LOCUS       NM_001421664             843 bp    mRNA    linear   PRI 10-OCT-2023
DEFINITION  Homo sapiens SLX1A-like (LOC130134321), transcript variant 2, mRNA.
ACCESSION   NM_001421664
VERSION     NM_001421664.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CP068262.2.
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-450               CP068262.2         30580345-30580794
            451-502             CP068262.2         30581262-30581313
            503-630             CP068262.2         30583497-30583624
            631-718             CP068262.2         30583793-30583880
            719-843             CP068262.2         30583960-30584084
FEATURES             Location/Qualifiers
     source          1..843
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16"
     gene            1..843
                     /gene="LOC130134321"
                     /note="SLX1A-like"
                     /db_xref="GeneID:130134321"
     exon            1..450
                     /gene="LOC130134321"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    23..25
                     /gene="LOC130134321"
                     /note="upstream in-frame stop codon"
     misc_feature    26..28
                     /gene="LOC130134321"
                     /note="upstream_AUG_codon; putative N-terminal extension:
                     MVRARRLDSSLASAVGLLHPPPDRRGARTGATASCRLPPDSPRELVPKQAPCSPSDPA
                     LPWTLGHGNQPPAVVPEPQGP"
     CDS             263..748
                     /gene="LOC130134321"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="SLX1A-like isoform 2"
                     /protein_id="NP_001408593.1"
                     /db_xref="GeneID:130134321"
                     /translation="

MGPAGVAARPGRFFGVYLLYCLNPRYRGRVYVGFTVNTARRVQQHNGGRKKGGAWRTSGRGPWEMVLVVHGFPSSVAALRDEEGPLCCPHPGCLLRAHVICLAEEFLQEEPGQLLPLEGQCPCCEKSLLWGDLIWLCQMDTEKEVEDSELEEAHWTDLLET"

     misc_feature    299..508
                     /gene="LOC130134321"
                     /note="Catalytic GIY-YIG domain of yeast
                     structure-specific endonuclease subunit SLX1 and its
                     eukaryotic homologs; Region: GIY-YIG_SLX1; cd10455"
                     /db_xref="CDD:198402"
     misc_feature    order(305..313,353..361)
                     /gene="LOC130134321"
                     /note="GIY-YIG motif/motif A; other site"
                     /db_xref="CDD:198402"
     misc_feature    order(311..313,353..355,359..361,383..385,395..397,
                     506..508)
                     /gene="LOC130134321"
                     /note="putative active site [active]"
                     /db_xref="CDD:198402"
     misc_feature    506..508
                     /gene="LOC130134321"
                     /note="putative metal binding site [ion binding]; other
                     site"
                     /db_xref="CDD:198402"
     exon            451..502
                     /gene="LOC130134321"
                     /inference="alignment:Splign:2.1.0"
     exon            503..630
                     /gene="LOC130134321"
                     /inference="alignment:Splign:2.1.0"
     exon            631..718
                     /gene="LOC130134321"
                     /inference="alignment:Splign:2.1.0"
     exon            719..843
                     /gene="LOC130134321"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gggactcgggcggagccgatgctgaatggtacgcgctcgccgactggacagcagtctggcttccgcggtcggacttctacacccgcctccagacaggagaggggcacgtaccggcgctacggcttcctgcaggctgcctccggatagtccccgagagcttgttccgaagcaagcaccctgcagccctagcgatccagccctcccctggaccctaggtcacggcaatcaaccccctgctgtggttcccgaaccccaaggcccgatgggtcccgcgggggtcgcggcgaggccagggcgctttttcggcgtctacctgctctactgcctgaacccccggtaccggggccgcgtctacgtggggttcactgtcaacactgctcgtcgggtccagcagcacaatgggggccgcaaaaaaggcggggcctggcggaccagcgggcgagggccctgggagatggtgctcgtcgtgcacggcttcccgtcctccgtggccgcccttcgggatgaagaggggcccttgtgttgcccccaccctggctgcctgctaagggcccatgtgatctgcctggcagaggagtttcttcaggaagaaccagggcagcttctgcccctagagggccaatgcccttgctgtgagaagtcactgctttggggagacctgatctggctgtgccagatggacactgagaaagaagtagaagactcagaattagaagaggcacactggacagacctgctggagacctgatcctcagtgtccttaccccctcctacctcttttctgtgccacctgctgtgggtccagcaggtttttacttgagtacaataaaaagtctgagtcaa

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