2024-09-29 10:24:49, GGRNA.v2 : RefSeq release 225 (Jul, 2024)
LOCUS NM_001425148 6114 bp mRNA linear PRI 17-JUN-2024 DEFINITION Homo sapiens DEAD-box helicase 6 (DDX6), transcript variant 6, mRNA. ACCESSION NM_001425148 VERSION NM_001425148.1 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 6114) AUTHORS Yao,G., Yu,S., Hou,F., Xiao,Z., Li,G., Ji,X. and Wang,J. TITLE Rab3B enhances the stabilization of DDX6 to promote lung adenocarcinoma aggressiveness JOURNAL Mol Med 30 (1), 75 (2024) PUBMED 38834947 REMARK GeneRIF: Rab3B enhances the stabilization of DDX6 to promote lung adenocarcinoma aggressiveness. Publication Status: Online-Only REFERENCE 2 (bases 1 to 6114) AUTHORS Ripin,N., Macedo de Vasconcelos,L., Ugay,D.A. and Parker,R. TITLE DDX6 modulates P-body and stress granule assembly, composition, and docking JOURNAL J Cell Biol 223 (6) (2024) PUBMED 38536035 REMARK GeneRIF: DDX6 modulates P-body and stress granule assembly, composition, and docking. REFERENCE 3 (bases 1 to 6114) AUTHORS Deng,X., Liu,Z., Wang,B., Ma,J. and Meng,X. TITLE The DDX6/KIFC1 signaling axis, as regulated by YY1, contributes to the malignant behavior of pancreatic cancer JOURNAL FASEB J 38 (7), e23581 (2024) PUBMED 38551642 REMARK GeneRIF: The DDX6/KIFC1 signaling axis, as regulated by YY1, contributes to the malignant behavior of pancreatic cancer. REFERENCE 4 (bases 1 to 6114) AUTHORS Naito,S., Tanaka,H., Jiang,J.J., Tarumi,M., Hashimoto,A., Tanaka,Y., Murakami,K., Kubota,S.I., Hojyo,S., Hashimoto,S. and Murakami,M. TITLE DDX6 is involved in the pathogenesis of inflammatory diseases via NF-kappaB activation JOURNAL Biochem Biophys Res Commun 703, 149666 (2024) PUBMED 38377944 REMARK GeneRIF: DDX6 is involved in the pathogenesis of inflammatory diseases via NF-kappaB activation. REFERENCE 5 (bases 1 to 6114) AUTHORS Majerciak,V., Zhou,T., Kruhlak,M.J. and Zheng,Z.M. TITLE RNA helicase DDX6 and scaffold protein GW182 in P-bodies promote biogenesis of stress granules JOURNAL Nucleic Acids Res 51 (17), 9337-9355 (2023) PUBMED 37427791 REMARK GeneRIF: RNA helicase DDX6 and scaffold protein GW182 in P-bodies promote biogenesis of stress granules. REFERENCE 6 (bases 1 to 6114) AUTHORS Akiyama,K., Akao,Y., Yokoyama,M., Nakagawa,Y., Noguchi,T., Yagi,K. and Nishi,Y. TITLE Expression of two dead box genes (DDX1 and DDX6) is independent of that of MYCN in human neuroblastoma cell lines JOURNAL Biochem Mol Biol Int 47 (4), 563-568 (1999) PUBMED 10319407 REFERENCE 7 (bases 1 to 6114) AUTHORS Zhang,W.J. and Wu,J.Y. TITLE Functional properties of p54, a novel SR protein active in constitutive and alternative splicing JOURNAL Mol Cell Biol 16 (10), 5400-5408 (1996) PUBMED 8816452 REFERENCE 8 (bases 1 to 6114) AUTHORS Akao,Y., Marukawa,O., Morikawa,H., Nakao,K., Kamei,M., Hachiya,T. and Tsujimoto,Y. TITLE The rck/p54 candidate proto-oncogene product is a 54-kilodalton D-E-A-D box protein differentially expressed in human and mouse tissues JOURNAL Cancer Res 55 (15), 3444-3449 (1995) PUBMED 7614484 REFERENCE 9 (bases 1 to 6114) AUTHORS Akao,Y., Seto,M., Yamamoto,K., Iida,S., Nakazawa,S., Inazawa,J., Abe,T., Takahashi,T. and