LOCUS       XM_015485274            7431 bp    mRNA    linear   ROD 01-JUL-2022
DEFINITION  PREDICTED: Marmota marmota marmota argonaute RISC component 1
            (LOC107141957), transcript variant X2, mRNA.
ACCESSION   XM_015485274
VERSION     XM_015485274.2
DBLINK      BioProject: PRJNA298354
KEYWORDS    RefSeq.
SOURCE      Marmota marmota marmota (Alpine marmot)
  ORGANISM  Marmota marmota marmota
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
            Sciuromorpha; Sciuridae; Xerinae; Marmotini; Marmota.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_026000082) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jul 1, 2022 this sequence version replaced XM_015485274.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Marmota marmota marmota Annotation
                                           Release 101
            Annotation Version          :: 101
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 9.0
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7431
                     /organism="Marmota marmota marmota"
                     /mol_type="mRNA"
                     /sub_species="marmota"
                     /db_xref="taxon:9994"
                     /chromosome="Unknown"
                     /sex="male"
                     /tissue_type="Spleen"
                     /collected_by="Dr Markus Ralser"
     gene            1..7431
                     /gene="LOC107141957"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 6 mRNAs, 27 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 49 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:107141957"
     CDS             211..2784
                     /gene="LOC107141957"
                     /codon_start=1
                     /product="protein argonaute-1 isoform X2"
                     /protein_id="XP_015340760.1"
                     /db_xref="GeneID:107141957"
                     /translation="

MEAGPSGAAAGTYLPPLQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIKPDKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGEGKDRIFKVSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRNIDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQTVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGGRNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVTHPPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRFKPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKNERIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSHISGQSNGRDPQALAKAVQVHQDTLRTMYFA"

     misc_feature    310..702
                     /gene="LOC107141957"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:435368"
     misc_feature    730..882
                     /gene="LOC107141957"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:430160"
     misc_feature    883..1245
                     /gene="LOC107141957"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(1039..1041,1084..1086,1126..1128,1138..1140,
                     1192..1194,1213..1215,1219..1221)
                     /gene="LOC107141957"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1378..2655
                     /gene="LOC107141957"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1789..1791,1801..1803,1837..1848,1855..1857,
                     1879..1881,1888..1890,1900..1902,1912..1914)
                     /gene="LOC107141957"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(1993..1995,1999..2001,2209..2211,2623..2625)
                     /gene="LOC107141957"
                     /note="active site"
                     /db_xref="CDD:240015"
     polyA_site      7431
                     /gene="LOC107141957"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      

