LOCUS       NM_213396               2176 bp    mRNA    linear   VRT 17-MAR-2024
DEFINITION  Danio rerio fasciculation and elongation protein zeta 1 (zygin I)
            (fez1), mRNA.
ACCESSION   NM_213396
VERSION     NM_213396.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2176)
  AUTHORS   Haws,W., England,S., Grieb,G., Susana,G., Hernandez,S., Mirer,H.
            and Lewis,K.
  TITLE     Analyses of binding partners and functional domains for the
            developmentally essential protein Hmx3a/HMX3
  JOURNAL   Sci Rep 13 (1), 1151 (2023)
   PUBMED   36670152
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2176)
  AUTHORS   Lee,H.J., Hou,Y., Maeng,J.H., Shah,N.M., Chen,Y., Lawson,H.A.,
            Yang,H., Yue,F. and Wang,T.
  TITLE     Epigenomic analysis reveals prevalent contribution of transposable
            elements to cis-regulatory elements, tissue-specific expression,
            and alternative promoters in zebrafish
  JOURNAL   Genome Res 32 (7), 1424-1436 (2022)
   PUBMED   35649578
REFERENCE   3  (bases 1 to 2176)
  AUTHORS   Messina,A., Boiti,A. and Vallortigara,G.
  TITLE     Asymmetric distribution of pallial-expressed genes in zebrafish
            (Danio rerio)
  JOURNAL   Eur J Neurosci 53 (2), 362-375 (2021)
   PUBMED   32692463
REFERENCE   4  (bases 1 to 2176)
  AUTHORS   Pasquier,J., Cabau,C., Nguyen,T., Jouanno,E., Severac,D.,
            Braasch,I., Journot,L., Pontarotti,P., Klopp,C., Postlethwait,J.H.,
            Guiguen,Y. and Bobe,J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2176)
  AUTHORS   Elkon,R., Milon,B., Morrison,L., Shah,M., Vijayakumar,S.,
            Racherla,M., Leitch,C.C., Silipino,L., Hadi,S., Weiss-Gayet,M.,
            Barras,E., Schmid,C.D., Ait-Lounis,A., Barnes,A., Song,Y.,
            Eisenman,D.J., Eliyahu,E., Frolenkov,G.I., Strome,S.E., Durand,B.,
            Zaghloul,N.A., Jones,S.M., Reith,W. and Hertzano,R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2176)
  AUTHORS   Aoki,M., Segawa,H., Naito,M. and Okamoto,H.
  TITLE     Identification of possible downstream genes required for the
            extension of peripheral axons in primary sensory neurons
  JOURNAL   Biochem Biophys Res Commun 445 (2), 357-362 (2014)
   PUBMED   24513284
REFERENCE   7  (bases 1 to 2176)
  AUTHORS   Andersen,I.S., Reiner,A.H., Aanes,H., Alestrom,P. and Collas,P.
  TITLE     Developmental features of DNA methylation during activation of the
            embryonic zebrafish genome
  JOURNAL   Genome Biol 13 (7), R65 (2012)
   PUBMED   22830626
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2176)
  AUTHORS   Ritter,D.I., Dong,Z., Guo,S. and Chuang,J.H.
  TITLE     Transcriptional enhancers in protein-coding exons of vertebrate
            developmental genes
  JOURNAL   PLoS One 7 (5), e35202 (2012)
   PUBMED   22567096
REFERENCE   9  (bases 1 to 2176)
  AUTHORS   Jeong,J.Y., Einhorn,Z., Mathur,P., Chen,L., Lee,S., Kawakami,K. and
            Guo,S.
  TITLE     Patterning the zebrafish diencephalon by the conserved zinc-finger
            protein Fezl
  JOURNAL   Development 134 (1), 127-136 (2007)
   PUBMED   17164418
  REMARK    GeneRIF: fez1 is crucial for establishing regional subdivisions
            within the diencephalon and may also play a role in the development
            of the telencephalon and hypothalamus.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC059593.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059593.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA4476735 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2176
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="wild type"
                     /db_xref="taxon:7955"
                     /chromosome="10"
                     /map="10"
     gene            1..2176
                     /gene="fez1"
                     /gene_synonym="wu:fj14c12; zgc:73258"
                     /note="fasciculation and elongation protein zeta 1 (zygin
                     I)"
                     /db_xref="GeneID:406705"
                     /db_xref="ZFIN:ZDB-GENE-040426-2723"
     exon            1..28
                     /gene="fez1"
                     /gene_synonym="wu:fj14c12; zgc:73258"
                     /inference="alignment:Splign:2.1.0"
     exon            29..398
                     /gene="fez1"
                     /gene_synonym="wu:fj14c12; zgc:73258"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    55..57
                     /gene="fez1"
                     /gene_synonym="wu:fj14c12; zgc:73258"
                     /note="upstream in-frame stop codon"
     CDS             82..1266
                     /gene="fez1"
                     /gene_synonym="wu:fj14c12; zgc:73258"
                     /codon_start=1
                     /product="fasciculation and elongation protein zeta-1"
                     /protein_id="NP_998561.1"
                     /db_xref="GeneID:406705"
                     /db_xref="ZFIN:ZDB-GENE-040426-2723"
                     /translation="

