LOCUS       NM_200892               2090 bp    mRNA    linear   VRT 15-OCT-2021
DEFINITION  Danio rerio endoplasmic reticulum protein 44 (erp44), mRNA.
ACCESSION   NM_200892
VERSION     NM_200892.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2090)
  AUTHORS   Bayes A, Collins MO, Reig-Viader R, Gou G, Goulding D, Izquierdo A,
            Choudhary JS, Emes RD and Grant SG.
  TITLE     Evolution of complexity in the zebrafish synapse proteome
  JOURNAL   Nat Commun 8, 14613 (2017)
   PUBMED   28252024
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2090)
  AUTHORS   Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I,
            Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y and
            Bobe J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2090)
  AUTHORS   Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
            Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
            Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
            GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
            Hertzano R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2090)
  AUTHORS   Long Y, Yan J, Song G, Li X, Li X, Li Q and Cui Z.
  TITLE     Transcriptional events co-regulated by hypoxia and cold stresses in
            Zebrafish larvae
  JOURNAL   BMC Genomics 16, 385 (2015)
   PUBMED   25975375
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2090)
  AUTHORS   Wang DY, Abbasi C, El-Rass S, Li JY, Dawood F, Naito K, Sharma P,
            Bousette N, Singh S, Backx PH, Cox B, Wen XY, Liu PP and Gramolini
            AO.
  TITLE     Endoplasmic reticulum resident protein 44 (ERp44) deficiency in
            mice and zebrafish leads to cardiac developmental and functional
            defects
  JOURNAL   J Am Heart Assoc 3 (5), e001018 (2014)
   PUBMED   25332179
  REMARK    GeneRIF: ERp44 plays a critical role in embryonic heart development
            and is crucial in regulating cardiac cell Ca(2+) signaling, ER
            stress, ROS-induced oxidative stress, and activation of the
            intrinsic mitochondrial apoptosis pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2090)
  AUTHORS   Cuello S, Ximenez-Embun P, Ruppen I, Schonthaler HB, Ashman K,
            Madrid Y, Luque-Garcia JL and Camara C.
  TITLE     Analysis of protein expression in developmental toxicity induced by
            MeHg in zebrafish
  JOURNAL   Analyst 137 (22), 5302-5311 (2012)
   PUBMED   23014190
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC063992.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063992.1, BC066767.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA2168446, SAMEA2168447
                                           [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2090
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="16"
                     /map="16"
     gene            1..2090
                     /gene="erp44"
                     /gene_synonym="txndc4; zgc:77883"
                     /note="endoplasmic reticulum protein 44"
                     /db_xref="GeneID:393866"
                     /db_xref="ZFIN:ZDB-GENE-040426-1902"
     exon            1..128
                     /gene="erp44"
                     /gene_synonym="txndc4; zgc:77883"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..1298
                     /gene="erp44"
                     /gene_synonym="txndc4; zgc:77883"
                     /note="thioredoxin domain containing 4 (endoplasmic
                     reticulum)"
                     /codon_start=1
                     /product="endoplasmic reticulum resident protein 44"
                     /protein_id="NP_957186.1"
                     /db_xref="GeneID:393866"
                     /db_xref="ZFIN:ZDB-GENE-040426-1902"
                     /translation="

MKLSSIIPVPELHYFTLLLVTGLYNPGRGEITSLDSGNIDDILNGAGVALVNFYADWCRFSQMLHPIFEEASNIVREEYPDATQVVFGRVDCDQHSDLAQRYRISKYPTLKLFRNGMMMKREYRGQRSVTAIADFIRQQKVDPIKEIENLEEISTVDRSRRTIIGYFEKRDSDNYRTYEKVANILRDDCAFLAAFGEVSKPERFSGDNIIYKPLGENAPDMVYMGSLTNFDLSYAWTQDKCVPLVREITFENGEELTEEGIPFLILFHQKDDTESLEKFQQEVARQLISEKGSINFLHADCDKFRHPLLHIQKTPADCPVIAIDSFRHMYVFPEFSDLAVPGKLRQFVLDLHSGKLHREFHHGPDPTDSTPGQQEENREVPSNPPESSFQKLAPSETRYTILRDRDEL"