cagctggccgggcgctcgcagggggagctgctgcaggctccgcggcggcggcggcaacggaggctgcgggggcggcggcgcgagcggccgggcttgggggggtgccgagcccggcccgggagcccgagcagcgagagcgcgggatacctaggcccctcacgttggagtccacagtctccgggccgcctgacctccgcacgggtatatgggatggaagcgggaccctcgggagcagctgcgggcacctacctgccccccctgcagcaggtattccaggcacctcgacggcctggcattggcactgtggggaaaccaatcaagctcttggccaattactttgaggtggacattcctaagatcgacgtctaccactacgaggtggacatcaagccggataagtgtcctcgcagagttaatcgggaagtggtggaatacatggtccagcatttcaagcctcagatctttggtgatcgcaagcccgtgtatgatggaaagaagaacatttacactgtcacagcactgcctattggcaacgaacgggtcgactttgaggtgacaatccctggggaagggaaggatcgaatttttaaggtctccatcaagtggctagccattgtgagctggcgcatgctgcatgaggccctggtcagtggccagatccctgttcccctggagtcggtgcaagccttggatgtggccatgaggcacctggcatccatgaggtacacccctgtgggccgctccttcttctcaccgcctgagggctactaccacccgctggggggtgggcgcgaggtctggttcggctttcaccagtctgtgcgccctgccatgtggaagatgatgctcaacattgatgtctcagccactgccttctacaaggcgcagccagtgattgagttcatgtgtgaggtgttggacatcaggaacatagacgagcagcccaagcccctcacggactctcagcgtgttcgctttaccaaggaaattaagggcctgaaggtggaagtgacccattgtggacagatgaagaggaaataccgtgtgtgtaatgttacccgccgccctgctagccatcagacgtttcccttgcagctggaaagtggacagactgtagagtgcacagtggcacaatatttcaagcagaaatataaccttcagctcaagtatccccacctaccttgcctgcaagttggccaagaacaaaagcatacctatttgcccctagaggtctgtaacattgtggctgggcagcgctgcataaagaagctgactgacaaccagacttcaaccatgataaaggctacagctaggtcagccccagacagacaggaggagataagtcgcctgatgaagaatgccagctacaacctagatccctacatccaggaatttggaatcaaagtgaaagatgacatgacggaggtgacggggcgagtgctgccggcgcccatcttgcagtacggcggccggaaccgggccattgccacacccaatcaaggtgtttgggacatgcgggggaaacagttctacaatgggattgagatcaaagtctgggccatcgcctgcttcgcaccccaaaaacagtgtcgagaagaggtgctcaagaacttcacagaccagctgcggaagatttccaaggatgcagggatgcccatccagggtcagccttgtttctgcaaatacgcacaaggggctgacagcgtggagcccatgttccggcatctcaagaacacctactcagggctgcagctcattatcgtcatcctgccagggaagacgccagtgtatgctgaggtgaaacgagttggagatactcttttgggaatggcaacacagtgtgtgcaggtgaagaacgtggtcaagacctcacctcagactctatccaacctctgcctcaagatcaatgtcaaacttggtggcattaacaacatcctagtcccacaccagcgctctgctgtctttcaacagccagtgatattcctaggagcagatgttacacaccccccagcaggggatgggaaaaaaccttctatcacagcagtagtaggcagtatggatgcccaccccagccgatactgtgctactgtgcgggtacagcgaccacggcaggagatcattgaagacttgtcctacatggtgcgtgagctgctcatccaattctacaagtccacccgctttaagccgacgcgcatcatcttctatcgagatggggtcccagaaggccagcttccccagatcctccactatgagctactggccattcgcgatgcctgcatcaaactggaaaaggactaccagcctgggatcacttatattgtggtgcagaaacgccatcacacccgccttttttgtgctgacaagaatgagcgaattgggaagagtggtaacatcccagctgggaccactgtggacaccaacatcacccacccatttgagtttgacttctatctgtgcagccatgcaggcatccagggtaccagccgaccatcccattactatgtcctttgggatgacaaccgtttcacagcggatgagcttcagatattgacataccagctgtgccacacttatgtacgatgcacacgttccgtctctatcccagcaccagcctactatgcccgcctagtggctttccgggcacgataccacctggtggacaaggagcatgacagtggagaggggagccacatatcggggcagagcaatgggcgggacccccaggccctggccaaagccgtgcaggttcaccaggatactctgcgcaccatgtacttcgcttgaaggcagaacgctgttacctcactggatagaagaaagctttccaagccccaggagctgtgccgcccaaatccagaggaagcaaggaggagggaggtggggtagggaggagtgtaggaggccttgtttctttctacagagggggtgtaacggtggggaatagggccagcaagacagaccaccagccagaatctctgatattaacctcatgctccccacccctcacctcatctcgtcacatctggccctgaccccactggaccaagaggggcagcactggtgcccaccatacacacaggtgtctcatgtgactcacagtgctaactaaagactcatgcttgacagcttggtaaggtcagctctgcagccctgcggacaaaagctggtaggtttgggtttgctactttagttggaaaagtaaagggcttgagaaagtgggtgggaggagggaaggatttttttttttaggagccttaatcaaaaaaggtctagatttgtctaaaaagaaaaatgaaaccagacccagatcaatattttaggatactagatgttttcatgggttcagaatccagtttgtaggaagatttttaatgctaatagttttggttgctcctccccagctgccacccccacccaccacccttattcctctccacattttctaccccaccctacgcctccttcctgacagtcatccagccctcctagcaacacttaaggcactatggcacttagctctgaagtgacacgaccctgtcttccttccgcctgctggtgggtaaccagtgccttccctgtaatggtaatgctgcagaactgcaaccttttgtacctttctttgggggatggggtgggggtgggagaggaggtaggtggggaagaaatatcctgaacacaacaagcctccagccagaatgccagctattttgcatttaaaggaattgacttccacattcattgagctttggaaaagattacaacctcaagatggttaaaatccattgacatttgcactttcagacatgacaagtctcggagctgctgagatgactggcccttggcctttccacttttgcctcttttttccccatacctgccaccctgccctggtctagagttactttcatagcatttctcactcttggcttcttttttttccccctgatggtcaagtttcttgtgtttcaatatttcttaaatggggtgtcttataacagaagatccttaggtttaaaataagaaaaagaaaactaaatgttatttttataccacaacttgagtctattgccaaaatctggaaatcgctcccatgcctgatgagtttacatcccggaaacattgagccatcagaaggaactgtgtacctgacttgtcttctggcctggctaggtaaggggtggtggtctccccaaggtggagctcgggctctatccttcctctgtgcagaaaatacctttttcttgctgcaggctcccttctctgcactgtcctgcactctttcctgcaaatgcatcttcccttcctttggactggactgtcctttgactcatcccagattctagcatgtcctgtggacaggctgggaattttgctgctccctaatgcttctgtttacacaaaggaatttttcctggtttcccactagggcatgtgagtgggtggcatggtttttcctttttctttttctttctctttctttctttttttttttttttgtcttgagatatggggtggggtttggctctcttgcaagactggaaacgaagggggttcttatgctgaccttgaagcaaggtcccctctttccttggctgctgccccccccgtccgtccccccccccgtgtcctgaggagtttcaacttcagtggggaaattcctctttttgaagagcttgggcttgggtatccccctctggttatgaagccatggtaccttagatctagcccaggcttggagaccagctgggagaaggagggtctgaatcctggtctgtggagttagagctacccttttctttccaaggcagcccttgtgcagacccagatttgctatgcaaaacaatttatcccaggttctgttctggttggctacattgttcaacaacttcataaaacgtagcacaaacattcattatggagaaagcaacaggactgttgagtaactcctcctgtatttttttcctgctggctacagtatggggtgccccatgggcacaagcccagctgaaaaacagaatggagggctctgggaggaggcagcttactggagagcctacattccttacacaagtgcctaaagagagtgatgccaacactccatctgccctgtccatcgccttcacatacagtctacttcatgttctgtcaccctttagggagggagctctcctaggacagtgggctctgcatgttctctatttgggtacattttggggctgtgataagggcactattcctggagggtctagtcattcaccagcatttgcaaatgtccatagggaacaggtggcaggccctacttgcaggagcaagtttgtactctctccttctctatctctgcctcactctctccagttgtgttttaagctggggcttgaaaggcatatttggtcctttggcattgcacatgcctttgaagaaataaaagcaagagaagcagtttgggcaatgataagaaaattacttcttgcctaatgtaatggaaaaatatgtttgagacttgaaaaatacccttgacaatgttgattattcttgttcgaagggtgttacacgcacagtaagaagtggtgttgcaagcaagccaaagcttggtttaagtagtgcttcttaccaggctccaaggaagcactgagagggccctggttagactcatcctcttagacaggcctctaactccctttgttccactgttttgcctgccttttcctattctcactttccttggcttcctcttccttttttctgttcactcagcttgcttcctggccagcctgcctgcctgcctgcctatgtgatgatgaattctctgcatggctgcagtgatcccactgttagttgacaaagttaggcttatccccttgtctgcagaagaccaagaacctgctccccacacccagtggtattaaccctgggttggactatcctcaagcttacactagggcagagcagtaggtctgcccaactggcatgaaatcaggagggtttctgtcatttccatatttatccactccttggatctggtttctctcatattttctggttctgcttccttttctctttacctgagacttccctttgttgaggatattccagggttgagctatttgggtattcagggttggagggttagaagatagatacagaggaagaagggagtgtttggaagagaatggagagagtttggattaaagatgagaaaggaaagcagtgctctttgtccagtccaacacgaccctttggtgtcgaggtgctactgttgccttctggggttaaacctggggctattgttgctgggaacacttagaataaggctaaagagggtacctagaagtttgaaacctccctaaaaagctcctagtccccacctgtgagatagctcctctgtggtgtcctctttggctgagaagcagtgtttttggatagtttcttttcttttctttttttttttttgtccagaatgatgtgaataagactgcacacatgataaacagccaagaagacactgttttcttaccttgctgatgtggtatctgcaaggctagacctggcattctgtgtgacaaaaaaggatggaagctccttccttttcagggtagagaagtcatctcaaactagccaaaaggcagttttggaaacaatgttggggaaagtaatttttatttatttactgggtttgggcagatccaggatggtagctgggaagcctttcttcttcaagtctgatcatggcagggatatgcagggcactcttccctctaggccttctaagcagactggggaggagggaattctctggttttctctttccctccacttactaggacttgcctcctcccttggccgggagagaggctgggttggtgctctccccttactctactcctgacgtagaacctctggctgctgtttgggagcccaagaaagggagtggaaggaatgggctcaaaacaaaacaatgatgtggggaaggcagatttcctactttaaaaaggaaaatgggaaactctccaagaattgtgcaagtaaagacaatgtgtccaaatgcactgagtcccctggtgtagtagcaataaggaaaaatgaaatgactttcctgtacacacagtccaacctgattggtgtgtgatgttgcacttagcagccatgtggtgggcatgtgtgactactctgggtttcactttagtttctaaactttttatccctctcaagtccagcatggatggggaagtgtccctggagccccacagctgtgtacttgtttgcgtttgtttccctttgagatttgtgtttgtgtcctgctttgagctgtaccttgtccagtccattgtgaaattatcccagcagctgtattgtacagttccttcagaagcaagcaacagcagcagcacaattctgtgttttataaagacaacagtggcttctatttctaaa

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