2024-05-06 10:28:14, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_001410774 3579 bp mRNA linear PRI 01-JAN-2023 DEFINITION Homo sapiens actin related protein 8 (ACTR8), transcript variant 2, mRNA. ACCESSION NM_001410774 XM_011534249 VERSION NM_001410774.1 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3579) AUTHORS Zhang S, Zhou B, Wang L, Li P, Bennett BD, Snyder R, Garantziotis S, Fargo DC, Cox AD, Chen L and Hu G. TITLE INO80 is required for oncogenic transcription and tumor growth in non-small cell lung cancer JOURNAL Oncogene 36 (10), 1430-1439 (2017) PUBMED 27641337 REFERENCE 2 (bases 1 to 3579) AUTHORS Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA and Mann M. TITLE A human interactome in three quantitative dimensions organized by stoichiometries and abundances JOURNAL Cell 163 (3), 712-723 (2015) PUBMED 26496610 REFERENCE 3 (bases 1 to 3579) AUTHORS Cao L, Ding J, Dong L, Zhao J, Su J, Wang L, Sui Y, Zhao T, Wang F, Jin J and Cai Y. TITLE Negative Regulation of p21Waf1/Cip1 by Human INO80 Chromatin Remodeling Complex Is Implicated in Cell Cycle Phase G2/M Arrest and Abnormal Chromosome Stability JOURNAL PLoS One 10 (9), e0137411 (2015) PUBMED 26340092 REMARK Publication Status: Online-Only REFERENCE 4 (bases 1 to 3579) AUTHORS Osakabe A, Takahashi Y, Murakami H, Otawa K, Tachiwana H, Oma Y, Nishijima H, Shibahara KI, Kurumizaka H and Harata M. TITLE DNA binding properties of the actin-related protein Arp8 and its role in DNA repair JOURNAL PLoS One 9 (10), e108354 (2014) PUBMED 25299602 REMARK GeneRIF: Plays a regulatory role in the binding of Arp8 to DNA. Publication Status: Online-Only REFERENCE 5 (bases 1 to 3579) AUTHORS Vassileva I, Yanakieva I, Peycheva M, Gospodinov A and Anachkova B. TITLE The mammalian INO80 chromatin remodeling complex is required for replication stress recovery JOURNAL Nucleic Acids Res 42 (14), 9074-9086 (2014) PUBMED 25016522 REFERENCE 6 (bases 1 to 3579) AUTHORS Yao T, Song L, Jin J, Cai Y, Takahashi H, Swanson SK, Washburn MP, Florens L, Conaway RC, Cohen RE and Conaway JW. TITLE Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex JOURNAL Mol Cell 31 (6), 909-917 (2008) PUBMED 18922472 REFERENCE 7 (bases 1 to 3579) AUTHORS Aoyama N, Oka A, Kitayama K, Kurumizaka H and Harata M. TITLE The actin-related protein hArp8 accumulates on the mitotic chromosomes and functions in chromosome alignment JOURNAL Exp Cell Res 314 (4), 859-868 (2008) PUBMED 18163988 REMARK GeneRIF: Expression of truncated hArp8 proteins and depletion of endogenous hArp8 by RNA interference caused misalignment of mitotic chromosomes, suggesting that chromosome-associated hArp8 has a role in chromosome behavior. REFERENCE 8 (bases 1 to 3579) AUTHORS Wu S, Shi Y, Mulligan P, Gay F, Landry J, Liu H, Lu J, Qi HH, Wang W, Nickoloff JA, Wu C and Shi Y. TITLE A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair