LOCUS       NM_131881               1207 bp    mRNA    linear   VRT 04-DEC-2022
DEFINITION  Danio rerio iroquois homeobox 7 (irx7), mRNA.
ACCESSION   NM_131881
VERSION     NM_131881.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1207)
  AUTHORS   Farmer DT, Patel P, Choi R, Liu CY and Crump JG.
  TITLE     A comprehensive series of Irx cluster mutants reveals diverse roles
            in facial cartilage development
  JOURNAL   Development 148 (16) (2021)
   PUBMED   34338288
REFERENCE   2  (bases 1 to 1207)
  AUTHORS   Qiu Y, Fung L, Schilling TF and Nie Q.
  TITLE     Multiple morphogens and rapid elongation promote segmental
            patterning during development
  JOURNAL   PLoS Comput Biol 17 (6), e1009077 (2021)
   PUBMED   34161317
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1207)
  AUTHORS   Menon T, Borbora AS, Kumar R and Nair S.
  TITLE     Dynamic optima in cell sizes during early development enable normal
            gastrulation in zebrafish embryos
  JOURNAL   Dev Biol 468 (1-2), 26-40 (2020)
   PUBMED   32937161
REFERENCE   4  (bases 1 to 1207)
  AUTHORS   Nitzan M, Karaiskos N, Friedman N and Rajewsky N.
  TITLE     Gene expression cartography
  JOURNAL   Nature 576 (7785), 132-137 (2019)
   PUBMED   31748748
REFERENCE   5  (bases 1 to 1207)
  AUTHORS   Marass M, Beisaw A, Gerri C, Luzzani F, Fukuda N, G S, Kuenne C,
            Reischauer S and Stainier DYR.
  TITLE     Genome-wide strategies reveal target genes of Npas4l associated
            with vascular development in zebrafish
  JOURNAL   Development 146 (11) (2019)
   PUBMED   31097478
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1207)
  AUTHORS   Cheng CW, Yan CH, Hui CC, Str U and Cheng SH.
  TITLE     The homeobox gene irx1a is required for the propagation of the
            neurogenic waves in the zebrafish retina
  JOURNAL   Mech Dev 123 (3), 252-263 (2006)
   PUBMED   16457994
REFERENCE   7  (bases 1 to 1207)
  AUTHORS   Lecaudey V, Anselme I, Dildrop R, R U and Schneider-Maunoury S.
  TITLE     Expression of the zebrafish Iroquois genes during early nervous
            system formation and patterning
  JOURNAL   J Comp Neurol 492 (3), 289-302 (2005)
   PUBMED   16217788
REFERENCE   8  (bases 1 to 1207)
  AUTHORS   Lecaudey V, Anselme I, Rosa F and Schneider-Maunoury S.
  TITLE     The zebrafish Iroquois gene iro7 positions the r4/r5 boundary and
            controls neurogenesis in the rostral hindbrain
  JOURNAL   Development 131 (13), 3121-3131 (2004)
   PUBMED   15175248
  REMARK    GeneRIF: iro7 has a dual function in the hindbrain of the zebrafish
            embryo: it is required for the proper positioning of the
            prospective r4/r5 boundary and it promotes neurogenesis in the
            anterior hindbrain
REFERENCE   9  (bases 1 to 1207)
  AUTHORS   Feij CG, Manzanares M, de la Calle-Mustienes E, G JL and Allende
            ML.
  TITLE     The Irx gene family in zebrafish: genomic structure, evolution and
            initial characterization of irx5b
  JOURNAL   Dev Genes Evol 214 (6), 277-284 (2004)
   PUBMED   15064948
REFERENCE   10 (bases 1 to 1207)
  AUTHORS   Itoh M, Kudoh T, Dedekian M, Kim CH and Chitnis AB.
  TITLE     A role for iro1 and iro7 in the establishment of an anteroposterior
            compartment of the ectoderm adjacent to the midbrain-hindbrain
            boundary
  JOURNAL   Development 129 (10), 2317-2327 (2002)
   PUBMED   11973265
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF398433.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF398433.1, AF414133.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505371
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1207
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="23"
                     /map="23"
     gene            1..1207
                     /gene="irx7"
                     /gene_synonym="cb263; iro7; zgc:109841; ziro7"
                     /note="iroquois homeobox 7"
                     /db_xref="GeneID:140746"
                     /db_xref="ZFIN:ZDB-GENE-020103-1"
     exon            1..231
                     /gene="irx7"
                     /gene_synonym="cb263; iro7; zgc:109841; ziro7"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..969
                     /gene="irx7"
                     /gene_synonym="cb263; iro7; zgc:109841; ziro7"
                     /note="iroquois homeobox protein 7"
                     /codon_start=1
                     /product="iroquois homeobox 7"
                     /protein_id="NP_571956.1"
                     /db_xref="GeneID:140746"
                     /db_xref="ZFIN:ZDB-GENE-020103-1"
                     /translation="

