LOCUS       NM_200404               1314 bp    mRNA    linear   VRT 29-JUL-2023
DEFINITION  Danio rerio claudin 15a (cldn15a), mRNA.
ACCESSION   NM_200404 XM_691088
VERSION     NM_200404.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1314)
  AUTHORS   Zhang FL, Yang YL, Zhang Z, Yao YY, Xia R, Gao CC, Du DD, Hu J, Ran
            C, Liu Z and Zhou ZG.
  TITLE     Surface-Displayed Amuc_1100 From Akkermansia muciniphila on
            Lactococcus lactis ZHY1 Improves Hepatic Steatosis and Intestinal
            Health in High-Fat-Fed Zebrafish
  JOURNAL   Front Nutr 8, 726108 (2021)
   PUBMED   34722607
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1314)
  AUTHORS   Ding Q, Zhang Z, Li Y, Liu H, Hao Q, Yang Y, Ringo E, Olsen RE,
            Clarke JL, Ran C and Zhou Z.
  TITLE     Propionate induces intestinal oxidative stress via Sod2
            propionylation in zebrafish
  JOURNAL   iScience 24 (6), 102515 (2021)
   PUBMED   34142031
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1314)
  AUTHORS   Wu N, Xu X, Wang B, Li XM, Cheng YY, Li M, Xia XQ and Zhang YA.
  TITLE     Anti-foodborne enteritis effect of galantamine potentially via
            acetylcholine anti-inflammatory pathway in fish
  JOURNAL   Fish Shellfish Immunol 97, 204-215 (2020)
   PUBMED   31843701
REFERENCE   4  (bases 1 to 1314)
  AUTHORS   Bruch-Bertani JP, Uribe-Cruz C, Pasqualotto A, Longo L, Ayres R,
            Beskow CB, Barth AL, Lima-Morales D, Meurer F, Tayguara Silveira
            Guerreiro G, da Silveira TR, Alvares-da-Silva MR and Dall'Alba V.
  TITLE     Hepatoprotective Effect of Probiotic Lactobacillus rhamnosus GG
            Through the Modulation of Gut Permeability and Inflammasomes in a
            Model of Alcoholic Liver Disease in Zebrafish
  JOURNAL   J Am Coll Nutr 39 (2), 163-170 (2020)
   PUBMED   31241423
REFERENCE   5  (bases 1 to 1314)
  AUTHORS   Espenschied ST, Cronan MR, Matty MA, Mueller O, Redinbo MR, Tobin
            DM and Rawls JF.
  TITLE     Epithelial delamination is protective during pharmaceutical-induced
            enteropathy
  JOURNAL   Proc Natl Acad Sci U S A 116 (34), 16961-16970 (2019)
   PUBMED   31391308
REFERENCE   6  (bases 1 to 1314)
  AUTHORS   Xu F, Ye YT, Cai CF, Wu P, Song L, Liu M, Yao LJ, Dong JJ, Huang
            YW, Gong Z, Qin J and Song L.
  TITLE     Observation of the middle intestinal tight junction structure,
            cloning and studying tissue distribution of the four Claudin genes
            of the grass carp (Ctenopharyngodon idellus)
  JOURNAL   Fish Physiol Biochem 40 (6), 1783-1792 (2014)
   PUBMED   25074470
REFERENCE   7  (bases 1 to 1314)
  AUTHORS   Baltzegar DA, Reading BJ, Brune ES and Borski RJ.
  TITLE     Phylogenetic revision of the claudin gene family
  JOURNAL   Mar Genomics 11, 17-26 (2013)
   PUBMED   23726886
REFERENCE   8  (bases 1 to 1314)
  AUTHORS   Clelland ES and Kelly SP.
  TITLE     Tight junction proteins in zebrafish ovarian follicles: stage
            specific mRNA abundance and response to 17beta-estradiol, human
            chorionic gonadotropin, and maturation inducing hormone
  JOURNAL   Gen Comp Endocrinol 168 (3), 388-400 (2010)
   PUBMED   20553723
REFERENCE   9  (bases 1 to 1314)
  AUTHORS   Noel ES, Casal-Sueiro A, Busch-Nentwich E, Verkade H, Dong PD,
            Stemple DL and Ober EA.
  TITLE     Organ-specific requirements for Hdac1 in liver and pancreas
            formation
  JOURNAL   Dev Biol 322 (2), 237-250 (2008)
   PUBMED   18687323
REFERENCE   10 (bases 1 to 1314)
  AUTHORS   Bagnat M, Cheung ID, Mostov KE and Stainier DY.
  TITLE     Genetic control of single lumen formation in the zebrafish gut
  JOURNAL   Nat Cell Biol 9 (8), 954-960 (2007)
   PUBMED   17632505
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC054577.1.
            