     misc_feature    156..479
                     /gene="erp44"
                     /gene_synonym="txndc4; zgc:77883"
                     /note="PDIa family, endoplasmic reticulum protein 44
                     (ERp44) subfamily; ERp44 is an ER-resident protein,
                     induced during stress, involved in thiol-mediated ER
                     retention. It contains an N-terminal TRX domain, similar
                     to that of PDIa, with a CXFS motif followed by...; Region:
                     PDI_a_ERp44; cd02996"
                     /db_xref="CDD:239294"
     misc_feature    243..245
                     /gene="erp44"
                     /gene_synonym="txndc4; zgc:77883"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239294"
     misc_feature    501..773
                     /gene="erp44"
                     /gene_synonym="txndc4; zgc:77883"
                     /note="PDIb family, ERp44 subfamily, first redox inactive
                     TRX-like domain b; ERp44 is an endoplasmic reticulum
                     (ER)-resident protein, induced during stress, involved in
                     thiol-mediated ER retention. It contains an N-terminal TRX
                     domain with a CXFS motif followed...; Region: PDI_b_ERp44;
                     cd03070"
                     /db_xref="CDD:239368"
     misc_feature    804..1136
                     /gene="erp44"
                     /gene_synonym="txndc4; zgc:77883"
                     /note="PDIb' family, ERp44 subfamily, second redox
                     inactive TRX-like domain b'; ERp44 is an endoplasmic
                     reticulum (ER)-resident protein, induced during stress,
                     involved in thiol-mediated ER retention. It contains an
                     N-terminal TRX domain with a CXFS motif...; Region:
                     PDI_b'_ERp44; cd03072"
                     /db_xref="CDD:239370"
     exon            129..201
                     /gene="erp44"
                     /gene_synonym="txndc4; zgc:77883"
                     /inference="alignment:Splign:2.1.0"
     exon            202..241
                     /gene="erp44"
                     /gene_synonym="txndc4; zgc:77883"
                     /inference="alignment:Splign:2.1.0"
     exon            242..357
                     /gene="erp44"
                     /gene_synonym="txndc4; zgc:77883"
                     /inference="alignment:Splign:2.1.0"
     exon            358..542
                     /gene="erp44"
                     /gene_synonym="txndc4; zgc:77883"
                     /inference="alignment:Splign:2.1.0"
     exon            543..658
                     /gene="erp44"
                     /gene_synonym="txndc4; zgc:77883"
                     /inference="alignment:Splign:2.1.0"
     exon            659..833
                     /gene="erp44"
                     /gene_synonym="txndc4; zgc:77883"
                     /inference="alignment:Splign:2.1.0"
     exon            834..945
                     /gene="erp44"
                     /gene_synonym="txndc4; zgc:77883"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1087
                     /gene="erp44"
                     /gene_synonym="txndc4; zgc:77883"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1190
                     /gene="erp44"
                     /gene_synonym="txndc4; zgc:77883"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..2066
                     /gene="erp44"
                     /gene_synonym="txndc4; zgc:77883"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ggagaaggaggtggtgtcgagagactggcaagattcaacaacatcgcaacctcaaccaacaccactatacaatgaaattatcatcaataatacccgttcccgaactgcactacttcaccctcctgctggtaacgggtctgtataatccaggacgaggggaaataaccagtctggactctggaaacatcgatgacatcctcaacggagcaggtgtggctctagtcaacttctatgcagactggtgtcgttttagtcagatgctgcaccccatctttgaggaggcgtcaaatatagtgcgcgaggaatatccagacgctacccaggtggtgttcggccgggtcgactgtgaccaacactctgatctagcgcagcgctacaggataagcaaataccccacactgaagctgttcaggaatggcatgatgatgaagcgagagtacagaggtcaaaggtcagtgaccgccatcgccgacttcatccgccagcagaaagtggatccaattaaagagatcgaaaatctggaggaaatcagcactgtagataggagcagacgcaccatcattggttactttgaaaaaagggactcggacaattaccgtacttatgagaaagtggccaacattctgagagacgactgtgctttcctggcagcttttggggaggtttctaagcccgaacgttttagtggtgataacattatttataaaccattgggagaaaatgctcctgacatggtctacatgggctcgcttacaaattttgacctcagttacgcctggacgcaagacaagtgtgtaccgctagtccgagaaatcacatttgaaaacggagaggaactgacagaggagggaatcccgttcctgatcctcttccatcagaaggatgacacagagagtttggagaaatttcagcaagaagtggctcgtcagcttattagtgaaaagggttctataaatttccttcatgctgattgcgataagttccggcaccctctacttcacattcagaagacacctgccgattgccctgtaatcgccatcgatagtttccgccacatgtatgtcttcccagagttcagcgaccttgcggttccaggaaagctgaggcagtttgtattggacctgcactcaggaaagttgcacagagagtttcatcacggcccagaccccacagacagcactccaggacagcaagaggagaacagagaggtgcccagtaatcccccagagagctccttccagaaattggcccccagtgagacacgctacaccatcctcagggaccgagacgagctgtgatgtcacattcgccatcgagacccaacccagaacccagcagtctgtcggtgccagtctggcactgatgctgcctgcgcaacgtctattttcataattttattttagatattaaaaaaagaaggtgaacccctgagctttttttggggtggggaatgaagaggagcgtttttacttttgtttctggagcttgtaaatatgtttgtgctctgtgggtcttgtctaaattaaaagtatgatttttttttttcgcccttttttttattttgccctacatttttgtcagcccgagtcccttttttgtaggaaaaaattggtacattggtggtcctccttgttgggaacgcacatagagtttatcttggatcttgagagttcggccaagtggaatcatgggaaaaagtgtagtctaagaacaaacctgcagtcaacctgtgctgtttcactccagtcctcaactgtgtgtgtgtgtgtgtttgtgtgtgtgcgtgaatgagcgtgtgtgtgtttgtgtctgcgcacatgtatgttacatgtgcttattagtctgtatttgtatgtactgtactggtccagacttgtttaaattcacactcgctaagatccagactcgctagtctcatatcatcccattccagcagggggagtggtcaggggggcggggttatctgggggtccggttcagagggatgggggattatttgtaaatctgtcatctcagatggggacgaggaaaggaaaagtaaattaaaaacattttacaagattctaaaaaaaaaaaaaaaaaaaaaaaaa

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