Ueda,R. TITLE The RCK gene associated with t(11;14) translocation is distinct from the MLL/ALL-1 gene with t(4;11) and t(11;19) translocations JOURNAL Cancer Res 52 (21), 6083-6087 (1992) PUBMED 1394235 REFERENCE 10 (bases 1 to 6114) AUTHORS Lu,D. and Yunis,J.J. TITLE Cloning, expression and localization of an RNA helicase gene from a human lymphoid cell line with chromosomal breakpoint 11q23.3 JOURNAL Nucleic Acids Res 20 (8), 1967-1972 (1992) PUBMED 1579499 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP004609.1, AP002954.1, KF510139.1, KF511134.1 and KF510354.1. Summary: This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2012]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR12921934.813191.1, DRR138512.159374.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682 [ECO:0006172] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-56 AP004609.1 7895-7950 c 57-523 AP004609.1 3060-3526 c 524-587 AP002954.1 159535-159598 c 588-692 AP002954.1 158046-158150 c 693-760 KF510139.1 1-68 c 761-819 AP002954.1 146636-146694 c 820-966 AP002954.1 143622-143768 c 967-1061 AP002954.1 141626-141720 c 1062-1184 AP002954.1 138336-138458 c 1185-1313 AP002954.1 137188-137316 c 1314-1430 AP002954.1 135585-135701 c 1431-1494 AP002954.1 134674-134737 c 1495-1596 AP002954.1 133816-133917 c 1597-1779 AP002954.1 133119-133301 c 1780-2626 AP002954.1 129665-130511 c 2627-2712 KF511134.1 1-86 c 2713-3675 AP002954.1 128617-129579 c 3676-4054 KF510354.1 1-379 4055-6114 AP002954.1 126177-128236 c FEATURES Location/Qualifiers source 1..6114 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="11" /map="11q23.3" gene 1..6114 /gene="DDX6" /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54" /note="DEAD-box helicase 6" /db_xref="GeneID:1656" /db_xref="HGNC:HGNC:2747" /db_xref="MIM:600326" exon 1..56 /gene="DDX6" /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54" /inference="alignment:Splign:2.1.0" exon 57..523 /gene="DDX6" /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54" /inference="alignment:Splign:2.1.0" misc_feature 315..317 /gene="DDX6" /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54" /note="upstream in-frame stop codon" CDS 324..1772 /gene="DDX6" /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54" /EC_number="3.6.4.13" /note="isoform 2 is encoded by transcript variant 6; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6 (RNA helicase, 54kD); DEAD box-6; probable ATP-dependent RNA helicase DDX6; oncogene RCK; DEAD box protein 6; ATP-dependent RNA helicase p54; DEAD (Asp-Glu-Ala-Asp) box polypeptide 6; DEAD (Asp-Glu-Ala-Asp) box helicase 6" /codon_start=1 /product="probable ATP-dependent RNA helicase DDX6 isoform 2" /protein_id="NP_001412077.1" /db_xref="GeneID:1656" /db_xref="HGNC:HGNC:2747" /db_xref="MIM:600326" /translation="
MSTARTENPVIMGLSSQNGQLRGPVKPTGGPGGGGTQTQQQMNQLKNTNTINNGTQQQAQSMTTTIKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPSPIQESIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTRELALQVSQICIQVSKHMGGAKVMATTGGTNLRDDIMRLDDTVHVVIATPGRILDLIKKGVAKVDHVQMIVLDEADKLLSQDFVQIMEDIILTLPKNRQILLYSATFPLSVQKFMNSHLQKPYEINLMEELTLKGVTQYYAYVTERQKVHCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYSCFYIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLHRIGRSGRFGHLGLAINLITYDDRFNLKSIEEQLGTEIKPIPSNIDKSLYVAEYHSEPVEDEKP"
