LOCUS       NM_001032607            2732 bp    mRNA    linear   INV 04-MAY-2019
DEFINITION  Ciona intestinalis beta-catenin (cibeta-catenin), mRNA.
ACCESSION   NM_001032607
VERSION     NM_001032607.1
KEYWORDS    RefSeq.
SOURCE      Ciona intestinalis (vase tunicate)
  ORGANISM  Ciona intestinalis
            Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
            Cionidae; Ciona.
REFERENCE   1  (bases 1 to 2732)
  AUTHORS   Oda-Ishii I, Kubo A, Kari W, Suzuki N, Rothbacher U and Satou Y.
  TITLE     A Maternal System Initiating the Zygotic Developmental Program
            through Combinatorial Repression in the Ascidian Embryo
  JOURNAL   PLoS Genet. 12 (5), e1006045 (2016)
   PUBMED   27152625
  REMARK    GeneRIF: Third, Gata.a directs specific gene expression in the
            animal hemisphere domain, because beta-catenin/Tcf7 weakens the
            Gata.a-binding activity for target sites through a physical
            interaction in the vegetal cells. Thus, repressive regulation
            through protein-protein interactions among the maternal
            transcription factors is essential to establish the first distinct
            domains of gene expression in the chordate embryo.
            Erratum:[PLoS Genet. 2016 Oct 14;12 (10 ):e1006392. PMID: 27741234]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2732)
  AUTHORS   Rothbacher U, Bertrand V, Lamy C and Lemaire P.
  TITLE     A combinatorial code of maternal GATA, Ets and beta-catenin-TCF
            transcription factors specifies and patterns the early ascidian
            ectoderm
  JOURNAL   Development 134 (22), 4023-4032 (2007)
   PUBMED   17965050
  REMARK    GeneRIF: Initially distributed throughout the embryo, Ci-GATAa
            activity is progressively repressed in vegetal territories by
            accumulating maternal beta-catenin.
REFERENCE   3  (bases 1 to 2732)
  AUTHORS   Satou Y, Kawashima T, Shoguchi E, Nakayama A and Satoh N.
  TITLE     An integrated database of the ascidian, Ciona intestinalis: towards
            functional genomics
  JOURNAL   Zool. Sci. 22 (8), 837-843 (2005)
   PUBMED   16141696
REFERENCE   4  (bases 1 to 2732)
  AUTHORS   Imai KS, Hino K, Yagi K, Satoh N and Satou Y.
  TITLE     Gene expression profiles of transcription factors and signaling
            molecules in the ascidian embryo: towards a comprehensive
            understanding of gene networks
  JOURNAL   Development 131 (16), 4047-4058 (2004)
   PUBMED   15269171
REFERENCE   5  (bases 1 to 2732)
  AUTHORS   Satou Y and Satoh N.
  TITLE     Genomewide surveys of developmentally relevant genes in Ciona
            intestinalis
  JOURNAL   Dev. Genes Evol. 213 (5-6), 211-212 (2003)
   PUBMED   12736827
REFERENCE   6  (bases 1 to 2732)
  AUTHORS   Satou Y, Yamada L, Mochizuki Y, Takatori N, Kawashima T, Sasaki A,
            Hamaguchi M, Awazu S, Yagi K, Sasakura Y, Nakayama A, Ishikawa H,
            Inaba K and Satoh N.
  TITLE     A cDNA resource from the basal chordate Ciona intestinalis
  JOURNAL   Genesis 33 (4), 153-154 (2002)
   PUBMED   12203911
REFERENCE   7  (bases 1 to 2732)
  AUTHORS   Imai K, Takada N, Satoh N and Satou Y.
