LOCUS       NM_131767               1880 bp    mRNA    linear   VRT 08-OCT-2023
DEFINITION  Danio rerio claudin 3c (cldn3c), mRNA.
ACCESSION   NM_131767
VERSION     NM_131767.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1880)
  AUTHORS   Gong J, Qian P, Hu Y, Guo C, Wei G, Wang C, Cai C, Wang H and Liu
            D.
  TITLE     Claudin h Is Essential for Hair Cell Morphogenesis and Auditory
            Function in Zebrafish
  JOURNAL   Front Cell Dev Biol 9, 663995 (2021)
   PUBMED   34046408
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1880)
  AUTHORS   Zhang XH, Zhou CC, Li CY, Hua Y, Li K, Wei P and He MF.
  TITLE     Isoliquiritin exert protective effect on telencephalon infarction
            injury by regulating multi-pathways in zebrafish model of ischemic
            stroke
  JOURNAL   Phytomedicine 83, 153469 (2021)
   PUBMED   33535128
REFERENCE   3  (bases 1 to 1880)
  AUTHORS   Lu J, Liu R, Miao A, Chen X, Xiao W, Wang Y, Cao D, Pan J, Li L and
            Luo Y.
  TITLE     The role of cldnh during the early retinal development in zebrafish
  JOURNAL   Exp Eye Res 200, 108207 (2020)
   PUBMED   32866532
REFERENCE   4  (bases 1 to 1880)
  AUTHORS   Solis CJ, Hamilton MK, Caruffo M, Garcia-Lopez JP, Navarrete P,
            Guillemin K and Feijoo CG.
  TITLE     Intestinal Inflammation Induced by Soybean Meal Ingestion Increases
            Intestinal Permeability and Neutrophil Turnover Independently of
            Microbiota in Zebrafish
  JOURNAL   Front Immunol 11, 1330 (2020)
   PUBMED   32793187
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1880)
  AUTHORS   Ferrero G, Gomez E, Lyer S, Rovira M, Miserocchi M, Langenau DM,
            Bertrand JY and Wittamer V.
  TITLE     The macrophage-expressed gene (mpeg) 1 identifies a subpopulation
            of B cells in the adult zebrafish
  JOURNAL   J Leukoc Biol 107 (3), 431-443 (2020)
   PUBMED   31909502
REFERENCE   6  (bases 1 to 1880)
  AUTHORS   Clelland ES and Kelly SP.
  TITLE     Tight junction proteins in zebrafish ovarian follicles: stage
            specific mRNA abundance and response to 17beta-estradiol, human
            chorionic gonadotropin, and maturation inducing hormone
  JOURNAL   Gen Comp Endocrinol 168 (3), 388-400 (2010)
   PUBMED   20553723
REFERENCE   7  (bases 1 to 1880)
  AUTHORS   Xie J, Farage E, Sugimoto M and Anand-Apte B.
  TITLE     A novel transgenic zebrafish model for blood-brain and
            blood-retinal barrier development
  JOURNAL   BMC Dev Biol 10, 76 (2010)
   PUBMED   20653957
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1880)
  AUTHORS   Gomez GA, Veldman MB, Zhao Y, Burgess S and Lin S.
  TITLE     Discovery and characterization of novel vascular and hematopoietic
            genes downstream of etsrp in zebrafish
  JOURNAL   PLoS One 4 (3), e4994 (2009)
   PUBMED   19308258
REFERENCE   9  (bases 1 to 1880)
  AUTHORS   Woods IG, Wilson C, Friedlander B, Chang P, Reyes DK, Nix R, Kelly
            PD, Chu F, Postlethwait JH and Talbot WS.
  TITLE     The zebrafish gene map defines ancestral vertebrate chromosomes
  JOURNAL   Genome Res 15 (9), 1307-1314 (2005)
   PUBMED   16109975
REFERENCE   10 (bases 1 to 1880)
  AUTHORS   Loh YH, Christoffels A, Brenner S, Hunziker W and Venkatesh B.
  TITLE     Extensive expansion of the claudin gene family in the teleost fish,
            Fugu rubripes
  JOURNAL   Genome Res 14 (7), 1248-1257 (2004)
   PUBMED   15197168
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF359434.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF359434.1, EH452865.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505390, SAMEA4476742
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1880
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="21"
                     /map="21"
     gene            1..1880
                     /gene="cldn3c"
                     /gene_synonym="cldnh; fc56d05; wu:fc56d05"
                     /note="claudin 3c"
                     /db_xref="GeneID:81587"
                     /db_xref="ZFIN:ZDB-GENE-010328-8"
     exon            1..43
                     /gene="cldn3c"
                     /gene_synonym="cldnh; fc56d05; wu:fc56d05"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    42..44
                     /gene="cldn3c"
                     /gene_synonym="cldnh; fc56d05; wu:fc56d05"
                     /note="upstream in-frame stop codon"
     exon            44..1859
                     /gene="cldn3c"
                     /gene_synonym="cldnh; fc56d05; wu:fc56d05"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..707
                     /gene="cldn3c"
                     /gene_synonym="cldnh; fc56d05; wu:fc56d05"
                     /note="claudin h"
                     /codon_start=1
                     /product="claudin 3c"
                     /protein_id="NP_571842.1"
                     /db_xref="GeneID:81587"
                     /db_xref="ZFIN:ZDB-GENE-010328-8"
                     /translation="

