LOCUS       NM_204559               2289 bp    mRNA    linear   VRT 23-SEP-2023
DEFINITION  Gallus gallus msh homeobox 2 (MSX2), mRNA.
ACCESSION   NM_204559
VERSION     NM_204559.2
KEYWORDS    RefSeq.
SOURCE      Gallus gallus (chicken)
  ORGANISM  Gallus gallus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
            Phasianidae; Phasianinae; Gallus.
REFERENCE   1  (bases 1 to 2289)
  AUTHORS   Tang H, Finn RD and Thomas PD.
  TITLE     TreeGrafter: phylogenetic tree-based annotation of proteins with
            Gene Ontology terms and other annotations
  JOURNAL   Bioinformatics 35 (3), 518-520 (2019)
   PUBMED   30032202
REFERENCE   2  (bases 1 to 2289)
  AUTHORS   Burge S, Kelly E, Lonsdale D, Mutowo-Muellenet P, McAnulla C,
            Mitchell A, Sangrador-Vegas A, Yong SY, Mulder N and Hunter S.
  TITLE     Manual GO annotation of predictive protein signatures: the InterPro
            approach to GO curation
  JOURNAL   Database (Oxford) 2012, bar068 (2012)
   PUBMED   22301074
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2289)
  AUTHORS   Sumoy L, Wang CK, Lichtler AC, Pierro LJ, Kosher RA and Upholt WB.
  TITLE     Identification of a spatially specific enhancer element in the
            chicken Msx-2 gene that regulates its expression in the apical
            ectodermal ridge of the developing limb buds of transgenic mice
  JOURNAL   Dev Biol 170 (1), 230-242 (1995)
   PUBMED   7601312
REFERENCE   4  (bases 1 to 2289)
  AUTHORS   Robert B, Lyons G, Simandl BK, Kuroiwa A and Buckingham M.
  TITLE     The apical ectodermal ridge regulates Hox-7 and Hox-8 gene
            expression in developing chick limb buds
  JOURNAL   Genes Dev 5 (12B), 2363-2374 (1991)
   PUBMED   1684333
REFERENCE   5  (bases 1 to 2289)
  AUTHORS   Yokouchi Y, Ohsugi K, Sasaki H and Kuroiwa A.
  TITLE     Chicken homeobox gene Msx-1: structure, expression in limb buds and
            effect of retinoic acid
  JOURNAL   Development 113 (2), 431-444 (1991)
   PUBMED   1685987
REFERENCE   6  (bases 1 to 2289)
  AUTHORS   Coelho CN, Sumoy L, Rodgers BJ, Davidson DR, Hill RE, Upholt WB and
            Kosher RA.
  TITLE     Expression of the chicken homeobox-containing gene GHox-8 during
            embryonic chick limb development
  JOURNAL   Mech Dev 34 (2-3), 143-154 (1991)
   PUBMED   1680378
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAENSK010000256.1.
            
            On Sep 23, 2021 this sequence version replaced NM_204559.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13267654.21203.1,
                                           SRR13267659.273418.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA103992323, SAMEA103992393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-440               JAENSK010000256.1  8006663-8007102
            441-2289            JAENSK010000256.1  8010597-8012445
FEATURES             Location/Qualifiers
     source          1..2289
                     /organism="Gallus gallus"
                     /mol_type="mRNA"
                     /db_xref="taxon:9031"
                     /chromosome="13"
                     /map="13"
     gene            1..2289
                     /gene="MSX2"
                     /gene_synonym="HOX-8; HOX8; Msx-2"
                     /note="msh homeobox 2"
                     /db_xref="CGNC:66198"
                     /db_xref="GeneID:395245"
     exon            1..440
                     /gene="MSX2"
                     /gene_synonym="HOX-8; HOX8; Msx-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..865
                     /gene="MSX2"
                     /gene_synonym="HOX-8; HOX8; Msx-2"
                     /note="homeobox-containing Hox-8; CHOX-8; GHox-8; homeobox
                     protein Hox-8; msh homeobox homolog 2; msh homeo box
                     homolog 2"
                     /codon_start=1
                     /product="homeobox protein MSX-2"
                     /protein_id="NP_989890.1"
                     /db_xref="CGNC:66198"
                     /db_xref="GeneID:395245"
                     /translation="

