LOCUS       NM_131823               1764 bp    mRNA    linear   VRT 29-MAY-2023
DEFINITION  Danio rerio iroquois homeobox 1b (irx1b), mRNA.
ACCESSION   NM_131823
VERSION     NM_131823.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1764)
  AUTHORS   Song M, Yuan X, Racioppi C, Leslie M, Stutt N, Aleksandrova A,
            Christiaen L, Wilson MD and Scott IC.
  TITLE     GATA4/5/6 family transcription factors are conserved determinants
            of cardiac versus pharyngeal mesoderm fate
  JOURNAL   Sci Adv 8 (10), eabg0834 (2022)
   PUBMED   35275720
REFERENCE   2  (bases 1 to 1764)
  AUTHORS   Farmer DT, Patel P, Choi R, Liu CY and Crump JG.
  TITLE     A comprehensive series of Irx cluster mutants reveals diverse roles
            in facial cartilage development
  JOURNAL   Development 148 (16) (2021)
   PUBMED   34338288
REFERENCE   3  (bases 1 to 1764)
  AUTHORS   Clement Y, Torbey P, Gilardi-Hebenstreit P and Roest Crollius H.
  TITLE     Enhancer-gene maps in the human and zebrafish genomes using
            evolutionary linkage conservation
  JOURNAL   Nucleic Acids Res 48 (5), 2357-2371 (2020)
   PUBMED   31943068
REFERENCE   4  (bases 1 to 1764)
  AUTHORS   Staudt N, Giger FA, Fielding T, Hutt JA, Foucher I, Snowden V,
            Hellich A, Kiecker C and Houart C.
  TITLE     Pineal progenitors originate from a non-neural territory limited by
            FGF signalling
  JOURNAL   Development 146 (22) (2019)
   PUBMED   31754007
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1764)
  AUTHORS   Jung IH, Jung DE, Chung YY, Kim KS and Park SW.
  TITLE     Iroquois Homeobox 1 Acts as a True Tumor Suppressor in Multiple
            Organs by Regulating Cell Cycle Progression
  JOURNAL   Neoplasia 21 (10), 1003-1014 (2019)
   PUBMED   31450023
REFERENCE   6  (bases 1 to 1764)
  AUTHORS   Dildrop R and Ruther U.
  TITLE     Organization of Iroquois genes in fish
  JOURNAL   Dev Genes Evol 214 (6), 267-276 (2004)
   PUBMED   15133664
REFERENCE   7  (bases 1 to 1764)
  AUTHORS   Feijoo CG, Manzanares M, de la Calle-Mustienes E, Gomez-Skarmeta JL
            and Allende ML.
  TITLE     The Irx gene family in zebrafish: genomic structure, evolution and
            initial characterization of irx5b
  JOURNAL   Dev Genes Evol 214 (6), 277-284 (2004)
   PUBMED   15064948
REFERENCE   8  (bases 1 to 1764)
  AUTHORS   Shu X, Cheng K, Patel N, Chen F, Joseph E, Tsai HJ and Chen JN.
  TITLE     Na,K-ATPase is essential for embryonic heart development in the
            zebrafish
  JOURNAL   Development 130 (25), 6165-6173 (2003)
   PUBMED   14602677
REFERENCE   9  (bases 1 to 1764)
  AUTHORS   Kudoh T, Wilson SW and Dawid IB.
  TITLE     Distinct roles for Fgf, Wnt and retinoic acid in posteriorizing the
            neural ectoderm
  JOURNAL   Development 129 (18), 4335-4346 (2002)
   PUBMED   12183385
REFERENCE   10 (bases 1 to 1764)
  AUTHORS   Itoh M, Kudoh T, Dedekian M, Kim CH and Chitnis AB.
  TITLE     A role for iro1 and iro7 in the establishment of an anteroposterior
            compartment of the ectoderm adjacent to the midbrain-hindbrain
            boundary
  JOURNAL   Development 129 (10), 2317-2327 (2002)
   PUBMED   11973265
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY017308.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY017308.1, BC077101.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505377, SAMEA4476800
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1764
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="19"
                     /map="19"
     gene            1..1764
                     /gene="irx1b"
                     /gene_synonym="iro1; ziro1"
                     /note="iroquois homeobox 1b"
                     /db_xref="GeneID:114430"
                     /db_xref="ZFIN:ZDB-GENE-010716-1"
     exon            1..372
                     /gene="irx1b"
                     /gene_synonym="iro1; ziro1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    94..96
                     /gene="irx1b"
                     /gene_synonym="iro1; ziro1"
                     /note="upstream in-frame stop codon"
     CDS             127..1464
                     /gene="irx1b"
                     /gene_synonym="iro1; ziro1"
                     /note="iroquois homeobox protein 1, b"
                     /codon_start=1
                     /product="iroquois-class homeodomain protein IRX-1b"
                     /protein_id="NP_571898.1"
                     /db_xref="GeneID:114430"
                     /db_xref="ZFIN:ZDB-GENE-010716-1"
                     /translation="

