LOCUS       NM_001039831            2478 bp    mRNA    linear   VRT 11-AUG-2023
DEFINITION  Danio rerio taste receptor, type 1, member 2, tandem duplicate 1
            (tas1r2.1), mRNA.
ACCESSION   NM_001039831
VERSION     NM_001039831.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2478)
  AUTHORS   Del Vecchio G, Murashita K, Verri T, Gomes AS and Ronnestad I.
  TITLE     Leptin receptor-deficient (knockout) zebrafish: Effects on nutrient
            acquisition
  JOURNAL   Gen Comp Endocrinol 310, 113832 (2021)
   PUBMED   34089707
REFERENCE   2  (bases 1 to 2478)
  AUTHORS   Ohmoto M, Okada S, Nakamura S, Abe K and Matsumoto I.
  TITLE     Mutually exclusive expression of Galphaia and Galpha14 reveals
            diversification of taste receptor cells in zebrafish
  JOURNAL   J Comp Neurol 519 (8), 1616-1629 (2011)
   PUBMED   21452212
REFERENCE   3  (bases 1 to 2478)
  AUTHORS   Oike H, Nagai T, Furuyama A, Okada S, Aihara Y, Ishimaru Y, Marui
            T, Matsumoto I, Misaka T and Abe K.
  TITLE     Characterization of ligands for fish taste receptors
  JOURNAL   J Neurosci 27 (21), 5584-5592 (2007)
   PUBMED   17522303
REFERENCE   4  (bases 1 to 2478)
  AUTHORS   Alioto TS and Ngai J.
  TITLE     The repertoire of olfactory C family G protein-coupled receptors in
            zebrafish: candidate chemosensory receptors for amino acids
  JOURNAL   BMC Genomics 7, 309 (2006)
   PUBMED   17156446
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2478)
  AUTHORS   Ishimaru Y, Okada S, Naito H, Nagai T, Yasuoka A, Matsumoto I and
            Abe K.
  TITLE     Two families of candidate taste receptors in fishes
  JOURNAL   Mech Dev 122 (12), 1310-1321 (2005)
   PUBMED   16274966
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB200900.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB200900.1, AB289805.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA708836 [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2478
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Wako-Riken"
                     /db_xref="taxon:7955"
                     /chromosome="8"
                     /map="8"
     gene            1..2478
                     /gene="tas1r2.1"
                     /gene_synonym="tas1r2a"
                     /note="taste receptor, type 1, member 2, tandem duplicate
                     1"
                     /db_xref="GeneID:664691"
                     /db_xref="ZFIN:ZDB-GENE-070917-1"
     CDS             1..2478
                     /gene="tas1r2.1"
                     /gene_synonym="tas1r2a"
                     /note="taste receptor, type 1, member 2a; zfT1R2a; T1Rb2;
                     taste receptor, type 1, member 2.1"
                     /codon_start=1
                     /product="taste receptor type 1 member 2.1"
                     /protein_id="NP_001034920.1"
                     /db_xref="GeneID:664691"
                     /db_xref="ZFIN:ZDB-GENE-070917-1"
                     /translation="

MLLDSNYIFLLGFINSLFFNFCSLASDFSLEGDFLLGGLFPLHEIDQVTPVFTPETTECFRYTASPSGFQMLQVMRFAVEEINNSSTLLPNVSLGYELFDHCSNTRNFGSLLSFISKNGSIKPNVKRINYQSDVIALTGPYGSTRTISIAPLITMDLIPLVNYGASSSVLSNKLQYPSFVRTVPSNKDMINMIIHMIRWFGWNWVAFLGSKDAYSTDGLNLFNTYINNTGICVAYQERLNLDANYSQTLKKIDMLNINVIVVFAVPQYAVNIINTAIADNIRDKVWIASETWSMNQQLPREPGVEKIGTVIGITDRLLTLPGFNEFILKDMGTANVNASKFQTNTCNQKCDYCPSLTAEDIINENPSFSFAIYAAMYTIAHALHKVLQCDTKGCPKNTPFEPYMLLGEMKKLDFPLNGRQVKYDKNYDPPISYAVVLWHTDENSPQFEMVGTYDTYPKTVFTIDNSRFPWRNDSIPFSNCSVECKPGFARQPEGFHSCCFTCKKCPRNSYVDYSQDPYTCFPCAVSDWSDEGSTACKTRAVVYLEFTEITSIAVMISVLFLIILLIGILGLFTYNFNTPVVRSAGGDMCLLMLLCLTISSISVFFFFGKPSSVHCLVRNAIFAFFFTVCLSCLTVRSFQIICVFKMAAQFPRLHSLWVKHNGQWLFIAFSSFIHLISCVIWTTVSPDIPIADSWTFKDQTLLMCEMVNTITFTVVLFISWFLGFLCLVFSYMGRDLPKNYNEAKSITFSLILYYLSWIVYFTAYLSIKSKYIMLLNAMAQISSIYGILFSYFIPKSYIMIFQPQKNTAAYFQTSIQNYTQTISRS"

