LOCUS       NM_001128292            2435 bp    mRNA    linear   VRT 14-OCT-2021
DEFINITION  Danio rerio prospero homeobox 2 (prox2), mRNA.
ACCESSION   NM_001128292 XM_001919487
VERSION     NM_001128292.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2435)
  AUTHORS   Xie Y, Kaufmann D, Moulton MJ, Panahi S, Gaynes JA, Watters HN,
            Zhou D, Xue HH, Fung CM, Levine EM, Letsou A, Brennan KC and Dorsky
            RI.
  TITLE     Lef1-dependent hypothalamic neurogenesis inhibits anxiety
  JOURNAL   PLoS Biol 15 (8), e2002257 (2017)
   PUBMED   28837622
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2435)
  AUTHORS   Emerson SE, St Clair RM, Waldron AL, Bruno SR, Duong A, Driscoll
            HE, Ballif BA, McFarlane S and Ebert AM.
  TITLE     Identification of target genes downstream of semaphorin6A/PlexinA2
            signaling in zebrafish
  JOURNAL   Dev Dyn 246 (7), 539-549 (2017)
   PUBMED   28440030
REFERENCE   3  (bases 1 to 2435)
  AUTHORS   Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I,
            Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y and
            Bobe J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2435)
  AUTHORS   Pistocchi A, Bartesaghi S, Cotelli F and Del Giacco L.
  TITLE     Identification and expression pattern of zebrafish prox2 during
            embryonic development
  JOURNAL   Dev Dyn 237 (12), 3916-3920 (2008)
   PUBMED   19035352
  REMARK    GeneRIF: prox1 loss- and gain-of-function assays have been carried
            out to search for regulative effects on prox2 expression
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from EF517402.2.
            
            On Sep 16, 2008 this sequence version replaced NM_001128292.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF517402.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505372
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2435
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="17"
                     /map="17"
     gene            1..2435
                     /gene="prox2"
                     /note="prospero homeobox 2"
                     /db_xref="GeneID:100003863"
                     /db_xref="ZFIN:ZDB-GENE-081003-3"
     exon            1..13
                     /gene="prox2"
                     /inference="alignment:Splign:2.1.0"
     exon            14..1338
                     /gene="prox2"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1809
                     /gene="prox2"
                     /codon_start=1
                     /product="prospero homeobox protein 2"
                     /protein_id="NP_001121764.2"
                     /db_xref="GeneID:100003863"
                     /db_xref="ZFIN:ZDB-GENE-081003-3"
                     /translation="

MNLSPPEANMHKVSDGGCMEVSKPDHLLPCFRRSAYEEPLASYHSGSIISHLLRKTIHNKLTSLDSSLLYLPSTNADSESNTTDDFPAEDQSGSEDLSVGVDAERPLNEHLQAKRARVENIIRGMAGSPNARTHGEADSDCRKENKRKQRLPQHQEPSRTKSSKDEECHKLKEQLQSMQRLLHQLQEKISHVYDQNYLENEELDDDRSENQTFGFSSDRAVKSFQETLKCELSRTVSESIDMVFKKLSKSLPKQSPPQHAETENAINPDSHSEQSDSEEMPKSRSSFEDQTEALSLVVRKPSLSQGVKRPFPLHQTPFQFGYSAPLHDSQILEHLLKFGPHSAFSALPCLPATLERASPESLDHPWESVRSKVSGAAAAGHQLQLQHQRAAPAGLLAVDSLCLPHVKMEVADLQSMADRSSYMALNIQEGLTPNHLKKAKLMFFYTRYPSSNLLKNFFPDVKFNRCITSQLIKWFSNFREFYYIQMEKFARQAIIDGVTDVKDISVSRESELFRALNMHYNKANDFQVPDRFLEVAEVTLQEFYSAISLSKDSDPSWKKAIYKVICKLDSDVPEEFKSPSYL"

     misc_feature    1348..1806
                     /gene="prox2"
                     /note="Homeo-prospero domain; Region: HPD; pfam05044"
                     /db_xref="CDD:461534"
     exon            1339..1446
                     /gene="prox2"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1641
                     /gene="prox2"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..2435
                     /gene="prox2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2417..2422
                     /regulatory_class="polyA_signal_sequence"
                     /gene="prox2"
     regulatory      2420..2425
                     /regulatory_class="polyA_signal_sequence"
                     /gene="prox2"
ORIGIN      

