LOCUS       XM_011616862            3932 bp    mRNA    linear   VRT 27-MAY-2025
DEFINITION  PREDICTED: Takifugu rubripes NRDE-2, necessary for RNA
            interference, domain containing (nrde2), mRNA.
ACCESSION   XM_011616862
VERSION     XM_011616862.2
DBLINK      BioProject: PRJNA543527
KEYWORDS    RefSeq.
SOURCE      Takifugu rubripes (Fugu rubripes)
  ORGANISM  Takifugu rubripes
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Neoteleostei;
            Acanthomorphata; Eupercaria; Tetraodontiformes; Tetradontoidea;
            Tetraodontidae; Takifugu.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_042286.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jul 5, 2019 this sequence version replaced XM_011616862.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_901000725.2-RS_2025_05
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 05/15/2025
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3932
                     /organism="Takifugu rubripes"
                     /mol_type="mRNA"
                     /db_xref="taxon:31033"
                     /chromosome="2"
     gene            1..3932
                     /gene="nrde2"
                     /note="NRDE-2, necessary for RNA interference, domain
                     containing; Derived by automated computational analysis
                     using gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 2 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 35 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:101064945"
     CDS             58..3657
                     /gene="nrde2"
                     /codon_start=1
                     /product="protein NRDE2 homolog"
                     /protein_id="XP_011615164.2"
                     /db_xref="GeneID:101064945"
                     /translation="

MRRSVMALFPAFAEVEPKRAESSSKELDWLNNKTFQTGDAISLHNCFLETTKNVRTEKEQSLDSQLSSPHEEQERLLPKKKKKKSEKKRKNKKHKKKSGKYSDSSGSESETIYPSDLKREEENGSQAAPLASSFSWLDDVQLPTAQLFCVDRKPDPANWTYKSLYRGDIAKYRRKGNSSLGLDPRKQEVSWEESQSKKKKKGTNKKAADRYYSAVNRQMLKSEALVSIFPTNSECSGATGPALFLPLTDDQENTKGPPGGDVQSTAVNPLGVYDSSTTLWLQGKGQQVHAEQENLDMKSEPSATPLTGRTEEFNRRLREQPTDTQLWIKFIKFQDELSTTVFGNEEGEQGITSVDCRKSSYRAVLEKKLSIAERAIATNPCSITLQLERLKICQELLEPSVLAKEWKKLVFLHPNSAPLWREYLLFTQSYFSSFAVSKVNAAYGKCLSTLSAVRDGSMVSHPALPGVEEDMLDIFIQQCHFLRQAGHSEKAISLFQAMMDFTFFKPDSVQKLTTKQQVEFFEPFWDSGEARVGEIGARGWKMWMLQQERGGWIQPSEEEEEEEEEDEEEVKDRSQPRHTIWLDVESSREAAHWLPWRPDKAKGQSEEDCEDPDRQVLFDDIGPSLILLPSPELQLRLLVQFLAFLGLPTDFALSAAPRSPDILLENLSLLTHGVDPQRPLTYQDLPDTGVNPVGLMTTLQGNRKWVGLGKQGEKFVANLLKMVQPVLRVDSQTNLALSRVRYEKLKVLRCLCSGNKKRLRSQGKSSKRIAKQLLKESDNRSSLVLWREYGHLEWLIGNLEEARKVFSTAMALGGNKGLRNPALCDLCLLWAQLEVEEVARAPGAGLTDVTASPALHVLTQLAEAASPASQTLSPVSILKARKLYDQALTARLSALDQTRKKGQEDPPGENIRLRGLAGSYALFQYLTVGIQAANAVYSQARERMEALHHSLISNMQNVSEKDDSLARAADASHSEADSSHTQDSVSRLASDCEALAVQQAALLRYHKSVSVFPLATVREMLTSALSTWPTSAPLWSIYVQVENRYHSAGRARRFFHSITRSNSCMVPRLFAIVAEQQRKQLIDAALGSCGPCVALPTLPENGLSNRIRGLFENIVSKEAGSRCPLVWRMYMHFLVSDGKIEKALGIFYKALQNVPWAKGVYMDGVQLFPGRIQEFVDVMTEKELRLRLPIEELDILLEE"

     misc_feature    499..804
                     /gene="nrde2"
                     /note="MTR4-interacting domain (MID) found in nuclear
                     exosome regulator NRDE2 and similar proteins; Region:
                     NRDE2_MID; cd22200"
                     /db_xref="CDD:412062"
     misc_feature    order(499..522,529..534,544..549,553..555,559..603,
                     610..618,622..630,661..669,679..684,688..693,700..720,
                     745..756,775..804)
                     /gene="nrde2"
                     /note="MTR4 binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:412062"
     misc_feature    991..1995
                     /gene="nrde2"
                     /note="necessary for RNA interference; Region: NRDE-2;
                     pfam08424"
                     /db_xref="CDD:462472"
ORIGIN      

