LOCUS       XM_074041446            3823 bp    mRNA    linear   ROD 19-MAY-2025
DEFINITION  PREDICTED: Castor canadensis nuclear factor kappa B subunit 1
            (Nfkb1), transcript variant X3, mRNA.
ACCESSION   XM_074041446
VERSION     XM_074041446.1
DBLINK      BioProject: PRJNA1254772
KEYWORDS    RefSeq.
SOURCE      Castor canadensis (American beaver)
  ORGANISM  Castor canadensis
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
            Castorimorpha; Castoridae; Castor.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_133394) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_047511655.1-RS_2025_05
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 05/09/2025
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3823
                     /organism="Castor canadensis"
                     /mol_type="mRNA"
                     /db_xref="taxon:51338"
                     /chromosome="9"
     gene            1..3823
                     /gene="Nfkb1"
                     /note="nuclear factor kappa B subunit 1; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 18 Proteins, and 100% coverage of the annotated
                     genomic feature by RNAseq alignments, including 32 samples
                     with support for all annotated introns"
                     /db_xref="GeneID:109682963"
     CDS             228..3143
                     /gene="Nfkb1"
                     /codon_start=1
                     /product="nuclear factor NF-kappa-B p105 subunit isoform
                     X3"
                     /protein_id="XP_073897547.1"
                     /db_xref="GeneID:109682963"
                     /translation="

MAEDNPYGGTGQIFHLNALPHTIFKAELFPPDMPLSTADGPYLQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCEDGICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTDACVRGYNPGLLVHPELGYLQAEGGGDRQLTDQEKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDFSPTDVHRQFAIVFKTPKYKDVNITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQRKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGAGGSTGNPGPGYGFPHYGFPTYGGITFHPGTTKSNAGMKHGIINTECENDPEGYDNSDDRETVNLSGKESKPTEQDKESGKSSSGNEVTLTYRVGVKEENACRFQDNLFLEKAMQLAKRHANALFDYAVTGDVKVLLAVQRHLTAVQDENGDSVLHLAIIHLHAQLVRDLLEVTSGLVSDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRSGADLSLLDRLGNSVLHLAAKEGHDTILSIVLKHRKAALLIDHPNGEGLNAIHIAVMSNSLPCLLLLVASGADVNARERKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTKLAALLKAAGADPLVENFEPLYDLDDPWENAGEDEGVVPGTTPLDMAANWQVFDILNGKPYEPEFTPDEQGDMKQLNEDAKLQLYKLLEIPDPDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEVSGGTIKELVEALRQMGYTEAIEVIQAAFCTSGTTVSSPKKNTSQAHLLPHSPSTRQHIDELQDSDSICDSGVETSFRKLSFTESLTGSSSLITLNKMPHNYGQEGPIEGKI"

     misc_feature    348..953
                     /gene="Nfkb1"
                     /note="N-terminal sub-domain of the Rel homology domain
                     (RHD) of nuclear factor of kappa B1 (NF-kappa B1); Region:
                     RHD-n_NFkB1; cd07935"
                     /db_xref="CDD:143651"
     misc_feature    order(390..392,396..401,405..410,417..428,651..653,
                     657..662,951..953)
                     /gene="Nfkb1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143651"
     misc_feature    972..1277
                     /gene="Nfkb1"
                     /note="IPT domain of the transcription factor NFkappaB and