  TITLE     (beta)-catenin mediates the specification of endoderm cells in
            ascidian embryos
  JOURNAL   Development 127 (14), 3009-3020 (2000)
   PUBMED   10862739
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB210325.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB210325.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN07436332, SAMN07436333
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2732
                     /organism="Ciona intestinalis"
                     /mol_type="mRNA"
                     /db_xref="taxon:7719"
                     /chromosome="9"
                     /map="9"
     gene            1..2732
                     /gene="cibeta-catenin"
                     /gene_synonym="CTNNB1"
                     /note="beta-catenin"
                     /db_xref="GeneID:445806"
     misc_feature    50..52
                     /gene="cibeta-catenin"
                     /gene_synonym="CTNNB1"
                     /note="upstream in-frame stop codon"
     CDS             74..2383
                     /gene="cibeta-catenin"
                     /gene_synonym="CTNNB1"
                     /codon_start=1
                     /product="beta-catenin"
                     /protein_id="NP_001027779.1"
                     /db_xref="GeneID:445806"
                     /translation="

MAEMMMNRNEMVPDAKSQVRMWGWDSGIQSGATTASPSISGASHHDGNFPDTNQVLGEWQREFTMEEANQIHDQFVRTRADRVRDVLFPETMMEESGPVPSTQYESNTATSVQRLAEPSQQLKKAVVNLINYQDDADLATKAIPELTGLLNDDDQVVVQQAAQMVHMLSKKVASRQAIMNSPAMVSALVRAMQNATDPETQRYCTGALHNLSHHKQGLLSIFKSGGIPALVKMLSSPIESVVFYAITTLHNLLLHQEGAKEAVRLAGGLQKMVYLLSRDNVKFLAIDTDCLQILAYGNQESKLIILASNGPQELVRIMRTYDYEKLLWTTSRVIKVLSVCSSNKPAIVEAGGMQALGMHLGSPSQRLLQNCLWSLRNLSDAGTKQDHVENLLQMLVQLLSSNDINVVTCAAGILSNLTCNNMSNKTRVCQVGGIEALVRTVLQAGDREDITEPTVCALRHLTSRHPDAEMAQNAVRLHYGLPVLVKLLHPPSRWPLIKAVVGLIRNLALCAANHAALREHGAIPRLVQLLMRAHQDTQRRTSMASSHSQMSAAYVDGVRMEEIVEGTTGTLHILAREPHSRSVIRGLNTIPLFVQLLYSQVENIQRVAAGVLCELAQDKESADLIENEGASAPLTELLHSKNEGVATYAAAALFRMSEDKSQDYKKRLSVELTSSLFKDDGALYNGADLMDPCMQGYQHQMTPPMSHQSSVSSVHNSHHSGFPQAEGQQPMDFQQHLVPPADYPLPDLSNDLDLEPMIGVQQPWLDTDL"

     misc_feature    284..496
                     /gene="cibeta-catenin"
                     /gene_synonym="CTNNB1"
                     /note="alpha-catenin binding domain found in catenin
                     beta-1 (CTNNB1), catenin gamma (CTNNG) and similar
                     proteins; Region: CTNNAbd_CTNNB1-like; cd21719"
                     /db_xref="CDD:439240"
     misc_feature    order(287..298,308..313,317..325,332..337,344..346,
                     401..409,413..418,425..430,437..439,446..472)
                     /gene="cibeta-catenin"
                     /gene_synonym="CTNNB1"
                     /note="CNTTA binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:439240"
     misc_feature    500..>2038
                     /gene="cibeta-catenin"
                     /gene_synonym="CTNNB1"
                     /note="cellulose synthase-interactive protein;
                     Provisional; Region: PLN03200"
                     /db_xref="CDD:215629"
     misc_feature    500..577
                     /gene="cibeta-catenin"
                     /gene_synonym="CTNNB1"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    596..712
                     /gene="cibeta-catenin"
                     /gene_synonym="CTNNB1"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    734..829
                     /gene="cibeta-catenin"
                     /gene_synonym="CTNNB1"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    order(800..802,812..814,824..826,926..928,938..940,
                     950..952,1055..1057,1067..1069,1079..1081)
                     /gene="cibeta-catenin"
                     /gene_synonym="CTNNB1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:293788"
     misc_feature    851..961
                     /gene="cibeta-catenin"
                     /gene_synonym="CTNNB1"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    977..1084
                     /gene="cibeta-catenin"
                     /gene_synonym="CTNNB1"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    1103..1213