JOURNAL Nat Struct Mol Biol 14 (12), 1165-1172 (2007) PUBMED 18026119 REFERENCE 9 (bases 1 to 3579) AUTHORS Jin J, Cai Y, Yao T, Gottschalk AJ, Florens L, Swanson SK, Gutierrez JL, Coleman MK, Workman JL, Mushegian A, Washburn MP, Conaway RC and Conaway JW. TITLE A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex JOURNAL J Biol Chem 280 (50), 41207-41212 (2005) PUBMED 16230350 REFERENCE 10 (bases 1 to 3579) AUTHORS Hassel S, Eichner A, Yakymovych M, Hellman U, Knaus P and Souchelnytskyi S. TITLE Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry JOURNAL Proteomics 4 (5), 1346-1358 (2004) PUBMED 15188402 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC012467.9. On Aug 15, 2022 this sequence version replaced XM_011534249.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR14243140.4961166.1, SRR14038194.1901467.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682 [ECO:0006172] ##Evidence-Data-END## COMPLETENESS: full length. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-174 AC012467.9 34257-34430 175-345 AC012467.9 35987-36157 346-456 AC012467.9 37629-37739 457-561 AC012467.9 38345-38449 562-735 AC012467.9 38709-38882 736-829 AC012467.9 39383-39476 830-962 AC012467.9 40016-40148 963-1116 AC012467.9 41732-41885 1117-1212 AC012467.9 42969-43064 1213-1353 AC012467.9 43572-43712 1354-1618 AC012467.9 44600-44864 1619-1782 AC012467.9 45951-46114 1783-3579 AC012467.9 47234-49030 FEATURES Location/Qualifiers source 1..3579 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="3" /map="3p21.1" gene 1..3579 /gene="ACTR8" /gene_synonym="ARP8; hArp8; INO80N" /note="actin related protein 8" /db_xref="GeneID:93973" /db_xref="HGNC:HGNC:14672" /db_xref="MIM:619716" exon 1..174 /gene="ACTR8" /gene_synonym="ARP8; hArp8; INO80N" /inference="alignment:Splign:2.1.0" exon 175..345 /gene="ACTR8" /gene_synonym="ARP8; hArp8; INO80N" /inference="alignment:Splign:2.1.0" exon 346..456 /gene="ACTR8" /gene_synonym="ARP8; hArp8; INO80N" /inference="alignment:Splign:2.1.0" CDS 385..1926 /gene="ACTR8" /gene_synonym="ARP8; hArp8; INO80N" /note="isoform 2 is encoded by transcript variant 2; INO80 complex subunit N; ARP8 actin related protein 8 homolog" /codon_start=1 /product="actin-related protein 8 isoform 2" /protein_id="NP_001397703.1" /db_xref="CCDS:CCDS93290.1" /db_xref="GeneID:93973" /db_xref="HGNC:HGNC:14672" /db_xref="MIM:619716" /translation="
MVDQAIWSKKMSNGTRRIPVSPEQARSYNKQMRPAILDHCSGNKWTNTSHHPEYLVGEEALYVNPLDCYNIHWPIRRGQLNIHPGPGGSLTAVLADIEVIWSHAIQKYLEIPLKDLKYYRCILLIPDIYNKQHVKELVNMILMKMGFSGIVVHQESVCATYGSGLSSTCIVDVGDQKTSVCCVEDGVSHRNTRLCLAYGGSDVSRCFYWLMQRAGFPYRECQLTNKMDCLLLQHLKETFCHLDQDISGLQDHEFQIRHPDSPALLYQFRLGDEKLQAPMALFYPATFGIVGQKMTTLQHRSQGDPEDPHDEHYLLATQSKQEQSAKATADRKSASKPIGFEGDLRGQSSDLPERLHSQEVDLGSAQGDGLMAGNDSEEALTALMSRKTAISLFEGKALGLDKAILHSIDCCSSDDTKKKMYSSILVVGGGLMFHKAQEFLQHRILNKMPPSFRRIIENVDVITRPKDMDPRLIAWKGGAVLACLDTTQELWIYQREWQRFGVRMLRERAAFVW"
