LOCUS       XM_071060768            1962 bp    mRNA    linear   PLN 31-JAN-2025
DEFINITION  Madurella fahalii Cell death protease (KEX1), partial mRNA.
ACCESSION   XM_071060768
VERSION     XM_071060768.1
DBLINK      BioProject: PRJNA1216027
            BioSample: SAMD00817542
            Sequence Read Archive: DRR594085, DRR594086
KEYWORDS    RefSeq.
SOURCE      Madurella fahalii
  ORGANISM  Madurella fahalii
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Sordariomycetes; Sordariomycetidae; Sordariales; Sordariales
            incertae sedis; Madurella.
REFERENCE   1
  AUTHORS   Yoshioka,I., Fahal,A.H., Kaneko,S. and Yaguchi,T.
  TITLE     Itraconazole resistance in Madurella fahalii resulting from another
            homologue of gene encoding cytochrome P450 14-alpha sterol
            demethylase (CYP51)
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1962)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (30-JAN-2025) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (bases 1 to 1962)
  AUTHORS   Yaguchi,T. and Yoshioka,I.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-SEP-2024) Contact:Takashi Yaguchi Chiba University,
            Medical Mycology Research Center; 1-8-1 Inohana, Chuo-ku, Chiba,
            Chiba 260-8673, Japan
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. This record is derived from an annotated genomic
            sequence (NW_027263972).
            COMPLETENESS: incomplete on both ends.
FEATURES             Location/Qualifiers
     source          1..1962
                     /organism="Madurella fahalii"
                     /mol_type="mRNA"
                     /strain="IFM 68171"
                     /isolation_source="Mycetoma"
                     /host="Homo sapiens"
                     /culture_collection="IFM:68171"
                     /db_xref="taxon:1157608"
                     /chromosome="Unknown"
                     /geo_loc_name="Sudan"
                     /collection_date="2022"
     gene            <1..>1962
                     /gene="KEX1"
                     /locus_tag="MFIFM68171_05348"
                     /db_xref="GeneID:98176091"
     CDS             1..1962
                     /gene="KEX1"
                     /locus_tag="MFIFM68171_05348"
                     /note="BUSCO:EOG092623WR;
                     COG:E,O;
                     EggNog:ENOG503NVHT;
                     GO_component: GO:0005802 - trans-Golgi network [Evidence
                     IEA];
                     GO_function: GO:0004185 - serine-type carboxypeptidase
                     activity [Evidence IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA];
                     GO_process: GO:0006915 - apoptotic process [Evidence IEA];
                     InterPro:IPR001563;
                     InterPro:IPR018202;
                     InterPro:IPR029058;
                     MEROPS:MER0006006;
                     PFAM:PF00450;
                     SECRETED:SignalP(1-30)"
                     /codon_start=1
                     /product="Cell death protease"
                     /protein_id="XP_070916869.1"
                     /db_xref="GeneID:98176091"
                     /translation="

MALLGPSLAGWMRLPAIATALALSWTATLAVADGAAGDYFVHSLPGAPEGPLVKMHAGHIEITPEHNGNLFFWHFQNKHIANKQRTVIWLNGGPGCSSEDGALMEIGPYRVKDQDTLVYNEGAWNEFANVLFVDNPVGTGYSYADTNAYVSELDEMADQFITFLEKWYALFPEYEHDDIYIAGESYAGQHIPYIAKHILARNKLATTKHKWNLMGLLIGNGWISPPEQYDAYLQFAYQKGLVEKGSDAANKLEVQHRICQKQLAISEGVVDNQDCEKILQDILQYTATRGNDNQLQCYNMYDVRLKDTYPSCGMNWPPDLATVTPYLRRKDVTDALHVSPNKATGWVECNGQVHQKFHPVKSRPSVDLLPDLLAEIPIMLFSGAEDLICNHLGTEALISNMAWNGGRGFELSPGTWAPRRDWTFEGEAAGFWQEARNLTYVVFYNSSHMVPFDHPRRSRDMLDRFMGVDITNIGGRPTDSRLDGEKGPETTVGGAAGNGTADQQAEKEKLDKAKWEAYRRSGFVVLIVVAVAAALWLFFVWRDRRRRQGYQNLPGGGEASPVGRAGGPSSNSERGRTLAMFRSQRNRRDLEAGDFDESQLDDLTVQTPMTATAAEAYEERDTRYSLGGVSDDDEEEEGKENKNENEKANGGSS"

ORIGIN      

atggcccttcttggtccgtctcttgcgggctggatgcgcctgcctgccatcgctacagcgctcgctctatcatggacggcaaccttggccgtcgccgacggtgcagccggcgactattttgtccattcgctaccgggcgcacctgagggacctctggtaaagatgcacgctgggcacatcgagattacgcccgaacacaacggcaacctcttcttttggcatttccaaaataagcacatcgccaacaagcagcggaccgtcatctggctgaatggcggcccggggtgcagctcggaggacggcgcattgatggagattggcccctaccgagtgaaggaccaggacacgctcgtctacaatgaaggcgcctggaacgagttcgcaaatgtcctgttcgtcgacaaccccgtgggcaccggctacagctacgccgacaccaacgcctacgtgagcgagctggatgagatggccgaccagttcatcacctttttggagaagtggtacgccctgttcccagagtacgaacatgacgatatttacatcgccggagagtcctacgccggccagcacattccctacatcgcgaagcacatcctggctcggaacaagcttgccaccacgaaacacaaatggaacttgatgggcctccttatcggaaacggatggatctcgccgcccgagcagtatgacgcctacctccaattcgcctaccagaagggcctggtggaaaagggaagcgacgccgccaacaagctcgaagtccagcaccgtatctgtcagaagcagctcgccatcagcgagggcgtcgtcgacaatcaagactgcgaaaagatcctccaggacattttgcaatacacggccacccgcggcaacgacaaccaacttcaatgctacaacatgtacgacgtccgcctcaaagacacatatccatcgtgcggcatgaactggcccccagacctcgctaccgttacgccgtatctccgccgtaaagacgtcactgacgcccttcacgtcagccccaacaaagccactggctgggtggaatgtaacggccaagtccaccaaaagttccacccggtcaagtcccggccctcggttgacctcctcccggacctccttgccgaaatccccatcatgctcttctcgggtgccgaggacctcatctgcaaccacctcggcaccgaagcgctcatcagcaacatggcctggaacggcggccgcgggttcgagctctcccccgggacgtgggcgccccgccgcgactggaccttcgagggcgaggcggccggcttctggcaggaggcgcgcaacctgacgtacgtcgtcttctacaactccagccacatggtgccctttgaccacccgcgccgctcgcgcgacatgctcgaccgcttcatgggcgtcgacatcaccaacattggcgggcgtcccaccgacagccggctggacggcgagaaggggcccgagaccaccgtcggcggcgctgccggcaacggcaccgccgaccagcaggccgagaaggagaagctggacaaggccaagtgggaggcgtaccgccgctccggcttcgtcgtgctcatcgtggtggcggtggccgccgcgctgtggctgttcttcgtctggcgcgatcggaggcggaggcaggggtaccaaaaccttcccggcggtggagaggcgagtccggtcggaagggcgggcgggccttcgtcaaacagcgagcgggggaggactctggcgatgtttaggagtcagaggaaccggagggatctggaagcgggcgactttgacgagagccagttggatgatttgactgtgcaaacacccatgacggcaacggcggctgaggcgtacgaggagcgggatacgaggtacagcctgggaggggtaagcgacgacgacgaggaggaggaggggaaggagaacaagaacgagaacgagaaagcaaatggaggttcgtcgtga

//