LOCUS       NM_001003733            1880 bp    mRNA    linear   VRT 14-OCT-2021
DEFINITION  Danio rerio claudin 8.1 (cldn8.1), mRNA.
ACCESSION   NM_001003733
VERSION     NM_001003733.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1880)
  AUTHORS   Solis CJ, Hamilton MK, Caruffo M, Garcia-Lopez JP, Navarrete P,
            Guillemin K and Feijoo CG.
  TITLE     Intestinal Inflammation Induced by Soybean Meal Ingestion Increases
            Intestinal Permeability and Neutrophil Turnover Independently of
            Microbiota in Zebrafish
  JOURNAL   Front Immunol 11, 1330 (2020)
   PUBMED   32793187
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1880)
  AUTHORS   Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I,
            Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y and
            Bobe J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1880)
  AUTHORS   Shu Y, Lou Q, Dai Z, Dai X, He J, Hu W and Yin Z.
  TITLE     The basal function of teleost prolactin as a key regulator on ion
            uptake identified with zebrafish knockout models
  JOURNAL   Sci Rep 6, 18597 (2016)
   PUBMED   26726070
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1880)
  AUTHORS   McKee R, Gerlach GF, Jou J, Cheng CN and Wingert RA.
  TITLE     Temporal and spatial expression of tight junction genes during
            zebrafish pronephros development
  JOURNAL   Gene Expr Patterns 16 (2), 104-113 (2014)
   PUBMED   25460834
REFERENCE   5  (bases 1 to 1880)
  AUTHORS   Baltzegar DA, Reading BJ, Brune ES and Borski RJ.
  TITLE     Phylogenetic revision of the claudin gene family
  JOURNAL   Mar Genomics 11, 17-26 (2013)
   PUBMED   23726886
REFERENCE   6  (bases 1 to 1880)
  AUTHORS   Kumai Y, Bahubeshi A, Steele S and Perry SF.
  TITLE     Strategies for maintaining Na(+) balance in zebrafish (Danio rerio)
            during prolonged exposure to acidic water
  JOURNAL   Comp Biochem Physiol A Mol Integr Physiol 160 (1), 52-62 (2011)
   PUBMED   21600298
REFERENCE   7  (bases 1 to 1880)
  AUTHORS   Clelland ES and Kelly SP.
  TITLE     Tight junction proteins in zebrafish ovarian follicles: stage
            specific mRNA abundance and response to 17beta-estradiol, human
            chorionic gonadotropin, and maturation inducing hormone
  JOURNAL   Gen Comp Endocrinol 168 (3), 388-400 (2010)
   PUBMED   20553723
REFERENCE   8  (bases 1 to 1880)
  AUTHORS   Woods IG, Wilson C, Friedlander B, Chang P, Reyes DK, Nix R, Kelly
            PD, Chu F, Postlethwait JH and Talbot WS.
  TITLE     The zebrafish gene map defines ancestral vertebrate chromosomes
  JOURNAL   Genome Res 15 (9), 1307-1314 (2005)
   PUBMED   16109975
REFERENCE   9  (bases 1 to 1880)
  AUTHORS   Kollmar R, Nakamura SK, Kappler JA and Hudspeth AJ.
  TITLE     Expression and phylogeny of claudins in vertebrate primordia
  JOURNAL   Proc Natl Acad Sci U S A 98 (18), 10196-10201 (2001)
   PUBMED   11517306
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC077161.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC077161.1 [ECO:0000332]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1880
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="15"
                     /map="15"
     gene            1..1880
                     /gene="cldn8.1"
                     /gene_synonym="cldn8; cldn8b; wu:fa01e05; zgc:91900"
                     /note="claudin 8.1"
                     /db_xref="GeneID:445278"
                     /db_xref="ZFIN:ZDB-GENE-011018-1"
     exon            1..1856
                     /gene="cldn8.1"
                     /gene_synonym="cldn8; cldn8b; wu:fa01e05; zgc:91900"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..835
                     /gene="cldn8.1"
                     /gene_synonym="cldn8; cldn8b; wu:fa01e05; zgc:91900"
                     /note="claudin 8"
                     /codon_start=1
                     /product="claudin-8"
                     /protein_id="NP_001003733.1"
                     /db_xref="GeneID:445278"
                     /db_xref="ZFIN:ZDB-GENE-011018-1"
                     /translation="

