80012"
                     /db_xref="HGNC:HGNC:15682"
                     /db_xref="MIM:620031"
     exon            1..32
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..3054
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /note="isoform 3 is encoded by transcript variant 3; early
                     development regulator 3; polyhomeotic-like protein 3;
                     homolog of polyhomeotic 3; early development regulatory
                     protein 3; polyhomeotic like 3"
                     /codon_start=1
                     /product="polyhomeotic-like protein 3 isoform 3"
                     /protein_id="NP_001424924.1"
                     /db_xref="GeneID:80012"
                     /db_xref="HGNC:HGNC:15682"
                     /db_xref="MIM:620031"
                     /translation="

MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSSSQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSINLSTSPTPAQLISRSQASSSTSGSITQQTMLLGSTSPTLTASQAQMYLRAQMLIFTPATTVAAVQSDIPVVSSSSSSSCQSAATQVQNLTLRSQKLGVLSSSQNGPPKSTSQTQSLTICHNKTTVTSSKISQRDPSPESNKKGESPSLESRSTAVTRTSSIHQLIAPASYSPIQPHSLIKHQQIPLHSPPSKVSHHQLILQQQQQQIQPITLQNSTQDPPPSQHCIPLQNHGLPPAPSNAQSQHCSPIQSHPSPLTVSPNQSQSAQQSVVVSPPPPHSPSQSPTIIIHPQALIQPHPLVSSALQPGPNLQQSTANQVQATAQLNLPSHLPLPASPVVHIGPVQQSALVSPGQQIVSPSHQQYSSLQSSPIPIASPPQMSTSPPAQIPPLPLQSMQSLQVQPEILSQGQVLVQNALVSEEELPAAEALVQLPFQTLPPPQTVAVNLQVQPPAPVDPPVGMHLNQCHLHKVFSLKVYQVEDVCEEEMPEESDECVRMDRTPPPPTLSPAAITVGRGEDLTSEHPLLEQVELPAVASVSASVIKSPSDPSHVSVPPPPLLLPAATTRSNSTSMHSSIPSIENKPPQAIVKPQILTHVIEGFVIQEGLEPFPVSRSSLLIEQPVKKRPLLDNQVINSVCVQPELQNNTKHADNSSDTEMEDMIAEETLEEMDSELLKCEFCGKMGYANEFLRSKRFCTMSCAKRYNVSCSKKFALSRWNRKPDNQSLGHRGRRPSGPDGAAREHILRQLPITYPSAEEDLASHEDSVPSAMTTRLRRQSERERERELRDVRIRKMPENSDLLPVAQTEPSIWTVDDVWAFIHSLPGCQDIADEFRAQEIDGQALLLLKEDHLMSAMNIKLGPALKICARINSLKES"

     exon            33..198
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            199..354
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            355..432
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            433..591
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            592..690
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            691..937
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1806
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1854
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..2008
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2259
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            2260..2419
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2534
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            2535..2667
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            2668..2899
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            2900..12700
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5042..5047
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /note="hexamer: ATTAAA"
     polyA_site      5063
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
     regulatory      12679..12684
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /note="hexamer: AATAAA"
     polyA_site      12700
                     /gene="PHC3"
                     /gene_synonym="EDR3; HPH3"
                     /note="major polyA site"
ORIGIN      