tccagagcaacagagtatcaaagatcagcagtttacgggctcatattcacctgtaaaatcatgaatctgagtccacctgaagcgaacatgcacaaagtgagcgacggcggctgcatggaggtcagcaaacccgatcatctgctgccgtgctttcgcagaagcgcatacgaagagcctctcgcttcctaccacagcggctccatcatctctcacctcctgcgcaaaaccatccacaacaagctgacgtcgctggacagcagcctcctgtaccttccgtctactaacgctgactccgagtccaacacgacggatgatttcccagcagaggaccagagcggcagtgaggatctgtctgtgggtgtggacgctgagcggcctctaaatgaacacctccaggccaaacgcgcccgcgtggagaacatcatacggggaatggcaggttcaccaaacgccaggacacacggagaagcagatagcgactgtagaaaggagaacaagcggaagcaaaggctcccgcagcatcaggaacccagcagaaccaaatccagcaaagacgaagagtgccacaagctgaaggagcagctccagagcatgcagcgcctgctgcatcagctccaggagaagatctcgcacgtctacgatcaaaactatctggagaacgaagaacttgatgatgacaggagcgaaaaccaaacctttggtttcagctcggatagagcggtgaagagtttccaggagactcttaaatgcgagctgagcagaactgtgagcgaaagcatcgatatggtcttcaagaagctctccaagagtctcccgaagcagagtccgccgcagcatgcagaaaccgagaacgctatcaatccggactctcactcggagcagtcggattctgaggagatgcccaaaagcaggagctcgtttgaggatcagactgaagcgctatcccttgtggttcgcaagccctccttgagtcagggtgtgaaacgtccctttccgctccaccagacgccgtttcagttcggctacagcgcgcctctgcatgacagccagatcctggagcacctgctgaagttcggccctcactctgcgttctctgcgctgccctgtttgcctgcaacactggagagggcgtcgccggagtctctggatcacccgtgggagagcgtgaggtcaaaggtcagtggcgcggcggcagcgggtcaccagctccagctccagcaccagcgcgcagctcctgcaggactgctggccgtggactcgctctgcctgccgcatgtcaagatggaggtggcagatctgcagagcatggctgaccgcagctcctacatggccctcaatattcaggaaggtctgaccccgaaccatctgaagaaagccaagctcatgttcttctacacgcgataccccagctcaaacctgctcaagaacttcttccctgacgtcaagttcaaccgctgcatcacgtctcagctcatcaagtggttcagtaacttccgggagttttactacatccagatggagaagtttgctcgtcaggccatcatcgacggcgttaccgatgtgaaagacatatcggtcagcagagagtccgagctcttccgcgcactcaacatgcactacaacaaagccaacgacttccaggttccagacagattcctggaggtggccgaagtcacgcttcaggagttttacagcgccatctcgctctccaaagactcagacccatcctggaagaaagccatctacaaggtgatctgcaaactggacagtgacgttcccgaggagttcaagtctccctcctacctgtaaagagagagagagagagcgccaccttcaggacactttcatccactccttcatcacacatgctccttttataggtcaatggtcagctttctattcaaatctacatgtgtatctgctgtgtgtgttgtttcacatcgtcagtgggatgggcttgtctattaatagtttgcagtttgggtttcagtgtaagatattttctgctttgtaaaccaccgtggacgaatgtgtggtgtgttttcaggtcaacaacgctcctcgttatgcagatttcgtggttcaatgtggatttgtctgtttactttctgttttcgaaatctaatgacacacaatcatgatctgtaagatatttagaaggaaacgtgtaaataagtatactttagctgtatgatgaacactgccgtttacatcagatgactatatatgattgcatgtagaagcatttccctcaaatcactcttatttatcctgtatagtttgcatatttttgttactcattatctagtggtgtgtggcttttcatttaacaagggttcacattgtagcagtttgttttgttgccgttgaggattctgatataatttatttctttaatttggaagaaatgtaaaacaataaataaagaaacaaac

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