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Previous release (v1)
2026-10-10 06:44:47, GGRNA.v2 : RefSeq release 233 (Jan, 2026)
LOCUS NM_198210 2758 bp mRNA linear VRT 16-SEP-2024
DEFINITION Danio rerio heat shock protein 90, beta (grp94), member 1
(hsp90b1), mRNA.
ACCESSION NM_198210
VERSION NM_198210.2
KEYWORDS RefSeq.
SOURCE Danio rerio (zebrafish)
ORGANISM Danio rerio
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE 1 (bases 1 to 2758)
AUTHORS Park,K.H., Makki,H.M.M., Kim,S.H., Chung,H.J. and Jung,J.
TITLE Narirutin ameliorates alcohol-induced liver injury by targeting
MAPK14 in zebrafish larvae
JOURNAL Biomed Pharmacother 166, 115350 (2023)
PUBMED 37633055
REFERENCE 2 (bases 1 to 2758)
AUTHORS Fu,J.L., Zheng,S.Y., Wang,Y., Hu,X.B., Xiao,Y., Wang,J.M.,
Zhang,L., Wang,L., Nie,Q., Hou,M., Bai,Y.Y., Gan,Y.W., Liang,X.M.,
Xie,L.L. and Li,D.W.
TITLE HSP90beta prevents aging-related cataract formation through
regulation of the charged multivesicular body protein (CHMP4B) and
p53
JOURNAL Proc Natl Acad Sci U S A 120 (31), e2221522120 (2023)
PUBMED 37487085
REFERENCE 3 (bases 1 to 2758)
AUTHORS Wang,Z., Wang,X., Shi,L., Cai,Y. and Hu,B.
TITLE Wolfram syndrome 1b mutation suppresses Mauthner-cell axon
regeneration via ER stress signal pathway
JOURNAL Acta Neuropathol Commun 10 (1), 184 (2022)
PUBMED 36527091
REMARK Publication Status: Online-Only
REFERENCE 4 (bases 1 to 2758)
AUTHORS Ellis,J.L., Evason,K.J., Zhang,C., Fourman,M.N., Liu,J., Ninov,N.,
Delous,M., Vanhollebeke,B., Fiddes,I., Otis,J.P., Houvras,Y.,
Farber,S.A., Xu,X., Lin,X., Stainier,D.Y.R. and Yin,C.
TITLE A missense mutation in the proprotein convertase gene furinb causes
hepatic cystogenesis during liver development in zebrafish
JOURNAL Hepatol Commun 6 (11), 3083-3097 (2022)
PUBMED 36017776
REFERENCE 5 (bases 1 to 2758)
AUTHORS Crouzier,L., Richard,E.M., Diez,C., Denus,M., Peyrel,A.,
Alzaeem,H., Cubedo,N., Delaunay,T., Maurice,T. and Delprat,B.
TITLE NCS1 overexpression restored mitochondrial activity and behavioral
alterations in a zebrafish model of Wolfram syndrome
JOURNAL Mol Ther Methods Clin Dev 27, 295-308 (2022)
PUBMED 36320410
REMARK Publication Status: Online-Only
REFERENCE 6 (bases 1 to 2758)
AUTHORS Thakur,P.C., Stuckenholz,C., Rivera,M.R., Davison,J.M., Yao,J.K.,
Amsterdam,A., Sadler,K.C. and Bahary,N.
TITLE Lack of de novo phosphatidylinositol synthesis leads to endoplasmic
reticulum stress and hepatic steatosis in cdipt-deficient zebrafish
JOURNAL Hepatology 54 (2), 452-462 (2011)
PUBMED 21488074
REFERENCE 7 (bases 1 to 2758)
AUTHORS Yeyati,P.L., Bancewicz,R.M., Maule,J. and van Heyningen,V.
TITLE Hsp90 selectively modulates phenotype in vertebrate development
JOURNAL PLoS Genet 3 (3), e43 (2007)
PUBMED 17397257
REFERENCE 8 (bases 1 to 2758)
AUTHORS Song,H.D., Sun,X.J., Deng,M., Zhang,G.W., Zhou,Y., Wu,X.Y.,
Sheng,Y., Chen,Y., Ruan,Z., Jiang,C.L., Fan,H.Y., Zon,L.I.,
Kanki,J.P., Liu,T.X., Look,A.T. and Chen,Z.
TITLE Hematopoietic gene expression profile in zebrafish kidney marrow
JOURNAL Proc Natl Acad Sci U S A 101 (46), 16240-16245 (2004)
PUBMED 15520368
REFERENCE 9 (bases 1 to 2758)
AUTHORS Sumanas,S., Larson,J.D. and Miller Bever,M.