            On Aug 29, 2007 this sequence version replaced XM_691088.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054577.1, BC153629.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA4476729, SAMEA4476748
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1314
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="7"
                     /map="7"
     gene            1..1314
                     /gene="cldn15a"
                     /gene_synonym="cldn15; cldn15l; zgc:63943"
                     /note="claudin 15a"
                     /db_xref="GeneID:573644"
                     /db_xref="ZFIN:ZDB-GENE-040426-1305"
     exon            1..379
                     /gene="cldn15a"
                     /gene_synonym="cldn15; cldn15l; zgc:63943"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    148..150
                     /gene="cldn15a"
                     /gene_synonym="cldn15; cldn15l; zgc:63943"
                     /note="upstream in-frame stop codon"
     CDS             163..831
                     /gene="cldn15a"
                     /gene_synonym="cldn15; cldn15l; zgc:63943"
                     /note="claudin 15 like"
                     /codon_start=1
                     /product="claudin-15a"
                     /protein_id="NP_956698.1"
                     /db_xref="GeneID:573644"
                     /db_xref="ZFIN:ZDB-GENE-040426-1305"
                     /translation="

MDPIIEAVALFLGFVSWTMVGITIPNRYWKVSSLDGTVITTSTLYENLWMSCATDSTGVHQCREFPSLLALSGYIQASRALMIAAVVSGTFGVVATLIGMQCSKAGGENYVLKGRIAGTGGVFFLLQGLCTMISVSWYAANITQEFFNPLYPGQKYEIGEALYIGWASAVLAICGGVCLMFSCKLGTEKKTAYSYHPTRETVYSASASRRETQSTYGKNAYV"

     misc_feature    217..693
                     /gene="cldn15a"
                     /gene_synonym="cldn15; cldn15l; zgc:63943"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:473919"
     exon            380..544
                     /gene="cldn15a"
                     /gene_synonym="cldn15; cldn15l; zgc:63943"
                     /inference="alignment:Splign:2.1.0"
     exon            545..626
                     /gene="cldn15a"
                     /gene_synonym="cldn15; cldn15l; zgc:63943"
                     /inference="alignment:Splign:2.1.0"
     exon            627..734
                     /gene="cldn15a"
                     /gene_synonym="cldn15; cldn15l; zgc:63943"
                     /inference="alignment:Splign:2.1.0"
     exon            735..1227
                     /gene="cldn15a"
                     /gene_synonym="cldn15; cldn15l; zgc:63943"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gtgcggtccagctctccatggaacagaaaaccaattaaacctggatatattctataacttttcagcaaaaggtgttcgtgttttgaaaacaaataaaggacaaacttcacaggaatactaagcctggatgatttttgcagtttgtgttaatctgcagctacaatggatccgatcattgaagccgtggctctgtttcttggctttgtaagttggacaatggttggcatcacaattcctaaccgctactggaaagtgtcctctttagacgggactgtgatcaccacatcgaccctgtatgagaatctgtggatgtcctgcgccacggactcgacaggggtccaccagtgccgtgaattcccgtctctgctcgctctatctggttacatccaggcgtcccgtgctctcatgattgcggcggtggtgtcgggcacattcggggtggtggcgactctcatcggcatgcagtgctcgaaggccggcggggaaaactacgtgctcaaaggcagaatagccggtaccggaggcgttttctttctcctgcaaggtttgtgcacgatgatatcagtgtcatggtacgctgccaacatcactcaagagtttttcaacccactctaccctgggcaaaagtatgagattggagaggctttatacattggatgggcctctgctgtcctcgccatctgtggtggagtttgtctcatgttcagctgcaaattaggcacagaaaaaaagactgcttactcataccatcccacccgtgaaacagtttactcagcatctgcatccaggagagaaacccagagcacttatggaaaaaatgcttacgtgtaaatcaagcttttctggtcaatttcaaaagcaacgttgactgttggtattctgtctagtaatgctatatcagtgcaattatgtaaatatttatactacactctctattttaaggccatctaagaataagtcatgaatcaagtaaaaagttaccatgtcagttttgctgtgcaaaaacaccatggaggacattatatagagctgattccctgtacaggaataaaatgccttcggttgtgttcagaatgtttttgttgcagttacatgaatcaagtattttaagaaaagacaagaaagattcattatgtgttgattatcttgtctgcatttatttgtaaaaaataaaacctgttttatatgatgtattttatacaagcattaaacataaaatacataacaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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