LOCUS       NM_001011661             558 bp    mRNA    linear   VRT 20-NOV-2022
DEFINITION  Danio rerio guanylate cyclase activator 1d (guca1d), mRNA.
ACCESSION   NM_001011661
VERSION     NM_001011661.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 558)
  AUTHORS   Dong XR, Wan SM, Zhou JJ, Nie CH, Chen YL, Diao JH and Gao ZX.
  TITLE     Functional Differentiation of BMP7 Genes in Zebrafish: bmp7a for
            Dorsal-Ventral Pattern and bmp7b for Melanin Synthesis and Eye
            Development
  JOURNAL   Front Cell Dev Biol 10, 838721 (2022)
   PUBMED   35372349
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 558)
  AUTHORS   Shi WJ, Huang GY, Jiang YX, Ma DD, Chen HX, Huang MZ, Hou LP, Xie L
            and Ying GG.
  TITLE     Medroxyprogesterone acetate affects eye growth and the
            transcription of associated genes in zebrafish
  JOURNAL   Ecotoxicol Environ Saf 193, 110371 (2020)
   PUBMED   32114246
REFERENCE   3  (bases 1 to 558)
  AUTHORS   Shi WJ, Jiang YX, Ma DD, Huang GY, Xie L, Chen HX, Huang MZ and
            Ying GG.
  TITLE     Dydrogesterone affects the transcription of genes in visual cycle
            and circadian rhythm network in the eye of zebrafish
  JOURNAL   Ecotoxicol Environ Saf 183, 109556 (2019)
   PUBMED   31509926
REFERENCE   4  (bases 1 to 558)
  AUTHORS   Lim S, Scholten A, Manchala G, Cudia D, Zlomke-Sell SK, Koch KW and
            Ames JB.
  TITLE     Structural Characterization of Ferrous Ion Binding to Retinal
            Guanylate Cyclase Activator Protein 5 from Zebrafish Photoreceptors
  JOURNAL   Biochemistry 56 (51), 6652-6661 (2017)
   PUBMED   29172459
REFERENCE   5  (bases 1 to 558)
  AUTHORS   Pinto CL, Kalasekar SM, McCollum CW, Riu A, Jonsson P, Lopez J,
            Swindell EC, Bouhlatouf A, Balaguer P, Bondesson M and Gustafsson
            JA.
  TITLE     Lxr regulates lipid metabolic and visual perception pathways during
            zebrafish development
  JOURNAL   Mol Cell Endocrinol 419, 29-43 (2016)
   PUBMED   26427652
REFERENCE   6  (bases 1 to 558)
  AUTHORS   Sulmann S, Vocke F, Scholten A and Koch KW.
  TITLE     Retina specific GCAPs in zebrafish acquire functional selectivity
            in Ca2+-sensing by myristoylation and Mg2+-binding
  JOURNAL   Sci Rep 5, 11228 (2015)
   PUBMED   26061947
  REMARK    Erratum:[Sci Rep. 2015;5:13508. PMID: 26329014]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 558)
  AUTHORS   Fries R, Scholten A, Saftel W and Koch KW.
  TITLE     Zebrafish guanylate cyclase type 3 signaling in cone photoreceptors
  JOURNAL   PLoS One 8 (8), e69656 (2013)
   PUBMED   23940527
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 558)
  AUTHORS   Ratscho N, Scholten A and Koch KW.
  TITLE     Expression profiles of three novel sensory guanylate cyclases and
            guanylate cyclase-activating proteins in the zebrafish retina
  JOURNAL   Biochim Biophys Acta 1793 (6), 1110-1114 (2009)
   PUBMED   19168097
  REMARK    GeneRIF: Data show that high guanylate cyclase activities in larval
            eye preparations and the precisely controlled coexpression of
            guanylate cyclases and GCAPs 3, 4, and 7 coincide with the onset of
            visual function at 3-4 days post fertilization.
REFERENCE   9  (bases 1 to 558)
  AUTHORS   Behnen P, Scholten A, Ratscho N and Koch KW.
  TITLE     The cone-specific calcium sensor guanylate cyclase activating
            protein 4 from the zebrafish retina
  JOURNAL   J Biol Inorg Chem 14 (1), 89-99 (2009)
   PUBMED   18777180
REFERENCE   10 (bases 1 to 558)
  AUTHORS   Imanishi Y, Yang L, Sokal I, Filipek S, Palczewski K and Baehr W.
  TITLE     Diversity of guanylate cyclase-activating proteins (GCAPs) in
            teleost fish: characterization of three novel GCAPs (GCAP4, GCAP5,
            GCAP7) from zebrafish (Danio rerio) and prediction of eight GCAPs
            (GCAP1-8) in pufferfish (Fugu rubripes)
  JOURNAL   J Mol Evol 59 (2), 204-217 (2004)
   PUBMED   15486694
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY850384.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY850384.1, BC162987.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2168448, SAMEA3505370
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..558
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="21"
                     /map="21"
     gene            1..558
                     /gene="guca1d"
                     /gene_synonym="gcap4; si:rp71-1p14.1"
                     /note="guanylate cyclase activator 1d"
                     /db_xref="GeneID:494573"
                     /db_xref="ZFIN:ZDB-GENE-040724-231"
     CDS             1..558
                     /gene="guca1d"
                     /gene_synonym="gcap4; si:rp71-1p14.1"
                     /codon_start=1
                     /product="guanylate cyclase activator 1d"
                     /protein_id="NP_001011661.1"
                     /db_xref="GeneID:494573"
                     /db_xref="ZFIN:ZDB-GENE-040724-231"
                     /translation="

