LOCUS       NM_001002587             781 bp    mRNA    linear   VRT 05-OCT-2024
DEFINITION  Danio rerio lens intrinsic membrane protein 2.3 (lim2.3), mRNA.
ACCESSION   NM_001002587
VERSION     NM_001002587.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 781)
  AUTHORS   Wei,X.Y., Jia,P.P., Hu,H., Liu,L., Li,T.Y., Li,Y.Z. and Pei,D.S.
  TITLE     Multi-omics reveal mechanisms underlying chronic kidney disease of
            unknown etiology (CKDu) pathogenesis using zebrafish
  JOURNAL   Environ Pollut 337, 122524 (2023)
   PUBMED   37683759
REFERENCE   2  (bases 1 to 781)
  AUTHORS   Arcanjo,C., Armant,O., Floriani,M., Cavalie,I., Camilleri,V.,
            Simon,O., Orjollet,D., Adam-Guillermin,C. and Gagnaire,B.
  TITLE     Tritiated water exposure disrupts myofibril structure and induces
            mis-regulation of eye opacity and DNA repair genes in zebrafish
            early life stages
  JOURNAL   Aquat Toxicol 200, 114-126 (2018)
   PUBMED   29751158
REFERENCE   3  (bases 1 to 781)
  AUTHORS   Li,X.Q., Cai,H.C., Zhou,S.Y., Yang,J.H., Xi,Y.B., Gao,X.B.,
            Zhao,W.J., Li,P., Zhao,G.Y., Tong,Y., Bao,F.C., Ma,Y., Wang,S.,
            Yan,Y.B., Lu,C.L. and Ma,X.
  TITLE     A novel mutation impairing the tertiary structure and stability of
            gammaC-crystallin (CRYGC) leads to cataract formation in humans and
            zebrafish lens
  JOURNAL   Hum Mutat 33 (2), 391-401 (2012)
   PUBMED   22052681
REFERENCE   4  (bases 1 to 781)
  AUTHORS   Ye,M., Berry-Wynne,K.M., Asai-Coakwell,M., Sundaresan,P., Footz,T.,
            French,C.R., Abitbol,M., Fleisch,V.C., Corbett,N., Allison,W.T.,
            Drummond,G., Walter,M.A., Underhill,T.M., Waskiewicz,A.J. and
            Lehmann,O.J.
  TITLE     Mutation of the bone morphogenetic protein GDF3 causes ocular and
            skeletal anomalies
  JOURNAL   Hum Mol Genet 19 (2), 287-298 (2010)
   PUBMED   19864492
REFERENCE   5  (bases 1 to 781)
  AUTHORS   French,C.R., Erickson,T., French,D.V., Pilgrim,D.B. and
            Waskiewicz,A.J.
  TITLE     Gdf6a is required for the initiation of dorsal-ventral retinal
            patterning and lens development
  JOURNAL   Dev Biol 333 (1), 37-47 (2009)
   PUBMED   19545559
REFERENCE   6  (bases 1 to 781)
  AUTHORS   Vihtelic,T.S., Fadool,J.M., Gao,J., Thornton,K.A., Hyde,D.R. and
            Wistow,G.
  TITLE     Expressed sequence tag analysis of zebrafish eye tissues for
            NEIBank
  JOURNAL   Mol Vis 11, 1083-1100 (2005)
   PUBMED   16379021
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC076199.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC076199.1, EH998354.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505371
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..781
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="15"
                     /map="15"
     gene            1..781
                     /gene="lim2.3"
                     /gene_synonym="zgc:92719"
                     /note="lens intrinsic membrane protein 2.3"
                     /db_xref="GeneID:436860"
                     /db_xref="ZFIN:ZDB-GENE-040718-327"
     exon            1..103
                     /gene="lim2.3"
                     /gene_synonym="zgc:92719"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    72..74
                     /gene="lim2.3"
                     /gene_synonym="zgc:92719"
                     /note="upstream in-frame stop codon"
     exon            104..294
                     /gene="lim2.3"
                     /gene_synonym="zgc:92719"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..638
                     /gene="lim2.3"
                     /gene_synonym="zgc:92719"
                     /note="lens membrane protein mp19-3"
                     /codon_start=1
                     /product="lens intrinsic membrane protein 2.3"
                     /protein_id="NP_001002587.1"
                     /db_xref="GeneID:436860"
                     /db_xref="ZFIN:ZDB-GENE-040718-327"
                     /translation="

MYSFMGGGLFCAGVGNILLVISTATDYWMQYRQSSSYMHQGLWRYCVPGKCMTHTDSIAYWDATRAFMILATLACFFGMIIGVMAFINYSSFTGFDRTFAAGILYFISCFFVLLAMAVYTGMTVNYYGKRYGNWRFSWSYIMGWVSVVLTFFSGIFYMCAYRMHEPRGPMSR"

     misc_feature    120..590
                     /gene="lim2.3"
                     /gene_synonym="zgc:92719"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:473919"
     exon            295..444
                     /gene="lim2.3"
                     /gene_synonym="zgc:92719"
                     /inference="alignment:Splign:2.1.0"
     exon            445..579
                     /gene="lim2.3"
                     /gene_synonym="zgc:92719"
                     /inference="alignment:Splign:2.1.0"
     exon            580..757
                     /gene="lim2.3"
                     /gene_synonym="zgc:92719"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

caaaaaataactgccaatcgctcatggaaatctgcctgcgttggcataattcagcttcacactattaaatctgacaatatttttgggaaaagataaaaagcagtgtgtgtaggtgcaagatgtacagctttatgggaggtggattgttttgtgcaggagtgggaaacatactcctggtgatctccactgccaccgattactggatgcagtaccgccagtccagcagctacatgcaccagggcctatggcgctactgtgtacctggaaaatgcatgacacacacagacagcattgcatactgggacgccacccgggccttcatgatcctggccaccttagcttgtttctttggcatgatcatcggtgtcatggctttcatcaactactcctcttttaccggctttgacaggacctttgctgcgggaattctctatttcatttcatgcttctttgtgctgctggccatggctgtctacactggtatgacagtcaactactatgggaaacgttatgggaactggcggttctcttggtcatatataatgggctgggtttctgtggtgctcactttcttttcagggatcttctatatgtgtgcttaccggatgcatgaaccaagaggacccatgtcacgctgatgcttttcagttcagatccactacagtctgatcatgtcatccctgatcccttcattttagaactgtcatttatagtttattttagaattacagaactcaaataaatgactgatactgaaaaaaaaaaaaaaaaaaaaaaaaaa

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