LOCUS       NM_200189               1711 bp    mRNA    linear   VRT 15-OCT-2021
DEFINITION  Danio rerio cytochrome b5 reductase 1 (cyb5r1), mRNA.
ACCESSION   NM_200189
VERSION     NM_200189.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1711)
  AUTHORS   Bayes A, Collins MO, Reig-Viader R, Gou G, Goulding D, Izquierdo A,
            Choudhary JS, Emes RD and Grant SG.
  TITLE     Evolution of complexity in the zebrafish synapse proteome
  JOURNAL   Nat Commun 8, 14613 (2017)
   PUBMED   28252024
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1711)
  AUTHORS   Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I,
            Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y and
            Bobe J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1711)
  AUTHORS   Tzung KW, Goto R, Saju JM, Sreenivasan R, Saito T, Arai K, Yamaha
            E, Hossain MS, Calvert MEK and Orban L.
  TITLE     Early depletion of primordial germ cells in zebrafish promotes
            testis formation
  JOURNAL   Stem Cell Reports 4 (1), 61-73 (2015)
   PUBMED   25434820
  REMARK    Erratum:[Stem Cell Reports. 2015 Jul 14;5(1):156. PMID: 28039741]
REFERENCE   4  (bases 1 to 1711)
  AUTHORS   Chen YS, Luo WI, Lee TL, Yu SS and Chang CY.
  TITLE     Identification of the proteins required for fatty acid desaturation
            in zebrafish (Danio rerio)
  JOURNAL   Biochem Biophys Res Commun 440 (4), 671-676 (2013)
   PUBMED   24103751
REFERENCE   5  (bases 1 to 1711)
  AUTHORS   Nishio S, Gibert Y, Bernard L, Brunet F, Triqueneaux G and Laudet
            V.
  TITLE     Adiponectin and adiponectin receptor genes are coexpressed during
            zebrafish embryogenesis and regulated by food deprivation
  JOURNAL   Dev Dyn 237 (6), 1682-1690 (2008)
   PUBMED   18489000
REFERENCE   6  (bases 1 to 1711)
  AUTHORS   van der Meulen T, Schipper H, van den Boogaart JG, Huising MO,
            Kranenbarg S and van Leeuwen JL.
  TITLE     Endurance exercise differentially stimulates heart and axial muscle
            development in zebrafish (Danio rerio)
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 291 (4), R1040-R1048 (2006)
   PUBMED   16966387
REFERENCE   7  (bases 1 to 1711)
  AUTHORS   van der Meulen T, Schipper H, van Leeuwen JL and Kranenbarg S.
  TITLE     Effects of decreased muscle activity on developing axial
            musculature in nicb107 mutant zebrafish (Danio rerio)
  JOURNAL   J Exp Biol 208 (Pt 19), 3675-3687 (2005)
   PUBMED   16169945
REFERENCE   8  (bases 1 to 1711)
  AUTHORS   Song HD, Sun XJ, Deng M, Zhang GW, Zhou Y, Wu XY, Sheng Y, Chen Y,
            Ruan Z, Jiang CL, Fan HY, Zon LI, Kanki JP, Liu TX, Look AT and
            Chen Z.
  TITLE     Hematopoietic gene expression profile in zebrafish kidney marrow
  JOURNAL   Proc Natl Acad Sci U S A 101 (46), 16240-16245 (2004)
   PUBMED   15520368
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY398332.1.
            
            On Feb 9, 2004 this sequence version replaced NM_200189.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY398332.1, BC045880.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2168446, SAMEA2168447
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1711
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="11"
                     /map="11"
     gene            1..1711
                     /gene="cyb5r1"
                     /gene_synonym="dia1; wu:fb13e02; wu:fb15h03; zgc:56042"
                     /note="cytochrome b5 reductase 1"
                     /db_xref="GeneID:336553"
                     /db_xref="ZFIN:ZDB-GENE-030131-8497"
     exon            1..74
                     /gene="cyb5r1"
                     /gene_synonym="dia1; wu:fb13e02; wu:fb15h03; zgc:56042"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    18..20
                     /gene="cyb5r1"
                     /gene_synonym="dia1; wu:fb13e02; wu:fb15h03; zgc:56042"
                     /note="upstream in-frame stop codon"
     CDS             60..974
                     /gene="cyb5r1"
                     /gene_synonym="dia1; wu:fb13e02; wu:fb15h03; zgc:56042"
                     /EC_number="1.6.2.2"
                     /note="diaphorase (NADH) (cytochrome b-5 reductase)"
                     /codon_start=1
                     /product="NADH-cytochrome b5 reductase 1"
                     /protein_id="NP_956483.1"
                     /db_xref="GeneID:336553"
                     /db_xref="ZFIN:ZDB-GENE-030131-8497"
                     /translation="

