LOCUS       XM_007533088            7478 bp    mRNA    linear   MAM 11-OCT-2023
DEFINITION  PREDICTED: Erinaceus europaeus argonaute RISC component 1 (AGO1),
            transcript variant X2, mRNA.
ACCESSION   XM_007533088
VERSION     XM_007533088.2
DBLINK      BioProject: PRJNA986567
KEYWORDS    RefSeq.
SOURCE      Erinaceus europaeus (western European hedgehog)
  ORGANISM  Erinaceus europaeus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae;
            Erinaceinae; Erinaceus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_080174) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Oct 11, 2023 this sequence version replaced XM_007533088.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_950295315.1-RS_2023_10
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 10/04/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7478
                     /organism="Erinaceus europaeus"
                     /mol_type="mRNA"
                     /db_xref="taxon:9365"
                     /chromosome="13"
     gene            1..7478
                     /gene="AGO1"
                     /note="argonaute RISC component 1; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 4
                     mRNAs, 52 Proteins"
                     /db_xref="GeneID:103122473"
     CDS             252..2825
                     /gene="AGO1"
                     /codon_start=1
                     /product="protein argonaute-1 isoform X2"
                     /protein_id="XP_007533150.1"
                     /db_xref="GeneID:103122473"
                     /translation="

MEAGPSGAAAGAYLPPLQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIKPDKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGEGKDRIFKVSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRNIDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQTVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGGRNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVTHPPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRFKPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKNERIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSHISGQSNGRDPQALAKAVQVHQDTLRTMYFA"

     misc_feature    351..743
                     /gene="AGO1"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:406799"
     misc_feature    771..923
                     /gene="AGO1"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:400854"
     misc_feature    924..1286
                     /gene="AGO1"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(1080..1082,1125..1127,1167..1169,1179..1181,
                     1233..1235,1254..1256,1260..1262)
                     /gene="AGO1"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1419..2696
                     /gene="AGO1"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1830..1832,1842..1844,1878..1889,1896..1898,
                     1920..1922,1929..1931,1941..1943,1953..1955)
                     /gene="AGO1"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(2034..2036,2040..2042,2250..2252,2664..2666)
                     /gene="AGO1"
                     /note="active site"
                     /db_xref="CDD:240015"
     polyA_site      7478
                     /gene="AGO1"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      