TITLE Zebrafish chaperone protein GP96 is required for otolith formation
during ear development
JOURNAL Dev Biol 261 (2), 443-455 (2003)
PUBMED 14499652
REFERENCE 10 (bases 1 to 2758)
AUTHORS Zeng,S. and Gong,Z.
TITLE Expressed sequence tag analysis of expression profiles of zebrafish
testis and ovary
JOURNAL Gene 294 (1-2), 45-53 (2002)
PUBMED 12234666
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from BC063951.1.
On Jan 25, 2004 this sequence version replaced NM_198210.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC063951.1, AF510108.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA3505370, SAMEA3505371
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..2758
/organism="Danio rerio"
/mol_type="mRNA"
/db_xref="taxon:7955"
/chromosome="4"
/map="4"
gene 1..2758
/gene="hsp90b1"
/gene_synonym="fb61d09; GP96; GRP94; tra-1; tra1;
wu:fb61d09; wu:fq25g01"
/note="heat shock protein 90, beta (grp94), member 1"
/db_xref="GeneID:386590"
/db_xref="ZFIN:ZDB-GENE-031002-1"
exon 1..132
/gene="hsp90b1"
/gene_synonym="fb61d09; GP96; GRP94; tra-1; tra1;
wu:fb61d09; wu:fq25g01"
/inference="alignment:Splign:2.1.0"
misc_feature 60..62
/gene="hsp90b1"
/gene_synonym="fb61d09; GP96; GRP94; tra-1; tra1;
wu:fb61d09; wu:fq25g01"
/note="upstream in-frame stop codon"
CDS 84..2465
/gene="hsp90b1"
/gene_synonym="fb61d09; GP96; GRP94; tra-1; tra1;
wu:fb61d09; wu:fq25g01"
/note="tumor rejection antigen (gp96) 1; heat shock
protein 90kDa beta (grp94), member 1"
/codon_start=1
/product="endoplasmin precursor"
/protein_id="NP_937853.1"
/db_xref="GeneID:386590"
/db_xref="ZFIN:ZDB-GENE-031002-1"
/translation="
MRRLWIIGLLCALLAFASVKADDDVDIDGTVEEDLGKSRDGSRTDDEVVQREEEAIQLDGLNTSQLKEIRDKAEKHAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLLSLTNEDALAGNEELTIKIKSDKEKNMLHITDTGIGMTKEELVKNLGTIAKSGTSEFLNKMTEVQDDSQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHMWESDSNQFSVIEDPRGDTLGRGTTITLVMKEEASDYLELETIKNLVKKYSQFINFPIYVWSSKTETVEEPIEDEAEAEKEEATEDEAEVEEEEEDKDKPKTKKVEKTVWDWELMNDIKPIWQRPAKEVEEDEYTAFYKTFSRDTDEPLSHIHFTAEGEVTFKSILFVPASAPRGLFDEYGTKKNDFIKLFVRRVFITDDFHDMMPKYLNFIKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIAEEQYNDKFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQTSHSDTVLSSLEQYVERMKEKQDKIYFMAGTSRKEAESSPFVEKLLKKGYEVVYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESDKAKEKREALEKEFEPLTTWMKDKALKEQIEKAVLSQRLTNSPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTLEINPKHPLIKEMLRRVNEDAEDKTAADLAVVLFETATLRSGYQLQDTKAYGERIERMLRLSMNVDLDAQVEEEPEEEPEEQTEEAEDEEEVQADEAEEESEATSKDEL"
sig_peptide 84..146
/gene="hsp90b1"
/gene_synonym="fb61d09; GP96; GRP94; tra-1; tra1;
wu:fb61d09; wu:fq25g01"
/inference="COORDINATES: ab initio prediction:SignalP:6.0"
misc_feature 330..908
/gene="hsp90b1"
/gene_synonym="fb61d09; GP96; GRP94; tra-1; tra1;
wu:fb61d09; wu:fq25g01"
/note="Histidine kinase-like ATPase domain of human
cytosolic Hsp90 and its homologs including Escherichia
coli HtpG, and related domains; Region:
HATPase_Hsp90-like; cd16927"
/db_xref="CDD:340404"
misc_feature order(333..338,345..347,357..359,582..584,666..668)