MSYAMSTTVAVTVGVVLVSTAGLLGYYYFNRKRKILITLIDPSEKYKLRLVDKEIISHDTRRFRFALPSPEHVLGLPVGKHVYLSARIDGNLIVRPYTPVSSDDDKGFVDLVVKIYFRDVHPKFPEGGKMSQYLESLRIGDVIDFRGPGGLLEYKGAGRLDIQADKKAPAETKTVKSLGLIAGGTGITPMLQLIRDITKNPNDTTTCSLLFANQTEKDILLKDELEEIQARHSDRFKLWFTVDRAPADWEYSQGFISAEMIQDHLPPPSDDSMILMCGPPPMIQFACNPNLDKLGYRQSQRFAY"

     misc_feature    <174..971
                     /gene="cyb5r1"
                     /gene_synonym="dia1; wu:fb13e02; wu:fb15h03; zgc:56042"
                     /note="nitrate reductase [NADPH]; Region: PLN02252"
                     /db_xref="CDD:215141"
     exon            75..221
                     /gene="cyb5r1"
                     /gene_synonym="dia1; wu:fb13e02; wu:fb15h03; zgc:56042"
                     /inference="alignment:Splign:2.1.0"
     exon            222..294
                     /gene="cyb5r1"
                     /gene_synonym="dia1; wu:fb13e02; wu:fb15h03; zgc:56042"
                     /inference="alignment:Splign:2.1.0"
     exon            295..401
                     /gene="cyb5r1"
                     /gene_synonym="dia1; wu:fb13e02; wu:fb15h03; zgc:56042"
                     /inference="alignment:Splign:2.1.0"
     exon            402..531
                     /gene="cyb5r1"
                     /gene_synonym="dia1; wu:fb13e02; wu:fb15h03; zgc:56042"
                     /inference="alignment:Splign:2.1.0"
     exon            532..615
                     /gene="cyb5r1"
                     /gene_synonym="dia1; wu:fb13e02; wu:fb15h03; zgc:56042"
                     /inference="alignment:Splign:2.1.0"
     exon            616..701
                     /gene="cyb5r1"
                     /gene_synonym="dia1; wu:fb13e02; wu:fb15h03; zgc:56042"
                     /inference="alignment:Splign:2.1.0"
     exon            702..801
                     /gene="cyb5r1"
                     /gene_synonym="dia1; wu:fb13e02; wu:fb15h03; zgc:56042"
                     /inference="alignment:Splign:2.1.0"
     exon            802..1690
                     /gene="cyb5r1"
                     /gene_synonym="dia1; wu:fb13e02; wu:fb15h03; zgc:56042"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

aaaataaatgtttagtctgaaggttttctctgaccgacgcttgtagtctatccctcgtcatgagctacgcgatgtccaccacagtagcagtgacggttggagtggtgctggtgtcaacagctgggctgctgggttattattacttcaacaggaagaggaaaatactcataaccctaattgatccttctgaaaaatacaagttgcgactagtagacaaagagatcataagtcatgatacccggagatttcggttcgccctgcctagtccagagcatgttttgggattaccagtgggcaagcatgtttatctctctgccaggattgatgggaatctgattgtgcgtccttacacaccggtgtccagcgatgatgacaaaggattcgttgatctagtcgtgaagatttattttagggatgtgcacccaaagtttcctgaagggggaaagatgtcccaatacctggagagtttgcggatcggagatgtgattgacttcagaggaccaggaggtttgctggagtacaagggcgcaggtcgcttggatatacaggccgataagaaggcccctgcagagaccaagactgtaaaatctctgggtcttattgctggaggaacaggcattacgccaatgttgcagctgattcgtgacatcaccaagaacccaaatgacacgactacatgcagcctgttgtttgccaatcagactgagaaggacattctgctgaaggatgagctggaggagattcaggccaggcattctgatcgcttcaaactctggttcaccgtggaccgagctccggcagattgggagtacagtcagggcttcatcagcgctgagatgattcaggaccatcttcctccacccagtgatgactctatgatcctgatgtgtggtccacctcctatgatccagttcgcctgtaatccaaacctggacaagctgggctacaggcagagccagcgcttcgcctattaggccgttctcaatgtttagggccagaccacaaattactccaaagatactgagttgcgcacaatcgtatttggcattttaaatctgatcttacaaagcaaatagctcttttatggacagtatataatacacattaaatgtttaagtgctagactgtccagagataattggttcttcatattaaaagcctttaattcagtaataagaaacatgatctgctgtctcctcaggctttatattcaccgttgtggctcatgataagatgctgatactacaaaaacaaacgcacttaaaaaaagcaccagtgctgcttgctggtttaatgctgaatattatattcatgtgcctatatgtgagctatgagttcattgttgtatgtgcacattgttatatgctgtcactggagtatttttgtatgcatgttgtactccttatgtttgtctcgttaatcgtatttaaatttaaaaagcaacacagttgttttgtatgaaatgcactaaagtaaaagcatattaaagtgttttcactgggagcttgtattattttcttctttaatgtggccaaataagagttgttttggttgtgatgtgctcacatttgcattgatattataaaaactgacttgtatttgaatctaaaaagcaatcaagttgttttatataaaatgtatgtatggaaaggtaaaacaagagatcattattaaacatattaaacaatcaaaaaaaaaaaaaaaaaaaaaa

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