     misc_feature    82..1434
                     /gene="tas1r2.1"
                     /gene_synonym="tas1r2a"
                     /note="ligand-binding domain of the T1R taste receptor;
                     Region: PBP1_taste_receptor; cd06363"
                     /db_xref="CDD:380586"
     misc_feature    order(313..318,322..327,334..339,346..348,373..375,
                     442..444,451..453,463..468,658..660)
                     /gene="tas1r2.1"
                     /gene_synonym="tas1r2a"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:380586"
     misc_feature    order(421..423,490..498,640..642,871..873)
                     /gene="tas1r2.1"
                     /gene_synonym="tas1r2a"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:380586"
     misc_feature    1426..1587
                     /gene="tas1r2.1"
                     /gene_synonym="tas1r2a"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1645..2403
                     /gene="tas1r2.1"
                     /gene_synonym="tas1r2a"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    1648..1722
                     /gene="tas1r2.1"
                     /gene_synonym="tas1r2a"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    1756..1821
                     /gene="tas1r2.1"
                     /gene_synonym="tas1r2a"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    1846..1914
                     /gene="tas1r2.1"
                     /gene_synonym="tas1r2a"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    1993..2043
                     /gene="tas1r2.1"
                     /gene_synonym="tas1r2a"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    2122..2193
                     /gene="tas1r2.1"
                     /gene_synonym="tas1r2a"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    2227..2295
                     /gene="tas1r2.1"
                     /gene_synonym="tas1r2a"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    2308..2385
                     /gene="tas1r2.1"
                     /gene_synonym="tas1r2a"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     exon            1..182
                     /gene="tas1r2.1"
                     /gene_synonym="tas1r2a"
                     /inference="alignment:Splign:2.1.0"
     exon            183..480
                     /gene="tas1r2.1"
                     /gene_synonym="tas1r2a"
                     /inference="alignment:Splign:2.1.0"
     exon            481..1212
                     /gene="tas1r2.1"
                     /gene_synonym="tas1r2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1422
                     /gene="tas1r2.1"
                     /gene_synonym="tas1r2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1543
                     /gene="tas1r2.1"
                     /gene_synonym="tas1r2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..2478
                     /gene="tas1r2.1"
                     /gene_synonym="tas1r2a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

atgcttcttgatagcaattacattttccttttgggatttattaatagtttatttttcaatttttgttccttagcatcagacttcagcttggaaggagatttcttattgggtggtcttttccccttacatgaaatcgaccaagtgacccccgtttttacgccagagactactgaatgctttaggtacactgcctcaccatctggctttcagatgttgcaagtaatgaggtttgccgttgaagagattaataattccagcactcttctgcccaatgtttccctgggctatgaattgtttgaccattgttcaaatactaggaatttcggttcacttttaagtttcatctcaaaaaatggatccattaaacctaacgtaaaacgcatcaactatcaatctgatgtgatcgctttaacagggccatatggaagcacacggactatttcaatagcaccactgatcacaatggaccttataccattggtgaattatggagcttcaagctctgtattaagcaataaacttcagtatccctcttttgtaagaacagtgcccagcaacaaagacatgataaatatgattatccacatgatacggtggtttggatggaactgggtcgcctttcttggtagcaaagatgcttatagtacagatggactgaatctgtttaacacctacataaacaacactggcatttgtgtggcctatcaagaacgtctaaaccttgatgcaaactacagtcagacacttaaaaagattgatatgcttaacatcaatgtcattgtggtgtttgctgtgccacaatatgcagtcaacataatcaatactgccatagcggacaacatccgagacaaagtatggattgcgagtgaaacctggtctatgaatcaacagcttccaagggagccaggagttgagaaaatcggaacagtcattggcattacagaccgattgttgacattacctggatttaatgaattcatccttaaagatatggggacggctaatgttaatgccagtaaattccagacaaatacatgtaatcagaagtgtgattactgcccatcgttgacagcagaagacattattaacgagaatccctcattctccttcgctatctatgctgccatgtataccatagctcatgcgttacataaagttttgcaatgtgacacaaaaggctgcccgaaaaatacaccatttgagccatatatgcttctgggagagatgaaaaaactggattttccactcaatggacgacaagtgaaatatgataaaaattatgatccacccatcagttatgctgttgtactctggcacacagatgagaattccccacagtttgagatggtgggcacgtatgacacatatccaaaaactgtttttaccattgacaactcgcgctttccttggcgtaacgattctatccctttctcaaactgctctgttgagtgtaaaccgggattcgcaaggcaacctgaaggttttcatagttgctgttttacgtgtaaaaaatgcccacgtaacagctatgtggattattcacaggatccctatacctgctttccatgtgcggtgagtgattggtctgatgagggcagtacagcatgtaagacacgagctgttgtctacctcgagtttacagaaatcacctcaattgctgtcatgatttctgtcttgttccttattattcttcttattggcatattgggccttttcacctacaatttcaacacacccgtggtgaggtctgctggcggagacatgtgtctccttatgttgctctgcctgactatttctagcataagtgtgttctttttcttcggaaaaccttcatctgtacattgcctcgtgagaaatgccatatttgcttttttcttcactgtctgtctttcatgtttgactgttcgatcttttcagattatttgcgtttttaaaatggctgctcagttccctagattgcacagcctatgggttaaacataatggccaatggctatttattgcattttcttcatttattcacttaatttcttgtgtgatatggacgactgtctctcctgatatacccatcgctgactcgtggacttttaaagatcaaactcttctcatgtgtgaaatggtaaacactatcacttttactgtagttttgtttataagctggtttctcggtttcctgtgtctcgtgttttcatacatgggaagagatctgccaaaaaattacaatgaggccaaatcaataaccttcagtctcattctgtactatctgagctggattgtgtacttcaccgcatacctctcaatcaaaagtaaatacattatgcttctgaacgcaatggcccagatatctagcatttatggaattctcttcagctatttcattccaaaatcttacataatgatattccagccacagaagaacactgctgcatactttcagacatctattcaaaattacactcaaaccattagtaggtcttag

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