LOCUS       NM_131637               1968 bp    mRNA    linear   VRT 25-JUN-2025
DEFINITION  Danio rerio claudin 7b (cldn7b), mRNA.
ACCESSION   NM_131637
VERSION     NM_131637.3
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1968)
  AUTHORS   Jedrychowska,J., Vardanyan,V., Wieczor,M., Marciniak,A., Czub,J.,
            Amini,R., Jain,R., Shen,H., Choi,H., Kuznicki,J. and Korzh,V.
  TITLE     Mutant analysis of Kcng4b reveals how the different functional
            states of the voltage-gated potassium channel regulate ear
            development
  JOURNAL   Dev Biol 513, 50-62 (2024)
   PUBMED   38492873
REFERENCE   2  (bases 1 to 1968)
  AUTHORS   Mi,J., Liu,K.C. and Andersson,O.
  TITLE     Decoding pancreatic endocrine cell differentiation and beta cell
            regeneration in zebrafish
  JOURNAL   Sci Adv 9 (33), eadf5142 (2023)
   PUBMED   37595046
REFERENCE   3  (bases 1 to 1968)
  AUTHORS   Lu,F., Leach,L.L. and Gross,J.M.
  TITLE     A CRISPR-Cas9-mediated F0 screen to identify pro-regenerative genes
            in the zebrafish retinal pigment epithelium
  JOURNAL   Sci Rep 13 (1), 3142 (2023)
   PUBMED   36823429
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1968)
  AUTHORS   Zhang,F.L., Yang,Y.L., Zhang,Z., Yao,Y.Y., Xia,R., Gao,C.C.,
            Du,D.D., Hu,J., Ran,C., Liu,Z. and Zhou,Z.G.
  TITLE     Surface-Displayed Amuc_1100 From Akkermansia muciniphila on
            Lactococcus lactis ZHY1 Improves Hepatic Steatosis and Intestinal
            Health in High-Fat-Fed Zebrafish
  JOURNAL   Front Nutr 8, 726108 (2021)
   PUBMED   34722607
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1968)
  AUTHORS   Phatak,M., Kulkarni,S., Miles,L.B., Anjum,N., Dworkin,S. and
            Sonawane,M.
  TITLE     Grhl3 promotes retention of epidermal cells under endocytic stress
            to maintain epidermal architecture in zebrafish
  JOURNAL   PLoS Genet 17 (9), e1009823 (2021)
   PUBMED   34570762
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1968)
  AUTHORS   Gallardo,V.E., Liang,J., Behra,M., Elkahloun,A., Villablanca,E.J.,
            Russo,V., Allende,M.L. and Burgess,S.M.
  TITLE     Molecular dissection of the migrating posterior lateral line
            primordium during early development in zebrafish
  JOURNAL   BMC Dev Biol 10, 120 (2010)
   PUBMED   21144052
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1968)
  AUTHORS   Clelland,E.S. and Kelly,S.P.
  TITLE     Tight junction proteins in zebrafish ovarian follicles: stage
            specific mRNA abundance and response to 17beta-estradiol, human
            chorionic gonadotropin, and maturation inducing hormone
  JOURNAL   Gen Comp Endocrinol 168 (3), 388-400 (2010)
   PUBMED   20553723
REFERENCE   8  (bases 1 to 1968)
  AUTHORS   Davey,C., Tallafuss,A. and Washbourne,P.
  TITLE     Differential expression of neuroligin genes in the nervous system
            of zebrafish
  JOURNAL   Dev Dyn 239 (2), 703-714 (2010)
   PUBMED   20063411
REFERENCE   9  (bases 1 to 1968)
  AUTHORS   Reischauer,S., Levesque,M.P., Nusslein-Volhard,C. and Sonawane,M.
  TITLE     Lgl2 executes its function as a tumor suppressor by regulating ErbB
            signaling in the zebrafish epidermis
  JOURNAL   PLoS Genet 5 (11), e1000720 (2009)
   PUBMED   19911055
REFERENCE   10 (bases 1 to 1968)
  AUTHORS   Loh,Y.H., Christoffels,A., Brenner,S., Hunziker,W. and Venkatesh,B.
  TITLE     Extensive expansion of the claudin gene family in the teleost fish,
            Fugu rubripes
  JOURNAL   Genome Res 14 (7), 1248-1257 (2004)
   PUBMED   15197168
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000010.1.
            