misc_feature 324..443 /gene="DDX6" /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54" /note="propagated from UniProtKB/Swiss-Prot (P26196.2); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 429..431 /gene="DDX6" /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54" /note="Phosphothreonine. /evidence=ECO:0007744|PubMed:17525332; propagated from UniProtKB/Swiss-Prot (P26196.2); phosphorylation site" misc_feature 609..695 /gene="DDX6" /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54" /note="propagated from UniProtKB/Swiss-Prot (P26196.2); Region: Q motif" misc_feature 1056..1067 /gene="DDX6" /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54" /note="propagated from UniProtKB/Swiss-Prot (P26196.2); Region: DEAD box" misc_feature 1176..1268 /gene="DDX6" /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54" /note="propagated from UniProtKB/Swiss-Prot (P26196.2); Region: Gyf binding. /evidence=ECO:0000269|PubMed:31439631" misc_feature 1239..1769 /gene="DDX6" /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54" /note="propagated from UniProtKB/Swiss-Prot (P26196.2); Region: RecA-like domain 2. /evidence=ECO:0000269|PubMed:31439631" exon 524..587 /gene="DDX6" /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54" /inference="alignment:Splign:2.1.0" exon 588..692 /gene="DDX6" /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54" /inference="alignment:Splign:2.1.0" exon 693..819 /gene="DDX6" /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54" /inference="alignment:Splign:2.1.0" exon 820..966 /gene="DDX6" /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54" /inference="alignment:Splign:2.1.0" exon 967..1061 /gene="DDX6" /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54" /inference="alignment:Splign:2.1.0" exon 1062..1184 /gene="DDX6" /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54" /inference="alignment:Splign:2.1.0" exon 1185..1313 /gene="DDX6" /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54" /inference="alignment:Splign:2.1.0" exon 1314..1430 /gene="DDX6" /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54" /inference="alignment:Splign:2.1.0" exon 1431..1494 /gene="DDX6" /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54" /inference="alignment:Splign:2.1.0" exon 1495..1596 /gene="DDX6" /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54" /inference="alignment:Splign:2.1.0" exon 1597..1779 /gene="DDX6" /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54" /inference="alignment:Splign:2.1.0" exon 1780..6114 /gene="DDX6" /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54" /inference="alignment:Splign:2.1.0" regulatory 6090..6095 /regulatory_class="polyA_signal_sequence" /gene="DDX6" /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54" /note="hexamer: AATAAA" polyA_site 6114 /gene="DDX6" /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54" /note="major polyA site" ORIGIN