                     related transcription factors. NFkappaB is considered a
                     central regulator of stress responses, activated by
                     different stressful conditions, including physical stress,
                     oxidative stress, and exposure to...; Region:
                     IPT_NFkappaB; cd01177"
                     /db_xref="CDD:238582"
     misc_feature    order(975..977,981..989,993..1001,1119..1127,1164..1166,
                     1200..1202,1257..1259,1266..1268,1272..1274)
                     /gene="Nfkb1"
                     /note="ankyrin protein binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:238582"
     misc_feature    order(981..986,990..992,1029..1031,1035..1037,1041..1043,
                     1140..1145,1152..1154,1158..1160)
                     /gene="Nfkb1"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238582"
     misc_feature    order(1044..1046,1050..1052,1143..1148)
                     /gene="Nfkb1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238582"
     misc_feature    1710..2531
                     /gene="Nfkb1"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    order(1848..1850,1854..1856,1866..1871,1878..1886,
                     1890..1895,1905..1907,1914..1916,1959..1961,1965..1967,
                     1971..1973,1983..1988,1995..2003,2007..2012,2022..2024,
                     2031..2033,2058..2060,2064..2066,2070..2072,2082..2087,
                     2094..2102,2106..2111,2121..2123,2130..2132)
                     /gene="Nfkb1"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    1848..1961
                     /gene="Nfkb1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1965..2060
                     /gene="Nfkb1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    order(2172..2174,2178..2180,2190..2195,2202..2210,
                     2214..2219,2229..2231,2238..2240,2265..2267,2274..2276,
                     2280..2282,2292..2297,2304..2312,2316..2321,2334..2336,
                     2343..2345,2370..2372,2376..2378,2382..2384,2394..2399,
                     2406..2414,2418..2420)
                     /gene="Nfkb1"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    2172..2267
                     /gene="Nfkb1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    2274..2372
                     /gene="Nfkb1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    2661..2885
                     /gene="Nfkb1"
                     /note="Death domain of the Nuclear Factor-KappaB1
                     precursor protein p105; Region: Death_NFkB1_p105; cd08797"
                     /db_xref="CDD:260063"
     polyA_site      3823
                     /gene="Nfkb1"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      

cgcgcgtcctgcgcttccctccgccggcgctgcggacatggcgcggggctgactggcccggcccggcccggtgagaccgcgcgccctatccgcacccgggctcgtccgggcttcggctccggccggccgctacctcttctgtccccaacgccgctggccagcgacgcccggagggggagcccgcaggcgcagggaggccgcgcgcggacccgccaccaggctccagaatggctgaagacaatccatatggagggactggacaaatatttcacttgaatgcattgccccatacaatatttaaagcagaattatttccaccagatatgccactgtcaacagcagatggcccataccttcaaatattagagcaacctaaacagagaggatttcgtttccgttatgtatgtgaaggcccatcacatggtgggcttcctggtgcatctagtgaaaagaacaagaagtcctatcctcaggtcaaaatctgcaactatgtgggacctgcaaaagttattgttcagttggtcaccaatggaaaaaatatccacttgcatgcccacagcctggtgggaaaacactgtgaggacgggatctgcactgtgactgctggacccaaggacatggtggtcggctttgcaaatttgggaatacttcatgtgacgaagaaaaaagtctttgaaacactggaggcacgaatgacggatgcatgtgtaaggggctataatcctggactgttggtgcaccctgaacttggctatctgcaggcagaaggtggaggggaccgacaactcacagatcaagaaaaggagcttatccggcaagcagcgctgcagcagacaaaggagatggatctcagcgtggtgcgcctcatgttcacggcttttctccctgacagcactgggagcttcacaaggcgtctggaacccgtggtatcagacgccatctatgacagcaaagcccccaatgcatccaacttgaaaattgtaagaatggacaggacagcaggatgtgtaactggaggggaagaaatttatcttctctgtgacaaagttcagaaggatgacatccagattcgattttatgaagaggaggaaaacggtggagtttgggagggatttggagatttttctcccacagatgtccatagacaatttgccattgtcttcaaaactccaaagtataaggatgtcaacattacgaaaccagcttctgtgtttgtccaacttcggaggaaatctgatttggaaactagcgaaccaaaaccttttctctactacccggaaatcaaagataaagaggaagtgcagaggaagcggcagaagctcatgcccaacttttcggatagtttcggtggtggcagtggtgcgggagctggaggcggaggcatgtttggtagtggcggtgcaggagggagtactggaaatccaggtccagggtatggctttccacactatggatttcctacatatggtgggattaccttccatcctggaaccactaaatccaatgctgggatgaagcatggaatcataaacactgaatgtgaaaatgaccctgaaggttatgacaacagtgatgacagagagactgtaaatctctctgggaaagaaagcaaacccacagaacaagataaggagtcgggcaagtccagcagcgggaatgaggttactctgacgtacagggtgggagtaaaggaagagaatgcttgtaggtttcaggataacctcttcctagagaaggccatgcagctcgccaaacgtcacgccaatgccctttttgactatgcagtaacgggagatgtgaaggtgctgctggctgtccagcgccatctcactgcagtgcaggatgagaatggagacagtgtcttacacttagccatcatccaccttcatgctcagcttgtgagagatctgctagaagtcacatctggtttggtttctgatgacattatcaacatgagaaacgatctgtaccagacacccttacacttggcagtgatcactaagcaggaagatgtggtggaggacttgctgaggtctggggccgacctgagccttctggaccgtttgggtaactctgttttgcacctagctgccaaagaaggacatgatacaattctcagtatcgtactcaaacacagaaaggcagcactacttattgaccaccccaatggggaaggtctgaatgccatacacatagccgtgatgagcaatagtctgccatgtctgctgctgctggtggcctctggggcagatgtcaatgctcgggagcggaagtctgggcgcacggcactgcacctggctgtggaacatgacaacatttctttggcgggctgcctactcctggagggtgatgcccatgtggacagtaccacctatgatggaactacacccttacatattgcagctgggagagggtccaccaaactggcagcgcttctcaaagcagcaggagcagatcccttggtagagaactttgagcctctgtatgacctagatgacccatgggagaatgctggagaggatgagggagtggtgcctggaaccacacctctggatatggctgccaactggcaggtgtttgacatattaaatgggaaaccatatgagccagagttcacacctgatgaacaaggagatatgaaacagcttaacgaagatgcaaagctacaactctacaagttgctagaaattcctgatccagacaaaaactgggctactctggcacagaaattaggtctggggatacttaataatgcctttcggctgagtcctgctccttctaaaactcttatggataactatgaggtctctgggggaactatcaaagagctggtggaggccttgcgacagatgggctacactgaggcaattgaagtgatccaggcagccttctgcacctcaggaaccacagtgtccagccccaagaagaacacctctcaggctcacttgctgccccactcaccttccacaaggcagcacatagatgagcttcaagacagtgacagcatctgtgacagtggtgtggagacatccttccgcaaactcagctttacagagtctctgactggcagcagctcattgataactctgaacaaaatgccccacaattacgggcaggaaggaccaatagaaggcaaaatttagcctacagacgatttccctcaccagtaaaccaaaaccctaaaattccagtgcatcgtcccaaagaaggaaggtaaagtgcatccagaggtgctcagaggagaaccagcctgccgggatcattctggatttccttccaggccttctaaacttggcttcctttcttggttcttacatgaattttagttggtccacgtacagatagtatatagcaatcacagcactcggggtgagctgacatgtcgctgggggtgacgggtttattgagctttaccggctgctgctggattacagctgcttcctgttgtccttgctgctgtccctctgctgccgtcccaatgtccccacctggtgatctttctagccgccatggcacaatgttcattcagattaaggattaagaaaagagatattttaaaatgagagtcacttgatatgcaataaaaaggcttattgctttttctaatgtgcttctctgtgatttgaaaaaaaaaaacccatgaacttattaatatttaaacatggctgcaatcagtgccgaaaatagtattttcccctttttctgcattttgctattgtaaatatgttttttagatcaaatactttaaaagaaaaaaaatgttggatataaaatgctattttttattttacttttataataaaaggaaaagcaaattgttgaa

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