                     /gene="cibeta-catenin"
                     /gene_synonym="CTNNB1"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    1247..1324
                     /gene="cibeta-catenin"
                     /gene_synonym="CTNNB1"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    order(1295..1297,1307..1309,1319..1321,1427..1429,
                     1439..1441,1451..1453,1565..1567,1577..1579,1589..1591)
                     /gene="cibeta-catenin"
                     /gene_synonym="CTNNB1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:293788"
     misc_feature    1346..1462
                     /gene="cibeta-catenin"
                     /gene_synonym="CTNNB1"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    1487..1594
                     /gene="cibeta-catenin"
                     /gene_synonym="CTNNB1"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    1613..1798
                     /gene="cibeta-catenin"
                     /gene_synonym="CTNNB1"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    1814..1918
                     /gene="cibeta-catenin"
                     /gene_synonym="CTNNB1"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    1937..2041
                     /gene="cibeta-catenin"
                     /gene_synonym="CTNNB1"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
ORIGIN      

ataagtttttatttttattgttaaaaccttttatcctgcgttaaactgttgagactcaccactgcatatcagcatggctgaaatgatgatgaacagaaatgaaatggtgccggacgccaagtcccaggtccggatgtggggttgggattctggcattcagtcaggggcaaccacagcctccccatcaataagtggggcaagccaccacgatgggaacttccccgatacaaaccaagtactcggggaatggcaacgagagtttacaatggaagaagcaaaccaaatccatgatcagtttgtgcgcacacgtgccgatcgtgtccgcgacgtgctgttccctgaaaccatgatggaggaaagtgggcccgtcccaagcacacaatacgagtcgaacacggcaacatccgtgcagagattggcagaaccatcgcaacaacttaagaaggcagtggtaaacttgatcaattatcaggacgatgccgacctcgccacgaaagcgatccccgagttgactggtcttctcaatgatgacgaccaagtggttgttcaacaagcagcacaaatggtgcacatgttgtccaagaaagttgcgagtagacaagcgataatgaatagcccggccatggtgtcggctctcgttagagccatgcagaacgccaccgaccccgagacccagcgttattgtaccggcgccctacacaacttgtcgcatcacaaacaaggattgttgtcaatattcaaatccgggggaattcctgctcttgtcaaaatgctcagttccccaattgagtcggttgtgttctacgcgatcaccaccctgcataacctacttttgcaccaagagggagctaaagaggccgtgagattggcaggggggttgcagaaaatggtgtatctattgtcgcgtgacaacgtaaagtttctggcaattgacaccgattgtttacaaatcctagcttatggaaatcaagagagcaagttgatcattcttgcgagcaacggaccccaggaattggtccgcatcatgaggacttacgattatgagaagttattatggacgactagtcgcgtgatcaaggtgctgtcggtttgttcgagtaacaaaccagccatcgtagaagcaggtggaatgcaagcacttggcatgcaccttgggtcaccctcacaaaggctgttacaaaactgtttgtggagtcttcgaaacttatctgatgctggaaccaaacaagatcatgtggagaacttgctacagatgcttgtccagcttctatcatcgaatgacatcaacgtggttacatgcgctgcggggattctaagcaaccttacttgcaacaacatgagtaataagaccagagtgtgtcaggttggaggaatcgaagctttggtgcgcactgtgttgcaagctggtgatcgtgaggatatcacggaacccacagtgtgtgcgttgcgtcatcttacttcgcgtcacccagacgctgagatggcacaaaatgctgttcggttgcattacggcctcccagtgttggtcaaactgcttcacccaccttcaagatggccgctcattaaggctgttgttggtttgattagaaacttggctttgtgcgctgccaaccacgcggcacttcgtgagcatggggcgataccacggcttgtgcaactactaatgcgtgcccaccaagacacacagcgtaggacaagcatggcgtcgagtcatagccagatgtctgctgcttatgtggacggagtacgaatggaggaaatagtggaaggaacaactggaacactccatatattggctcgtgaacctcacagtagatcggtcatccgaggacttaacacaatccctctgtttgtgcaacttctttattcacaggttgagaacatccagcgggtggcagcaggcgtgttgtgcgaattagcgcaagacaaggaaagtgccgacctcatcgagaacgagggggcgagcgctccattgaccgagttgttgcattccaaaaatgaaggagttgccacgtacgcggctgctgcattattccgcatgtccgaggataaatcgcaagattacaagaagagattgtctgttgagttgacgagctccttgttcaaggatgatggagctttatataatggtgcggacctaatggacccctgcatgcaaggttaccaacaccagatgacccccccgatgtctcatcaaagctccgtcagttcagttcataactcgcaccattctgggttcccacaagcagaaggccaacaacccatggactttcaacaacacctcgtccccccggcagattacccgctaccagacctttcaaacgacttggaccttgaaccaatgattggtgttcaacaaccatggctcgatactgacctctaagggattggatgagggatgacgactttgtaaagactctacaatcatgaacattattgaaaccccggataatttttacttgtacagaacttttataatttgctgaatcatcattgaaggttttgctgaatcatgttggaagtgaatttcttaaaaagaaattttgttaaaattgttttcggaaaaatgttagtgaatgatttatggtgcttccatggtgattatgacatcacagccagttcgttttatattgtttttatgacgtagccttaaacctggtaaccatagcaactctgtagcttcgtgtgaataaaataaaatgtacagaaaataaaaaaaaaaaaaaaaaaaa

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