misc_feature 535..1908 /gene="ACTR8" /gene_synonym="ARP8; hArp8; INO80N" /note="Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037" /db_xref="CDD:450142" exon 457..561 /gene="ACTR8" /gene_synonym="ARP8; hArp8; INO80N" /inference="alignment:Splign:2.1.0" exon 562..735 /gene="ACTR8" /gene_synonym="ARP8; hArp8; INO80N" /inference="alignment:Splign:2.1.0" exon 736..829 /gene="ACTR8" /gene_synonym="ARP8; hArp8; INO80N" /inference="alignment:Splign:2.1.0" exon 830..962 /gene="ACTR8" /gene_synonym="ARP8; hArp8; INO80N" /inference="alignment:Splign:2.1.0" exon 963..1116 /gene="ACTR8" /gene_synonym="ARP8; hArp8; INO80N" /inference="alignment:Splign:2.1.0" exon 1117..1212 /gene="ACTR8" /gene_synonym="ARP8; hArp8; INO80N" /inference="alignment:Splign:2.1.0" exon 1213..1353 /gene="ACTR8" /gene_synonym="ARP8; hArp8; INO80N" /inference="alignment:Splign:2.1.0" exon 1354..1618 /gene="ACTR8" /gene_synonym="ARP8; hArp8; INO80N" /inference="alignment:Splign:2.1.0" exon 1619..1782 /gene="ACTR8" /gene_synonym="ARP8; hArp8; INO80N" /inference="alignment:Splign:2.1.0" exon 1783..3579 /gene="ACTR8" /gene_synonym="ARP8; hArp8; INO80N" /inference="alignment:Splign:2.1.0" regulatory 1973..1978 /regulatory_class="polyA_signal_sequence" /gene="ACTR8" /gene_synonym="ARP8; hArp8; INO80N" /note="hexamer: TATAAA" polyA_site 1992 /gene="ACTR8" /gene_synonym="ARP8; hArp8; INO80N" /note="major polyA site" regulatory 2043..2048 /regulatory_class="polyA_signal_sequence" /gene="ACTR8" /gene_synonym="ARP8; hArp8; INO80N" /note="hexamer: AATGAA" polyA_site 2059 /gene="ACTR8" /gene_synonym="ARP8; hArp8; INO80N" regulatory 2127..2132 /regulatory_class="polyA_signal_sequence" /gene="ACTR8" /gene_synonym="ARP8; hArp8; INO80N" /note="hexamer: AATAAA" polyA_site 2149 /gene="ACTR8" /gene_synonym="ARP8; hArp8; INO80N" /note="major polyA site" regulatory 3559..3564 /regulatory_class="polyA_signal_sequence" /gene="ACTR8" /gene_synonym="ARP8; hArp8; INO80N" /note="hexamer: AGTAAA" polyA_site 3579 /gene="ACTR8" /gene_synonym="ARP8; hArp8; INO80N" ORIGIN
cttttccgggtggtggcgcgccgggacgccgagggctgggaggtgcggagcgccaggagccaggcggagcccccgcagggacaccgctccgatctcccgcacgccccaccgtctggttgtgtgcgctcctgcccgggctctggcctcagcttccccgaccataaaacgaccacgcaaatccagagcaacttcatcattgtcatacatccaggttcaacaactttaaggattggtcgagccacagacactcttcctgccagcattcctcacgtcattgcccgaagacacaaacaacaagggcagcccctatacaaggacagttggctcctaagggagggactaaataaaccagaaagtaatgaacaaagacaaaatggccttaaaatggtggatcaagcaatatggtctaaaaagatgtccaatggtacaagacgcattcctgtgtcccctgaacaggcacgctcctacaataagcagatgcgacctgcaattttagatcactgttcgggaaataagtggacaaacacatctcatcaccctgagtatttagtaggagaagaggccttgtatgttaatccactggactgttacaatattcactggcctatcagaagaggtcagttaaatattcacccaggccctgggggctctcttacagctgttctggcagatattgaagtaatatggtctcatgcgatacaaaaatacttggaaatcccactgaaagatttaaagtattatagatgtatcttgttaattcctgatatctataataagcagcatgtgaaagaactagtgaatatgatactaatgaagatgggtttttcagggattgtggtccatcaggagtctgtgtgtgccacctatggaagtggcttaagcagcacgtgtattgtagacgttggggaccagaagacaagtgtatgctgtgtggaggatggggtgtctcatcggaatactcggctttgtctggcatacggaggatctgatgtgtcaagatgtttttactggctaatgcagcgagctgggttcccttacagagaatgccagttaacaaataaaatggattgtcttcttctgcaacaccttaaagaaactttttgtcatttagatcaggacatctctgggcttcaggaccatgagtttcagattcgacatcctgattctcctgccctgctttaccagtttcgattaggagatgaaaaactgcaggctccaatggctttgttttaccccgcaacttttggaatcgttggacagaaaatgacgactttgcagcacagatctcagggcgatcctgaggatcctcacgatgaacattacctgctggccacacagagcaaacaagaacagtctgcaaaagctactgctgaccgaaagtctgcatccaaacctattggatttgaaggggatcttcgtggccagtcctctgatcttccagaaagactccattcccaggaggtagatttggggtctgcacagggagatggcctgatggccggcaacgattccgaggaggccctcactgcactgatgtccaggaagactgccatctcgctgtttgaaggaaaagccctgggcctggataaagccatcctccatagcatagactgctgttcatctgacgacaccaaaaagaagatgtacagctccatcctagtggtgggaggtggtttgatgtttcataaagctcaagaatttctgcagcacagaattctcaacaaaatgccaccatccttcaggcgaattattgaaaatgtggatgtgatcacaaggcctaaggacatggacccccggctgattgcatggaaaggaggggcagtgttggcttgtttggatacaacacaggaactgtggatttatcagcgagagtggcagcgctttggtgtccgcatgttacgagagcgggctgcgtttgtgtggtgaatggggaggaaatgtcactgccgaagaccaaaaacaagcttcttggtataaaagactcttacagaatatgtgtattgtaatttattgatctggatgcttaagtgtcatggacagtaaatgaatttgaactttatgttgaggacatgacattggtttgaaaatataaactgcttttgagcagtttagtcagggcatttgagaataaataggaactttctcttcagttgtaaactctcttgccctctctcagggtctcataaactccccagtgatgtaaacgttgctattgaaggttctcatgtggtgaagcccttcatttaagttggcttgaatctcatcagcaggcagcctcatgcaaccatgagggatagtatgtgacgagggagaactgtccactcatgccattttctctcttgtctagtatttcattaggatctaaagttgtctgagttaaatgcacttatgtgactcatgtgtcctcttagaatcccaaatagggggaaaaagttttggtggtttttgttttttttttcattttctgttggattacagaaaaagaatgggacccattcaggtctcgatttccaaaggtaaagatggaaggctgggcagactggcttttgttacctgacatgccgtagggtgagcttagaggaagaaagaaaacaatttttatttggccaaaacagaacaaatgctgaaaaggaaatcttgtttttttcctaaagccaaatagaaatgatttgggtataatttaagagtccttgtgttgtacagatatggtgactgatgtagttattaatactaccaacttagtcatcaagcctcaattttcctttacctgaaggattaagtgaaagcttttggagttcatgatgttcagtatgatcagttaaccttaacctctgagcatcctgaagcaaaatctaaataatgcagctattaccactggtggtccaggctctggtgaagccctctgagcccaggaggaagagaaagcattgtccagaggtaggaacacagtctgggagcccagagctctgggaggagtgggaaaatgctgcttcctgctgcttgcttctaggcacctgcttccgccatctcacttaccatggctagagatgggggtgagactggggaaggacaaaagcagggaacagataagtgatggaaatcagaagggaatatagaaagaactctggatgtggagaaatgccggtacctgagcattttgtatcaatgggagtaccctctgtaactgctcagtaggttacaaatgaagagtccaccagtattagaaacaatttaaacttgccagtaccaactgggatgtgtgccttcaatttgaaaattgtatgttttattttttaaatttgttaacagcattaatttatagagtattgatgtcatttatgtttctgaggtgtttcaacacaattttggatcagctgcctgtttgcaaaaacataatatatttctgttaaacagttcttcacctaacagcatattgctcttataactggtagagctgtttcaaaggaagttggtttctggtccaagttttgacctaaaccatgtccatcttctattaccagcacttacaagcactgtgaaaactgatcatgacaaataagtaaaatttgctacattaaa
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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