LOCUS       NM_001080573            2204 bp    mRNA    linear   VRT 16-SEP-2024
DEFINITION  Danio rerio dystrobrevin, beta b (dtnbb), mRNA.
ACCESSION   NM_001080573 XM_683158
VERSION     NM_001080573.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2204)
  AUTHORS   Bayes A, Collins MO, Reig-Viader R, Gou G, Goulding D, Izquierdo A,
            Choudhary JS, Emes RD and Grant SG.
  TITLE     Evolution of complexity in the zebrafish synapse proteome
  JOURNAL   Nat Commun 8, 14613 (2017)
   PUBMED   28252024
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2204)
  AUTHORS   Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I,
            Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y and
            Bobe J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2204)
  AUTHORS   Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
            Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
            Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
            GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
            Hertzano R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2204)
  AUTHORS   Bohm S, Jin H, Hughes SM, Roberts RG and Hinits Y.
  TITLE     Dystrobrevin and dystrophin family gene expression in zebrafish
  JOURNAL   Gene Expr Patterns 8 (2), 71-78 (2008)
   PUBMED   18042440
REFERENCE   5  (bases 1 to 2204)
  AUTHORS   Jin H, Tan S, Hermanowski J, Bohm S, Pacheco S, McCauley JM,
            Greener MJ, Hinits Y, Hughes SM, Sharpe PT and Roberts RG.
  TITLE     The dystrotelin, dystrophin and dystrobrevin superfamily: new
            paralogues and old isoforms
  JOURNAL   BMC Genomics 8, 19 (2007)
   PUBMED   17233888
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from DQ516345.1.
            
            On Mar 11, 2007 this sequence version replaced XM_683158.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ516345.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA3505374,
                                           SAMEA3505383 [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2204
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="17"
                     /map="17"
     gene            1..2204
                     /gene="dtnbb"
                     /gene_synonym="bdtn; btnb; dtnb"
                     /note="dystrobrevin, beta b"
                     /db_xref="GeneID:559786"
                     /db_xref="ZFIN:ZDB-GENE-070117-3"
     CDS             1..1707
                     /gene="dtnbb"
                     /gene_synonym="bdtn; btnb; dtnb"
                     /codon_start=1
                     /product="dystrobrevin, beta b"
                     /protein_id="NP_001074042.1"
                     /db_xref="GeneID:559786"
                     /db_xref="ZFIN:ZDB-GENE-070117-3"
                     /translation="

MIEEGSKSSKSMVEKRQLFMEMRAQNFDVIRLSTYRTACKLRFVQKRCNLHLVDVWNMIEAFRDNGLSTLDHNAEINVSRLETILSSIFYQLNKRLPTTHQINVEQSIGLLLNFIVATYDSEGHGKLTVFAMKAMLATMCGGKILDKLRYVFSQISDSNGVMVFAKFDQFLREVLKLPTAVFEGPSFGYTEHSVRTCFPQQKKILLNTFLDVLMADPPPQCLVWLPLMHRLANVENVFHPVECSYCRSESMMGFRYRCQQCHGYQLCQSCFWRGHASGPHSNQHQMKEHSSWKSPAKKLSHAISKSLGCMPIGEPPHPVFPEAAERPQDLAHTTTLESPSRLDEEHRLIARYAARLAAEASNSTQCPPSDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRHRKDELERRMSALQESRRELMVQLEGLMRLLKAQTGTSPHSSPSHSASCTMPMPIRSTSAGSTPTHTPQDCLAGVGDDVLDAFSQGVPRNLRNDLLVAADSITNTMSSLVKELHSVDDGLEEEEENMRNGREKTESE"

