LOCUS       NM_001114715            1542 bp    mRNA    linear   VRT 03-APR-2024
DEFINITION  Danio rerio leucine zipper protein 2 (luzp2), transcript variant 1,
            mRNA.
ACCESSION   NM_001114715
VERSION     NM_001114715.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1542)
  AUTHORS   Thyme,S.B., Pieper,L.M., Li,E.H., Pandey,S., Wang,Y., Morris,N.S.,
            Sha,C., Choi,J.W., Herrera,K.J., Soucy,E.R., Zimmerman,S.,
            Randlett,O., Greenwood,J., McCarroll,S.A. and Schier,A.F.
  TITLE     Phenotypic Landscape of Schizophrenia-Associated Genes Defines
            Candidates and Their Shared Functions
  JOURNAL   Cell 177 (2), 478-491 (2019)
   PUBMED   30929901
REFERENCE   2  (bases 1 to 1542)
  AUTHORS   Elkon,R., Milon,B., Morrison,L., Shah,M., Vijayakumar,S.,
            Racherla,M., Leitch,C.C., Silipino,L., Hadi,S., Weiss-Gayet,M.,
            Barras,E., Schmid,C.D., Ait-Lounis,A., Barnes,A., Song,Y.,
            Eisenman,D.J., Eliyahu,E., Frolenkov,G.I., Strome,S.E., Durand,B.,
            Zaghloul,N.A., Jones,S.M., Reith,W. and Hertzano,R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC154442.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC154442.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA2168446, SAMEA2168447
                                           [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1542
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="18"
                     /map="18"
     gene            1..1542
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /note="leucine zipper protein 2"
                     /db_xref="GeneID:100137118"
                     /db_xref="ZFIN:ZDB-GENE-060503-278"
     exon            1..309
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    230..232
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /note="upstream in-frame stop codon"
     CDS             248..1288
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="leucine zipper protein 2 isoform 1 precursor"
                     /protein_id="NP_001108187.1"
                     /db_xref="GeneID:100137118"
                     /db_xref="ZFIN:ZDB-GENE-060503-278"
                     /translation="

MKFIGAVYLLFLLPALSFNSSYEGLEKKLKEVFTERTGILRHLSKTSKELDSIKGNLQSLKNEDAVPKKDVQRILELSHKQRDEMKSLQAALQKQLDDAAERAEKQQATIKFLKMEMEKKTKIIKDLQQENKSLKNKLLSGNKLCDIHAEESKKIQAQLKELRYGKKDLIFKGQQLMDLENKLKVAKDELEKAALDKESQLKALKDTVHICFSSVLHSQTASLHRFPATPTNLLRYSALVNNSRVTFQQPHMKDIPKVPRITTTSKLPVSSAVMRRESTGPKDCQMVKVGSDCSHNQTESSSVMKKTFGHSQSKTPEQNGQGQARTAEESVKTDGELKKTQSDKHN"

     misc_feature    248..>862
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; Region: EnvC; COG4942"
                     /db_xref="CDD:443969"
     sig_peptide     248..298
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     299..1285
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /product="Leucine zipper protein 2. /id=PRO_0000315277"
                     /note="propagated from UniProtKB/Swiss-Prot (A5D8S1.2)"
     misc_feature    302..304
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (A5D8S1.2); glycosylation site"
     misc_feature    638..640
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (A5D8S1.2); glycosylation site"
     misc_feature    731..817
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /note="propagated from UniProtKB/Swiss-Prot (A5D8S1.2);
                     Region: Leucine-zipper"
     misc_feature    968..970
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (A5D8S1.2); glycosylation site"
     misc_feature    1058..1285
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /note="propagated from UniProtKB/Swiss-Prot (A5D8S1.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1133..1135
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (A5D8S1.2); glycosylation site"
     exon            310..421
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            422..492
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            493..574
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            575..637
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            638..700
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            701..763
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            764..838
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            839..1006
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1111
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1183
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1531
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

tatttgaagccggagtgcctcgcactttcacatacacagaccgctcgcagcgttgcatctgtctgccgcggcgtgtgtgcctgcattaacgcgcgtgtgcaccacagacagagagagcgagagagagagagagagagagagagagagtggcgagccaaccaggagctaaagggagaagggaaaagcgagcgatcgagagaaaaagggggaaagagaaacgccgagtgcatgagagcaagacaaagcaatgaaattcatcggagccgtttacctcctgttcctcctccctgctttaagcttcaacagcagctatgaggggctggaaaagaagctgaaggaggttttcacagagaggacaggaattttacgacatctctccaaaacatcaaaggaactggacagcataaaaggaaacctgcagtcactgaagaatgaggatgctgtgcccaagaaggatgtgcagaggatcctggagctcagtcacaagcaaagggatgagatgaagtcactccaggcagctctgcagaaacaactggatgatgcagctgagcgtgcagagaaacagcaggccactataaagttcttaaagatggagatggaaaagaaaacgaaaatcatcaaagaccttcagcaagagaataaaagccttaagaacaaacttctgtccgggaacaagctctgtgacattcatgcagaagagtccaaaaaaatccaagcccaactgaaagagctgaggtatggcaaaaaggatttaatttttaagggtcaacagctgatggacttggagaacaaactcaaagtagccaaagatgaactggagaaggcagcgctggataaggagtcacagctaaaagccctgaaggacacagtgcatatctgcttctcgtctgttctacacagccagacagcaagtttacacagatttccagccacaccaaccaacctgttgaggtattcagccttggtcaacaactccagagtcacctttcagcagccacacatgaaggacatcccgaaagttccccggatcacaacaacaagtaaattgcctgtgagcagtgcggtaatgaggagagagagcacggggcccaaagactgccagatggtgaaggtgggatcagactgttcccacaatcagactgaaagctcatctgtgatgaaaaagacatttggacacagtcagtcgaagaccccagagcagaacggacaaggccaggcaaggacagcagaggaaagtgtgaaaacagatggggagctaaaaaagacacaatcggacaaacacaactgaagggacagtggaagacttggcagattttctgcatggtaaaaaaatgatgtcagatctgtttaagcccctcttcgttcactgagcttataagcacacacacacagatacatatgcacacaaacacgcgcacacacacacacactgtagccaaacacaatctacatacactaaatactcattctaacactgctaatgtagaaaagaaattcccaaaattaaattttgaacttttttaataaaaaaaaaaaaaaaaa

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