LOCUS       NM_001302232            3075 bp    mRNA    linear   VRT 01-JUL-2018
DEFINITION  Danio rerio protein argonaute-3 (LOC567622), mRNA.
ACCESSION   NM_001302232 XM_009292706
VERSION     NM_001302232.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from JX448393.1.
            
            On Oct 7, 2014 this sequence version replaced XM_009292706.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: JX448393.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA2168446, SAMEA2168447
                                           [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3075
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="AB"
                     /db_xref="taxon:7955"
                     /chromosome="16"
                     /map="16"
     gene            1..3075
                     /gene="LOC567622"
                     /gene_synonym="ago3a; eif2c1"
                     /note="protein argonaute-3"
                     /db_xref="GeneID:567622"
     exon            1..245
                     /gene="LOC567622"
                     /gene_synonym="ago3a; eif2c1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    224..226
                     /gene="LOC567622"
                     /gene_synonym="ago3a; eif2c1"
                     /note="upstream in-frame stop codon"
     CDS             227..2830
                     /gene="LOC567622"
                     /gene_synonym="ago3a; eif2c1"
                     /EC_number="3.1.26.n2"
                     /note="eukaryotic translation initiation factor 2C, 1;
                     argonaute 3a"
                     /codon_start=1
                     /product="protein argonaute-3"
                     /protein_id="NP_001289161.1"
                     /db_xref="GeneID:567622"
                     /translation="

MEIGTTGAVGAQSLFSMPRRPGYGTMGKPIKLLANCFQVEIPKMDVYLYEVDIKPEKCPRRVNREVVDSMVQHFKVTIFGDRRPVYDGKKSLYTANPLPVAPAGVDLDVTLPGEGGKDRPFKVSIKFVSLVSWHLLHEVLTGRSMPEPLELDKPISTNPVHAVDVVLRHLPSMKYTPVGRSFFSAPEGYDHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIQFMCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFREKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVRSANYEADPSVQEFQFKVRDEMAHVTGRVLPAPMLQYGGRVSTEHFMNRTVATPSHGVWDMRGKRFHTGVEIKMWAIACFATQRQCREEILKGFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEVIQDLSSMVRELLIQFYKSTRYKPTRTIFYRDGVSEGQFRQVLYYELLAIREACISLEKEYQPGITYIVVQKRHHTRLFCADRSERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNCFTADEFQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQSNGRDPQALAKAVQIHHDTLRTMYFA"

     misc_feature    443..727
                     /gene="LOC567622"
                     /gene_synonym="ago3a; eif2c1"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:465134"
     misc_feature    755..907
                     /gene="LOC567622"
                     /gene_synonym="ago3a; eif2c1"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:462567"
     misc_feature    908..1270
                     /gene="LOC567622"
                     /gene_synonym="ago3a; eif2c1"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(1064..1066,1109..1111,1151..1153,1163..1165,
                     1217..1219,1238..1240,1244..1246)
                     /gene="LOC567622"
                     /gene_synonym="ago3a; eif2c1"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1403..2701
                     /gene="LOC567622"
                     /gene_synonym="ago3a; eif2c1"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1835..1837,1847..1849,1883..1894,1901..1903,
                     1925..1927,1934..1936,1946..1948,1958..1960)
                     /gene="LOC567622"
                     /gene_synonym="ago3a; eif2c1"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(2039..2041,2045..2047,2255..2257,2669..2671)
                     /gene="LOC567622"
                     /gene_synonym="ago3a; eif2c1"
                     /note="active site"
                     /db_xref="CDD:240015"
     exon            246..417
                     /gene="LOC567622"
                     /gene_synonym="ago3a; eif2c1"
                     /inference="alignment:Splign:2.1.0"
     exon            418..538
                     /gene="LOC567622"
                     /gene_synonym="ago3a; eif2c1"
                     /inference="alignment:Splign:2.1.0"
     exon            539..747
                     /gene="LOC567622"
                     /gene_synonym="ago3a; eif2c1"
                     /inference="alignment:Splign:2.1.0"
     exon            748..884
                     /gene="LOC567622"
                     /gene_synonym="ago3a; eif2c1"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1019
                     /gene="LOC567622"
                     /gene_synonym="ago3a; eif2c1"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1107
                     /gene="LOC567622"
                     /gene_synonym="ago3a; eif2c1"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1255
                     /gene="LOC567622"
                     /gene_synonym="ago3a; eif2c1"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1375
                     /gene="LOC567622"
                     /gene_synonym="ago3a; eif2c1"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1519
                     /gene="LOC567622"
                     /gene_synonym="ago3a; eif2c1"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1653
                     /gene="LOC567622"
                     /gene_synonym="ago3a; eif2c1"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1838
                     /gene="LOC567622"
                     /gene_synonym="ago3a; eif2c1"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..1998
                     /gene="LOC567622"
                     /gene_synonym="ago3a; eif2c1"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2089
                     /gene="LOC567622"
                     /gene_synonym="ago3a; eif2c1"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2284
                     /gene="LOC567622"
                     /gene_synonym="ago3a; eif2c1"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2419
                     /gene="LOC567622"
                     /gene_synonym="ago3a; eif2c1"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2521
                     /gene="LOC567622"
                     /gene_synonym="ago3a; eif2c1"
                     /inference="alignment:Splign:2.1.0"
     exon            2522..2721
                     /gene="LOC567622"
                     /gene_synonym="ago3a; eif2c1"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..3075
                     /gene="LOC567622"
                     /gene_synonym="ago3a; eif2c1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

