LOCUS       XM_057783220            3930 bp    mRNA    linear   ROD 28-JUN-2023
DEFINITION  PREDICTED: Chionomys nivalis NRDE-2, necessary for RNA
            interference, domain containing (Nrde2), transcript variant X2,
            mRNA.
ACCESSION   XM_057783220
VERSION     XM_057783220.1
DBLINK      BioProject: PRJNA986173
KEYWORDS    RefSeq.
SOURCE      Chionomys nivalis (European snow vole)
  ORGANISM  Chionomys nivalis
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Cricetidae; Arvicolinae; Chionomys.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_080095) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_950005125.1-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/26/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3930
                     /organism="Chionomys nivalis"
                     /mol_type="mRNA"
                     /db_xref="taxon:269649"
                     /chromosome="10"
     gene            1..3930
                     /gene="Nrde2"
                     /note="NRDE-2, necessary for RNA interference, domain
                     containing; Derived by automated computational analysis
                     using gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 1 Protein"
                     /db_xref="GeneID:130883040"
     CDS             445..3450
                     /gene="Nrde2"
                     /codon_start=1
                     /product="nuclear exosome regulator NRDE2 isoform X2"
                     /protein_id="XP_057639203.1"
                     /db_xref="GeneID:130883040"
                     /translation="

MTDRKPDPANWEYKSLYRGDIARYKRKGDSCLGINPKKQCISWEGTSAVKKHSHKHLERYFTKKSVGLMHTEGIAVCGNTEPPSSEPVPFIPVKDSADVAPPVATWLNPLGIYDQSTTQWLQGQGPLEQEPKQPDSQRDRESAALKARVEEFNRKVRENPRDTQLWMAFVAFQDEVMRSPGLYALEDGEQEKHRKSLKLLLEKKLAVLERAIESNPSSVDLKLAKLQLCAEFWEPSALAKEWQKLLFLHPNNTDLWQRYLSFCQSQFGTFSVSKLHSLYGKCLSTLSAVKDGSILSHPVLPGTEEAMFALFLQQCHFLRQAGHSEKVISLFQAMVDFTFFKPDSVKELPTKVQVEFFEPFWDSGEPRVGEKGARGWRAWMHQQERGGWVLVNPDEDEEEPEEDDQEIKDKTLPRWQIWLAVERSRDQRHWRPWRPDKTKKQTEEDCEDPERQVLFDDIGQSLIRLSSPGLHFQLIEAFLQFLGVPSGFLPPASCLYLAMDESSVFDSELYDEKPLTYFNPSFSGISCVGYMEQLGCPRWTKGHSREGEDFIRNVFHLVLPLFSGKQKSQLCLSWLRYEVAKVIWCLHTKKKRLKSQGKNCKKLAKNLLKEPENRNNFCLWKQYAHLEWLLGNIEDARKVFDTALSMAGSNELKDRELCELSLLYAELEMELSPDSRGAATGRAVHVLTRLTESSPYGPYAGQVMATQVLKARKAYERALQDCLGQTCASDPAPAESLDCLGSLVKCFMLFQYLTVGIDAAVQIYGQVFAKLKGSVFPEGPGPEDSARSQSLSNVLEAVTLMHTSLLRFHMNSSVYPLAPLRETLSEALKLYPGNQVLWRAYVQIQNKSHSANKTRRFLDVVTRSAKHLEPWLFAIEAEKTRKRLVDSVQRVGGREVHATIPETGLTHRIRNLFENAIRSDKGSQCPLLWRMYLNFLVSLGNKERSKGVFYKALQSCPWAKVLYMDAMEYFPDELPEILDVMTEKELRVRLPLEELELLLED"

     misc_feature    451..729
                     /gene="Nrde2"
                     /note="MTR4-interacting domain (MID) found in nuclear
                     exosome regulator NRDE2 and similar proteins; Region:
                     NRDE2_MID; cd22200"
                     /db_xref="CDD:412062"
     misc_feature    order(451..465,472..477,487..492,496..498,502..546,
                     553..561,565..573,595..603,613..618,622..627,634..654,
                     679..690,700..729)
                     /gene="Nrde2"
                     /note="MTR4 binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:412062"
     misc_feature    895..1893
                     /gene="Nrde2"
                     /note="necessary for RNA interference; Region: NRDE-2;
                     pfam08424"
                     /db_xref="CDD:429988"
ORIGIN      