tttaaaaaaaagaattttaagtagcattcggattacgtcatattcctgcgactgtttatgcgacgctctgtaatggcgctgtttccagcttttgccgaagtagaacccaaaagagctgaatcttcctctaaagaattagattggctcaataataaaacctttcagactggcgatgccatctctcttcataattgttttttggagacgactaaaaatgtcaggactgagaaggaacaaagtctggacagtcaattaagctcgccacatgaggaacaggaaaggcttctgcccaagaaaaagaaaaagaaaagtgagaagaagaggaagaacaagaaacacaaaaagaaaagtgggaagtattcagacagcagtggctctgaatctgaaaccatttaccccagcgatctcaaaagagaagaggaaaatggatcacaggccgcaccattagcaagcagtttctcctggttggatgacgtccagttacccacagcgcagctgttctgtgtggaccgtaaaccagacccagccaactggacgtataaatccctgtacagaggagacatagcaaagtataggaggaaaggcaactcttctttgggactggacccacgtaaacaagaagtcagctgggaggaatcgcagtcaaagaagaagaagaaaggcacaaacaagaaagcagcggacagatattactctgcagtcaaccgtcagatgctgaagtctgaggcgcttgtttctatatttccaacaaattctgaatgcagtggtgccactggccctgctttatttcttccactgactgatgatcaggagaacacaaaaggaccacctggcggcgatgtgcagtcgacagccgtgaatcctctgggggtgtatgactcctctactaccctctggctccaggggaagggacagcaggtgcatgcagaacaggagaatctggacatgaagtcagagccaagtgcaacacctctgactgggagaactgaagagtttaacaggcggctgagagagcagccaacggacacacagctatggataaagtttataaaattccaggatgagttgagcacaacagtgtttggaaatgaagaaggcgaacaaggtattacttcagttgactgtcgaaagtcttcctaccgagcagtcctggagaaaaagctgagtattgcggagcgtgcaattgccaccaacccctgctccataactctgcagctggagagactcaagatctgccaggaactcttggagccttcagttctggccaaagagtggaagaaactggtgttccttcatccgaacagtgcccccttgtggcgagagtacctactgttcactcagagctacttcagcagtttcgcagtgtcaaaggtcaacgctgcctatgggaagtgtctgagcaccctcagtgcggtgcgtgacggcagcatggtctctcatccagccctgccgggagttgaggaggacatgttggatatcttcatccaacagtgccacttcctccgtcaggctggtcattcggagaaggccatttctctgttccaagccatgatggattttactttttttaaacccgacagcgtccaaaaattgaccaccaagcagcaggttgaattctttgagccattctgggacagtggagaggcgagggttggagagataggagccagaggctggaaaatgtggatgctccagcaagaaagaggcgggtggatacagcccagcgaagaggaagaagaggaggaagaagaggatgaggaggaagtgaaggatcgcagccagccgcgacacacaatctggttggatgtggagtcgtctcgggaggccgctcactggctgccctggaggcctgataaggccaagggtcagtcagaagaggactgtgaggatccagaccgacaggtgctgtttgatgacatcggtccttccctcattttactgccctcaccggagctccagcttcgtcttcttgtgcagtttctggcgttcctggggctgcccactgactttgcgctctctgcagcccctcgtagtcctgacatcctactggagaacctttctctcctcactcacggtgtcgacccccaacgtcctctgacctaccaagacctacccgacactggggtcaaccctgtagggctcatgacaactcttcagggaaacaggaagtgggtagggctcggcaagcaaggagagaaatttgttgccaatcttttaaaaatggtccagcctgttcttcgtgttgactctcaaactaatttagcactcagccgggtgcgctatgaaaaactcaaggtcttgcgctgcctgtgtagtggcaacaaaaagcgcctccgctctcaagggaagagcagcaagcgaatagcaaagcagcttctcaaggagtcagacaaccgctcgtcgctggttctgtggagggagtacggccacctggagtggctgataggcaacctagaagaggctcgcaaagtcttttctacagcaatggcattagggggcaacaaagggttgagaaaccctgctctctgtgacctgtgtctgctgtgggctcagctggaggtggaggaggtagcacgtgcgccgggcgcagggcttacagatgtcactgcgtctccagccctgcatgtgctaacacagctagcagaagcagcatccccagcctcccagaccctgtctccagtttccatcctgaaagcacggaagttatatgaccaggccttgactgccagattatcagctctggaccagaccaggaaaaaaggccaagaggatcctccgggagagaacattaggctcaggggcttggctggaagctatgctcttttccagtacctcacagtgggaattcaagcagctaatgctgtctatagccaggctagagagaggatggaggcgctacaccacagtctgatctccaacatgcagaatgttagcgaaaaagatgacagccttgctcgggccgccgacgccagccactccgaggctgattccagccacacgcaggactcagtgagcaggctggcttctgactgcgaggcactagcagtccagcaggcagcattgctcagatatcataagagtgtcagtgtgtttcccttggcaacagtgagagagatgctgacctctgccctctccacctggcccaccagcgcccctctttggagcatatatgtacaggtggagaatcggtaccacagtgctggtcgtgcacgccgcttttttcattctataactaggagcaacagctgcatggtgccacgcctttttgccattgttgctgaacaacaaaggaagcagttgatagatgctgctctggggtcctgtggcccatgcgttgccttgcccaccctgccagagaatggactcagcaaccgcatacggggattgttcgaaaacatcgtatcaaaagaggccggttctcgctgccctctagtctggagaatgtacatgcacttcctggtttcagatgggaagatagagaaagctctcgggatcttttataaggctttacagaatgtgccctgggccaagggtgtgtacatggacggagtgcagttgttccccgggcgcatacaggagtttgtcgatgtgatgacggagaaagaactccgactgagactgcctatagaagaactggacatactcctggaggagtaaatacacactgtgtgtgtacatcattatatagttctcagaaattagcttggtgtgtcactgttcagtcaataatcattgtcagacatgttgtcagtttcacataaataaaatgcagtacgtttatagtgatacaagaccttttcatttgtctaacctatgtacaagaatatcgggtttaaaatatgcaacagattgatttttagtggtgaatattttaatatacataatttgtcatgaaacggttattgataaagatgcattaaaaagttttaaaa

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