MSMGLEIGGIALGIIGWIISIVACALPMWRVSAFVGANIVTAQVIWEGLWMNCVVQSTGQMQCKVYDSMLALGQDLQASRAMTVIAIILAVLGVMISVMGAKCTNCIEDEGAKAKVMIVSGIMFIIAGILDLIPSAWVANQIIRDFYNPLLPGAQQRELGASIYIGFAAAALLIIGGAMLCCTCPPKEKKYKPARMGYSAPRSASAGYDKKDYV"

     misc_feature    147..602
                     /gene="cldn3c"
                     /gene_synonym="cldnh; fc56d05; wu:fc56d05"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:473919"
     regulatory      1841..1846
                     /regulatory_class="polyA_signal_sequence"
                     /gene="cldn3c"
                     /gene_synonym="cldnh; fc56d05; wu:fc56d05"
ORIGIN      

aggaaagattgagacggcttcaacaaagacatctcaacacttgatacaaaagtacacctaaaatgtcgatgggactggaaattgggggcattgccctgggtattattggttggataattagcattgtggcttgtgctcttcccatgtggcgtgtctcggccttcgttggcgccaacattgtcacggcgcaagtaatctgggaaggtttatggatgaactgtgtcgttcagagcactggacagatgcagtgtaaggtctacgactcaatgctggctttaggtcaagatctgcaggcgtccagagccatgactgtcattgccatcatcttggctgttctaggtgtgatgatctccgtcatgggcgccaaatgcaccaattgtattgaggatgaaggtgctaaggctaaagtgatgatcgtctctggcatcatgttcattattgctggcatcctggatctcattccttcagcctgggtggcaaaccagatcattcgggacttttacaacccgttactgcccggcgctcagcaaagagagctcggggcatccatttacataggtttcgctgctgccgctctcttaatcattggaggagccatgctgtgctgcacttgtcctccaaaagagaagaagtacaagccggcaagaatgggctattctgctccacgctcagccagcgctggatatgacaagaaggactatgtttaaatctgtagaagaagaaaaaaaaaacaaagacggatgaaaagggtgaacatgcatatgaaaggactccataatgaagggatgtgatgctgttaatatttgcttttcgttggtttaagactttgtgtgtgtaagggatgatgtctatcagggacttttttgtttgtatttcctctttgacatcatttttaatttgcctatttttgtttagctgtttgctttgtttgtgtacatggtgtcaaaatgtatcataaatgatttgagtatttcagtatggatatcaacgcattcttcagtaatttcagtccttctacttgagctaaattcaaagcacttcagatatttcatcttgccttctgatgtactgatcaaaattaagtaacatgatgctctaaacaagaaacaaatatcaaaatgttttacattagatttttgcactgtaaaacaaaaataactactaagaaaaaatgccatttccacagtgaaggtgctcactagtaccaaatgatggataacaggaagagaaaaaactctttacatgtatttgcttatgaaaatttcatgggacaccgaaactgaatatttgtgtatgatttaagtttcagttttgtcttatcttgatgttgcacacgaccaacttgactatgtatagttcccttaaaaacatttaatacacttcctttattgctcaaagaatttttatacagagtttaatagcgctcttgggtgtattttcacaacattttaagtactgtgactaatatttgtccattgtgtgtcctttatattattaagtgtgtgtggtaatgtaaaatggttcattggttgatatatgaaacaaatggtcagttacagtaaacaaaagactgctggagcggttttacctgctttggccctttgttcttgaaccagggcagtaatatgaacacggtttatgagagagaccactcaacagacaaaccttacacaagctgtactgtttgccataggtggtgcagacaaatccaaccaaaaccggtctggacaaacttctgacaagatgagggattgtgattgaaagtaaacttaaggcacaaaatgtttactttactatgtatatctgtatttaactccactgtaatttcaaatcaaacgtcaataaaaaagcttaatttaaaaaaaaaaaaaaaaaaaaaa

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