/gene="hsp90b1"
/gene_synonym="fb61d09; GP96; GRP94; tra-1; tra1;
wu:fb61d09; wu:fq25g01"
/note="homodimer interface [polypeptide binding]; other
site"
/db_xref="CDD:340404"
misc_feature order(390..392,402..407,411..416,423..425,522..524,
528..530,534..536,540..545,567..572,576..596,660..680,
714..716,720..722,813..818,822..824)
/gene="hsp90b1"
/gene_synonym="fb61d09; GP96; GRP94; tra-1; tra1;
wu:fb61d09; wu:fq25g01"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:340404"
misc_feature order(570..572,678..680)
/gene="hsp90b1"
/gene_synonym="fb61d09; GP96; GRP94; tra-1; tra1;
wu:fb61d09; wu:fq25g01"
/note="ATP-lid; other site"
/db_xref="CDD:340404"
misc_feature 852..2348
/gene="hsp90b1"
/gene_synonym="fb61d09; GP96; GRP94; tra-1; tra1;
wu:fb61d09; wu:fq25g01"
/note="Hsp90 protein; Region: HSP90; pfam00183"
/db_xref="CDD:459703"
exon 133..235
/gene="hsp90b1"
/gene_synonym="fb61d09; GP96; GRP94; tra-1; tra1;
wu:fb61d09; wu:fq25g01"
/inference="alignment:Splign:2.1.0"
exon 236..377
/gene="hsp90b1"
/gene_synonym="fb61d09; GP96; GRP94; tra-1; tra1;
wu:fb61d09; wu:fq25g01"
/inference="alignment:Splign:2.1.0"
exon 378..494
/gene="hsp90b1"
/gene_synonym="fb61d09; GP96; GRP94; tra-1; tra1;
wu:fb61d09; wu:fq25g01"
/inference="alignment:Splign:2.1.0"
exon 495..826
/gene="hsp90b1"
/gene_synonym="fb61d09; GP96; GRP94; tra-1; tra1;
wu:fb61d09; wu:fq25g01"
/inference="alignment:Splign:2.1.0"
exon 827..938
/gene="hsp90b1"
/gene_synonym="fb61d09; GP96; GRP94; tra-1; tra1;
wu:fb61d09; wu:fq25g01"
/inference="alignment:Splign:2.1.0"
exon 939..1058
/gene="hsp90b1"
/gene_synonym="fb61d09; GP96; GRP94; tra-1; tra1;
wu:fb61d09; wu:fq25g01"
/inference="alignment:Splign:2.1.0"
exon 1059..1175
/gene="hsp90b1"
/gene_synonym="fb61d09; GP96; GRP94; tra-1; tra1;
wu:fb61d09; wu:fq25g01"
/inference="alignment:Splign:2.1.0"
exon 1176..1313
/gene="hsp90b1"
/gene_synonym="fb61d09; GP96; GRP94; tra-1; tra1;
wu:fb61d09; wu:fq25g01"
/inference="alignment:Splign:2.1.0"
exon 1314..1391
/gene="hsp90b1"
/gene_synonym="fb61d09; GP96; GRP94; tra-1; tra1;
wu:fb61d09; wu:fq25g01"
/inference="alignment:Splign:2.1.0"
exon 1392..1457
/gene="hsp90b1"
/gene_synonym="fb61d09; GP96; GRP94; tra-1; tra1;
wu:fb61d09; wu:fq25g01"
/inference="alignment:Splign:2.1.0"
exon 1458..1727
/gene="hsp90b1"
/gene_synonym="fb61d09; GP96; GRP94; tra-1; tra1;
wu:fb61d09; wu:fq25g01"
/inference="alignment:Splign:2.1.0"
exon 1728..1973
/gene="hsp90b1"
/gene_synonym="fb61d09; GP96; GRP94; tra-1; tra1;
wu:fb61d09; wu:fq25g01"
/inference="alignment:Splign:2.1.0"
exon 1974..2110
/gene="hsp90b1"
/gene_synonym="fb61d09; GP96; GRP94; tra-1; tra1;
wu:fb61d09; wu:fq25g01"
/inference="alignment:Splign:2.1.0"
exon 2111..2189
/gene="hsp90b1"
/gene_synonym="fb61d09; GP96; GRP94; tra-1; tra1;
wu:fb61d09; wu:fq25g01"
/inference="alignment:Splign:2.1.0"
exon 2190..2345
/gene="hsp90b1"
/gene_synonym="fb61d09; GP96; GRP94; tra-1; tra1;
wu:fb61d09; wu:fq25g01"
/inference="alignment:Splign:2.1.0"
exon 2346..2438
/gene="hsp90b1"
/gene_synonym="fb61d09; GP96; GRP94; tra-1; tra1;