MGNNHASLDDILAEDMHHWYNKFMRESPSGLITLFELKSILGLQGMNEDANSYVDQVFCTFDMDRDGYIDFVEYIAAISLMLKGEINQKLKWYFKLFDQDGNGKIDKDELETIFTAIQDITRNRDIVPEEIVALIFEKIDVNGEGELTLEEFIEGAKEHPEIMDMLKILMDLTPVLLIIVEGRQK"

     misc_feature    82..228
                     /gene="guca1d"
                     /gene_synonym="gcap4; si:rp71-1p14.1"
                     /note="EF-hand, calcium binding motif; A diverse
                     superfamily of calcium sensors and calcium signal
                     modulators; most examples in this alignment model have 2
                     active canonical EF hands. Ca2+ binding induces a
                     conformational change in the EF-hand motif, leading to...;
                     Region: EFh; cl08302"
                     /db_xref="CDD:415501"
     misc_feature    <157..477
                     /gene="guca1d"
                     /gene_synonym="gcap4; si:rp71-1p14.1"
                     /note="Ca2+-binding protein, EF-hand superfamily [Signal
                     transduction mechanisms]; Region: FRQ1; COG5126"
                     /db_xref="CDD:444056"
     exon            1..195
                     /gene="guca1d"
                     /gene_synonym="gcap4; si:rp71-1p14.1"
                     /inference="alignment:Splign:2.1.0"
     exon            196..345
                     /gene="guca1d"
                     /gene_synonym="gcap4; si:rp71-1p14.1"
                     /inference="alignment:Splign:2.1.0"
     exon            346..433
                     /gene="guca1d"
                     /gene_synonym="gcap4; si:rp71-1p14.1"
                     /inference="alignment:Splign:2.1.0"
     exon            434..558
                     /gene="guca1d"
                     /gene_synonym="gcap4; si:rp71-1p14.1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

atgggtaacaaccatgccagtctggatgacatcctcgcggaggacatgcaccactggtataacaaattcatgagagagtctccgtcaggcctcatcactctctttgagctcaagtctattctggggctgcagggaatgaatgaggacgccaacagttacgtggatcaggtgttctgcactttcgacatggacagggatggatatatcgactttgtggagtacatcgctgctattagcttaatgctcaagggagaaatcaaccagaaactcaagtggtacttcaaactttttgaccaggatggaaacgggaagattgacaaggacgaattggaaacaatatttacagctatacaagacatcacaagaaatcgtgacattgtgccagaggaaatagtggcccttatatttgaaaagattgatgttaacggagagggtgaactgacactggaagagttcatcgaaggagctaaagaacatcccgaaattatggatatgctgaagatattgatggacctcactccagtcctattaataattgtcgaagggcgacagaaataa

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