     misc_feature    160..642
                     /gene="dtnbb"
                     /gene_synonym="bdtn; btnb; dtnb"
                     /note="EF-hand-like motif found in dystrobrevins and
                     similar proteins; Region: EFh_DTN; cd16244"
                     /db_xref="CDD:320002"
     misc_feature    160..285
                     /gene="dtnbb"
                     /gene_synonym="bdtn; btnb; dtnb"
                     /note="EF-hand-like motif [structural motif]; Region:
                     EF-hand-like motif"
                     /db_xref="CDD:320002"
     misc_feature    310..414
                     /gene="dtnbb"
                     /gene_synonym="bdtn; btnb; dtnb"
                     /note="EF-hand-like motif [structural motif]; Region:
                     EF-hand-like motif"
                     /db_xref="CDD:320002"
     misc_feature    430..540
                     /gene="dtnbb"
                     /gene_synonym="bdtn; btnb; dtnb"
                     /note="EF-hand-like motif [structural motif]; Region:
                     EF-hand-like motif"
                     /db_xref="CDD:320002"
     misc_feature    571..642
                     /gene="dtnbb"
                     /gene_synonym="bdtn; btnb; dtnb"
                     /note="EF-hand-like motif [structural motif]; Region:
                     EF-hand-like motif"
                     /db_xref="CDD:320002"
     misc_feature    721..867
                     /gene="dtnbb"
                     /gene_synonym="bdtn; btnb; dtnb"
                     /note="Zinc finger, ZZ type. Zinc finger present in
                     dystrophin and dystrobrevin. The ZZ motif coordinates two
                     zinc ions and most likely participates in ligand binding
                     or molecular scaffolding. Dystrophin attaches actin
                     filaments to an integral membrane...; Region:
                     ZZ_dystrophin; cd02334"
                     /db_xref="CDD:239074"
     misc_feature    order(727..729,736..738,772..774,781..783,799..801,
                     808..810,838..840,850..852)
                     /gene="dtnbb"
                     /gene_synonym="bdtn; btnb; dtnb"
                     /note="Zinc-binding sites [ion binding]; other site"
                     /db_xref="CDD:239074"
     misc_feature    order(727..729,736..738,799..801,808..810)
                     /gene="dtnbb"
                     /gene_synonym="bdtn; btnb; dtnb"
                     /note="zinc cluster 1 [ion binding]; other site"
                     /db_xref="CDD:239074"
     misc_feature    order(730..732,763..765,769..771,787..789,793..795)
                     /gene="dtnbb"
                     /gene_synonym="bdtn; btnb; dtnb"
                     /note="putative charged binding surface [active]"
                     /db_xref="CDD:239074"
     misc_feature    order(766..768,811..813,856..858,865..867)
                     /gene="dtnbb"
                     /gene_synonym="bdtn; btnb; dtnb"
                     /note="putative hydrophobic binding surface [active]"
                     /db_xref="CDD:239074"
     misc_feature    order(772..774,781..783,838..840,850..852)
                     /gene="dtnbb"
                     /gene_synonym="bdtn; btnb; dtnb"
                     /note="zinc cluster 2 [ion binding]; other site"
                     /db_xref="CDD:239074"
     misc_feature    940..>1257
                     /gene="dtnbb"
                     /gene_synonym="bdtn; btnb; dtnb"
                     /note="type I restriction enzyme EcoKI subunit R;
                     Provisional; Region: hsdR; PRK11448"
                     /db_xref="CDD:236912"
     misc_feature    <1135..>1374
                     /gene="dtnbb"
                     /gene_synonym="bdtn; btnb; dtnb"
                     /note="Uncharacterized conserved protein YhaN, contains
                     AAA domain [Function unknown]; Region: YhaN; COG4717"
                     /db_xref="CDD:443752"
     exon            1..67
                     /gene="dtnbb"
                     /gene_synonym="bdtn; btnb; dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            68..148
                     /gene="dtnbb"
                     /gene_synonym="bdtn; btnb; dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            149..362
                     /gene="dtnbb"
                     /gene_synonym="bdtn; btnb; dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            363..448
                     /gene="dtnbb"
                     /gene_synonym="bdtn; btnb; dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            449..603
                     /gene="dtnbb"
                     /gene_synonym="bdtn; btnb; dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            604..709
                     /gene="dtnbb"
                     /gene_synonym="bdtn; btnb; dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            710..876
                     /gene="dtnbb"
                     /gene_synonym="bdtn; btnb; dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1001
                     /gene="dtnbb"
                     /gene_synonym="bdtn; btnb; dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1092
                     /gene="dtnbb"
                     /gene_synonym="bdtn; btnb; dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1178
                     /gene="dtnbb"
                     /gene_synonym="bdtn; btnb; dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1292
                     /gene="dtnbb"
                     /gene_synonym="bdtn; btnb; dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1389
                     /gene="dtnbb"
                     /gene_synonym="bdtn; btnb; dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1549
                     /gene="dtnbb"
                     /gene_synonym="bdtn; btnb; dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1639
                     /gene="dtnbb"
                     /gene_synonym="bdtn; btnb; dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1693
                     /gene="dtnbb"
                     /gene_synonym="bdtn; btnb; dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1727
                     /gene="dtnbb"
                     /gene_synonym="bdtn; btnb; dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..2204
                     /gene="dtnbb"
                     /gene_synonym="bdtn; btnb; dtnb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