MASGALEIVGMCVTIIGLIGVSASTGMPMWRVTAFIGENIIVMETRYEGLWMNCYRQANIRMQCKVYDSLLALTPDLQAARGLMCTSVALTGVGLLIAIVGMKCTACIQDNDRAKRMVLIISGCMILAGCFCCLIPVSWTGNAIIRDFYNPLLIDAQRRELGEALYIGWVSSAFLFAGGCIFICCSGSLDKGPDPKYMYSRNAPAPYVAYQPQPVAYHPQPRSVYSPSGPPSFIEQSYQPSRQQSFIQPSRQQSFIQPSRHPSARSAVAYL"

     misc_feature    32..565
                     /gene="cldn8.1"
                     /gene_synonym="cldn8; cldn8b; wu:fa01e05; zgc:91900"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:473919"
     misc_feature    608..>784
                     /gene="cldn8.1"
                     /gene_synonym="cldn8; cldn8b; wu:fa01e05; zgc:91900"
                     /note="YppG-like protein; Region: YppG; pfam14179"
                     /db_xref="CDD:372950"
ORIGIN      

cacacacacctctgcagtcatggcgagcggtgcgctggagatcgtgggaatgtgcgtgaccataatcggcctcatcggggtctcggccagcactgggatgcccatgtggcgcgtgaccgcgttcatcggagaaaacatcatcgtgatggagacccgctatgagggactgtggatgaactgctaccggcaggccaacattcggatgcagtgtaaagtgtacgactccctgctggcgctcactccggatctccaggccgctcgaggactcatgtgtacctccgtggctttgactggtgtgggtttactgatcgctattgttgggatgaaatgcacggcatgcattcaggacaacgatcgggccaagcgaatggttctgattatcagtggatgcatgatccttgccggatgcttctgctgcctgattcctgtctcctggactgggaatgccattattcgggacttctataatccactgctcatagacgctcagcgaagggaactaggggaggctttgtatatcggatgggtatcatctgcattcttgtttgccggaggatgcatctttatatgctgcagtggttctctagacaagggtccggatccgaagtatatgtactccaggaatgcacctgctccatatgtggcctaccagcctcaacctgtggcctaccacccgcagccacggtcagtgtacagcccgtccggcccaccgtcattcattgagcaatcataccaaccatccagacagcagtccttcattcagccttccagacagcagtcgttcatacagccctctcgtcatccatccgcccgcagcgctgtggcttatctctgaaatccagcaggactgtgtgtatttgcatttgtggttatgtgcaagcatgtttgtgtgtgttttagagaaatgaatgggacttctcttaaaagaaaaaaaaatgtaaagtctattaaaataacttggaagatagtcgtacatttcattttcgagattatttttgggaaaaaaactaacattacatttctaattctgctttttgaagcacatgaaagactgaaagatgagagaaaatgaagaaaagtactacgtggagcagaaaatggaacattttaaatggctttatgtgtaacaacgttggagctattttttttttcttgtttcaatgttctggacacatttttaatgcatttctacttttaacaaaagaaaaacaaacattttttaagaagttttagaaacacatgtaacatttcaaatggatttagatgtagcaaagttagtcatgcattacattttccttgttttttattctttggattgtttccggcaacttttaagtgttgcttctactttgttttaaatagaagcaagttaataactgtgacagatgaagaattgtttgaaatatttttaattgtcatgttaaagtaccgatcactcctcaggatgttgtcaagtgttacttgaggtatttttgactgaaaactgcactctaaataatgctgggttattgtaaaccaatggtctcgaactcaattcctggagggtcacatctttgtatagtttaacaaaaatgtgcagaggtgcggccctccaggagtttgagacctatgttttaaacaaacctttgggcaaatatggacagacccaaatagtatgatagaaaatgtgttgtttagttaaacatgaacccaaggttgggttagtctatttgtcatcataatgttgggtcattttagagtctaagactacaaactaaagttgtttcatattcatatgtcatgtttttttgttgttgttgtaaatatcaaagcacaaaaaaatgtaatgatttaattaaataaattgaaataaccttaaaaaaaaaaaaaaaaaaaaaaaa

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