ggagcttcgagtcaacaataaaggaccgagggtgccgagcgggagtggcctcgttgattgacgtgagtgaattcagatataactcaagcttgttagagggctttttaaaaataaaaagttgattccgtgcaagagagcaagttactgctgcttaccgttcagagacttacaggtgcttgcctgcattgcaataaaggactcatttattgagcaagacttatatttatctcttcattttggagagcctaataaactgttattacagtttctctactgactttcaaaagttttgaagtttgaaagacctttgcaattaaaacagcatgagcacggccagaacagagaaccctgttataatgggtctgtccagtcaaaatggtcagctgagaggccctgtgaaacccactggtggccctggaggagggggcacacagacacagcaacagatgaaccagctgaaaaacaccaacacaatcaataatggcactcagcagcaagcacagagtatgaccaccactattaaacctggtgatgactggaaaaagactttaaaactccctccaaaggatctaagaatcaaaacttcggatgtgacctccacaaaaggaaatgagtttgaagattactgtttgaaacgggagttactgatgggaatttttgaaatgggctgggaaaagccatctcctattcaggagagcattcccattgctttatctggtagggatatcttagctagagcaaaaaatggaacaggcaagagcggtgcctacctcattcccttacttgaacggctagacctgaagaaggacaatatacaagcaatggtgattgttcccactagagaacttgctctacaggtcagtcaaatttgcatccaggtcagcaaacacatgggaggggccaaagtgatggcaaccacaggaggaaccaatttacgagatgacataatgaggcttgatgatacagtgcacgtggtgattgctacccctgggagaatcctggatcttattaagaaaggagtagcaaaggttgatcatgtccagatgatagtattggatgaggcagataagttgctgtcacaggattttgtgcagataatggaggatattattctcacgctacctaaaaacaggcagattttactatattccgctactttccctcttagtgtacagaagttcatgaattcccatttgcagaaaccctatgagattaacctgatggaggaactaactctgaagggagtaacccagtactacgcatatgtaactgagcgccaaaaagtacactgcctcaacacacttttctccaggcttcagataaaccagtcgatcattttctgtaactcctctcagcgagttgaattgctagccaagaagatttctcaactgggttattcttgcttctatattcatgctaaaatgaggcaggaacatcgaaatcgtgtatttcatgatttccgaaatggcttatgccgcaatcttgtttgcactgatctgtttacccgaggtattgatatacaagctgtgaatgtggtaataaactttgatttcccaaagctggcagagacctatctccatcgtattggaagatcaggtcgctttggtcatcttggcttagccatcaacttgatcacatatgatgatcgcttcaacctgaaaagtattgaggagcagctgggaacagaaattaaacctattccgagcaacattgataagagcctgtatgtggcagaataccacagcgagcctgtagaagatgagaaaccttaacaagcatgctttgacaaattacaaaaggctcgtttggatctgtgacacatcgttttggggggaatgctcctctctttgtgggtttttcatcttttattttggaactatgaagacttaaaagagctcagacattttctttttttaactggtgaagagaaaaaggctgaaaagaaggaatataccttttttgttccacttgtttgcactgtgtgctgactgaacattagttgcactaactgctggtttttaaaaaatgttttctggggaaaggggacaaggaaggaaaagaaagaagagaaggggagaaaccctaaaaagagaagaatcttaatgaacacacaagcttgtcaatgatttcaaaattctccaacagctgactctcgtgcatttcaacttctccctgattcctcatccgttttttaagcctgaagagcttattacttatttgtgcgaagtgccttatgctatgagaccattcagaatatcatcttttagacacagcccgaggaatcaacaatagtaactctttctttccgtttttttttctttttcttttaaaaaatgtcttcttattttggtttcaggttgaagtctcttccctttctacccagtactcgagcccagggctagaagttgaaactcactagtaatgttaaacaccattttttttttctttttggggaggagttgatatgcaactgcagttcatccgcactgtaaatacatgtatttaaaaaaacaatcccaagtaaaaatttcttctgggctgagtagataaaaaacatcatcgctcccaaaggaaagagcagtctatcattgcaggagccatatgacaagcctttgtgctctatagcagacactaaagactgggttacatatgcctccagtagtagtatggcacttgatgtgtagacatgtcagagccttggccctctttcctctgtggcaaagcgtgtcccatagaaaattgggtgtgtatacttgtataactttgtaaataagttttttttctgggttcatatatatatatatatatacatatatatatatttttttttggatgaaggttgctgggattaaggggattagagtgattatgggagcagctaaagatgagaggggctcagttttacgcaacactaaattctagaaagtactttggcctcgtgctgtagagagcagatttctatggtaccctgtgttagtaaaggggcccagaaatctgggatgtactgtttgctgccacactgtctcatctagtacctttggagtaggtttaccagagagagcaaggaagcttcaaaacattgataattcaacatttattttgagaagctctgattttgcttcttccccctttctaaaagtttgaggaatatttcaagctctgcaacagggggcaaagattaatctaccttgcagtgtaggaattctattgagtggcagtgtcattgagcagtatatatataaagcacagatttgcatttcagaatattagccagtaccagctttggtaatgttagcagttctggagcttaattttctgtggatcatttcctgtagtgtgtaaatgtgttgccctctgcccgctttgatacataaacttttgcaggaatgggcaacctgagagctgttaactttcatgctacagaaagctgcttgccattctcttgcattgtgacaagaattgttacctgtcattttgcactgtaaattgctggcagatgctttacagtcaatagtgttgctttaaattgtgcccctcccaacatgcttgatgtttggcctgatctccaggcaaaaggagtgagatgaatcaaaaccagtgaacttttttttttaatgtttttaattcccttttaacccagtgtactaggtcaatcaggaggcatctggaaagggggggaaaaaagcaaaaaacaaaattaaaaaaaattgatttccatattttatttttcaaaaccctaaaatattacaaaataagtcccgcatatactttaatgttttaactcttttggacaaaggaatcaattacttgaagttgcttttttgactctgcctacttctgagcaaactatttgcgactcacccacaattccttggagatcaaaatcctacagatgcctcctgatgggacatagccctaactccttaacaactgtagcaagaactgcacggtacaaacccaaaaaagaacaagctcatctatttggaacccaagcctcatattttctgtccagtcaatgttggttactaaatagaaaacctaattaaggaagtaacttttttccagggaggggtgggagagggaatttaaaaggtgtcaacttttgaccaaaaaaattgtgcccttgtaccgatgcagctctctttctcccccacctcttgcgagataagagggatcattcatgtagaagaaaagagtataaatgcaattctgtatctcgctagagaacgtgtgggtgactaaacaaaaagtgcagtctccttcaccaactttagactgcgtggtgccacatgcctgtgggtccctcttaaagcacagacttaaaatggaaagtattactgaagtatagcctctaatgaggagtggcacttaaactatctgggacaccactactggacacggtcttgtagaggcagctgtccagttttggtgcttgactcttgaataggaattgttaaatggaaagatgctctgaggactaggtcaaagcctggtctttttttttttttttttttttttctttcttttttgggccctcataataagcattgttactattggaagttgttttcacattctttccaatattaaatatgtatttttttaagtaatgataatattttccagtggctcatttggatgagaactaccctctatttttaatattaaaactacatccaactcatcatttagcctttggttgtacagttgtgtaatgggctatggactgttacacaccttaccacctctaggcctatgttttttctttccccatatattctgatggggataaatactgttttgcctctcccataggaatggaatacatttattctaaaatgatctttcacagaagtaagagagagggaaacctaaatatacctctaaattgtttgaagttggtcccagcagcataaaatgggttggccccaaagggttggagggtgggcttggttatcagtatttgttttcagaatgagatgggagcatctttcctttgccacgtgctttgtgcttgataacatcatgcttggttcaaacgacaactcagcacaaagccttgagtataaattgttggaatcaaaacatctcattctgatgacgtggtttaattttttaatttttttttttaataggggtgggagggagggtactttgccccagaagggagggtgtctgcactaaggatttagaaacactttggaagctcataacctcatcagaaactgcctttagccacactcctgaccttctagatgagtaacaaaaaaatgaaataagttcttggaaattaagccatttattttaatttgctatttttttcaatgttctaggtatctttaaatttgttattgtggaatcattttcctgccagatacctttatcaaaattattggcctcatgagagctgaagtaagtcagctttttggtgaactttagtggacttctgtgagattgtagttgtactttgtatctctaaatctaaagatagttttttaaaactcccaaagaaaatctgctctcctttctgatctaaaaactcatctttggggtaaagagttaagtgtccaaaggttgtcacagttcatgaggtcagagggagctagcctggcacctggactctgcccatccacagctgacagattccaacagaagtgtatttaaattctccagtagacaatgctgggtaagggagggggtagggctgggttattaagatacaggctgctgtattttacattggttgtgtgggaaggggagcctggagaaaacaaagtcactattcccttttttgaaacaggaaaaaaaattattttttgttcagtaaaaatggtagagaattccaatgtccctagccacaagggaccagttccactgagaagtgaacagtgggaactcaaaatttcagaaacattgggggaagggaaaattggctttctcttaattggcagatgttccagtggggggggggggggctctgtttttgttgggatgtgttatgttgtatgtacgcatatatggaccggagtctgctgagtttataaggttccaaaaatatggtaaaatcttggtttttgttaatttatctcaataaaagcccactggaactccaaa
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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