atgattgaagagggaagtaaaagcagcaagtctatggtggagaagagacagctcttcatggagatgagggctcaaaactttgatgtcattcgcctttcaacgtacaggacagcatgtaagctacgatttgtccagaaacgctgcaaccttcacctagtggatgtgtggaacatgatcgaagcttttcgcgacaacgggttgagcacgctagaccacaacgccgagattaacgtgtcccgcctggagaccattttgtcctcaatcttctaccagctcaacaagcggctgcccaccacgcaccagataaacgtggagcagtccatcggcctgctgctaaacttcatcgtggccacttatgacagtgaaggccatgggaaactcacagtgtttgctatgaaggcaatgctagctacgatgtgtggtggtaaaatactggataaattacgttatgtattttcccagatctcagactccaacggggtgatggtctttgccaaatttgaccagttcctgagggaggtgttgaagctcccgacggcagtgttcgaggggccttcgttcggctacactgagcactccgtgagaacatgcttccctcagcagaagaagatcttgctgaatacgtttttggatgtgttgatggcagatccacccccgcagtgcctcgtatggctacctctcatgcaccgactcgctaatgtagagaatgtcttccatccagtggaatgttcatactgccggagtgagagcatgatgggttttcggtaccgctgccagcagtgtcatggctaccagctttgtcagagctgcttttggcgcggtcatgccagcggccctcatagcaaccagcaccagatgaaggagcactcatcatggaagtctccagcaaagaagctcagccacgccatcagtaaatctctgggctgcatgccgatcggagagcctccgcatcctgtgtttcccgaggcagcagaaagacctcaggatctcgcacacactaccactcttgagagtcccagccgactggatgaagagcatcgtctcattgctcgatatgcggctcgtctggcagccgaagccagcaactccactcaatgccctccgtctgatctaagcttcaactttgatgctaataagcagcagcggcaactcattgcagagctggagaataaaaacagggagatcctgcaggagatccagcgtttgcgtctggaacatgaacaggcttctcaaccgacccctgaaaaagcccagcagaacccaacacttctggcagagctacgactgctgcggcacagaaaagatgagctggagaggcgcatgtcagctctgcaggagagcaggagagagctgatggtccagctggagggcctcatgaggctcctgaaggctcagacggggacctcgccacactcatcgcccagccacagtgccagctgcaccatgcctatgcccatccgctccacctcggccggctcaacccccacacacacgccgcaggactgtctggcaggggttggagacgacgtgctggatgccttctctcagggtgtaccaagaaatctccgtaatgatcttttagtggctgcagactcgatcacaaacactatgtcatcactagtgaaagaacttcactcagtggatgacgggcttgaggaagaggaagagaacatgcgaaatggacgggagaagactgagtcagagtaaaagaatataggatgtttcattgtcatcgctgaagcattctgggaaaaggcactccaccccttcattctgagccccaggaaaggaccagcgacttcaagaaggaaaaaatctccctggcattcgcacattgacaaatgcatgctcttccccaactgggtttcactatgtgaaacaagctcttcatcacaccttgcacagagcaagtgtatttattaggcagtatataaatatatataaatatatataaatatagctctatgtctatctgtataaactcatcgtcatcatcctgttactcatgagaatggcttgtttgtgctttcttactctctaaaaacgaacgcactgtgcattttcatcacgtcactcagatctgatctatgctgtagctatttttccccacgctgggagcatttttttgtttggttttgtatagctagtgtaatttttgttgtgttttaatgcatggagtggctctgctggattggtggagaggc

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