wu:fb61d09; wu:fq25g01"
/inference="alignment:Splign:2.1.0"
exon 2439..2720
/gene="hsp90b1"
/gene_synonym="fb61d09; GP96; GRP94; tra-1; tra1;
wu:fb61d09; wu:fq25g01"
/inference="alignment:Splign:2.1.0"
ORIGIN
cgaggcgtggagggctctgcaaaagctcaaggcgttaatctgctattgagtctcattaataaaccgtttttctttcaaaaacaatgaggcggctgtggattatcggtctcctctgtgcacttttggcgttcgcatctgtaaaagctgatgatgatgttgacattgatggcacagtagaagaggaccttgggaagagcagagacggatcccgcaccgatgacgaggttgttcagagggaggaggaggccattcagctagatggtttaaacacctcacaattaaaggaaattcgtgataaagcagaaaagcatgcgttccaggcagaagtgaatcgaatgatgaaactgatcatcaattctctatataagaacaaagagatcttcctgagagagctgatctctaatgcttccgatgccttggataagatccggctgctgtctctgaccaatgaagatgcccttgccggaaatgaagagctcactattaaaattaagtctgacaaagagaagaatatgcttcacatcactgacactggtattggcatgaccaaagaagaactggtgaagaaccttggtaccatcgccaaatctggaaccagcgagttcctgaacaaaatgacagaggtgcaggacgacagtcagtccacctctgagctgattggtcagttcggtgtgggcttctactccgctttccttgtggccgataaggtcattgtcacttccaagcacaacaacgacacccagcacatgtgggaatctgattccaatcagttctctgtcatcgaggacccacgtggagacactctaggcagaggcaccaccatcacgttggtgatgaaagaggaagcttctgactaccttgagctggagaccattaagaacctggtgaagaaatactcccaattcatcaacttccccatctacgtatggagcagcaagaccgagaccgtagaagagcctattgaggatgaggctgaggcagagaaggaagaagccactgaagatgaagctgaagttgaggaagaggaggaagacaaggacaaaccaaagactaagaaggtggagaagactgtgtgggattgggagctgatgaatgacattaaacccatctggcagagacctgcaaaggaagtggaggaagatgaatatacagccttctataaaactttctccagggacactgatgagccactgtcacacattcacttcaccgctgaaggcgaagtcactttcaagtccatcctctttgttcctgcatctgcacccagaggtctttttgacgagtatggcaccaagaagaatgacttcattaagctgttcgtgcgtagagtcttcatcactgatgacttccatgacatgatgcccaagtacctcaacttcatcaagggtgttgtggactctgacgatctgcctctgaacgtgtccagagagactctgcagcaacacaaactgctcaaggttatccgtaaaaagctggtgcgcaagaccctggatatgatcaagaagatcgctgaggagcagtacaacgataagttctggaaagagtttggcaccaacattaagctgggcgtgattgaggatcactccaacagaacccgcctggccaaactgctccgcttccagacctcccacagcgacaccgtgctgtccagtctggagcagtatgtggagaggatgaaggagaagcaggacaagatctacttcatggctggaacaagcaggaaggaggctgaatcatctccatttgtggagaagcttcttaagaaaggatatgaagtggtctatctgactgaaccagtggatgagtactgcattcaggcccttcctgagtttgatggcaaacgcttccagaacgtggcgaaggagggtgtgaagttcgacgagagcgataaggccaaggaaaagagggaagctttggagaaagagtttgagccccttactacctggatgaaagataaggccctgaaggaacaaatcgagaaggctgttttgtcccaaaggttgacaaactctccatgtgctctggttgccagtcagtatggatggtctggaaacatggaacgtatcatgaaagctcaggcttaccagacaggaaaagacatttccacaaattattatgcaagccaaaagaagacattagaaatcaaccccaaacatccactcatcaaagagatgctaaggagagtcaacgaagacgctgaggataagacggccgcagatttagccgtagtgctgtttgagaccgccacactgcgatcaggataccagctccaagacaccaaagcctacggagaaagaatagagcgcatgctgcggctcagcatgaatgtagaccttgacgctcaggtagaggaagagccagaggaggaaccagaagaacagacagaggaagctgaggatgaggaggaggtccaggcagatgaagcagaagaggaatcagaggccacatccaaagatgagctgtaatgtgtaaatttggaagggatgggaaggggtgtctgactgtgatgcagagtgaagatggcgacgtcaacgcggttgtcttttctctgtgcgggtgggcttgggggataggagctgttttttttaaagcgctgcttttgtgtttgcaatttctttttttacattcctccatgattgtaaatttgttaatatttaactgacccagttgtggagtgctgactcctgtccacagaacgattaaatgtttccggaaaaggaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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