            On Jun 25, 2025 this sequence version replaced NM_131637.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ011788.1, BC066408.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA3505372,
                                           SAMEA3505373 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-399               JBMGRA010000010.1  27046352-27046750   c
            400-564             JBMGRA010000010.1  27044240-27044404   c
            565-649             JBMGRA010000010.1  27043892-27043976   c
            650-1968            JBMGRA010000010.1  27041208-27042526   c
FEATURES             Location/Qualifiers
     source          1..1968
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="10"
                     /map="10"
     gene            1..1968
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /note="claudin 7b"
                     /db_xref="GeneID:60635"
                     /db_xref="ZFIN:ZDB-GENE-001103-5"
     exon            1..399
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    159..161
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /note="upstream in-frame stop codon"
     CDS             177..824
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /note="claudin-like protein ZF4A22; claudin-7"
                     /codon_start=1
                     /product="claudin-7-B"
                     /protein_id="NP_571712.1"
                     /db_xref="GeneID:60635"
                     /db_xref="ZFIN:ZDB-GENE-001103-5"
                     /translation="

MAHKGLQLLGFTLSLLGLIGLIIGTIMPQWKMSAYVGDNIITAIAMYQGLWMSCAYQSTGQQQCKVYDSVLQLDSALQATRALMVVAILLTVAGLGVASMGMKCTNCGGDDKVKKSRIAMTGGIILSVGALCSIVACGWFTSQIIRDFYNPFTPVNTKYEFGAAIFIAWAGAFLDIMGGGMLASSCSKGQSSPNYPKSSRPVKSSRPPSSSKEYV"

     misc_feature    186..722
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; pfam00822"
                     /db_xref="CDD:395662"
     misc_feature    198..260
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9YH92.1);
                     transmembrane region"
     misc_feature    420..482
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9YH92.1);
                     transmembrane region"
     misc_feature    528..590
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9YH92.1);
                     transmembrane region"
     misc_feature    663..725
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9YH92.1);
                     transmembrane region"
     misc_feature    732..821
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9YH92.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            400..564
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /inference="alignment:Splign:2.1.0"
     exon            565..649
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /inference="alignment:Splign:2.1.0"
     exon            650..1968
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

tgcggcttcggtgaacaggtgtttgagtcagggcttctccgatttttatttacattttaaacttattttattattttgaccaattcataatcggaaggctgctgaaagcgagcgatatttggacactaataagttatttgctaagcaggtttagtttttaaactcattctgagaagatggcacataaaggactgcaactcctagggtttactctatcgttgctagggttgattgggctcattattggcacaatcatgccccagtggaagatgtctgcttacgttggagataatataatcacagctattgcgatgtaccagggcctttggatgtcgtgcgcttaccagagcaccggccaacagcaatgcaaggtgtatgactccgtcctacaactcgacagtgctctccaggcaactcgtgcccttatggttgtagcaattcttcttacagtagctggactgggtgtggccagcatgggcatgaagtgtactaactgtggtggtgatgacaaggtcaaaaagtcccgcattgccatgacaggcggtataatcctctctgttggagccctctgtagcattgttgcctgtggctggtttacaagtcaaattatcagggatttctacaaccccttcacacctgtcaatacaaagtatgaatttggtgcagctattttcatcgcctgggctggtgcatttctcgatataatgggtggaggcatgttggcctcttcttgctcaaagggtcagtcatctcctaattaccctaagtcctccagacccgtcaagtcctccagaccacccagcagcagcaaggaatatgtttgagccatttgttcacgagctggaaaggacatgatcaatcccagagcatgggtagaagtttgccctgtcagctgatatgagatctgtttaatttggtttgtatgtttgactatagatagaaaaaacagctcagaaaggtatttttggccaacttttacttgtgttctgatacagcagcccaccaaaaatggtcacttctttcttttggttagctccttgttccaccttccccaccccgattataaaatgtgagtttgcaaaggggcttcttccccagagtcttcctcatttcagattactgtcacctttagtgaacatgaaagagggagacctgctcagggaaaaatcattactcatactgctctgttacaccacatctctgcttccagctgttaaacccttgcttgcatcattttaggaactgcgccagacactgaggtgcttatgaacaattaatacatgcattacatttttaaagctaagagtaacatgcaaataacctggttcactttgcagtcttttccctgtctggtccccatgccagcagaaacttttttcatacttcattttatacaaattagcaccctttaggtgaagtttcactcgtaagttcaatgaatcattcttttcagtgtatgctgatgaagctggattaaaactttagatggaaaaatgaagattaatttggtttggatgaggcttaacatgaagcactaaaatcaaattgctctttcttatgcaacatgaaccttttgatttgctgttgtcctttgttttgagtgtacaccttggtttttgtgcccatttaggaaggtaacatgttttttgtttttatacactccattaattggtcacaaaaaagctgtgaatattggcttagttgaatcactgctggttccaactatttttatgttaatgtaaaacttttttttatccataatatgaacatttaaaactggactatacttttttttttttttgctttggtctgtgcttgaaccatttgatgtgggttgcactcaagtctacttaggatagagtcacgtgaatgtctgtgactagcttatgcaaatatttaactttttaaaatgtttttgacttcaagtttgcaattgaaaaattttatgtaaataaattttttaaacag

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