caatctgtcaaccgtacccgaaatcccgaccggatagtttgagtcacataccgggcaaccaaacattatctccggtgacacacgagcctcagggaaggtggactaataccgagaggaatcgcttgcggtgggttaacgcaaccggtttgtgcggccataggacagtcagagtttctgaagttcatcaactgcgagccggggacggaaccggacagagacctcatgaatggaaatcggaactacaggagccgttggggcccagtccctgttctccatgccacggaggcccggctatggcaccatggggaaacctatcaaactgctggccaactgcttccaggtggagatcccaaagatggacgtctacctgtacgaggtggacatcaagcccgagaagtgtccacggagagtaaatagggaggtggtggactccatggtgcagcactttaaagtcaccatctttggggatcgaaggccagtttatgatgggaagaaaagtctctacaccgccaacccacttcctgtggcacctgcaggggtggatctggatgtcacgctgccaggtgaagggggcaaagaccggccctttaaagtctcaattaagtttgtgtctctggtgagctggcacctgctgcacgaggtgctaaccgggcgcagtatgccagagccgctggaactggacaagccaatcagcaccaacccagtgcacgctgtggatgtggtgctccgccatctgccctccatgaagtatacacccgtgggccgctcattcttctctgccccggagggttatgatcatcctctaggtggaggcagagaggtgtggttcggtttccatcagtctgttcggcccgccatgtggaaaatgatgctcaacattgatgtgtcagccacggctttctacaaagcacagccagtcattcagttcatgtgtgaagtcctggacatccacaacatcgacgagcagccgcgacccctcacagactcccacagagtcaaattcaccaaagaaatcaaaggtctgaaggtggaggtgacccactgcgggaccatgcggaggaagtaccgcgtctgcaatgtgacccgccggcctgccagccaccaaacgttccctttgcagttggagaacggccaaactgtagaacggacagtagctcagtatttcagagagaagtacaacctgcagctcaagtaccctcacctgccctgtctacaggtgggacaggagcagaaacacacatacctgcctctggaggtttgcaatattgtagcagggcagcggtgcatcaagaaactgacagataatcagacgtccaccatgatcaaagccacggcgcgctccgcaccagaccgacaggaggagatcagcagactggtgcgcagcgctaactatgaagccgacccgtccgtgcaggagtttcagtttaaggtccgggatgagatggcccacgtgacggggcgcgtgttgcccgcgcccatgctgcagtacgggggcagggtgagcacagagcactttatgaaccgcactgtcgccacaccgagtcacggcgtttgggacatgagaggaaagcggtttcacaccggcgtggagatcaagatgtgggccatcgcctgcttcgccacacagaggcagtgcagagaggagatcctcaagggttttaccgaccagctgcgcaaaatctcgaaggatgctgggatgccgattcagggtcagccgtgtttctgtaagtacgctcagggggccgacagcgtggagcccatgttcagacacctgaagaacacttactctggactgcagctcatcatcgtcatcctgcctggaaaaacccccgtctacgcggaagtgaagcgtgttggagacactcttctaggaatggccactcagtgtgtgcaggtgaagaacgtggtaaaaacctccccgcagacgctctccaacctctgcctgaaaatcaacgtcaaactcggcggcatcaacaacatcctcgtgccgcatcaacggccatcagttttccagcagccagtcatctttctgggggcggacgttacacatccccctgcaggagatgggaagaaaccgtccatcgcagcggtggtgggcagtatggacgctcatcccagcaggtattgtgccactgtgcgcgtccagagaccccgtcaggaggtcattcaggatttgtcctcaatggtgcgagagttactcatccagttctacaaatccactcgctacaagcccaccagaaccatcttctacagggacggtgtttctgagggccagttcagacaggtgttgtattatgagctgctggccattcgagaggcctgtatcagtctggagaaggagtaccagcccggcatcacgtatatagtggtgcagaaacgccaccacacacgcctcttctgtgccgaccgcagcgagagggtgggtcgcagtggaaacattcctgctggtacgacggtggatacagatatcacacacccttatgagtttgacttttacctctgcagtcatgctggaatacagggcaccagcaggccctcccactatcatgtcctgtgggacgacaactgcttcactgctgatgagttccagctgctcacctaccagctgtgccacacgtatgtgcgctgcacccgctccgtctccatccccgcgccagcctactacgcccacctggtggccttccgcgcccgataccacttggtggacaaagaacacgacagtgccgagggaagccatgtctccggacagagcaacggccgggacccccaagcgctggccaaagctgtgcagattcaccacgacaccctgaggaccatgtactttgcctaagccagctcacgttcatctagtcatgcacacaaacccgacaaccacacacacacacacacatgctgacaaacacacacacctcccagaatcctgtgcgtcctgaagggtcgatctctgtggcgattgaagcacggcccacccgacactgtgcagcaggacgaggaaggcctttaaggaagccgacctgctttaaaaccacacatggacctcggcgctattatgcaatattaaaccagccaactgag

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