LOCUS       XM_054350114            3634 bp    mRNA    linear   PRI 05-AUG-2025
DEFINITION  PREDICTED: Homo sapiens nuclear factor kappa B subunit 1 (NFKB1),
            transcript variant X1, mRNA.
ACCESSION   XM_054350114
VERSION     XM_054350114.1
DBLINK      BioProject: PRJNA807723
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060928) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3634
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     gene            1..3634
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /note="nuclear factor kappa B subunit 1; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 2 mRNAs, 139 ESTs, 773 long SRA reads, 6 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 77 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:4790"
                     /db_xref="HGNC:HGNC:7794"
                     /db_xref="MIM:164011"
     CDS             15..2924
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /codon_start=1
                     /product="nuclear factor NF-kappa-B p105 subunit isoform
                     X1"
                     /protein_id="XP_054206089.1"
                     /db_xref="GeneID:4790"
                     /db_xref="HGNC:HGNC:7794"
                     /db_xref="MIM:164011"
                     /translation="

MAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMALPTADGPYLQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCEDGICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQAEGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDFSPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQRKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITFHPGTTKSNAGMKHGTMDTESKKDPEGCDKSDDKNTVNLFGKVIETTEQDQEPSEATVGNGEVTLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMATSWQVFDILNGKPYEPEFTSDDLLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTSQAHSLPLSPASTRQQIDELRDSDSVCDSGVETSFRKLSFTESLTSGASLLTLNKMPHDYGQEGPLEGKI"

     misc_feature    141..746
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /note="N-terminal sub-domain of the Rel homology domain
                     (RHD) of nuclear factor of kappa B1 (NF-kappa B1); Region:
                     RHD-n_NFkB1; cd07935"
                     /db_xref="CDD:143651"
     misc_feature    order(183..185,189..194,198..203,210..221,444..446,
                     450..455,744..746)
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143651"
     misc_feature    765..1070
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /note="IPT domain of the transcription factor NFkappaB and
                     related transcription factors. NFkappaB is considered a
                     central regulator of stress responses, activated by
                     different stressful conditions, including physical stress,
                     oxidative stress, and exposure to...; Region:
                     IPT_NFkappaB; cd01177"
                     /db_xref="CDD:238582"
     misc_feature    order(768..770,774..782,786..794,912..920,957..959,
                     993..995,1050..1052,1059..1061,1065..1067)
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /note="ankyrin protein binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:238582"
     misc_feature    order(774..779,783..785,822..824,828..830,834..836,
                     933..938,945..947,951..953)
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238582"
     misc_feature    order(837..839,843..845,936..941)
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238582"
     misc_feature    1509..2291
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    order(1641..1643,1647..1649,1659..1664,1671..1679,
                     1683..1688,1698..1700,1707..1709,1752..1754,1758..1760,
                     1764..1766,1776..1781,1788..1796,1800..1805,1815..1817,
                     1824..1826,1851..1853,1857..1859,1863..1865,1875..1880,
                     1887..1895,1899..1904,1914..1916,1923..1925)
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    1641..1754
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1758..1853
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1965..2057
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    2067..2165
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    2460..2687
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /note="Death domain of the Nuclear Factor-KappaB1
                     precursor protein p105; Region: Death_NFkB1_p105; cd08797"
                     /db_xref="CDD:260063"
ORIGIN      