MPASSTGFANFFMDRNINMPAGYQLLGCPPGMQQPPPHLVGMAGMPLPFSGIPGYSFIPYPHPGHMAHISNSYDLKAASPYHQALLGRGGPYYTPYRPIPADDPSRVTKVATRESTSALKAWLSEHLKNPYPTKGEKIMLAIVTKMSLTQVSTWFANARRRLKKENRVSWASKGKSDEEDEEEEGESEEEGSLRKGTEDEDEIDPQTVDDEDEEDVVVSKSVEHRLAGGLEQQKESDKSDTLTKRESYKQIADVQKPKIWSLAETATSDIVKKPSDLKHLQTSPDFGQWWAGWPSRDSYSPVNLSTHDLLKQSQ"

     misc_feature    391..507
                     /gene="irx7"
                     /gene_synonym="cb263; iro7; zgc:109841; ziro7"
                     /note="Homeobox KN domain; Region: Homeobox_KN; pfam05920"
                     /db_xref="CDD:428673"
     misc_feature    787..831
                     /gene="irx7"
                     /gene_synonym="cb263; iro7; zgc:109841; ziro7"
                     /note="Motif in Iroquois-class homeodomain proteins
                     (only). Unknown function; Region: IRO; smart00548"
                     /db_xref="CDD:214716"
     exon            232..1182
                     /gene="irx7"
                     /gene_synonym="cb263; iro7; zgc:109841; ziro7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

aacaccagagctcagggagtaaggatgcctgcttcatcaacggggtttgcaaacttcttcatggacagaaacatcaacatgcctgctggatatcaattattaggctgcccacctggaatgcaacagccaccgccacatcttgtgggaatggccgggatgcccttacctttctcaggaataccgggctacagtttcatcccttatcctcatccgggacacatggcacacattagcaattcctatgacctcaaggctgcatcgccgtatcaccaagctctcctcggacggggaggaccatactacaccccgtatcgtcccatcccagctgacgaccccagtcgggtcactaaagttgccacccgggaaagcaccagcgctttgaaggcctggctcagcgagcacctgaaaaacccatatcccaccaaaggcgagaagatcatgcttgccatcgtcaccaaaatgagcctgacgcaggtgtcgacgtggttcgccaatgcgcgccgccggttaaaaaaagagaaccgggtcagctgggcgtccaaaggaaaatctgacgaggaggatgaggaagaagagggtgagagcgaagaggaagggtctttgaggaaaggcactgaggatgaagatgagatcgatcctcaaactgttgacgatgaggatgaagaggatgtcgtggtgtcaaagtcggtggagcaccgtttagcggggggactcgagcagcaaaaggaaagtgacaagtctgacactttgaccaaaagagagtcgtataaacaaatcgctgatgtccagaaacctaagatctggtctctggcggaaacggcgacctcagatatcgtcaagaaacccagcgatttgaaacatctccagacaagtccagatttcggacagtggtgggctggatggccttcaagggactcgtactctcctgtaaacctctccacacacgaccttctcaaacaaagtcaatgaaaccaagacactacagactgaatatttcttgcactttgagtccgtcaggaacgttttgttgttggatgtttgcataacagattttgaatccaatctcctggtttaaaaaccaaaggatgttgtgtaaatattgtacagctattttgtttaaattataaatgcatttaccagctgacttatttttgctaaaataaaaatgtggaaaaattgaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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