cgtccgccccctgggcctggcggtcgcgcctgcgcactagctgctggccgggcgctcgcagggggagctgctgcaggctccgcagcggcggcggcaacggaggcggcgggggcgacggtgcgagcggccgggcttggggggggagccgagcccggcccgggagcccgaggaggtagggcccgggctacctaggcccctcacgctggattccacagactctgggccgcctgacctccgcacgggtatatgggatggaagcgggaccctcgggagcagctgcgggcgcctacctgccccctctgcagcaggtgttccaggcacctcgccgaccgggcattggcactgtggggaaaccaatcaaactcctggccaattactttgaggtggatatcccgaagattgatgtataccattatgaggtggatatcaaaccagataaatgtccccgaagagtcaaccgggaagtggtggaatacatggtccagcatttcaagcctcagatctttggtgatcgcaagcctgtatatgatggaaagaagaacatttacactgttacagcactgcccattggaaatgaacgagttgactttgaggtgactatccctggagaagggaaggatcggatattcaaggtttccatcaaatggcttgccatcgtgagctggcgtatgctgcatgaggccctagtcagcggccagatccctgttccgctggagtctgtgcaagccctggatgtggccatgaggcacttggcatccatgaggtacaccccagtgggccgctccttcttctcaccgcctgagggctactaccacccgctggggggtgggcgcgaagtctggttcggctttcaccagtctgtgcgccctgccatgtggaagatgatgctcaacattgatgtctcggccactgccttctacaaggcgcaaccagtgattgagttcatgtgtgaggtgctggacatcaggaacatagatgaacagcccaagcccctcacagactctcagcgtgtgcgcttcaccaaggagatcaagggcttgaaggtggaagtgacccactgtgggcagatgaagaggaaataccgagtatgtaatgttacccgacgccctgcgagccatcagacgtttcccttgcaactggagagtggacagactgtggagtgcacagtggcacagtatttcaagcagaaatataaccttcagctcaagtatccccacctgccctgtctgcaagttggccaggaacaaaagcatacctacctacccctagaggtctgtaacattgtggctgggcagcggtgcatcaagaaactgacagataaccagacatcaaccatgataaaggctacagctaggtcggctcctgacagacaggaagagatcagccgactgatgaagaatgccagctataacctagatccctacatacaggaatttgggatcaaagtgaaggacgatatgacggaggtgacagggcgcgtgctgccggcgcccatcttgcagtacggcggccggaaccgggccattgctacacccaatcagggtgtctgggacatgagggggaaacagttctacaatgggattgagatcaaagtctgggccatcgcctgcttcgcaccccaaaaacagtgccgagaagaggtgctcaagaacttcacagaccagctgcggaagatttccaaggacgcagggatgcccatccagggccagccttgcttctgcaaatatgcacagggggcagacagtgtggagcccatgttccggcatctcaagaatacctattcagggctgcagctcatcatcgtcatcctaccaggaaagacgccagtatatgctgaggtgaaacgtgttggagatacactcttgggaatggctacacagtgtgtacaagtgaagaacgtggtcaagacttcacctcagactctatccaatctctgcctcaagatcaatgtcaaacttggtggcatcaacaacatccttgtcccacaccagcgctctgctgtttttcagcagccagtgatattcctgggagcagatgttacacaccccccagcaggagatgggaaaaagccttctatcacagcagttgtaggcagtatggatgctcaccccagccgttactgtgctactgtgcgggttcagcgaccgcggcaggaaatcattgaagacttatcttacatggtgcgagagctgctcattcagttctacaagtccacccgtttcaagcctactcgcattatcttctaccgagatggggttcctgaaggccaacttcctcagatccttcactatgagctgctggccattcgtgatgcctgcatcaaattggagaaggactaccagcctgggatcacatatattgtggtgcagaaacgccatcatacccgccttttttgtgctgacaagaatgagcgaattgggaagagtggtaacattccagctgggaccactgtggacaccaatatcacccatccatttgaatttgacttttatttgtgcagccacgcaggcatccagggtaccagcagaccatcccattactatgtcctttgggatgacaaccgtttcacagcagatgagctccagatcttgacataccagttgtgccacacttatgtacgatgcacacgctccgtctctattccagcacctgcctattacgcccgcttggtggctttccgggcacggtaccacctggtggacaaggagcatgacagtggagaggggagccacatatcagggcagagcaatgggcgggacccccaggccctggccaaagctgtgcaggttcatcaggatactctacgcaccatgtactttgcttgaaggcagaacgctgttacctcactggatagaagaaagcttttcaagccccaagagctgtgccgcccaaatccagaggaagcagggaagatggaggtggggtagggaggagtacagaaggccttgattccttctcagaggggactaacaggtggggagcaaggcctgtaagtcagaccaccagccagaaatctctgatatccacctcatgcccccccacacccctcaccgcatcttgtcacatctggccctgaccccactggaccaagaggggcagcaccggtgcccaccatacacacaggtgtctcatgtgactcacagtgctaaagactcatgcctgacagcttggtaaggttggttgtgcagccctgcggacaaaagctggtaggtttgagtttgatatattagatgggaaaatgaggggcttgaggcagcgggtaggaggagaggatgattttttaggagccttaatcagaaaaggtctagatttgtttaagaagaaaaatgaaaccagacccagattgatattttaggatactagatgttttaatggtgtgagaatcaagtttataggaagatttttaatgctaatggttttggttcctcttcccccagctgccacttcctttacccttaattcctttctccccaccttttctacccctcctccttagacctcctccctggcagacacccagccctatggcactatggcacttagctctgaagtgacatgaccctgtcttccttccgcctgctggtgggcaaccagtgccttccctgtaatggtaatgctgcagaactgcaaccttttgtacctttcttgtgagggtgggggtagggtggggaggggtggggagggagagaggaggtaggtgggggataagcctaactcaacaggtttccagctattttgcatttgaaggatttgacttccacattcattaagcttttttaaaagaccacaacctcagatggttaaaaatccattgacatttgcactttcagacataacaagtctccaagctgctgagatgactgacccctggtctttccacttaggtctcctttttcactgtcctccctcctccccaaccttcctgggtctggagttacttgagtagaatttctcactgttgggattccccctcccccaagggtcaaatctcttatgcttcaatatttcttaactggggtatcatataacaaaatcctgaagtaaaacgagcaaaatctaaatgttatttttataccataacttgagtctattgccaaaatctgcaaatccttcccatgcctgatgagtttacatcgcagaaacattgagccatcagaaggaactttacttgttctttggcttgacttggaaagaggtggttatctctcaaaggtgggactcaggctccactcttcctctgtgtagaaaaataccttttcttactataattccttcctctgcactgccctgcgctcttctatacaagtgcatttttccttcctctgaactgtcctctaacatgtcggcgcatcccaaactctaatgtgtcctgtggacaggctgagatattttgctgctccccgattgcttctgtttacagaaatgaatttctcctggtttcctactagggcatgtaagtgggtggcatgggatttttccccccccttctcctctcgcctagatagagagaagggtttgactgttctgcagaactggaaaagtacggggttctggcttggtgcctgttggccttgaagcaggaccccgtcttttcatgactgtttgttgtatcctgtcccacttcttgggattaggagttgcagtttccatgtagaaacttctctttttgaggagcctaaatttcggtttgcccccaaatggtgatgaagccatgtcactttaggcctgtccctgacttggaggcctgctggaggaagccctgaatcctgacctgtgcagttagagccaccatttccccttttcctgcaacccatgtacagactcagatttgctatgcaaaacagactatcccaggttgggttctggttggctactttgttcaatgagttcacaaaatgtagcacaaacactgactatagtgaaggcattgggactgttgagtaattcctcctttacccctttcctgccacctacagcatagggttccccctgggcctagcccagctgaagaacagaacagagggctctaggagggggtgactcactggagagcctacattccttacacaagtgcctacagagagtgatgccaacactccatctgccctgttcattgccttcatatactgtctacttcgtgttcagtcaccctttggagagaggagctcttgggacagcgggctctgcacattctcttcttgggtacattttaggactggtatcagggcactattcctggagggtccagtcattcaccagcatttgcaaatgtcaatagggagctggtagtagctaccagctcagcaacaaatgtgtgttctctccttttctttccttgctctactttcctcgtttgaattttagctggaatttgaaatacattttttagccctctggcagtgtgcatgccattcaagaaataaaagcaagacaggcagcttgggcaacgtcaaggaaataaactgcttagatttttttatttatatatattttaatttttgagacttgaaaaatacttttgaccttgaggatcattgcttgcaaggtggtgcatgcagaataagaagtgataatggcaataagctttggctttcttggcttggtttaagtggtgcttcttacttaaactccgagaaagctatggggagaccctggcctcattctctttgacagatcccttgctcccttcattccactcttgtcttccatttccttttcagtctctccctggcttccttgtcttttttctatttactcagcttgcttgctggcctgctgacctgttggcctgtctgcctatgtgatgatgaattctctgcatggctacaatgatcccactgttagctggcaaggtcagactttagcaccttgactgcagaaaacaaagcatctgttcctcaaaactagtgatcctgtctgggttgggctatcctcagacttacacaaggatggagccagcagatctgcctaactagcatgcaatcaggaggactggtggcaacttccatacctttccaccccttggagttggtttcctttgttgctatttctggatctggttctagttctctgtggaccttcatctatgggggtgtcccaaggatatgtgagataggaagactagggaatggagatgggatgagaagagaatgatggaaagacaatggaaagataaaaagtaggaaaggagaacactgctcactaataatttttccagtccagcctgagccattaggggttgaggtgctactaatagtctctggggacaagtctggggctgttattgctgagaatttagacttcgaataatgcagaagaaagtacccacaagtgtgaaacctcccctctaatctcaatctcctggttcccacctactagatagcttcccctgtagcgtcttctttggccacaccacaatgtcctttgataggtttccctttctcctctatagttccacacatgaggctagcacccaatgtgggcagccatagggagggagggatacatggacttattagctggcccatggggtgtctgtaagactggtgagacagtttttagatttggcatcatatgtgatcaagaaggatggaagttccttccccctcagggaggaaaagtcatctcaaactagccaaaatacaattttggaaactatattggggggagaagtgttttatttatatttacgtgacgtaggccaatccaggatggtggctgggatgtcttccttcttaaagtctgatcatggcagggatatgcagggcactctttcctatttggccttctcagctgattgaggagaagagataactgtttttctctatctcctcattttaataaatgaggacttggccgtctcccatgggtcgggagagaggctaggttggtgctcttccctttatatctactcctactgatttagaacctctggctgctgttcgggagcccaatcaagggagtggaaggaatgggctcaatacaaaacaagaaaaccagaataaggtggggaaggcagattttttttttttaatataaaggaaaataggaaaccctccaaggattgtgcaaataaagacaatgtgttgaatgcactgagtcccctggtgtagtagcaataaggaaaaatgcattaattttcctgtgcacacagtccaagctctttggtgtgtgatgttgcacttagcagccatctggtgggcatgtgtgactactctgggttccactttagtttctaaactttttatccctctgaagttcagcatggatgggggaatgttcctggagccccaaagctgtatacttgtttgcatttgtttccccttgagacttgtgtttgtgtcttgctttgagctgtaccttgtccagtccattgtaaaattactccaacagtggtaatgtacagttccttctgaaacaagcaaaagcagcagcacaactctgttttataaagacaacagtggcttctatttctaaaa

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