MEAPLVCLDEEFEDLRPCKMEELECEQPPCRPHKTIPLAPLCREDFSELENFSEMMSFKSMEDLVNEFDEKLNVCFHNYNTKTEGLAPVRNQSHAEEDEERLQDEDVWDALTDNYMPSSVSSWDDPTSETLNGNLSDQEIHEKDEDEMNEKNENANCLNEEPLITADQVIEEIVEMMENSPDPGETEEEEEDDIGVSSSKSSPSLLEEIRMLSQASNNNCSYEGLRLMPSSALLDILCRMEAAIREYSEELVAQLARRDELEFEKEVKNTFITALMEVQNRQKEQRELSKRRRKDKAMSLQGSTRPEKTGSMPAKRFSMEGLSNILQTGIRQTFGSSGTEKQYLNTVIPYEKKGTPPSVDDLQMLTKILYAMKEDSEKVPTLLTDYILKVLCPT"

     misc_feature    259..975
                     /gene="fez1"
                     /gene_synonym="wu:fj14c12; zgc:73258"
                     /note="FEZ-like protein; Region: FEZ; pfam07763"
                     /db_xref="CDD:462257"
     exon            399..498
                     /gene="fez1"
                     /gene_synonym="wu:fj14c12; zgc:73258"
                     /inference="alignment:Splign:2.1.0"
     exon            499..585
                     /gene="fez1"
                     /gene_synonym="wu:fj14c12; zgc:73258"
                     /inference="alignment:Splign:2.1.0"
     exon            586..751
                     /gene="fez1"
                     /gene_synonym="wu:fj14c12; zgc:73258"
                     /inference="alignment:Splign:2.1.0"
     exon            752..1026
                     /gene="fez1"
                     /gene_synonym="wu:fj14c12; zgc:73258"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1107
                     /gene="fez1"
                     /gene_synonym="wu:fj14c12; zgc:73258"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1183
                     /gene="fez1"
                     /gene_synonym="wu:fj14c12; zgc:73258"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1249
                     /gene="fez1"
                     /gene_synonym="wu:fj14c12; zgc:73258"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..2149
                     /gene="fez1"
                     /gene_synonym="wu:fj14c12; zgc:73258"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

agatacagaaggagagattcttctgcagggattgttccagcggcatcctccacgtgacagtgcgattacgaggacatcaggatggaggcccctctggtgtgcctggatgaggaattcgaggatctgcggccctgcaagatggaggagcttgaatgcgaacagcctccctgtcgacctcacaaaaccattcccttggccccgctgtgccgtgaagacttctccgagctggagaacttctccgaaatgatgagcttcaagtccatggaggatctggtcaatgaatttgacgagaagctgaacgtgtgcttccacaattacaacaccaagacagaaggtctggcacccgtgcgcaaccaatcacatgctgaggaggatgaggagaggcttcaggatgaagatgtgtgggatgctctgactgacaactacatgccctcctctgtgtccagctgggacgaccccacctcggaaacactcaacggcaacctctcggatcaggagatacacgaaaaagatgaggatgagatgaacgagaagaatgaaaatgccaactgtctgaatgaagaacctcttattacagctgatcaggtgattgaggagattgtggagatgatggaaaactcaccggatcctggagagacagaggaagaggaggaggatgatatcggggtctcttcctctaaaagcagcccgtctcttctggaggagatccgcatgctgtctcaggcctccaataacaactgctcctacgaaggtctgaggctgatgccgagctctgcactgcttgacatcttgtgccggatggaggcggcgattcgagagtattcagaggaactggtggctcagctggcccggagagatgagctggagttcgagaaggaggtgaagaacaccttcatcacagctctgatggaggtgcagaacagacagaaggagcagagggagctgagtaagcgcaggcgtaaagacaaggccatgagtctacagggatccacacgccccgaaaagaccggcagcatgcctgcgaaacgcttcagcatggagggtctctccaacatcctgcagacaggcatcagacagaccttcgggagctcaggcacagaaaaacagtacttgaacacagtcatcccgtatgagaaaaaggggactcctccatctgtggatgacttgcaaatgctcacaaaaattctttatgccatgaaagaagacagcgagaaggtcccaaccctcctgactgactatatattaaaagttctgtgtcctacctaaagtccagcgtgcgatctgctgttggtgagaccgtgaagaggacaagcgtctccattcatcctctatcagatctccagtccagctgcatgagctcccttacccactatcagcgagggaccctgaacatctaaccattcttctcttgcttatctaacgaccttcaaccttgctcatctcactgcccttcccgtattcacacatatccacgaggttcagaccacagcgcctggtgctttacatgttttctactacatatgttacaacgggccaaaagccatatggaacgtgtaagggtaacaggtgaactctaaacggtttaactctacgatcaggtactatttttatttttatttgtaaagatatgcctgacataaggcacatactgtactactcggtcattcacatctgttcagaacacaggagatgaggagaagggcattattattcacaatcgtcttagatgcatcgtttcgagagcacatttgaaaataatccatccagacattctgctttttgccgttttagtattgtaccgacgaggttggttggagatacagcatgttttagtgttctacattaatgccaagttatagggaaaacaaaaccttgtgacttctttttttttatttggggtaatctgagattttttggttttgttttgttcattctgtgtatgaaatatactacatgatgttgtttaattgacgatccatttgtcaaataaaaccattatgttagttttttttttactttaacattaattgtcattcatgccttgtgcttacatctttaatgtatatatttcttatttactaagggacatggaggaatgtgaagtattgctgagttatagttccaataaatgttaaaccctgtgaaaataaaaaaaaaaaaaaaaaaaaaaaaaaaa

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