MSFPQLGYPQFLNASQEVYGAERTGVMPSSPREGSSDNSANPATAAAAITPMLGMYANPWTVQNYSAFLPYNSAELALLSQMGSQYELKDNPGAHPPGFAVHAAPGFYPYGQYQYGDPARAKSATRETTSTLKAWLQEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKVTCCRSAEDRDGRIFDSDNEDDADKNDDEEEIDLETIDMDKAEEPRVDQNKEAANNPHAIENIETPRILSSPALKNTDSPMSSGNREQNVVKSVGEVSPGGAVCQRPGNSKPKIWSLAETATSPDNTQKLSIPSTPAGLRASPSTHPAFLSTNGIYTCQIGKLHNWASAAFLSANSLMGVRSLLSQNSNFPNHSPVTNPEKKPSSASGSPCLDSDNSSDSFSPKHNDQENVQRIESPTLASRSPFPVIHDRSHHETSQRALKTIS"

     misc_feature    <466..744
                     /gene="irx1b"
                     /gene_synonym="iro1; ziro1"
                     /note="Homeodomain-containing transcription factor
                     [Transcription]; Region: COG5576"
                     /db_xref="CDD:227863"
     misc_feature    532..648
                     /gene="irx1b"
                     /gene_synonym="iro1; ziro1"
                     /note="Homeobox KN domain; Region: Homeobox_KN; pfam05920"
                     /db_xref="CDD:428673"
     misc_feature    985..1038
                     /gene="irx1b"
                     /gene_synonym="iro1; ziro1"
                     /note="Motif in Iroquois-class homeodomain proteins
                     (only). Unknown function; Region: IRO; smart00548"
                     /db_xref="CDD:214716"
     exon            373..1345
                     /gene="irx1b"
                     /gene_synonym="iro1; ziro1"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1418
                     /gene="irx1b"
                     /gene_synonym="iro1; ziro1"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1745
                     /gene="irx1b"
                     /gene_synonym="iro1; ziro1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

actcatcactagacgttcctcctgaagagaccgcgcttctgcaccaagcgagagttattgctgtgattgaaagtggattgcccttctctcttgtaaatctccgacagagttcctcgggagttggacatgtcgttcccccaactgggttacccacagttcctaaacgcctcccaagaggtgtacggagcggagcgcacgggtgtaatgccgtcctctccacgcgagggaagctcggacaacagcgcaaatcccgcgactgcagcggctgctatcacgccgatgctcggcatgtatgcgaatccgtggaccgtgcaaaattatagcgccttcttaccttacaacagtgccgagctggccctgctctctcagatggggtcgcagtatgagctgaaggataaccccggggctcatcctccaggatttgcagtgcacgctgcgcccggtttttatccatacggccagtatcagtacggtgatccggcccgggccaagagcgctaccagagaaaccaccagcacactgaaagcatggttgcaggaacacaaaaagaacccgtatcccaccaaaggtgagaagatcatgctggccatcatcacgaagatgacccttacgcaggtgtccacctggttcgccaacgcgcgccggagactcaaaaaggagaataaagtgacctgttgtcgcagtgccgaggacagagacgggcgaattttcgacagcgacaacgaggatgatgcggacaaaaatgacgacgaggaagaaatcgatctggagaccatcgatatggacaaagcggaggagcccagagtggaccagaacaaggaagcagcgaataacccgcacgcgattgaaaacattgaaacaccgcggatattatcttccccagcacttaaaaacacggacagtcctatgtcgagtggtaatagagaacagaatgtggtcaaaagcgttggtgaggtgtctcctggtggagcagtgtgtcaaaggcctggaaacagcaaacccaaaatctggtctttggcggagacggcaacaagtcctgataatacgcagaaactcagtatcccgtcgacgcctgcaggcctcagggcctcaccttcaacccatcctgcttttctctccacaaacggaatttatacttgccagattgggaaactacacaattgggcgagcgccgctttccttagtgctaattctctgatgggtgtgcgctcacttttgagtcaaaacagtaactttccaaaccacagtcccgttactaaccccgaaaagaaaccttcgtctgcctctggatctccatgtcttgacagcgacaactcatccgacagtttcagtcccaaacataatgatcaagagaacgttcagagaattgaatctccaacacttgcatcaagatcaccgtttccagtcatccatgacaggtctcatcatgaaacatcacaacgcgctttgaagacaatttcttgaacacagaacttatcagaaacctctaaattatttaaagaaagtgaaatgtgacaatacagcaacagcatatacgtcatcggatagaccaaaatattttttgtatttcttattacgctcccatccagcaatataattttttttgtattttcttttctattcatttcagcatgtttgagtttaccgtgtaggtngcctgcatttcttttaaagagttaataagagttattggtcagaaattgtgaaaatgatatatttttgtgtaataaagaaaatgagataaaaaaaaaaaaaaaaaaaaaa

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