agtgatggaggagagaagatggcggaagcggaatttaaggaccatagtacagctatggatactgaaccaaacccgggaacatcttctgtgtcaacaacaaccagcagtaccaccaccaccaccatcaccacttcctcctctcgaatgcagcagccacagatctctgtctacagtggttcagaccgacatgctgtacaggtaattcaacaggcattgcatcggccccccagctcagctgctcagtaccttcagcaaatgtatgcagcccaacaacagcacttgatgctgcatactgcagctcttcagcagcagcatttaagcagctcccagcttcagagccttgctgctgttcaggcaagtttgtccagtggaagaccatctacatctcccacaggaagtgtcacacagcagtcaagtatgtcccaaacgtctatcaacctctccacttctcctacacctgcacagttaataagccgttcccaggcttccagttctaccagcggcagtattacccaacagactatgttactagggagtacttcccctaccctaacggcaagccaagctcaaatgtatctccgagctcaaatgctgattttcacacccgctaccactgtggctgctgtacagtctgacattcctgttgtctcgtcgtcatcgtcatcttcctgtcagtctgcagctactcaggttcagaatttaacattacgcagccagaagttgggtgtattatctagctcacagaatggtccaccaaaaagcactagtcaaactcagtcattgacaatttgtcataacaaaacaacagtgaccagttctaaaatcagccaacgagatccttctccagaaagtaataagaaaggagagagcccaagcctggaatcacgaagcacagctgtcacccggacatcaagtattcaccagttaatagcaccagcttcatattctccaattcagcctcattctctaataaaacatcagcagattcctcttcattcaccaccttccaaagtttcccatcatcagctgatattacaacagcagcaacagcaaattcagccaatcacacttcagaattcaactcaagacccacccccatcccagcactgtataccactccagaaccatggccttcctccagctcccagtaatgcccagtcacagcattgttcaccgattcagagtcatccctctcctttaacagtgtctcctaatcagtcacagtcagcacagcagtctgtagtggtgtctcctccaccacctcattcaccaagtcagtctcctactataattattcatccacaagcacttattcagccacaccctcttgtgtcatcagctctccagccagggccaaatttgcagcagtccactgctaatcaggtgcaagctacagcacagttgaatcttccatcccatcttccacttccagcttcccctgttgtacacattggcccagttcagcagtctgccttggtatccccaggccagcagattgtctctccatcacaccagcaatattcatccctgcagtcctctccaatcccaattgcaagtcctccacagatgtcgacatctcctccagctcagattccaccactgcccttgcagtctatgcagtctttacaagtgcagcctgaaattctgtcccagggccaggttttggtgcagaatgctttggtgtcagaagaggaacttccagctgcagaagctttggtccagttgccatttcagactcttcctcctccacagactgttgcggtaaacctacaagtgcaaccaccagcacctgttgatccaccagtgggaatgcatttgaaccagtgtcatctgcacaaagttttttctcttaaggtttatcaggtagaagatgtgtgtgaagaagaaatgccagaagagtcagatgaatgtgtccggatggatagaaccccaccaccacccactttgtctccagcagctataacagtggggagaggagaagatttgacttctgaacatcctttgttagagcaagtggaattacctgctgtggcatcagtcagtgcttcagtaattaaatctccatcagatccctcacatgtttctgttccaccacctccattgttacttccagctgccaccacaaggagtaacagtacatctatgcacagtagcattcccagtatagagaacaaacctccacaggctattgttaaaccacagatcctaacccatgttattgaaggctttgtgattcaggagggattggagccatttcctgtgagtcgttcctctttgctaatagaacagcctgtgaaaaaacggcctcttttggataatcaggtgataaattcagtgtgtgttcagccagagctacagaataatacaaaacatgcggataattcatctgacacagagatggaagacatgattgctgaagagacattagaagaaatggacagtgagttgctcaagtgtgaattctgtgggaaaatgggatatgctaatgaatttttgcggtcaaaacgattctgcactatgtcatgtgccaaaaggtacaatgttagctgttctaaaaaatttgcacttagtcgttggaatcgtaagcctgataatcaaagtcttgggcatcgtggccgtcgtccaagtggccctgatggggcagcgagagaacatatccttaggcagcttccaattacttatccatctgcagaagaagacttggcttctcatgaagattctgtgccatctgctatgacaactcgtctgcgcaggcagagcgagcgggaaagagaacgtgagcttcgggatgtgagaattcggaaaatgcctgagaacagtgacttgctaccagttgcacaaacagagccatctatatggacagttgatgatgtctgggccttcatccattctttgcctggctgccaggatatcgcagatgaattcagagcacaggagattgatggacaggcccttctcttgctgaaagaagaccatctcatgagtgcaatgaatatcaagctaggcccagccctgaagatctgtgcacgcatcaactctctgaaggaatcttaacaggaacatgaagccttgataaaacagcagttttacttttctcacaaaaacttgtaaggtaaaggcctaacttggtctagaatatgacacttattgtggtggatagccaagcacattgggatctccacatcaaatactgacatttcttctacaggtataataattcatcatgcattttcataattaataaacattggtaaaattaattttacaggttacatgaaacattgaaagacttgttacagagggccatgatatttttcaaagaaatgtgttatactagataatttttttaaaggtgatgtttatcattaatataaagaatccttttaaaagtaatttaatgatttacatttctcctcttttgattcaattttcttatacattttttctaccctattagttttctaaaggttgtcatgagaggtatattatggaataatttagtagtccagtgacagaatcgtatgaaatcagtgtacattttaaaaaacatgtcttttagacatatgctttatctataaaaaaggaattgtgttctagtatgaacaatactgatctggaagtgagaagagttagtttctattccaaacttgaccaagaatttggtttgactgagaacgttttcctctcagtttttgtacatttatttagagcagtggttctcagtggaggtcagttttgatcgccaggggacatctggcaatgttgagacattttggttgtcacagcttgggggtgggttcaggggagggttgctactggtgtctagtagttagaagccagagatgtttctaaacatcttataatgcacaggacagcacccctccactgtaaagaattattggttcaaaaatatcggtactgccaaggttgagaaactctgatatagaaggagtgataaatattgttttcacccaaaggaatacttttaaaggatgaagcttactaaacatatatgatggaagtattattcagataacattaatattctgctgaataattttttctagtttaatcatactagaaaaagaaaaaaaatctacaaattgtcctataaaataaggacaaacatgcaaataatttaactctcagaaagtactaattcattctgattatctttcatacctctgtgctcctctgcactgacgaagacataatatgattatacctatgaactagtgcacagccttttctggcaagaaaatagtttgtagcagatacgtggttgctctttggatttttttctattgttgaacatgctgggactagctagaatgcacattcctacttcctttaccaaacgtttgcatgcttcctgcaaagcacttaccaagtgatttctcttgaaccatcggatataattttgtatgtacatgtttgaggaaaaaaatgtaaagcaaaaccttttactgaacagtgttctatagaattatgacactaaaacaaaattgtttgtggaagccctgaaagctttatagtcctggacatcaaaaattttatttgagatgatgaatgttttgttttcatcttttcttatattaccacaattgagatattttagtaattgaaggaacatacacagatatttggcagaagtcgagtaaggaggggaaaaaaagagtccgtgagtttcagtcattttcactgctcttttcaaaaagattgtgttgagctggtagaagactaaagatgtcactgaagacatcacagatactatatttatcttttggctttgtgtacattagagaatgttgattatttttatacaaaaatacagcgggtaatttttttaatctttagatgcctcttgtttgaatgtatgctttgtggaattctttgtgtagtaatgttttaaaaaaagatgtttactgatagttacatgtaggattagaatatgtaatataatataaggctcatgttccagacctacgatagcttgtagt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