cttgtgaactgctgatagccccagtgatgctctcgagaagaccctgagatgaaagaactgataagagttcgtccttttgctcaatctccaggggacctgtgaccatcttccctcacttaactcctgagtcctctgaggtcacaactctccggtgagagtgatactagcaaaacagccacccaggttagcagaaagaagaagaaagagaaaaagaaaaagaggaaacatcagcaccacaagaaaactaagaggatacaggagcagtcgagcagcggtgggtctgagtcagacacagattctgggaaggacaggtcttccagaagcatcaaggacagtcagaaggaatctgagaaacccagtcagggaagtgatgctgttggtactgctgctgctggacaccggtccatttggctggaagacattcagactctagcagaagtcttcatgacagataggaaaccagatcctgccaactgggagtataaatctctttaccgaggggatatagcaaggtacaagaggaaaggagactcctgcctgggcattaatcctaagaaacagtgtatatcttgggaagggacttctgcagttaagaagcattcacacaagcacctggagcgctattttaccaagaagagtgtgggattaatgcacactgaggggattgctgtgtgtggtaacaccgagcctccctcctctgaaccagtcccgtttatcccagtgaaggactctgctgatgtggctcctcctgttgcaacatggctgaatcctctggggatttatgatcagtcaactacacagtggttacaaggacagggtccgctagagcaagaaccaaagcagccagactcacagcgggaccgggagagcgctgctcttaaggccagagtggaggagttcaacagaaaagtgcgggagaatcctcgggatactcagctgtggatggcctttgtagctttccaggatgaggtcatgaggagccctggcctgtatgcccttgaggacggagagcaggagaagcacaggaagtccctgaagctcctcctggagaagaagctggccgtgctagagcgagccatcgagagcaacccaagcagtgtggacctgaagctcgccaagctgcagctgtgtgcggagttctgggagcccagtgcgctggccaaggagtggcagaagctcctctttctgcatcccaacaacacggacctgtggcagcgctacctctccttttgccagagtcagtttggtaccttctctgtgtccaaactccacagtctgtatggcaagtgcttgagtaccttgtctgctgttaaggatggcagcatcttgtcccacccggtactaccaggcacagaggaggccatgtttgcactgtttcttcagcagtgccactttctgcggcaggccggccactcggagaaggtcatctctttgttccaggccatggttgacttcaccttcttcaagcctgacagtgtaaaagagctgcccaccaaagtacaggtggaattctttgaacccttctgggacagcggagagccccgtgttggggagaagggcgcccgaggctggcgggcgtggatgcaccagcaggagcgtggtggctgggtgcttgtcaatccagatgaggatgaggaggagccagaagaggatgaccaggagataaaagataagactctgcccaggtggcaaatctggcttgctgttgaacgttctcgagaccagaggcactggcggccctggcgtccagataagaccaagaagcaaacagaagaagactgtgaggaccccgagagacaggtgctgtttgatgacattgggcaatctctgatcagactttccagcccaggtcttcatttccaactcattgaggcctttctgcagttcttgggcgtgccttccggttttcttcctccagcctcctgcctttacctggccatggacgagagcagcgtctttgatagtgaactttatgatgaaaagcccttgacctacttcaacccttcattttcgggcattagctgtgttggctacatggagcagttgggctgtcctcgctggaccaaaggtcacagccgagagggcgaggattttatccgcaatgtcttccaccttgtgctgcctttgttctcaggcaagcagaagtctcagctctgcctctcctggttgcggtatgaggttgccaaggtcatttggtgtctacacactaaaaagaagcgattaaagtctcagggaaagaactgcaaaaaactagccaagaatctccttaaagagccagaaaaccgcaacaacttttgcctctggaaacagtatgcacacctggaatggttgcttggcaacatagaggatgccagaaaagtgttcgatacagcactcagcatggcaggcagcaatgagctgaaggaccgtgaactctgtgaactcagtctgctttatgccgagctggagatggaactgtcgcctgactcccgaggagcggccacaggccgagctgtccacgtgttaacgcgactgactgagagcagtccctacgggccctatgctgggcaggttatggccactcaggttctgaaagcccgaaaagcttatgaacgcgctctgcaggactgtctgggacagacttgtgcctcagacccagctcctgcagagtccttggactgcctggggagcctggtcaaatgctttatgcttttccagtatttgactgtcgggatcgatgctgctgtgcagatatatggacaggtgtttgccaagctgaagggctctgttttcccggaaggccctggcccggaggacagtgccaggtcccagagtttgagcaatgttctcgaggccgttaccctgatgcataccagtctgctgcgattccacatgaacagtagtgtgtaccctctggctccacttcgagagacgctctcagaggctctaaagctgtacccaggcaaccaggttctctggagggcatatgtacagattcagaataagtcccacagtgctaacaagaccaggagattcttggacgtagtcaccaggtctgccaaacacttggagccgtggctgtttgccatcgaagccgagaagacgaggaaaagactggtggactctgttcagagggtaggtggtagagaggtccacgccaccatcccagagactggccttacgcatcggatcaggaacttgtttgaaaatgcaattcggagcgacaagggcagccagtgcccccttctgtggaggatgtatttgaattttttggtttccttaggaaacaaggagagaagcaaaggtgtgttctacaaggccctccagagctgtccctgggcaaaggtgctgtacatggatgccatggagtacttcccagatgagctgccggagatcctggatgtgatgactgagaaggagcttcgtgtacgcctgcccctggaggagctggagctgctgctggaggactagagtcaacctccgaggaacggagccagtgaggacagtggggcccaggagagctccagctgtgcacgggcttactccactgtttgggtggggtttggacttactgttttacatattatatatgtgatcaactatgtacagatggagccaggccagtgataaaccttttatggtcgagatgtgtgcagctttttattccttctgctccactctgtgcattcgacactggcctgtcgcaccgcatgtgtttatgatcccgggctaggcctctgaccccagccacaggcctggcttgacgttgagacttcctcccgctttccctgggctggtaaccatccagcacagtagatggttatttaagcgtttcctgtcttgctctggtgaccagcaacgtttacaagggcctttgggtctgccaggcactgctcagaatctgccttccatcagaatccaggtgcccatgtgctcagcgggcagggtacc

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