ctcccggcttcagaatggcagaagatgatccatatttgggaaggcctgaacaaatgtttcatttggatccttctttgactcatacaatatttaatccagaagtatttcaaccacagatggcactgccaacagcagatggcccataccttcaaatattagagcaacctaaacagagaggatttcgtttccgttatgtatgtgaaggcccatcccatggtggactacctggtgcctctagtgaaaagaacaagaagtcttaccctcaggtcaaaatctgcaactatgtgggaccagcaaaggttattgttcagttggtcacaaatggaaaaaatatccacctgcatgcccacagcctggtgggaaaacactgtgaggatgggatctgcactgtaactgctggacccaaggacatggtggtcggcttcgcaaacctgggtatacttcatgtgacaaagaaaaaagtatttgaaacactggaagcacgaatgacagaggcgtgtataaggggctataatcctggactcttggtgcaccctgaccttgcctatttgcaagcagaaggtggaggggaccggcagctgggagatcgggaaaaagagctaatccgccaagcagctctgcagcagaccaaggagatggacctcagcgtggtgcggctcatgtttacagcttttcttccggatagcactggcagcttcacaaggcgcctggaacccgtggtatcagacgccatctatgacagtaaagcccccaatgcatccaacttgaaaattgtaagaatggacaggacagctggatgtgtgactggaggggaggaaatttatcttctttgtgacaaagttcagaaagatgacatccagattcgattttatgaagaggaagaaaatggtggagtctgggaaggatttggagatttttcccccacagatgttcatagacaatttgccattgtcttcaaaactccaaagtataaagatattaatattacaaaaccagcctctgtgtttgtccagcttcggaggaaatctgacttggaaactagtgaaccaaaacctttcctctactatcctgaaatcaaagataaagaagaagtgcagaggaaacgtcagaagctcatgcccaatttttcggatagtttcggcggtggtagtggtgctggagctggaggcggaggcatgtttggtagtggcggtggaggagggggcactggaagtacaggtccagggtatagcttcccacactatggatttcctacttatggtgggattactttccatcctggaactactaaatctaatgctgggatgaagcatggaaccatggacactgaatctaaaaaggaccctgaaggttgtgacaaaagtgatgacaaaaacactgtaaacctctttgggaaagttattgaaaccacagagcaagatcaggagcccagcgaggccaccgttgggaatggtgaggtcactctaacgtatgcaacaggaacaaaagaagagagtgctggagttcaggataacctctttctagagaaggctatgcagcttgcaaagaggcatgccaatgcccttttcgactacgcggtgacaggagacgtgaagatgctgctggccgtccagcgccatctcactgctgtgcaggatgagaatggggacagtgtcttacacttagcaatcatccaccttcattctcaacttgtgagggatctactagaagtcacatctggtttgatttctgatgacattatcaacatgagaaatgatctgtaccagacgcccttgcacttggcagtgatcactaagcaggaagatgtggtggaggatttgctgagggctggggccgacctgagccttctggaccgcttgggtaactctgttttgcacctagctgccaaagaaggacatgataaagttctcagtatcttactcaagcacaaaaaggcagcactacttcttgaccaccccaacggggacggtctgaatgccattcatctagccatgatgagcaatagcctgccatgtttgctgctgctggtggccgctggggctgacgtcaatgctcaggagcagaagtccgggcgcacagcactgcacctggctgtggagcacgacaacatctcattggcaggctgcctgctcctggagggtgatgcccatgtggacagtactacctacgatggaaccacacccctgcatatagcagctgggagagggtccaccaggctggcagctcttctcaaagcagcaggagcagatcccctggtggagaactttgagcctctctatgacctggatgactcttgggaaaatgcaggagaggatgaaggagttgtgcctggaaccacgcctctagatatggccaccagctggcaggtatttgacatattaaatgggaaaccatatgagccagagtttacatctgatgatttactagcacaaggagacatgaaacagctggctgaagatgtgaagctgcagctgtataagttactagaaattcctgatccagacaaaaactgggctactctggcgcagaaattaggtctggggatacttaataatgccttccggctgagtcctgctccttccaaaacacttatggacaactatgaggtctctgggggtacagtcagagagctggtggaggccctgagacaaatgggctacaccgaagcaattgaagtgatccaggcagcctccagcccagtgaagaccacctctcaggcccactcgctgcctctctcgcctgcctccacaaggcagcaaatagacgagctccgagacagtgacagtgtctgcgacagcggcgtggagacatccttccgcaaactcagctttaccgagtctctgaccagtggtgcctcactgctaactctcaacaaaatgccccatgattatgggcaggaaggacctctagaaggcaaaatttagcctgctgacaatttcccacaccgtgtaaaccaaagccctaaaattccactgcgttgtccacaagacagaagctgaagtgcatccaaaggtgctcagagagccggcccgcctgaatcattctcgatttaactcgagaccttttcaacttggcttcctttcttggttcataaatgaattttagtttggttcacttacagatagtatctagcaatcacaacactggctgagcggatgcatctggggatgaggttgcttactaagctttgccagctgctgctggatcacagctgctttctgttgtcattgctgttgtccctctgctacgttcctattgtcattaaaggtatcacggtcgccacctggcattccttctgaccacagcatcattttgcattcaaattaagggttaagaaaagagatattttaaaatgagagtcacttgatgtgccattttaaaaaaaaaggcatattgctttttctaatgtggttatttctctgatttgcaaaaaaaaaaaaaaaaaaaaaatacttgtcaatatttaaacatggttacaatcattgctgaaaatggtattttcccccttttctgcattttgctattgtaaatatgttttttagatcaaatactttaaaggaaaaaatgttggatttataaatgctattttttattttacttttataataaaaggaaaagcaaattgatgacctca

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