MASPSKAKEVFSSDEEGPAAGAEEHHKVKVSSLPFSVEALMSDKKPPKELPLAAAGGSADGATVGTSRNLLLPGHGSRDAHSPPGALTKTFDTASVKSENSEDGTSWIQEAGRYSPPPRHLSPTACTLRKHKTNRKPRTPFTTSQLLALERKFRQKQYLSIAERAEFSSSLNLTETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPMLPSGFSLPFPINSPIQAASLYGTSYPFHRPVLPIPPVGLYATPVGYSMYHLS"

     misc_feature    86..172
                     /gene="MSX2"
                     /gene_synonym="HOX-8; HOX8; Msx-2"
                     /note="propagated from UniProtKB/Swiss-Prot (P28362.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    224..457
                     /gene="MSX2"
                     /gene_synonym="HOX-8; HOX8; Msx-2"
                     /note="propagated from UniProtKB/Swiss-Prot (P28362.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    order(488..502,506..508,557..559,575..577,614..616,
                     620..625,632..637,641..649,653..658)
                     /gene="MSX2"
                     /gene_synonym="HOX-8; HOX8; Msx-2"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    494..655
                     /gene="MSX2"
                     /gene_synonym="HOX-8; HOX8; Msx-2"
                     /note="Homeobox domain; Region: Homeobox; pfam00046"
                     /db_xref="CDD:425441"
     misc_feature    order(494..496,503..505,623..625,632..637,644..646)
                     /gene="MSX2"
                     /gene_synonym="HOX-8; HOX8; Msx-2"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     exon            441..2289
                     /gene="MSX2"
                     /gene_synonym="HOX-8; HOX8; Msx-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

actcgcgcagtccccgcgcagggccgggcagaggcgcagcgcagctccccgggcggccccgctccagccacgctccgcattcgcgatggcttctccttccaaagcgaaggaggttttctcctccgacgaggagggcccggcggccggcgccgaggagcaccacaaagtcaaggtgtccagcttgccgttcagcgtggaagccctcatgtccgacaagaaaccccctaaagagctgccgctggccgcggcggggggcagcgccgacggggcgaccgtgggcacctccaggaacctgctgctgccgggccacggctcccgggacgcgcacagcccccccggggctcttacaaaaaccttcgacaccgcttcggtcaaatcggagaactcggaggacggcacgtcctggatccaagaggccgggagatattcgcctcctccaagacacctgagccctacagcctgcactctgaggaagcacaagacgaatcggaagccccgcaccccattcactacttcccagctgctggccctggagcgcaagttccgccagaagcagtacctgtccatcgccgagcgagccgaattctccagctccctcaacctcacagagacccaggtcaaaatctggttccaaaatcggagggccaaggccaagagactgcaggaggctgagctagagaagctcaaaatggcagcgaagccaatgttgccgtcggggttcagcctccctttccccatcaactcccccatccaggccgcctcactgtacggaacatcctacccttttcacagacctgtgcttcctatcccgcccgttggactctatgctactcctgtcggatatagcatgtaccacttatcttaaggagatcagaaaggcacagtgacagcgagagagacttcctggtggatctcatccagcctcaagaatgcagtacccaaccggtactggccgttctttctgcacgcttctatctgccatcccgagtgtacaggagttcgcgttagcaaagcaaggcatcctgtatgcaacaggctgggtgtcttctgagagcgctctgagtgctcacagtctgatcctcagagtgtttaaaaaaaaaaaaaaagtaaaaacgatttaaaaaaaaaaattgagcaactgtagggtttttatacggtgcatgtaaaattagggtgagaaagaacgggtggaaaaaacaatcttgccttacggaggcagggatttcccaacagcttcctgatggggcccaagctgtgtttaaagtaaaaggggtacgtgccctaaatccacactctcaagtgtcatcatttaatatgggggcaaggggagtgaaataaaaagctataagcaaggtgggttgggggggggggttgttttcttttgttgctgtcgtttaaagaaagcggagcccttagatacagacaccgtgtaaatagaagctagacccagtagagtccaagtgaagttcagagccagcaagttcctgcctttctaagggtaaggaaagcttttcacatcccagacctccgcagaccttttgcgacaagatgagcatcggggcccctaaatgcgtagtgtaaagcaacggctttacccaccagtggctcttgtaatgcttttatgtgtgtaaatcgcttcagcgtttctaaagcactgtgaggagaggtgaagcgcaaggcaggctgctctttatctctcccgattggcgcgcgtagagtatttttttcttgcagccaggtaatcttggctctgcaatgcttcttgaaaaccaggagggagggaaggaagtttctggggaaagaagacgtgggttgtttccacagtggtggtgagcaagggctgtcgaactcttctgcggagatgtttggggttttttattagtatctgcaacagtctgtattaaatagaagaatccctcgagtcttcctctcctccccttgccaaggatgccaactgaagtgactcatgcttcaagcccttctaaagagagatccgggtatcaaaagcagacaacgctacctgtgggacggtggggtgccaagagactgtgtaagcaacctgtccctgtgggagcttcccaagtgctggcagtgtcatcgtccccggtattctccttgtaattattgtattatgtgtattactcttgctaaactttgtgagaaaattactctgaaggctgtggagcactgaaggcagagcttctcctggatttattttcttagcatgttgataagaaaccctcctccgccccactccccctcacccccaccccccaaaaaatagaaaaa

//